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CDC14 cell division cycle 14 homolog B

CDC14B, hCdc14B
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Cdc14, PCNA, CDC2, E-cadherin, APC
Papers using CDC14B antibodies
Proteomic analysis of tardigrades: toward a better understanding of molecular mechanisms by anhydrobiotic organisms.
Supplier
Arkowitz Robert Alan, In PLoS ONE, 2009
... Human cDNAs encoding hCdc14A and hCdc14B (accession numbers AF064102.1 and AF064104.1)
Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication
Supplier
Wang Yisong et al., In The Journal of Cell Biology, 2003
... VS experiment, Cdc14B-GFP stable clones were treated with 1 μM of Z-L3VS (BIOMOL International, L.P.) in the ...
Papers on CDC14B
Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.
New
Zhang et al., Houston, United States. In Mol Cell Biol, Nov 2015
In mammals, the two Cdc14 homologues, Cdc14A and Cdc14B, have been proposed to regulate DNA damage repair, whereas the mitotic exit and cytokinesis rely on another phosphatase, PP2A-B55α.
Control of the pericentrosomal H2O2 level by peroxiredoxin I is critical for mitotic progression.
New
Rhee et al., Seoul, South Korea. In J Cell Biol, Aug 2015
In this paper, we show that reversible oxidative inactivation of centrosome-bound protein phosphatases such as Cdc14B by H2O2 is likely responsible for this inhibition.
Cooperative Action of Cdk1/cyclin B and SIRT1 Is Required for Mitotic Repression of rRNA Synthesis.
New
Grummt et al., Heidelberg, Germany. In Plos Genet, May 2015
Upon exit from mitosis, T852 is dephosphorylated by Cdc14B, which is sequestered in nucleoli during interphase and is activated upon release from nucleoli at prometaphase.
Global Characteristics of CSIG-Associated Gene Expression Changes in Human HEK293 Cells and the Implications for CSIG Regulating Cell Proliferation and Senescence.
Tong et al., Beijing, China. In Front Endocrinol (lausanne), 2014
Furthermore, we investigated the correlated expression patterns of Cdc14B, ESCO1, KPNA5, MAP3K3, and CSIG during cell cycle and senescence progression, which imply the important pathways CSIG regulating cell cycle and senescence.
Loss of CDC14B expression in clear cell renal cell carcinoma: meta-analysis of microarray data sets.
Kim et al., Ansan, South Korea. In Am J Clin Pathol, 2014
The most downregulated gene was validated in paired 80 ccRCC tissues by immunohistochemistry. RESULTS: CDC14B was the most downregulated gene among 1,761 DEGs.
An efficient fluorescent protein-based multifunctional affinity purification approach in mammalian cells.
McCollum et al., Worcester, United States. In Methods Mol Biol, 2013
Here we describe the general MAP purification method in detail, and show how it can be applied to a specific protein using the human Cdc14B phosphatase as an example.
Functional redundancy between Cdc14 phosphatases in zebrafish ciliogenesis.
Gould et al., Nashville, United States. In Dev Dyn, 2012
In vertebrates, CDC14 paralogs, CDC14A and CDC14B, have so far been implicated in processes ranging from DNA damage repair, meiosis, centrosome duplication to ciliogenesis.
Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression.
GeneRIF
Dong et al., Omaha, United States. In Biochem J, 2012
CDC (cell division cycle) 14A/B phosphatases associate with KIBRA, and CDK1-non-phosphorylatable KIBRA has greatly reduced interaction with CDC14B.
Multiple protein kinases influence the redistribution of fission yeast Clp1/Cdc14 phosphatase upon genotoxic stress.
Gould et al., Nashville, United States. In Mol Biol Cell, 2012
Clp1/Flp1, the Schizosaccharomyces pombe Cdc14 orthologue, and Cdc14B, a mammalian orthologue, also exit the nucleolus during interphase upon DNA replication stress or damage, respectively, implicating Cdc14 phosphatases in the response to genotoxic insults.
The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway.
GeneRIF
Malumbres et al., Madrid, Spain. In Cell Cycle, 2011
Cdc14B has oncogenic activity in mammals and point to the Ras-MAP kinase pathway as a major effector pathway during oncogenic transformation.
Early-onset aging and defective DNA damage response in Cdc14b-deficient mice.
GeneRIF
Zhang et al., Houston, United States. In Mol Cell Biol, 2011
Cdc14b is required for efficient DNA damage repair.
The DNA damage effector Chk1 kinase regulates Cdc14B nucleolar shuttling during cell cycle progression.
GeneRIF
Zhang et al., Houston, United States. In Cell Cycle, 2011
studies have revealed a novel interplay between Chk1 kinase and Cdc14B phosphatase involving radiation-induced nucleolar shuttling to facilitate error-free cell cycle progression and prevent genomic instability
Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity.
GeneRIF
Voit et al., Heidelberg, Germany. In Plos One, 2010
Cdc14B-dependent modulation of Cdc25 phosphatase and Cdk1/cyclin B activity is linked to correct chromosome segregation and bipolar spindle formation, processes that are required for proper progression through mitosis and maintenance of genomic stability.
Cdc14: a highly conserved family of phosphatases with non-conserved functions?
Review
Schiebel et al., Heidelberg, Germany. In J Cell Sci, 2010
Human CDC14B is even able to fulfill the essential functions of budding yeast Cdc14.
Prophase I arrest and progression to metaphase I in mouse oocytes: comparison of resumption of meiosis and recovery from G2-arrest in somatic cells.
Review
Motlik et al., Czech Republic. In Mol Hum Reprod, 2010
These common features include CDC14B-dependent activation of APC-CDH1 in prophase I arrested oocytes or G2-arrested somatic cells, and CDC25B-dependent cell cycle resumption in both oocytes and somatic cells.
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.
Impact
GeneRIF
Pagano et al., New York City, United States. In Cell, 2008
In response to genotoxic stress in G2, the phosphatase Cdc14B translocates from the nucleolus to the nucleoplasm and induces the activation of the ubiquitin ligase APC/C(Cdh1), with the consequent degradation of Plk1, a prominent mitotic kinase.
Cdc14B and APC/C tackle DNA damage.
Impact
Visintin et al., Milano, Italy. In Cell, 2008
Mitotic exit in budding yeast is regulated by the proteins Cdc14, APC/C(Cdh1), and Plk1.
Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation.
Impact
Lukas et al., Copenhagen, Denmark. In Nat Cell Biol, 2002
Disrupting the nuclear export signal (NES) led to Cdc14A being localized in nucleoli, which in unperturbed cells selectively contain Cdc14B (ref.
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