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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

CD80 molecule

CD80, B7-1
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: CD86, IgM, CAN, MHC, IL-10
Papers using CD80 antibodies
Dendritic cell podosomes are protrusive and invade the extracellular matrix using metalloproteinase MMP-14
Supplier
Figdor Carl G. et al., In Cellular and Molecular Life Sciences, 2009
... Louis, MO, USA), anti-HLA-DR/DP (Q5/13), anti-CD80 (all BD Biosciences, Mountain View, CA, USA), ...
T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
Supplier
Sherwin Robert et al., In The Journal of Experimental Medicine, 1997
... /RIP.B7-1 Transgenic Mice.
β-catenin as oncogene: the smoking gun
Supplier
Bruggen Pierre van der et al., In The Journal of Experimental Medicine, 1996
... Clonal subline BB49-SCCHN.B7 was selected on the basis of a high expression of B7-1, as determined by cytofluorimetric analysis with mAb BB1 (Becton Dickinson ...
Monoclonal T cells identified in early NOD islet infiltrates
Supplier
Janeway Charles A. et al., In The Journal of Experimental Medicine, 1995
... NOD-RIP-B7-1 transgenic mice were generated by ...
Papers on CD80
Regulatory T cells and minimal change nephropathy: in the midst of a complex network.
Review
New
Ghiggeri et al., Genova, Italy. In Clin Exp Immunol, Feb 2016
Oxidants, CD80 and CD40/CD40L have probably a relevant role at the start.
Transcriptome profiling in oral cavity and esophagus tissues from (S)-N'-nitrosonornicotine-treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis.
New
Kassie et al., Richmond, United States. In Mol Carcinog, Feb 2016
The most significant impact of exposure to (S)-NNN was alteration of genes involved in immune regulation (Aire, Ctla4, and CD80), inflammation (Ephx2 and Inpp5d) and cancer (Cdkn2a, Dhh, Fetub B, Inpp5d, Ly6E, Nr1d1, and Wnt6).
A Pilot Study of Operational Tolerance with a Regulatory T Cell-Based Cell Therapy in Living Donor Liver Transplantation.
New
Okumura et al., Sapporo, Japan. In Hepatology, Feb 2016
The cells were generated using a two-week co-culture of recipient lymphocytes with irradiated donor cells in the presence of anti-CD80/86 monoclonal antibodies.
Comparative studies on the immunoregulatory effects of three polysaccharides using high content imaging system.
New
Zhang et al., Shanghai, China. In Int J Biol Macromol, Feb 2016
APSII and GLPII significantly promoted the maturation of macrophages by the increase in the expression of MHCII, CD40, CD80 and CD86, while OGPII had less effects.
A fully human monoclonal antibody targeting PD-L1 with potent anti-tumor activity.
New
Xu et al., Suzhou, China. In Int Immunopharmacol, Feb 2016
Moreover, mAb B60-55 is an antagonistic antibody, which can block PD-L1 binding to its receptors, including PD-1 (PDCD1) and B7.1 (CD80).
Regulation of Immunity by Butyrophilins.
New
Impact
Trowsdale et al., Cambridge, United Kingdom. In Annu Rev Immunol, Feb 2016
They are considered to be members of the B7 family of costimulatory receptors, which includes B7.1 (CD80), B7.2 (CD86), and related molecules, such as PD-L1 (B7-H1, CD274), ICOS-L (CD275), and B7-H3 (CD276).
Antitumor effect of dendritic cells transfected with prostate-specific membrane antigen recombinant adenovirus on prostate cancer: An in vitro study.
New
Sui et al., Shenyang, China. In Mol Med Report, Feb 2016
The expression levels of the co-stimulatory molecules, CD80, CD83, CD86 and HLA‑DR, were significantly higher in the Ad‑PSMA‑DC group than in the other two groups (P<0.05).
The phenotype and function of murine bone marrow-derived dendritic cells is not affected by the absence of VDR or its ability to bind 1α,25-dihydroxyvitamin D3.
Review
New
Mathieu et al., Leuven, Belgium. In J Steroid Biochem Mol Biol, Oct 2015
DCs obtained from VDR null and VDR ΔAF2 bone marrow cells had comparable MHC-II, and costimulatory molecule CD86, CD80 and CD40 expression than DCs from wild-type bone marrow cells.
Clinical consequences of circulating CD28-negative T cells for solid organ transplantation.
Review
New
Betjes, Rotterdam, Netherlands. In Transpl Int, Sep 2015
UNASSIGNED: CD28 is an important costimulatory molecule expressed on T cells, interacting with CD80 and CD86 on antigen-presenting cells.
Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.
New
Impact
Klein et al., München, Germany. In Immunity, Jul 2015
Aire expression in thymic B cells coincided with major histocompatibility class II (MHCII) and CD80 upregulation and immunoglobulin class-switching.
Quiescence of Memory CD8(+) T Cells Is Mediated by Regulatory T Cells through Inhibitory Receptor CTLA-4.
New
Impact
Sarkar et al., United States. In Immunity, Jul 2015
These studies present the CTLA-4-CD28-CD80/CD86 axis as a potential target to accelerate vaccine-induced immunity and improve T cell memory quality in current cancer immunotherapies proposing transient Treg cell ablation.
Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without carboplatin in human epidermal growth factor receptor 2-positive and triple-negative primary breast cancers.
New
Impact
Loibl et al., Rostock, Germany. In J Clin Oncol, Apr 2015
mRNA expression of immune-activating (CXCL9, CCL5, CD8A, CD80, CXCL13, IGKC, CD21) as well as immunosuppressive factors (IDO1, PD-1, PD-L1, CTLA4, FOXP3) was measured in 481 tumors.
Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4.
Impact
Sakaguchi et al., Suita, Japan. In Immunity, 2015
Treg cells directly inhibited, via CTLA-4, B cell expression of CD80 and CD86, which was essential for Tfh cell formation.
Co-Stimulatory Blockade of the CD28/CD80-86/CTLA-4 Balance in Transplantation: Impact on Memory T Cells?
Review
Vanhove et al., Nantes, France. In Front Immunol, 2014
CD28 and CTLA-4 are prototypal co-stimulatory and co-inhibitory cell surface signaling molecules interacting with CD80/86, known to be critical for immune response initiation and regulation, respectively.
Thymic B Cells and Central T Cell Tolerance.
Review
Klein et al., München, Germany. In Front Immunol, 2014
Importantly, and in contrast to resting "mainstream" B cells in the periphery, thymic B cells display elevated levels of MHC class II and constitutively express CD80.
Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells.
GeneRIF
Chen et al., Cambridge, United States. In J Immunol, 2012
Although CD70 is required for dendritic cell-mediated delay of T cell tolerance induction, CD80 and CD86 are necessary for refunctionalizing the tolerized T cells in prostate tumor tissue
CD80 expression on B cells regulates murine T follicular helper development, germinal center B cell survival, and plasma cell generation.
GeneRIF
Shlomchik et al., New Haven, United States. In J Immunol, 2012
Mixed bone marrow chimeras demonstrated a B cell-intrinsic requirement for CD80 expression for normal T(FH) cell and PC development
Trogocytosis of CD80 and CD86 by induced regulatory T cells.
GeneRIF
Zhang et al., Toronto, Canada. In Cell Mol Immunol, 2012
These data demonstrate, for the first time, that iTregs can acquire CD80 and CD86 from mDCs, and the acquisition of CD86 may enhance their suppressive function.
Morphological characteristics and co-stimulatory molecule (CD80, CD86, CD40) expression in tumor infiltrating dendritic cells in human endometrioid adenocarcinoma.
GeneRIF
Wang et al., Jinan, China. In Eur J Obstet Gynecol Reprod Biol, 2012
Data suggest that expression of CD80, CD86, and CD40 on dendritic cells in normal endometrium is higher than on tumor infiltrating dendritic cells in endometrioid adenocarcinoma; this may reflect roles in antigen presentation/tumor escape.
CD80 and CD86 polymorphisms in populations of various ancestries: 5 new CD80 promoter alleles.
GeneRIF
Petzl-Erler et al., Curitiba, Brazil. In Hum Immunol, 2012
Data show that CD80 promoter and CD86 exon 8 allele frequencies vary significantly among populations of different ancestries.
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