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CD84 molecule

CD84
This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: SLAM, Ly9, CD2, SAP, Nail
Papers on CD84
CD84 is Markedly Upregulated in Kawasaki Disease Arteriopathy.
New
Rowley et al., Chicago, United States. In Clin Exp Immunol, 17 Apr 2014
METHODS: To identify dysregulated gene expression in KD CA, we performed high-throughput RNA sequencing on KD and control CA, validated potentially dysregulated genes by real-time RT-PCR, and localized protein expression by immunohistochemistry. RESULTS: Signaling lymphocyte activation molecule CD84 was upregulated 16-fold (p<0.01) in acute KD CA (within 2 months of onset) and 32-fold (p<0.01) in chronic CA (5 months to years after onset).
CD84 is a survival receptor for CLL cells.
New
Shachar et al., Israel. In Oncogene, 20 Mar 2014
CD84 belongs to the signaling lymphocyte activating molecule family of immunoreceptors, and has an unknown function in CLL cells.
Cell surface phenotype profiles distinguish stable and progressive chronic lymphocytic leukemia.
New
Christopherson et al., Sydney, Australia. In Leuk Lymphoma, 24 Feb 2014
Using an extended DotScan(™) CLL antibody microarray (Version 3; 182 CD antibodies), and with refined analysis of purified CD19 + B-cells, the following 27 CD antigens were differentially abundant for progressive CLL: CD11a, CD11b, CD11c, CD18, CD19, CD20 (two epitopes), CD21, CD22, CD23, CD24, CD25, CD38, CD40, CD43, CD45, CD45RA, CD52, CD69, CD81, CD84, CD98, CD102, CD148, CD180, CD196 and CD270.
Proteomic analysis of human osteoarthritis synovial fluid.
New
Pandey et al., Pune, India. In Clin Proteomics, Dec 2013
These novel proteins included ADAM-like decysin 1 (ADAMDEC1), alanyl (membrane) aminopeptidase (ANPEP), CD84, fibulin 1 (FBLN1), matrix remodelling associated 5 (MXRA5), secreted phosphoprotein 2 (SPP2) and spondin 2 (SPON2).
Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis.
New
Plenge et al., Boston, United States. In Plos Genet, Mar 2013
The SNP is predicted to disrupt transcription factor binding site motifs in the 3' UTR of an immune-related gene, CD84, and the allele associated with better response to etanercept was associated with higher CD84 gene expression in peripheral blood mononuclear cells (P = 1 × 10(-11) in 228 non-RA patients and P = 0.004 in 132 RA patients).
The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets.
Nieswandt et al., Würzburg, Germany. In J Thromb Haemost, 2012
The signaling lymphocyte activation molecule (SLAM) family receptor CD84 is highly expressed in platelets and immune cells, but its role in platelet physiology is not well explored.
Decreased microRNA-142-3p/5p expression causes CD4+ T cell activation and B cell hyperstimulation in systemic lupus erythematosus.
Lu et al., Changsha, China. In Arthritis Rheum, 2012
RESULTS: We confirmed that miR-142-3p and miR-142-5p were significantly down-regulated in SLE CD4+ T cells compared with healthy controls and observed that miR-142-3p/5p levels were inversely correlated with the putative SLE-related targets signaling lymphocytic activation molecule-associated protein (SAP), CD84, and interleukin-10 (IL-10).
CD84 negatively regulates IgE high-affinity receptor signaling in human mast cells.
GeneRIF
Martín et al., Barcelona, Spain. In J Immunol, 2012
CD84 is highly expressed in mast cells and that it contributes to the regulation of FcepsilonRI signaling
[Some considerations of immune metabolism at preeclampsia].
Sanikidze et al., In Georgian Med News, 2011
In peripheral blood serum of all pregnant women at 20th week of gestation relative content of T-lymphocyte subpopulations, active T-lymphocytes and natural killers (NK) were detected by the method of indirect immunofluorescence and in cyto-toxic test using monoclonal antibodies to CD4 and CD84, CD 16 (T-cell markers of HLA-DR antigen of second class of MHC (marker of active T-lymphocytes, "ICN Pharmaceutical", USA).
Susceptibility loci for the defective foreign protein-induced tolerance in New Zealand Black mice: implication of epistatic effects of Fcgr2b and Slam family genes.
GeneRIF
Nishimura et al., Yokohama, Japan. In Eur J Immunol, 2011
Data show that defective tolerance was observed only in Fcgr2b-deficient mice with autoimmune-type Slam family genes, indicating that epistatic effects of both genes are involved.
The role of SLAM/CD2 polymorphisms in systemic autoimmunity.
Review
Wakeland et al., Dallas, United States. In Curr Opin Immunol, 2010
Three members of this gene family, Ly108, Ly9, and CD84, exhibit polymorphisms that strongly influence susceptibility to systemic autoimmunity, notably in mice, but also in some human populations.
SLAM family receptors and SAP adaptors in immunity.
Review
Impact
Schwartzberg et al., Bethesda, United States. In Annu Rev Immunol, 2010
The signaling lymphocyte activation molecule (SLAM)-associated protein, SAP, was first identified as the protein affected in most cases of X-linked lymphoproliferative (XLP) syndrome, a rare genetic disorder characterized by abnormal responses to Epstein-Barr virus infection, lymphoproliferative syndromes, and dysgammaglobulinemia. SAP consists almost entirely of a single SH2 protein domain that interacts with the cytoplasmic tail of SLAM and related receptors, including 2B4, Ly108, CD84, Ly9, and potentially CRACC.
Mouse CD84 is a pan-leukocyte cell-surface molecule that modulates LPS-induced cytokine secretion by macrophages.
GeneRIF
Engel et al., Barcelona, Spain. In J Leukoc Biol, 2010
CD84 is a pan-leukocyte receptor, able to modulate signaling pathways downstream of TLR4, and regulates macrophage cell-fate decisions and effector functions.
Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84.
Impact
Schwartzberg et al., Bethesda, United States. In Immunity, 2010
We further found that the SLAM family member CD84 was required for prolonged T cell:B cell contact, optimal T follicular helper function, and germinal center formation in vivo.
The leukocyte receptor CD84 inhibits Fc epsilon RI-mediated signaling through homophilic interaction in transfected RBL-2H3 cells.
GeneRIF
Martin et al., Barcelona, Spain. In Mol Immunol, 2008
These data suggest that CD84 may play a role in modulating Fc epsilon RI-mediated signaling in mast cells.
Structure of CD84 provides insight into SLAM family function.
GeneRIF
Almo et al., United States. In Proc Natl Acad Sci U S A, 2007
The structure of CD84 provides insight into SLAM family function. Point mutations were studied.
Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules.
Review
Impact
Tangye et al., Australia. In Annu Rev Immunol, 2006
During the past eight years, it has been established that the SLAM family of cell surface receptors (SLAM, 2B4, NTB-A, Ly9, CD84) and the SAP family of adaptors (SAP, EAT-2, ERT) play critical roles in lymphocyte development, differentiation, and acquisition of effector functions.
Novel targets for antithrombotic drug discovery.
Review
Phillips et al., San Francisco, United States. In Blood Cells Mol Dis, 2006
Recent data using proteomics and genomics strategies have established that signaling pathways during platelet aggregation are triggered by two homophilic adhesion molecules, CD84 and CD150 (SLAM), and by a novel EGF-containing receptor, PEAR1, which are tyrosine-phosphorylated in a platelet-aggregation-dependent fashion (N.
Molecular and cellular pathogenesis of X-linked lymphoproliferative disease.
Review
Tangye et al., Philadelphia, United States. In Immunol Rev, 2005
SAP is expressed in T cells, natural killer (NK) cells, and NKT cells, where it binds to the cytoplasmic domain of the surface receptor SLAM (CD150) and the related receptors, 2B4 (CD244), CD84, Ly9 (CD229), NK-T-B-antigen, and CD2-like receptor-activating cytotoxic T cells.
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