Co-evolution of NK receptors and HLA ligands in humans is driven by reproduction.
Cambridge, United Kingdom. In Immunol Rev, Sep 2015
Invading placental trophoblast cells express human leukocyte antigen class I ligands (HLA-E, HLA-G, and HLA-C) for receptors on maternal uterine natural killer (NK) and myelomonocytic cells, CD94/NKG2, leukocyte immunoglobulin-like receptor (LILR), and killer immunoglobulin receptor (KIR).
NK cells: tuned by peptide?
Columbus, United States. In Immunol Rev, Sep 2015
Natural killer cells express multiple receptors for major histocompatibility complex (MHC) class I, including the killer cell immunoglobulin-like receptors (KIRs) and the C-type lectin-like CD94:NKG2 receptors.
Human KIR repertoires: shaped by genetic diversity and evolution.
Düsseldorf, Germany. In Immunol Rev, Sep 2015
The clonally distributed expression of KIRs leads to great combinatorial diversity that develops in the presence of the evolutionary older CD94/NKG2A receptor to create highly stochastic but tolerant repertoires of NK cells.
A bird's eye view of NK cell receptor interactions with their MHC class I ligands.
Melbourne, Australia. In Immunol Rev, Sep 2015
Human NK cells have evolved two broad strategies for recognition of human leukocyte antigen (HLA) class I molecules: (i) direct recognition of polymorphic classical HLA class I proteins by diverse receptor families such as the killer cell immunoglobulin-like receptors (KIRs), and (ii) indirect recognition of conserved sets of HLA class I-derived peptides displayed on the non-classical HLA-E for recognition by CD94-NKG2 receptors.