GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
CD97 molecule
CD97, CD97 antigen
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011] (from
NCBI)
Papers on
CD97
Microarray analyses of peripheral whole blood cells from ulcerative colitis patients: Effects of leukocytapheresis.
New
Kurume, Japan. In Int J Mol Med, 30 Apr 2013
After LCAP, genes with proinflammatory actions, such as CD97, CD74, human leukocyte antigen-DRβ1 and -DP light chain, were downregulated, while genes responsible for antimicrobial actions, such as neutrophil gelatinase-associated lipocalin, and acute phase reactions, such as haptoglobin α1S and α1-acid glycoprotein, were upregulated.
A Proteomics and Transcriptomics Approach to Identify Leukemic Stem Cell (LSC) Markers.
New
Groningen, Netherlands. In Mol Cell Proteomics, 31 Mar 2013
We identified 867 and 610 unique CD34 PM (-associated) proteins in these AML samples respectively, including previously described proteins such as CD47, CD44, CD135, CD96, and ITGA5, but also novel ones like CD82, CD97, CD99, PTH2R, ESAM, MET, and ITGA6.
Shear Stress-Dependent Downregulation of the Adhesion-G Protein-Coupled Receptor CD97 on Circulating Leukocytes upon Contact with Its Ligand CD55.
New
Amsterdam, Netherlands. In J Immunol, 27 Mar 2013
In this study, we investigated the interaction between the pan-leukocyte aGPCR CD97 and its ligand CD55.
CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model.
New
Bethesda, United States. In Oncogene, Aug 2012
CD97, a member of the adhesion family of G-protein-coupled receptors (GPCRs), complexes with and potentiates lysophosphatidic acid (LPA) receptor signaling to the downstream effector RHOA.
Novel report of expression and function of CD97 in malignant gliomas: correlation with Wilms tumor 1 expression and glioma cell invasiveness.
New
Norfolk, United States. In J Neurosurg, Apr 2012
One candidate target, CD97, was then selected for further investigation into its role by suppressing its expression using siRNA silencing, followed by proliferation and invasion assays.
Thy-1 (CD90) is an interacting partner for CD97 on activated endothelial cells.
New
Leipzig, Germany. In J Immunol, Mar 2012
In this study, we characterized the adhesion G-protein coupled receptor CD97, present on peripheral myeloid cells, as a novel interacting partner for Thy-1.
The invasion and metastasis promotion role of CD97 small isoform in gastric carcinoma.
Hangzhou, China. In Plos One, 2011
CD97 is over-expressed in the majority of gastric adenocarcinomas and is associated with its dedifferentiation and aggressiveness.
Triggering of the dsRNA sensors TLR3, MDA5, and RIG-I induces CD55 expression in synovial fibroblasts.
Amsterdam, Netherlands. In Plos One, 2011
CD55 is also a ligand for CD97, an adhesion-type G protein-coupled receptor abundantly present on leukocytes.
Immunohistochemical expression and prognostic value of CD97 and its ligand CD55 in primary gallbladder carcinoma.
Nanjing, China. In J Biomed Biotechnol, 2011
BACKGROUND: CD97 as a member of the EGF-TM7 family with adhesive properties plays an important role in tumor aggressiveness by binding its cellular ligand CD55, which is a complement regulatory protein expressed by cells to protect them from bystander complement attack.
F4/80 and the related adhesion-GPCRs.
Review
Oxford, United Kingdom. In Eur J Immunol, 2011
F4/80 is a member of the EGF-TM7 family of leukocyte plasma membrane heptahelical molecules, which includes CD97 and EMR2.
GPS autoproteolysis is required for CD97 to up-regulate the expression of N-cadherin that promotes homotypic cell-cell aggregation.
GeneRIF
Taiwan. In Febs Lett, 2011
expression of the wild type - but not the GPS cleavage-deficient CD97 up-regulates the expression of N-cadherin, leading to Ca(++)-dependent cell-cell aggregation.
A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense.
Amsterdam, Netherlands. In Plos One, 2010
BACKGROUND: In addition to its complement-regulating activity, CD55 is a ligand of the adhesion class G protein-coupled receptor CD97; however, the relevance of this interaction has remained elusive.
The impact of expressions of CD97 and its ligand CD55 at the invasion front on prognosis of rectal adenocarcinoma.
GeneRIF
Wenzhou, China. In Int J Colorectal Dis, 2010
Elevated expression of CD97 and its ligand CD55 at the invasion front correlate with tumor recurrence and metastasis, and CD95 may be a poor prognostic factor for rectal adenocarcinoma.
Role of CD97 isoforms in gastric carcinoma.
GeneRIF
Hangzhou, China. In Int J Oncol, 2010
the tumor promoting role of CD97 small isoform in cancer progression
Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease.
GeneRIF
Amsterdam, Netherlands. In Immunol Lett, 2010
complex cellular expression programmes rather than activation modes regulate the expression of EGF-TM7 receptors in macrophages
Deletion of either CD55 or CD97 ameliorates arthritis in mouse models.
GeneRIF
Amsterdam, Netherlands. In Arthritis Rheum, 2010
Insight into a role for CD55 interaction with CD97 in the pathogenesis of rheumatoid arthritis suggest that therapeutic strategies that disrupt CD55/CD97 may be clinically beneficial.
The role of CD97 in regulating adaptive T-cell responses.
Review
Nottingham, United Kingdom. In Adv Exp Med Biol, 2009
CD97 was identified as an early activation marker on T cells, having low expression on naive T cells.
CD97 in leukocyte trafficking.
Review
Amsterdam, Netherlands. In Adv Exp Med Biol, 2009
CD97 is a member of the EGF-TM7 family of adhesion G protein-coupled receptors (GPCRs) broadly expressed on leukocytes.
Decay-accelerating factor (CD55): a versatile acting molecule in human malignancies.
Review
Münster, Germany. In Biochim Biophys Acta, 2006
Here, DAF seems to dispose of several different functions reaching far beyond its immunological role, e.g., promotion of tumorigenesis, decrease of complement mediated tumor cell lysis, autocrine loops for cell rescue and evasion of apoptosis, neoangiogenesis, invasiveness, cell motility, and metastasis via oncogenic tyrosine kinase pathway activation, and specific seven-span transmembrane receptors (CD97) binding.
The expression and action of decay-accelerating factor (CD55) in human malignancies and cancer therapy.
Review
Münster, Germany. In Cell Oncol, 2005
promotion of tumorigenesis, decrease of complement mediated tumor cell lysis, autocrine loops for cell rescue and evasion of apoptosis, neoangiogenesis, invasiveness, cell motility, and metastasis via oncogenic tyrosine kinase pathways and specific seven-span transmembrane receptors (CD97) binding.
