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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Fc fragment of IgA, receptor for

CD89, IgA Fc receptor, FCAR, Fc alpha receptor
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IgA, V1a, CAN, IgA1, CD64
Papers using CD89 antibodies
Papers on CD89
The Fc-alpha receptor is a new target antigen for immunotherapy of myeloid leukemia.
New
Stein et al., Aachen, Germany. In Int J Cancer, Jan 2016
Here we investigate for the first time the potential of FcαRI (CD89) as a new target antigen expressed by different myeloid leukemic cell populations.
Molecular Insights into the Pathogenesis of IgA Nephropathy.
Review
New
Monteiro et al., Paris, France. In Trends Mol Med, Dec 2015
To date, three key molecules have been implicated in IC formation, correlating with disease progression/recurrence after transplantation: galactose-deficient IgA1 (Gd-IgA1), IgG anti-Gd-IgA1 antibodies, and soluble CD89 (an Fc receptor for IgA).
Role of IgA receptors in the pathogenesis of IgA nephropathy.
New
Monteiro et al., Paris, France. In J Nephrol, Dec 2015
Quantitative and structural changes of Gd-IgA1 play a key role in the development of the disease due to functional abnormalities of two IgA receptors: the FcαRI (CD89) expressed by blood myeloid cells and the transferrin receptor (CD71) on mesangial cells.
The era of the immunoglobulin A Fc receptor FcαRI; its function and potential as target in disease.
Review
New
van Egmond et al., Amsterdam, Netherlands. In Immunol Rev, Nov 2015
However, in the last decade it has become clear that IgA is a very potent stimulus to initiate pro-inflammatory cellular processes, especially after triggering the IgA Fc receptor (FcαRI) on neutrophils.
Fc receptor inside-out signaling and possible impact on antibody therapy.
Review
New
Leusen et al., Utrecht, Netherlands. In Immunol Rev, Nov 2015
This regulatory mechanism has been described for FcγRI (CD64), FcγRIIa (CD32a), and FcαRI (CD89) and is also well-known for integrins.
Up-regulation of CD64-expressing monocytes with impaired FcγR function reflects disease activity in polyarticular psoriatic arthritis.
New
Kleinau et al., Uppsala, Sweden. In Scand J Rheumatol, Nov 2015
Monocytes were analysed for the expression of FcRs for IgG (FcγR) class I (CD64), IIa (CD32a), IIb (CD32b), and III (CD16), the FcR for IgA (FcαR) (CD89), and surface-bound IgG.
Recurrent IgA nephropathy is predicted by altered glycosylated IgA, autoantibodies and soluble CD89 complexes.
New
Touré et al., Paris, France. In Kidney Int, Oct 2015
Here we evaluated the predictive value of three markers for IgAN recurrence: the presence of galactose-deficient IgA1, IgG anti-IgA autoantibodies, and IgA-soluble (s) CD89 complexes.
Gluten and IgA nephropathy: you are what you eat?
New
Barratt et al., Leicester, United Kingdom. In Kidney Int, Aug 2015
Using a double transgenic mouse model of IgA nephropathy that expresses both human IgA1 and human CD89, Papista et al. report that a gluten-free diet protects against the development of IgA deposition and glomerular injury, and that these events occur with the introduction of dietary gluten.
Enhancement of antibody-dependent cell-mediated cytotoxicity by endowing IgG with FcαRI (CD89) binding.
Tsui et al., Gaithersburg, United States. In Mabs, 2014
In addition to IgG, antibodies of the IgA isotype can also promote cell killing through engagement of myeloid lineage cells via interactions between the IgA-Fc and FcαRI (CD89).
IgA, IgA receptors, and their anti-inflammatory properties.
Review
Monteiro et al., Paris, France. In Curr Top Microbiol Immunol, 2013
IgA functions mainly through interaction with multiple receptors including IgA Fc receptor I (FcαRI), transferrin receptor 1 (CD71), asialoglycoprotein receptor (ASGPR), Fcα/μR, FcRL4, and DC-SIGN/SIGNR1.
[Formation of IgA deposits in Berger's disease: what we learned from animal models].
Review
Monteiro et al., Paris, France. In Biol Aujourdhui, 2012
Quantitative and structural changes of IgA1 play a key role in the development of the disease, due to functional abnormalities of two IgA receptors: the FcαR (CD89) expressed by blood myeloid cells and the transferrin receptor (TfR1) on mesangial cells.
Single nucleotidic polymorphism 844 A->G of FCAR is not associated with IgA nephropathy in Caucasians.
GeneRIF
Mariat et al., Saint-Étienne, France. In Nephrol Dial Transplant, 2012
FCAR polymorphism is not associated with high susceptibility to IGA nephropathy in caucasians.
Both IgA nephropathy and alcoholic cirrhosis feature abnormally glycosylated IgA1 and soluble CD89-IgA and IgG-IgA complexes: common mechanisms for distinct diseases.
GeneRIF
Monteiro et al., Paris, France. In Kidney Int, 2011
Abnormally glycosylated IgA1 and soluble CD89-IgA and IgA-IgG complexes, features of primary IgA nephropathy, are also present in alcoholic cirrhosis.
Negative regulation of inflammatory responses by immunoglobulin A receptor (FcαRI) inhibits the development of Toll-like receptor-9 signalling-accelerated glomerulonephritis.
GeneRIF
Tomino et al., Tokyo, Japan. In Clin Exp Immunol, 2011
These results suggest a role of anti-FcaRI Fab as a negative regulator in controlling the magnitude of the innate immune response
Interaction of human, rat, and mouse immunoglobulin A (IgA) with Staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor.
GeneRIF
Hogarth et al., Melbourne, Australia. In J Biol Chem, 2011
Glycosylation of the CH2/CH3 interface inhibits interaction with the pathogen IgA binding protein SSL7, while maintaining binding of pIgR, essential to the biosynthesis and transport of SIgA.
Targeting FcαRI on polymorphonuclear cells induces tumor cell killing through autophagy.
GeneRIF
van Egmond et al., Amsterdam, Netherlands. In J Immunol, 2011
In this study, human mammary carcinoma cells are efficiently killed when incubated with human neutrophils and tumor-specific FcalphaRI bispecific or immunoglobulin A antibodies.
Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc.
Impact
GeneRIF
Bjorkman et al., Pasadena, United States. In Nature, 2003
crystal structures of human FcalphaRI alone and in a complex with the Fc region of IgA1 (Fcalpha)
IgA Fc receptors.
Review
Impact
Van De Winkel et al., Paris, France. In Annu Rev Immunol, 2002
The IgA receptor family comprises a number of surface receptors including the polymeric Ig receptor involved in epithelial transport of IgA/IgM, the myeloid specific IgA Fc receptor (FcalphaRI or CD89), the Fcalpha/muR, and at least two alternative IgA receptors.
FcalphaRI-positive liver Kupffer cells: reappraisal of the function of immunoglobulin A in immunity.
Impact
van de Winkel et al., Utrecht, Netherlands. In Nat Med, 2000
Despite the well-recognized involvement of immunoglobulin (Ig) A in mucosal immunity, the function of its receptor, FcalphaRI (CD89), is poorly understood.
GM-CSF induces human neutrophil IgA-mediated phagocytosis by an IgA Fc receptor activation mechanism.
Impact
Golde et al., United States. In Nature, 1988
These results define a new mechanism for CSF-augmented host defence whereby neutrophil function can be modulated by CSF-mediated IgA Fc receptor activation.
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