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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CD70 molecule

CD70, CD27 ligand, CD27L
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD27, CAN, IgM, CD4, V1a
Papers on CD70
Melanoma-expressed CD70 is involved in invasion and metastasis.
New
Tilkin-Mariamé et al., Toulouse, France. In Br J Cancer, Feb 2016
BACKGROUND: CD70 is a costimulatory molecule of the tumour necrosis factor family expressed in activated immune cells and some solid tumours.
Discovery of pyrophosphate diesters as tunable, soluble and bioorthogonal linkers for site-specific antibody-drug conjugates.
New
Garbaccio et al., In J Am Chem Soc, Feb 2016
Building upon these findings, site-specific ADCs were made between this drug-linker combination and an antibody against human CD70, a receptor specifically expressed in immune cells but also found aberrantly expressed in multiple human carcinomas.
Crystal structure of the CTP1L endolysin reveals how its activity is regulated by a secondary translation product.
New
Meijers et al., Hamburg, Germany. In J Biol Chem, Jan 2016
The same oligomerization mechanism applies to the CD27L endolysin that targets Clostridium difficile and the CS74L endolysin that targets Clostridium sporogenes.
Intratumoral Delivery of TriMix mRNA Results in T-cell Activation by Cross-Presenting Dendritic Cells.
New
Breckpot et al., Brussels, Belgium. In Cancer Immunol Res, Jan 2016
We exploited this property to deliver mRNA encoding the costimulatory molecule CD70, the activation stimuli CD40 ligand, and constitutively active Toll-like receptor 4, referred to as TriMix mRNA.
Transcriptome profiling of human FoxP3(+) regulatory T cells.
New
Shevach et al., Bethesda, United States. In Hum Immunol, Jan 2016
Notably, a number of yet uncharacterized genes (RTKN2, LAYN, UTS2, CSF2RB, TRIB1, F5, CECAM4, CD70, ENC1 and NKG7) were identified and validated as being differentially expressed in human Tregs.
CD70: An emerging target in cancer immunotherapy.
Review
New
Pauwels et al., Antwerp, Belgium. In Pharmacol Ther, Nov 2015
Although normally restricted to activated T and B cells, constitutive expression of CD70 in tumor cells has been described.
Epigenetic mechanisms: An emerging role in pathogenesis and its therapeutic potential in systemic sclerosis.
Review
New
Xiao et al., Changsha, China. In Int J Biochem Cell Biol, Oct 2015
Certain cytokines or molecules, such as CD40, CD70, and Fli-1, are expressed at varying rates in SSc due to epigenetic modification and play important roles in SSc.
The CD27-CD70 pathway and pathogenesis of autoimmune disease.
Review
New
Bottaro et al., Camden, United States. In Semin Arthritis Rheum, Sep 2015
OBJECTIVE: To critically examine current evidence regarding the role of the CD27-CD70 pathway in the pathophysiology of autoimmune disease with a focus on understanding the contributions of this pathway as a potential new therapeutic target for systemic lupus erythematosus and rheumatoid arthritis.
Targeting the T-cell co-stimulatory CD27/CD70 pathway in cancer immunotherapy: rationale and potential.
Review
Borst et al., Amsterdam, Netherlands. In Immunotherapy, 2014
In 2013, cancer immunotherapy was named 'breakthrough of the year' based on the outcome of clinical trials with blocking antibodies to the T-cell co-inhibitory receptors CTLA-4 and PD-1.
[Systemic sclerosis. Part 2. Epigenetic factors in the pathogenesis of clinical manifestations].
Review
Sierakowski et al., In Przegl Lek, 2014
Current evidence demonstrates DNA heavy methylation (FLI1, NOS3, BMPRII) and hypomethylation of regulatory genes (CD40L, CD70), histone code modifications, abnormal expression of large spectrum of microRNAs.
Epitope-specific regulation of memory programming by differential duration of antigen presentation to influenza-specific CD8(+) T cells.
Impact
Randall et al., Birmingham, United States. In Immunity, 2014
Nucleoprotein (NP)-specific CD8(+) T cells encountered antigen on CD40-licensed, CD70-expressing, CD103(-)CD11b(hi) dendritic cells (DCs) at later times in the primary response.
The CD27 and CD70 costimulatory pathway inhibits effector function of T helper 17 cells and attenuates associated autoimmunity.
Impact
Borst et al., Amsterdam, Netherlands. In Immunity, 2013
The CD27 and CD70 costimulatory pathway impeded Th17 effector cell differentiation and associated autoimmunity in a mouse model of multiple sclerosis.
The CD70-CD27 axis, a new brake in the T helper 17 cell response.
Impact
Dong et al., Houston, United States. In Immunity, 2013
The CD70-CD27 interaction is known to positively regulate T cell expansion and effector function by providing costimulatory signals.
CD70 expression patterns in renal cell carcinoma.
GeneRIF
Camp et al., New Haven, United States. In Hum Pathol, 2012
The mean expression of CD70 was almost twice as high in renal cell carcinoma relative to normal kidney tissue
Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells.
GeneRIF
Chen et al., Cambridge, United States. In J Immunol, 2012
Although CD70 is required for dendritic cell-mediated delay of T cell tolerance induction, CD80 and CD86 are necessary for refunctionalizing the tolerized T cells in prostate tumor tissue
Association of CD27 and CD70 gene polymorphisms with risk of sporadic breast cancer in Chinese women in Heilongjiang Province.
GeneRIF
Li et al., Harbin, China. In Breast Cancer Res Treat, 2012
These results indicate that CD27 and CD70 gene polymorphisms may affect the risk of breast cancer and show that some SNPs are associated with breast cancer characteristics in a northern Chinese population.
CD70-driven costimulation induces survival or Fas-mediated apoptosis of T cells depending on antigenic load.
GeneRIF
van Gisbergen et al., Amsterdam, Netherlands. In J Immunol, 2012
CD70-driven costimulation induces survival or Fas-mediated apoptosis of T cells depending on antigenic load.
The CD4⁺ T-cell help signal is transmitted from APC to CD8⁺ T-cells via CD27-CD70 interactions.
GeneRIF
Schoenberger et al., Los Angeles, United States. In Nat Commun, 2011
The CD4+ T-cell help signal is transmitted from APC to CD8+ T-cells via CD27-CD70 interactions.
The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants.
Impact
van Lier et al., Amsterdam, Netherlands. In Immunity, 2011
CD70 and CD27 are costimulatory molecules that provide essential signals for the expansion and differentiation of CD8(+) T cells.
The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling.
Impact
Pulendran et al., Atlanta, United States. In Nat Immunol, 2010
ROS orchestrated T(H)2 responses by inducing oxidized lipids that triggered the induction of thymic stromal lymphopoietin (TSLP) by epithelial cells mediated by Toll-like receptor 4 (TLR4) and the adaptor protein TRIF; by suppressing production of the T(H)1-inducing molecules IL-12 and CD70 in lymph node DCs; and by inducing the DC-derived chemokine CCL7, which mediated recruitment of IL-4(+) basophils to the lymph node.
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