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CD97 molecule

CD97, CD97 antigen
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: Epidermal Growth Factor, CD55, Tropomyosin, caspase-3, EMR2
Papers on CD97
Time course of CD marker expression in patients with burns and its prognostic value.
Csontos et al., Pécs, Hungary. In Burns, Jun 2014
Expressions of CD11a, CD11b, CD18, CD49d, CD97 and CD14 were measured on granulocytes, lymphocytes and monocytes.
Prometastatic GPCR CD97 is a direct target of tumor suppressor microRNA-126.
Tirrell et al., Pasadena, United States. In Acs Chem Biol, Mar 2014
We discovered a new direct target of miR-126: CD97, a pro-metastatic G-protein-coupled receptor (GPCR) that has been reported to promote tumor cell invasion, endothelial cell migration, and tumor angiogenesis.
CD55 costimulation induces differentiation of a discrete T regulatory type 1 cell population with a stable phenotype.
Spendlove et al., Nottingham, United Kingdom. In J Immunol, Jan 2014
In this study, we show that costimulation of human naive CD4(+) cells through CD97/CD55 interaction drives Tr1 activation, expansion, and function.
The role of decay accelerating factor in environmentally induced and idiopathic systemic autoimmune disease.
Pollard et al., Durham, United States. In Autoimmune Dis, Dec 2013
This is supported by studies showing that interaction between DAF and its molecular partner, CD97, modifies expression of autoimmunity promoting cytokines.
Lysophosphatidylethanolamine utilizes LPA(1) and CD97 in MDA-MB-231 breast cancer cells.
Im et al., Pusan, South Korea. In Cell Signal, Nov 2013
Furthermore, the involvement of CD97 (an adhesion GPCR) in the action of LPA1 in MDA-MB-231 cells was demonstrated by siRNA transfection.
CD97 is a multifunctional leukocyte receptor with distinct roles in human cancers (Review).
Parsa et al., Chicago, United States. In Int J Oncol, Nov 2013
CD97 is the most broadly expressed member with roles in cell adhesion, migration and regulation of intercellular junctions.
Upregulation of skeletal muscle inflammatory genes links inflammation with insulin resistance in women with the metabolic syndrome.
Hopman et al., Nijmegen, Netherlands. In Exp Physiol, Oct 2013
The three most significantly upregulated of this group, interleukin 6 receptor (IL6R), histone deacetylase 9 (HDAC9) and CD97 molecule (CD97), were significantly correlated with insulin resistance.
Mice overexpressing CD97 in intestinal epithelial cells provide a unique model for mammalian postnatal intestinal cylindrical growth.
Hamann et al., Leipzig, Germany. In Mol Biol Cell, Jul 2013
The bipartite adhesion G protein-coupled receptor CD97 shows an expression gradient along the crypt-villus axis in the normal human intestine.
Leukemia surfaceome analysis reveals new disease-associated features.
Bourquin et al., Zürich, Switzerland. In Blood, Jul 2013
Nine candidate markers (CD18, CD63, CD31, CD97, CD102, CD157, CD217, CD305, and CD317) were validated by flow cytometry in patient samples at diagnosis and during chemotherapy.
Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55.
Hamann et al., Amsterdam, Netherlands. In J Immunol, May 2013
In this study, we investigated the interaction between the pan-leukocyte aGPCR CD97 and its ligand CD55.
Overexpression of CD97 confers an invasive phenotype in glioblastoma cells and is associated with decreased survival of glioblastoma patients.
Parsa et al., San Francisco, United States. In Plos One, 2012
CD97 is a member of the epidermal growth factor seven-span transmembrane family of adhesion G-protein coupled receptors.
Novel report of expression and function of CD97 in malignant gliomas: correlation with Wilms tumor 1 expression and glioma cell invasiveness.
Broaddus et al., Norfolk, United States. In J Neurosurg, 2012
we conclude that the possible upregulation of CD97 mediated by WT1 promotes cellular invasiveness-one of the most characteristic and challenging aspects of glial tumor cells.
Thy-1 (CD90) is an interacting partner for CD97 on activated endothelial cells.
Aust et al., Leipzig, Germany. In J Immunol, 2012
binding of leukocytes to activated endothelium mediated by the interaction of CD97 with Thy-1 is involved in firm adhesion of polymorphonuclear cells during inflammation and may play a role in the regulation of leukocyte trafficking to inflammatory sites.
LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells.
Kelly et al., Bethesda, United States. In Cancer Res, 2012
CD97 functioned to mediate invasion in prostate cancer cells, by associating with lysophosphatidic acid receptor 1 (LPAR1), leading to enhanced LPA-dependent RHO and extracellular signal-regulated kinase activation.
Immunohistochemical expression and prognostic value of CD97 and its ligand CD55 in primary gallbladder carcinoma.
Zhang et al., Nanjing, China. In J Biomed Biotechnol, 2011
CD97 and CD55 showed high expression at the invasive front of gallbladder carcinoma. CD97 and CD55 expression was associated with high histologic grade, advanced pathologic T stage, clinical stage and positive venous/lymphatic invasion.
F4/80 and the related adhesion-GPCRs.
Stacey et al., Oxford, United Kingdom. In Eur J Immunol, 2011
F4/80 is a member of the EGF-TM7 family of leukocyte plasma membrane heptahelical molecules, which includes CD97 and EMR2.
GPS autoproteolysis is required for CD97 to up-regulate the expression of N-cadherin that promotes homotypic cell-cell aggregation.
Lin et al., Taiwan. In Febs Lett, 2011
expression of the wild type - but not the GPS cleavage-deficient CD97 up-regulates the expression of N-cadherin, leading to Ca(++)-dependent cell-cell aggregation.
The role of CD97 in regulating adaptive T-cell responses.
Sutavani et al., Nottingham, United Kingdom. In Adv Exp Med Biol, 2009
CD97 was identified as an early activation marker on T cells, having low expression on naive T cells.
CD97 in leukocyte trafficking.
van Eenennaam et al., Amsterdam, Netherlands. In Adv Exp Med Biol, 2009
CD97 is a member of the EGF-TM7 family of adhesion G protein-coupled receptors (GPCRs) broadly expressed on leukocytes.
The expression and action of decay-accelerating factor (CD55) in human malignancies and cancer therapy.
Brandt et al., Münster, Germany. In Cell Oncol, 2005
promotion of tumorigenesis, decrease of complement mediated tumor cell lysis, autocrine loops for cell rescue and evasion of apoptosis, neoangiogenesis, invasiveness, cell motility, and metastasis via oncogenic tyrosine kinase pathways and specific seven-span transmembrane receptors (CD97) binding.
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