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CD97 molecule

CD97, CD97 antigen
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: Epidermal Growth Factor, CD55, Tropomyosin, caspase-3, CAN
Papers on CD97
Wilms tumor 1 gene, CD97, and the emerging biogenetic profile of glioblastoma.
Broaddus et al., Richmond, United States. In Neurosurg Focus, 31 Dec 2014
Further, this paper will examine the relationship of WT1 with CD97, a gene that codes for an epidermal growth factor receptor family member, an adhesion G-protein-coupled receptor, thought to promote tumor invasiveness and migration.
Expression of B-cell-associated genes in peripheral blood mononuclear cells of patients with symptomatic pulmonary embolism.
Song et al., Shanghai, China. In Mol Med Report, 19 Dec 2014
Expression levels of T‑cell‑dependent B‑cell‑activation genes, including EMR2, TNFSF9, CD86, ICOSLG, CD37 and CD97, were significantly upregulated in PE patients, whereas SPN mRNA expression was significantly downregulated compared with those of the control group.
Dissecting high from low responders in a vitamin D3 intervention study.
Carlberg et al., Kuopio, Finland. In J Steroid Biochem Mol Biol, 13 Dec 2014
In hematopoietic cells, the genes ASAP2, CAMP, CD14, CD97, DUSP10, G0S2, IL8, LRRC8A, NINJ1, NRIP1, SLC37A2 and THBD are known as primary vitamin D targets.
CD97 inhibits cell migration in human fibrosarcoma cells by modulating TIMP-2/MT1- MMP/MMP-2 activity - role of GPS autoproteolysis and functional cooperation between the N- and C-terminal fragments.
Lin et al., Taiwan. In Febs J, 30 Nov 2014
CD97 is a tumor-associated adhesion-class G-protein-coupled receptor involved in modulating cell migration.
Exposure to zearalenone mycotoxin alters in vitro porcine intestinal epithelial cells by differential gene expression.
Burlacu et al., Romania. In Toxicol Lett, 23 Nov 2014
The up-regulation of CD97 gene and the down-regulation of tumour suppressor genes (DKK-1, PCDH11X and TC531386) demonstrates the carcinogenic potential of ZEA.
Phage display discovery of novel molecular targets in glioblastoma-initiating cells.
Rich et al., Cleveland, United States. In Cell Death Differ, Aug 2014
Phage peptides bound to GICs were analyzed for their corresponding proteins and ranked based on prognostic value, identifying VAV3, a Rho guanine exchange factor involved tumor invasion, and CD97 (cluster of differentiation marker 97), an adhesion G-protein-coupled-receptor upstream of Rho, as potentially enriched in GICs.
Primary vitamin D receptor target genes as biomarkers for the vitamin D3 status in the hematopoietic system.
Carlberg et al., Kuopio, Finland. In J Nutr Biochem, Aug 2014
We studied chromatin domains containing genes for the adhesion molecules CD97 and LRRC8A, the glucose transporter SLC37A2 and the coactivator NRIP1.
Action and Signaling of Lysophosphatidylethanolamine in MDA-MB-231 Breast Cancer Cells.
Im et al., Pusan, South Korea. In Biomol Ther (seoul), Feb 2014
Previously, we reported that lysophosphatidylethanolamine (LPE), a lyso-type metabolite of phosphatidylethanolamine, can increase intracellular Ca(2+) ([Ca(2+)]i) via type 1 lysophosphatidic acid (LPA) receptor (LPA1) and CD97, an adhesion G-protein-coupled receptor (GPCR), in MDA-MB-231 breast cancer cells.
The role of decay accelerating factor in environmentally induced and idiopathic systemic autoimmune disease.
Pollard et al., Durham, United States. In Autoimmune Dis, Dec 2013
This is supported by studies showing that interaction between DAF and its molecular partner, CD97, modifies expression of autoimmunity promoting cytokines.
A relaxation technique enhances psychological well-being and immune parameters in elderly people from a nursing home: a randomized controlled study.
Albaladejo-Blazquez et al., Alacant, Spain. In Bmc Complement Altern Med, Dec 2013
RESULTS: Our findings reveal significant differences between the experimental and control groups in CD19, CD71, CD97, CD134, and CD137 lymphocyte subpopulations at the end of treatment.
Skeletal muscle expression of the adhesion-GPCR CD97: CD97 deletion induces an abnormal structure of the sarcoplasmatic reticulum but does not impair skeletal muscle function.
Aust et al., Leipzig, Germany. In Plos One, Dec 2013
CD97 is a widely expressed adhesion class G-protein-coupled receptor (aGPCR).
CD97 is a multifunctional leukocyte receptor with distinct roles in human cancers (Review).
Parsa et al., Chicago, United States. In Int J Oncol, Nov 2013
CD97 is the most broadly expressed member with roles in cell adhesion, migration and regulation of intercellular junctions.
Novel report of expression and function of CD97 in malignant gliomas: correlation with Wilms tumor 1 expression and glioma cell invasiveness.
Broaddus et al., Norfolk, United States. In J Neurosurg, 2012
we conclude that the possible upregulation of CD97 mediated by WT1 promotes cellular invasiveness-one of the most characteristic and challenging aspects of glial tumor cells.
Thy-1 (CD90) is an interacting partner for CD97 on activated endothelial cells.
Aust et al., Leipzig, Germany. In J Immunol, 2012
binding of leukocytes to activated endothelium mediated by the interaction of CD97 with Thy-1 is involved in firm adhesion of polymorphonuclear cells during inflammation and may play a role in the regulation of leukocyte trafficking to inflammatory sites.
LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells.
Kelly et al., Bethesda, United States. In Cancer Res, 2012
CD97 functioned to mediate invasion in prostate cancer cells, by associating with lysophosphatidic acid receptor 1 (LPAR1), leading to enhanced LPA-dependent RHO and extracellular signal-regulated kinase activation.
Immunohistochemical expression and prognostic value of CD97 and its ligand CD55 in primary gallbladder carcinoma.
Zhang et al., Nanjing, China. In J Biomed Biotechnol, 2011
CD97 and CD55 showed high expression at the invasive front of gallbladder carcinoma. CD97 and CD55 expression was associated with high histologic grade, advanced pathologic T stage, clinical stage and positive venous/lymphatic invasion.
F4/80 and the related adhesion-GPCRs.
Stacey et al., Oxford, United Kingdom. In Eur J Immunol, 2011
F4/80 is a member of the EGF-TM7 family of leukocyte plasma membrane heptahelical molecules, which includes CD97 and EMR2.
GPS autoproteolysis is required for CD97 to up-regulate the expression of N-cadherin that promotes homotypic cell-cell aggregation.
Lin et al., Taiwan. In Febs Lett, 2011
expression of the wild type - but not the GPS cleavage-deficient CD97 up-regulates the expression of N-cadherin, leading to Ca(++)-dependent cell-cell aggregation.
The role of CD97 in regulating adaptive T-cell responses.
Sutavani et al., Nottingham, United Kingdom. In Adv Exp Med Biol, 2009
CD97 was identified as an early activation marker on T cells, having low expression on naive T cells.
CD97 in leukocyte trafficking.
van Eenennaam et al., Amsterdam, Netherlands. In Adv Exp Med Biol, 2009
CD97 is a member of the EGF-TM7 family of adhesion G protein-coupled receptors (GPCRs) broadly expressed on leukocytes.
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