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CD86 molecule

CD86, B7-2
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: CD80, IgM, CAN, MHC, IL-10
Papers using CD86 antibodies
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
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Hill Adrian VS et al., In Molecular Therapy, 2008
... DC markers were stained using anti-mouse CD11c PE-Cy7 (clone N418), CD80 FITC (clone 16-10A1), and CD86 PE (clone GL1) (eBioscience, Hatfield, UK) for 30 ...
Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation.
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Matloubian Mehrdad, In PLoS ONE, 2007
... B7-2 transgenic Line 7 (B7), CD28WT transgenic ...
Semen-derived amyloid fibrils drastically enhance HIV infection.
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KewalRamani Vineet N., In PLoS ONE, 2006
... combined with the following panel of phycoerythrin (PE)-conjugated mouse anti-human monoclonal Abs (MAbs): anti-CD25, -CD80, -CD86 (all Becton Dickinson), and -CD83 (PN IM2218; ...
Polyethyleneimine as a transmembrane carrier of fluorescently labeled proteins and antibodies
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Liao Kuang-Wen et al., In International Journal of Nanomedicine, 2004
... FITC-conjugated antimouse major histocompatibility complex (MHC) I mAb, FITC-conjugated antimouse MHC II mAb, and FITC-conjugated antimouse CD86 mAb were purchased from Biolegend (San Diego, CA) ...
Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events.
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Lichterfeld Mathias, In PLoS ONE, 2002
... Antibodies used for flow cytometric analysis of DCs (anti-CD11c and CD86) were purchased from eBioscience (San Diego, CA) ...
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Papers on CD86
Tolerogenic Effect of Mouse Fibroblasts on Dendritic Cells.
New
Ghahary et al., Vancouver, Canada. In Immunology, Feb 2016
The results of our in vitro study showed that both co-inhibitory (PD-L1, PD-L2 and B7H4) and co-stimulatory (CD86) molecules were up-regulated when DCs were co-cultured with fibroblasts.
Comparative studies on the immunoregulatory effects of three polysaccharides using high content imaging system.
New
Zhang et al., Shanghai, China. In Int J Biol Macromol, Feb 2016
APSII and GLPII significantly promoted the maturation of macrophages by the increase in the expression of MHCII, CD40, CD80 and CD86, while OGPII had less effects.
A higher frequency of CD4(+)CXCR5(+) T follicular helper cells in patients with newly diagnosed Henoch-Schönlein purpura nephritis.
New
Jiang et al., Changchun, China. In Int Immunopharmacol, Feb 2016
The numbers of circulating CD4(+)CXCR5(+), CD4(+)CXCR5(+)ICOS(+) and CD4(+)CXCR5(+)PD-1(+) TFH cells, CD86(+)CD19(+), CD38(+)CD19(+) B cells and serum IL-2, IL-4, IL-17A, IL-21 and IFN-γ were significantly higher in HSPN patients (p<0.05)
IL-6 down-regulates HLA class II expression and IL-12 production of human dendritic cells to impair activation of antigen-specific CD4(+) T cells.
New
Taketomi et al., Sapporo, Japan. In Cancer Immunol Immunother, Feb 2016
Human leukocyte antigen (HLA)-DR and CD86 expression was significantly reduced in CD11b(+)CD11c(+) cells obtained from peripheral blood mononuclear cells (PBMCs) of healthy donors by IL-6 treatment and was STAT3 dependent.
Regulation of Immunity by Butyrophilins.
New
Impact
Trowsdale et al., Cambridge, United Kingdom. In Annu Rev Immunol, Feb 2016
They are considered to be members of the B7 family of costimulatory receptors, which includes B7.1 (CD80), B7.2 (CD86), and related molecules, such as PD-L1 (B7-H1, CD274), ICOS-L (CD275), and B7-H3 (CD276).
Antitumor effect of dendritic cells transfected with prostate-specific membrane antigen recombinant adenovirus on prostate cancer: An in vitro study.
New
Sui et al., Shenyang, China. In Mol Med Report, Feb 2016
The expression levels of the co-stimulatory molecules, CD80, CD83, CD86 and HLA‑DR, were significantly higher in the Ad‑PSMA‑DC group than in the other two groups (P<0.05).
MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins.
New
Impact
Tokunaga et al., Tokyo, Japan. In Nat Med, Dec 2015
MARCH8 downregulates several host transmembrane proteins, including major histocompatibility complex (MHC)-II, CD86, interleukin (IL)-1 receptor accessory protein, TNF-related apoptosis-inducing ligand (TRAIL) receptor 1 and the transferrin receptor.
Implication of B lymphocytes in the pathogenesis of ANCA-associated vasculitides.
Review
New
Mouthon et al., Paris, France. In Autoimmun Rev, Nov 2015
Perturbations of B-cell homeostasis have been identified in AAV with increased expression of CD38 and decreased expression of CD5 in active phase, contrasting with increased expression of CD25 and CD86 in remission state.
The phenotype and function of murine bone marrow-derived dendritic cells is not affected by the absence of VDR or its ability to bind 1α,25-dihydroxyvitamin D3.
Review
New
Mathieu et al., Leuven, Belgium. In J Steroid Biochem Mol Biol, Oct 2015
DCs obtained from VDR null and VDR ΔAF2 bone marrow cells had comparable MHC-II, and costimulatory molecule CD86, CD80 and CD40 expression than DCs from wild-type bone marrow cells.
Clinical consequences of circulating CD28-negative T cells for solid organ transplantation.
Review
New
Betjes, Rotterdam, Netherlands. In Transpl Int, Sep 2015
UNASSIGNED: CD28 is an important costimulatory molecule expressed on T cells, interacting with CD80 and CD86 on antigen-presenting cells.
Quiescence of Memory CD8(+) T Cells Is Mediated by Regulatory T Cells through Inhibitory Receptor CTLA-4.
New
Impact
Sarkar et al., United States. In Immunity, Jul 2015
These studies present the CTLA-4-CD28-CD80/CD86 axis as a potential target to accelerate vaccine-induced immunity and improve T cell memory quality in current cancer immunotherapies proposing transient Treg cell ablation.
Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4.
Impact
Sakaguchi et al., Suita, Japan. In Immunity, 2015
Treg cells directly inhibited, via CTLA-4, B cell expression of CD80 and CD86, which was essential for Tfh cell formation.
Evidence from Human and Animal Studies: Pathological Roles of CD8(+) T Cells in Autoimmune Peripheral Neuropathies.
Review
Zhang et al., Montréal, Canada. In Front Immunol, 2014
We also discuss the findings from our most recent studies using a transgenic mouse line (L31 mice) in which the T cell co-stimulator molecule B7.2 (CD86) is constitutively expressed in antigen presenting cells of the nervous tissues.
Protein kinase C-η controls CTLA-4-mediated regulatory T cell function.
Impact
Altman et al., Los Angeles, United States. In Nat Immunol, 2014
Defective activation of this complex in PKC-η-deficient Treg cells was associated with reduced depletion of CD86 from APCs by Treg cells.
Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells.
GeneRIF
Chen et al., Cambridge, United States. In J Immunol, 2012
Although CD70 is required for dendritic cell-mediated delay of T cell tolerance induction, CD80 and CD86 are necessary for refunctionalizing the tolerized T cells in prostate tumor tissue
B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production.
GeneRIF
Silva-Santos et al., Lisbon, Portugal. In J Immunol, 2012
B7 and CD28 interactions promote the proliferation and survival of murine gammadelta T cells following Plasmodium infection.
A conserved polylysine motif in CD86 cytoplasmic tail is necessary for cytoskeletal association and effective co-stimulation.
GeneRIF
Sékaly et al., Montréal, Canada. In Biochem Biophys Res Commun, 2012
these results reveal the critical importance of the cytoskeleton-dependent CD86 polarization to the IS and more specifically the K4 motif for effective co-signaling.
CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential.
GeneRIF
Kincade et al., Oklahoma City, United States. In Blood, 2012
CD86 represents an important tool for subdividing HSCs in several circumstances, identifying those unlikely to generate a full spectrum of hematopoietic cells.
The intertransmembrane region of Kaposi's sarcoma-associated herpesvirus modulator of immune recognition 2 contributes to B7-2 downregulation.
GeneRIF
Ishido et al., Yokohama, Japan. In J Virol, 2012
Phe119 and Ser120 in the MIR2 ITM region and Asp244 in the B7-2 JM region contribute to the recognition of B7-2 by MIR2.
The soluble CTLA-4 receptor and its role in autoimmune diseases: an update.
Review
Pesce et al., Genova, Italy. In Auto Immun Highlights, 2010
A soluble form of cytotoxic T-lymphocyte-associated antigen-4 (sCTLA-4) has been established and shown to possess CD80/CD86 binding activity and in vitro immunoregulatory functions.
More papers using CD86 antibodies
The CD16+ (FcγRIII+) Subset of Human Monocytes Preferentially Becomes Migratory Dendritic Cells in a Model Tissue Setting
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Schäkel Knut et al., In The Journal of Experimental Medicine, 2001
... Antibodies used for flow cytometric staining included purified mAbs to CD3, CD14, CD19, CD36, CD64, CD86, HLA-DR, HLA-DP (all from BD Biosciences), E-cadherin (Santa Cruz Biotechnology, ...
Blockade of Attachment and Fusion Receptors Inhibits HIV-1 Infection of Human Cervical Tissue
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Shattock Robin J. et al., In The Journal of Experimental Medicine, 2001
... CD1a-FITC, CD3-FITC, CD4-FITC, CD83-FITC, DC-SIGN-FITC, HLA-DR-FITC, CD3-PE, CD4-PE, CD8-PE, CD14-PE, CD20-PE, CD25-PE, CD80-PE, CD83-PE, and CD86-PE (BD Biosciences); CD3-FITC, HLA-DR-ECD (PE-Texas red), ...
Alternate replication in B cells and epithelial cells switches tropism of Epstein-Barr virus
Supplier
Garcia-Sastre Adolfo, In PLoS Pathogens, 2001
anti-CD86 (IT2.2),
Oxidized LDL-induced NF-kappa B activation and subsequent expression of proinflammatory genes are defective in monocyte-derived macrophages from CD36-deficient patients
Supplier
Daida Hiroyuki et al., In Lipids in Health and Disease, 1999
... Anti-CD14 antibody, anti-CD86 antibody, and anti-MR antibody were obtained from eBioscience (San Diego, CA) ...
Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1
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Rodriguez-Sosa Miriam et al., In International Journal of Biological Sciences, 1999
... azide) followed by incubation with allophycocyanin-conjugated anti-CD11c and fluorescein isothiocyanate or phycoerythrin (PE)-labeled anti-MHC-II, CD80, CD86, and OX40L Abs (all antibodies from BioLegend, San Diego, CA, USA) ...
CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha
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Banchereau Jacques et al., In The Journal of Experimental Medicine, 1995
... mAbs: CD2, CD11b, CD14, HLA-DR (Becton Dickinson); CD86 (BD PharMingen); CD9 (Ancell), CD32, CD36 (Caltag), CD40, ...
Accumulation of Immature Langerhans Cells in Human Lymph Nodes Draining Chronically Inflamed Skin
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Davoust J. et al., In The Journal of Experimental Medicine, 1995
... PE-conjugated CD14 (Leu-M3, mouse IgG2b), CD1a, and CD86 (mouse IgG2b) were obtained from Becton Dickinson.
Modulation of endothelial cell proliferation, adhesion, and motility by recombinant heparin-binding domain and synthetic peptides from the type I repeats of thrombospondin.
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Bereswill Stefan, In PLoS ONE, 1992
... Mouse-anti-human CD86-FITC and isotype controls were from Dako Cytomation A/S (Glostrup, Denmark) ...
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