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Killer cell lectin-like receptor subfamily D, member 1

CD94
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NKG2A, MHC, CAN, CD56, KIR
Papers on CD94
Blood cytotoxic/inflammatory mediators in non-eosinophilic asthma.
New
AMAZES Study Research Group et al., Adelaide, Australia. In Clin Exp Allergy, Jan 2016
We applied flow cytometry to measure T, CD28null, NK and NKT-like cells and their expression of granzyme B, perforin, and killer inhibitory/activating receptors CD94(Kp43), CD158b and CD107A.
Microenvironmental stresses induce HLA-E/Qa-1 surface expression and thereby reduce CD8(+) T-cell recognition of stressed cells.
New
Sato et al., Sapporo, Japan. In Eur J Immunol, Jan 2016
The induced Qa-1 on the stressed tumor model interacted with an inhibitory NKG2/CD94 receptor on activated CD8(+) T cells and attenuated their specific response to the antigen.
The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8(+) T Cells in Response to a Lethal Poxvirus Infection.
New
Impact
Colonna et al., Saint Louis, United States. In Immunity, Jan 2016
NKG2A, which is encoded by Klrc1, is a lectin-like inhibitory receptor that is expressed as a heterodimer with CD94 on NK cells and activated CD8(+) T cells.
Is parturition-timing machinery related to the number of inhibitor CD94/NKG2A positive uterine natural killer cells?
New
Yildiran et al., Samsun, Turkey. In Arch Gynecol Obstet, Jan 2016
It is likely that inhibitor CD94/NKG2A positive decidual natural killer cells (uNK) provide for the continuation of pregnancy.
Tim-3 Is Upregulated in NK Cells during Early Pregnancy and Inhibits NK Cytotoxicity toward Trophoblast in Galectin-9 Dependent Pathway.
New
Qu et al., Jinan, China. In Plos One, Dec 2015
Tim-3+ dNK expressed more levels of mature markers CD94 and CD69 than Tim-3- dNK cells and blocking Tim-3 significantly inhibited dNK IFN-γ and TNF-α secretion.
Identification of Anti-tumor Cells Carrying Natural Killer (NK) Cell Antigens in Patients With Hematological Cancers.
New
Villalba et al., Montpellier, France. In Ebiomedicine, Oct 2015
A high percentage of these cells expressed natural killer cell p46-related protein (NKp46), natural-killer group 2, member D (NKG2D) and killer inhibitory receptors (KIRs) and a low percentage expressed NKG2A and CD94.
Co-evolution of NK receptors and HLA ligands in humans is driven by reproduction.
Review
New
Colucci et al., Cambridge, United Kingdom. In Immunol Rev, Sep 2015
Invading placental trophoblast cells express human leukocyte antigen class I ligands (HLA-E, HLA-G, and HLA-C) for receptors on maternal uterine natural killer (NK) and myelomonocytic cells, CD94/NKG2, leukocyte immunoglobulin-like receptor (LILR), and killer immunoglobulin receptor (KIR).
NK cells: tuned by peptide?
Review
New
Khakoo et al., Columbus, United States. In Immunol Rev, Sep 2015
Natural killer cells express multiple receptors for major histocompatibility complex (MHC) class I, including the killer cell immunoglobulin-like receptors (KIRs) and the C-type lectin-like CD94:NKG2 receptors.
Human KIR repertoires: shaped by genetic diversity and evolution.
Review
New
Uhrberg et al., Düsseldorf, Germany. In Immunol Rev, Sep 2015
The clonally distributed expression of KIRs leads to great combinatorial diversity that develops in the presence of the evolutionary older CD94/NKG2A receptor to create highly stochastic but tolerant repertoires of NK cells.
A bird's eye view of NK cell receptor interactions with their MHC class I ligands.
Review
New
Brooks et al., Melbourne, Australia. In Immunol Rev, Sep 2015
Human NK cells have evolved two broad strategies for recognition of human leukocyte antigen (HLA) class I molecules: (i) direct recognition of polymorphic classical HLA class I proteins by diverse receptor families such as the killer cell immunoglobulin-like receptors (KIRs), and (ii) indirect recognition of conserved sets of HLA class I-derived peptides displayed on the non-classical HLA-E for recognition by CD94-NKG2 receptors.
Activating KIRs and NKG2C in Viral Infections: Toward NK Cell Memory?
Review
Moretta et al., Genova, Italy. In Front Immunol, 2014
The contribution of activating killer immunoglobulin-like receptors (KIRs) and CD94/NKG2C in regulating anti-viral responses has recently emerged.
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues.
Impact
Spits et al., Amsterdam, Netherlands. In Nat Immunol, 2013
ILC1 cells were distinct from natural killer (NK) cells as they lacked perforin, granzyme B and the NK cell markers CD56, CD16 and CD94, and could develop from RORγt(+) ILC3 under the influence of IL-12.
Downregulation of CD94/NKG2A inhibitory receptor on decreased γδ T cells in patients with systemic lupus erythematosus.
GeneRIF
He et al., Beijing, China. In Scand J Immunol, 2012
Results suggested that the low expression level of CD94/NKG2A upon gammadelta T cell activation might lead to the over-activation of gammadelta T cells in patients with SLE.
Human leukocyte antigen E in human cytomegalovirus infection: friend or foe?
Review
GeneRIF
Jiang et al., Wuxi, China. In Acta Biochim Biophys Sin (shanghai), 2012
Studies indicate that HLA-E interacts with CD94/NKG2 receptors expressed mainly on the surface of natural killer (NK) cells, thus confining its role to the regulation of NK-cell function.
The adaptor protein Crk controls activation and inhibition of natural killer cells.
Impact
Long et al., Rockville, United States. In Immunity, 2012
We imaged primary NK cells over lipid bilayers carrying IgG1 Fc to stimulate CD16 and human leukocyte antigen (HLA)-E to inhibit through receptor CD94-NKG2A.
Rat and mouse CD94 associate directly with the activating transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell cytotoxicity.
GeneRIF
Dissen et al., Oslo, Norway. In J Immunol, 2012
Rat CD94 coimmunoprecipitates with both DAP12 and DAP10 adaptor proteins.
Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A.
GeneRIF
Spee et al., Denmark. In Plos One, 2011
Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A
CD94 is essential for NK cell-mediated resistance to a lethal viral disease.
Impact
GeneRIF
Sigal et al., Philadelphia, United States. In Immunity, 2011
show that CD94, a molecule preferentially expressed by NK cells, is essential for the resistance of C57BL/6 mice to mousepox, a disease caused by the Orthopoxvirus ectromelia virus
Resistance to mousepox virus: CD94 on a special mission.
Impact
Trsan et al., Rijeka, Croatia. In Immunity, 2011
(2011) demonstrate that the deletion of CD94 abolishes resistance to mousepox infection.
Differential expression of NK receptors CD94 and NKG2A by T cells in rheumatoid arthritis patients in remission compared to active disease.
GeneRIF
Fearon et al., Dublin, Ireland. In Plos One, 2010
Loss of CD94 is associated with rheumatoid arthritis.
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