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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 30 Mar 2015.

CD97 molecule

CD97, CD97 antigen
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: Epidermal Growth Factor, CD55, Tropomyosin, caspase-3, CAN
Papers on CD97
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
New
Impact
Schiöth et al., Amsterdam, Netherlands. In Pharmacol Rev, 30 Apr 2015
The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98).
Dissecting high from low responders in a vitamin D3 intervention study.
New
Carlberg et al., Kuopio, Finland. In J Steroid Biochem Mol Biol, 30 Apr 2015
In hematopoietic cells, the genes ASAP2, CAMP, CD14, CD97, DUSP10, G0S2, IL8, LRRC8A, NINJ1, NRIP1, SLC37A2 and THBD are known as primary vitamin D targets.
Expression of B-cell-associated genes in peripheral blood mononuclear cells of patients with symptomatic pulmonary embolism.
New
Song et al., Shanghai, China. In Mol Med Report, 31 Mar 2015
Expression levels of T‑cell‑dependent B‑cell‑activation genes, including EMR2, TNFSF9, CD86, ICOSLG, CD37 and CD97, were significantly upregulated in PE patients, whereas SPN mRNA expression was significantly downregulated compared with those of the control group.
Expression and prognostic value of CD97 and its ligand CD55 in pancreatic cancer.
New
Zheng et al., Yichang, China. In Oncol Lett, 28 Feb 2015
UNASSIGNED: CD97 is a member of the epidermal growth factor-seven transmembrane family.
Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome.
New
Dahlman et al., Kuopio, Finland. In Am J Clin Nutr, Jan 2015
Immune-related pathways included leukocyte trafficking and macrophage recruitment (e.g., interferon regulatory factor 1, CD97), adaptive immune response (interleukin32, interleukin 6 receptor), and reactive oxygen species (neutrophil cytosolic factor 1). Interestingly, the regulatory region of the 128 genes was overrepresented for binding sites for the nuclear transcription factor κB. CONCLUSION: A healthy Nordic diet reduces inflammatory gene expression in SAT compared with a control diet independently of body weight change in individuals with features of the metabolic syndrome.
Proportional Upregulation of CD97 Isoforms in Glioblastoma and Glioblastoma-Derived Brain Tumor Initiating Cells.
New
Parsa et al., Chicago, United States. In Plos One, Dec 2014
CD97 is a novel glioma antigen that confers an invasive phenotype and poor survival in patients with glioblastoma (GBM), the most aggressive primary malignant brain tumor.
Wilms tumor 1 gene, CD97, and the emerging biogenetic profile of glioblastoma.
New
Broaddus et al., Richmond, United States. In Neurosurg Focus, Dec 2014
Further, this paper will examine the relationship of WT1 with CD97, a gene that codes for an epidermal growth factor receptor family member, an adhesion G-protein-coupled receptor, thought to promote tumor invasiveness and migration.
CD97 inhibits cell migration in human fibrosarcoma cells by modulating TIMP-2/MT1- MMP/MMP-2 activity--role of GPS autoproteolysis and functional cooperation between the N- and C-terminal fragments.
New
Lin et al., Taiwan. In Febs J, Nov 2014
CD97 is a tumor-associated adhesion-class G-protein-coupled receptor involved in modulating cell migration.
Exposure to zearalenone mycotoxin alters in vitro porcine intestinal epithelial cells by differential gene expression.
New
Burlacu et al., Romania. In Toxicol Lett, Nov 2014
The up-regulation of CD97 gene and the down-regulation of tumour suppressor genes (DKK-1, PCDH11X and TC531386) demonstrates the carcinogenic potential of ZEA.
A relaxation technique enhances psychological well-being and immune parameters in elderly people from a nursing home: a randomized controlled study.
Albaladejo-Blazquez et al., Alacant, Spain. In Bmc Complement Altern Med, 2013
RESULTS: Our findings reveal significant differences between the experimental and control groups in CD19, CD71, CD97, CD134, and CD137 lymphocyte subpopulations at the end of treatment.
The role of decay accelerating factor in environmentally induced and idiopathic systemic autoimmune disease.
Review
Pollard et al., Durham, United States. In Autoimmune Dis, 2013
This is supported by studies showing that interaction between DAF and its molecular partner, CD97, modifies expression of autoimmunity promoting cytokines.
CD97 is a multifunctional leukocyte receptor with distinct roles in human cancers (Review).
Review
Parsa et al., Chicago, United States. In Int J Oncol, 2013
CD97 is the most broadly expressed member with roles in cell adhesion, migration and regulation of intercellular junctions.
Novel report of expression and function of CD97 in malignant gliomas: correlation with Wilms tumor 1 expression and glioma cell invasiveness.
GeneRIF
Broaddus et al., Norfolk, United States. In J Neurosurg, 2012
we conclude that the possible upregulation of CD97 mediated by WT1 promotes cellular invasiveness-one of the most characteristic and challenging aspects of glial tumor cells.
Thy-1 (CD90) is an interacting partner for CD97 on activated endothelial cells.
GeneRIF
Aust et al., Leipzig, Germany. In J Immunol, 2012
binding of leukocytes to activated endothelium mediated by the interaction of CD97 with Thy-1 is involved in firm adhesion of polymorphonuclear cells during inflammation and may play a role in the regulation of leukocyte trafficking to inflammatory sites.
LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells.
GeneRIF
Kelly et al., Bethesda, United States. In Cancer Res, 2012
CD97 functioned to mediate invasion in prostate cancer cells, by associating with lysophosphatidic acid receptor 1 (LPAR1), leading to enhanced LPA-dependent RHO and extracellular signal-regulated kinase activation.
Immunohistochemical expression and prognostic value of CD97 and its ligand CD55 in primary gallbladder carcinoma.
GeneRIF
Zhang et al., Nanjing, China. In J Biomed Biotechnol, 2011
CD97 and CD55 showed high expression at the invasive front of gallbladder carcinoma. CD97 and CD55 expression was associated with high histologic grade, advanced pathologic T stage, clinical stage and positive venous/lymphatic invasion.
F4/80 and the related adhesion-GPCRs.
Review
Stacey et al., Oxford, United Kingdom. In Eur J Immunol, 2011
F4/80 is a member of the EGF-TM7 family of leukocyte plasma membrane heptahelical molecules, which includes CD97 and EMR2.
GPS autoproteolysis is required for CD97 to up-regulate the expression of N-cadherin that promotes homotypic cell-cell aggregation.
GeneRIF
Lin et al., Taiwan. In Febs Lett, 2011
expression of the wild type - but not the GPS cleavage-deficient CD97 up-regulates the expression of N-cadherin, leading to Ca(++)-dependent cell-cell aggregation.
The role of CD97 in regulating adaptive T-cell responses.
Review
Sutavani et al., Nottingham, United Kingdom. In Adv Exp Med Biol, 2009
CD97 was identified as an early activation marker on T cells, having low expression on naive T cells.
CD97 in leukocyte trafficking.
Review
van Eenennaam et al., Amsterdam, Netherlands. In Adv Exp Med Biol, 2009
CD97 is a member of the EGF-TM7 family of adhesion G protein-coupled receptors (GPCRs) broadly expressed on leukocytes.
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