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CDC14 Cdc14p

Cdc14, Cdc14p, Cdc14A
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, CAN, CDC2, CDC14B, Cdc7
Papers on Cdc14
Human phosphatase CDC14A is recruited to the cell leading edge to regulate cell migration and adhesion.
Schiebel et al., Heidelberg, Germany. In Proc Natl Acad Sci U S A, Feb 2016
Thus, we have uncovered an unanticipated role for hCDC14A in cell migration and adhesion that is clearly distinct from the mitotic and cytokinesis functions of Cdc14/Flp1 in budding and fission yeast.
FgCDC14 regulates cytokinesis, morphogenesis, and pathogenesis in Fusarium graminearum.
Xu et al., China. In Mol Microbiol, Nov 2015
Members of Cdc14 phosphatases are common in animals and fungi, but absent in plants.
Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.
Zhang et al., Houston, United States. In Mol Cell Biol, Nov 2015
In mammals, the two Cdc14 homologues, Cdc14A and Cdc14B, have been proposed to regulate DNA damage repair, whereas the mitotic exit and cytokinesis rely on another phosphatase, PP2A-B55α.
Dephosphorylation of Iqg1 by Cdc14 regulates cytokinesis in budding yeast.
Shannon et al., West Lafayette, United States. In Mol Biol Cell, Sep 2015
The Cdc14 phosphatase is required for normal cytokinesis and acts on specific Cdk phosphorylation sites.
Oncoprotein YAP regulates the spindle checkpoint activation in a mitotic phosphorylation-dependent manner through up-regulation of BubR1.
Dong et al., Omaha, United States. In J Biol Chem, Apr 2015
We found that the dynamic mitotic phosphorylation of YAP was CDC14-dependent.
LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C.
Kuninaka et al., Tokyo, Japan. In Plos One, 2014
In budding yeast, the Mitotic Exit Network (MEN) regulates anaphase promoting complex/cyclosome (APC/C) via the Dbf2-Cdc14 signaling cascade.
[Screening and bioinformatics analysis of differentially expressed genes in hyperplastic scar].
Liu et al., Nanchang, China. In Nan Fang Yi Ke Da Xue Xue Bao, 2014
The dysregulated genes in hyperplastic scar were involved in cell cycles, cell proliferation, immune response and cell adhesion (CDKN1C, CDKN2A, CTNNA3, COL6A3, and HOXB4) and in signaling pathway of focal adhesion, TGF-beta signaling pathway, p53 signaling pathway, cell cycle, and tumor-associated pathways (TGFβ1, CDKN1C, CDKN2A, CDC14A , ITGB6, and EGF).
Global analysis of cdc14 dephosphorylation sites reveals essential regulatory role in mitosis and cytokinesis.
Teng et al., Taipei, Taiwan. In Mol Cell Proteomics, 2014
Cdc14 is the major phosphatase required for the exit from the M phase.
Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression.
Dong et al., Omaha, United States. In Biochem J, 2012
CDC (cell division cycle) 14A/B phosphatases associate with KIBRA, and CDK1-non-phosphorylatable KIBRA has greatly reduced interaction with CDC14B.
Dependence of Chs2 ER export on dephosphorylation by cytoplasmic Cdc14 ensures that septum formation follows mitosis.
Yeong et al., Singapore, Singapore. In Mol Biol Cell, 2012
Chs2 endoplasmic reticulum export requires the direct reversal of the inhibitory Cdk1 phosphorylation sites by Cdc14 phosphatase
Cdc14 phosphatase promotes segregation of telomeres through repression of RNA polymerase II transcription.
Aragón et al., London, United Kingdom. In Nat Cell Biol, 2011
Inactivation of Cdc14 causes silencing defects at the intergenic spacer sequences of ribosomal genes during interphase and at Y' repeats in subtelomeric regions during mitosis.
Functions of the mitotic B-type cyclins CLB1, CLB2, and CLB3 at mitotic exit antagonized by the CDC14 phosphatase.
Juang et al., Taiwan. In Fungal Genet Biol, 2011
CLB activities are antagonized by the CDC14 phosphatase in order to couple cell cycle progression with cytokinesis at mitotic exit
Computational modelling of mitotic exit in budding yeast: the role of separase and Cdc14 endocycles.
Novak et al., Oxford, United Kingdom. In J R Soc Interface, 2011
Computational modelling of mitotic exit in budding yeast: the role of separase and Cdc14 endocycles.
Cdc14: a highly conserved family of phosphatases with non-conserved functions?
Schiebel et al., Heidelberg, Germany. In J Cell Sci, 2010
However, analysis of the human Cdc14 proteins (CDC14A, CDC14B and CDC14C) by overexpression or by depletion using small interfering RNA (siRNA) has suggested functions that are quite different from those of ScCdc14.
Cdc14 and condensin control the dissolution of cohesin-independent chromosome linkages at repeated DNA.
Amon et al., Cambridge, United States. In Cell, 2004
Here we show that in budding yeast separation of the ribosomal DNA (rDNA) and telomeres also requires Cdc14, a protein phosphatase known for its role in mitotic exit.
Protein tyrosine phosphatases: strategies for distinguishing proteins in a family containing multiple drug targets and anti-targets.
Baxter et al., San Diego, United States. In Curr Pharm Des, 2003
Eight PTP subfamilies, classified by active site information and overall PTP catalytic domain structure similarity, are reviewed here: 1) the tyrosine-specific PTPs, 2) the dual-specificity PTPs, 3) the cdc25 subclass; 4) the Pten subclass; 5) the myotubularins, 6) the PRL subclass, 7) the low molecular weight PTPs, and 8) the newly defined cdc14 subclass.
Regulation of CDC14: pathways and checkpoints of mitotic exit.
Yu et al., Dallas, United States. In Front Biosci, 2003
The Cdc14 family of phosphatases antagonizes the action of Cdk1, and is thus a major player in controlling the mitotic exit.
Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation.
Lukas et al., Copenhagen, Denmark. In Nat Cell Biol, 2002
human Cdc14A phosphatase disrupts centrosome separation
Mitochondrial DNA synthesis in cell cycle mutants of Saccharomyces cerevisiae.
Fangman et al., In Cell, 1975
In contrast to cdc8 and cdc21, mitochondrial DNA replication continues for a long time at the nonpermissive temperature in five other cell division cycle mutants in which nuclear DNA synthesis ceases within one cell cycle: cdc4, cdc7, and cdc28, which are defective in the initiation of nuclear DNA synthesis, and cdc14 and cdc23, which are defective in nuclear division.
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