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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CD69 molecule

CD69
This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: CD4, CD25, CD8, CAN, Interleukin-2
Papers using CD69 antibodies
Roundabout 4 is expressed on hematopoietic stem cells and potentially involved in the niche-mediated regulation of the side population phenotype
Supplier
Clarkson B et al., In Blood Cancer Journal, 2008
... Alexa Fluor 700 anti-CD69 (clone FN50) was purchased from BioLegend.
APOBEC3G/CEM15 (hA3G) mRNA levels associate inversely with human immunodeficiency virus viremia.
Supplier
Hope Thomas J., In PLoS Pathogens, 2004
... PE conjugated anti-mouse CD24, Tri-color conjugated anti-human CD25 and PE conjugated anti-human CD69 monoclonal antibodies and isotype controls were purchased from BD Biosciences (San Jose, CA) ...
Immunization with the truncated adhesin Moraxella catarrhalis immunoglobulin D-binding protein (MID764-913) is protective against M. catarrhalis in a mouse model of pulmonary clearance.
Supplier
Stevenson Freda Kathryn, In PLoS Pathogens, 2003
... CD3, CD14, CD16, CD19, CD45, CD56, CD83 monoclonal antibodies (mAbs), FITC-conjugated mouse anti-human CD19, CD86, CD69 and HLA-DR mAbs were purchased from DAKO (Glostrup, Denmark) ...
The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling
Supplier
Weiss Arthur et al., In The Journal of Cell Biology, 1999
... 7-AAD, anti-CD5 (L17F12), anti-CD25 (2A3), anti-CD69 (L78), anti-CD3ɛ (SK7), and anti-mCD45 (30F-11) are from BD Biosciences.
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Papers on CD69
Immunomodulatory potential of Rhein, an anthraquinone moiety of Cassia occidentalis seeds.
New
Das et al., Lucknow, India. In Toxicol Lett, Feb 2016
Lymphocyte receptor expression analysis revealed that Rhein exposure significantly down regulate the expression of CD3e, CD4, CD8, CD28, CD69 molecules in T-cells.
High proportion of CD95(+) and CD38(+) in cultured CD8(+) T cells predicts acute rejection and infection, respectively, in kidney recipients.
New
Paz-Artal et al., Madrid, Spain. In Transpl Immunol, Feb 2016
UNASSIGNED: The aim of this study was to find noninvasive T-cell markers able to predict rejection or infection risk after kidney transplantation.
TG4010 immunotherapy and first-line chemotherapy for advanced non-small-cell lung cancer (TIME): results from the phase 2b part of a randomised, double-blind, placebo-controlled, phase 2b/3 trial.
New
Impact
Limacher et al., Strasbourg, France. In Lancet Oncol, Jan 2016
TG4010 is a modified vaccinia Ankara expressing MUC1 and interleukin 2. In a previous study, TG4010 combined with chemotherapy showed activity in non-small-cell lung cancer and the baseline value of CD16, CD56, CD69 triple-positive activated lymphocytes (TrPAL) was shown to be potentially predictive of TG4010 efficacy.
Tim-3 Is Upregulated in NK Cells during Early Pregnancy and Inhibits NK Cytotoxicity toward Trophoblast in Galectin-9 Dependent Pathway.
New
Qu et al., Jinan, China. In Plos One, Dec 2015
Tim-3+ dNK expressed more levels of mature markers CD94 and CD69 than Tim-3- dNK cells and blocking Tim-3 significantly inhibited dNK IFN-γ and TNF-α secretion.
T cells from patients with Candida sepsis display a suppressive immunophenotype.
New
Hotchkiss et al., Saint Louis, United States. In Crit Care, Dec 2015
Compared to control patients, CD8 T cells from patients with Candidemia had evidence of cellular activation as indicated by increased CD69 expression while CD4 T cells had decreased expression of the major positive co-stimulatory molecule CD28.
Effect of a high and low dose of caffeine on human lymphocyte activation in response to antigen stimulation.
New
Bishop et al., Auckland, New Zealand. In Appl Physiol Nutr Metab, Nov 2015
The number of antigen-stimulated NK CD69(+) cells increased in 6CAF at 1 h compared with PLA (P = 0.021).
CD69 is the crucial regulator of intestinal inflammation: a new target molecule for IBD treatment?
Review
Niess et al., Lille, France. In J Immunol Res, 2014
CD69 has been identified as an early activation marker of lymphocytes.
[Immunological Aspects in Oncology--Circulating γδ T Cells].
Review
Dubská et al., In Klin Onkol, 2014
Detailed immunophenotyping was also conducted describing representation of memory subsets (using CD45RO and CD27 markers) and presence of surface markers HLADr, CD69, CD25, CD28, CCR7, CTLA 4, ICOS, PD 1L and PD 1 between γδ T cells of the controls and breast carcinoma patients.
Natural killer cells as effectors of selection and differentiation of stem cells: role in resolution of inflammation.
Review
Tseng et al., Los Angeles, United States. In J Immunotoxicol, 2014
Therefore, it is proposed that CD16(+)CD56(dim)CD69(-) NK cells were important for the selection of stem cells, whereas the CD16(dim/-)CD56(dim/+)CD69(+) anergized NK cells were important for differentiation and eventual regeneration of the tissues and the resolution of inflammation, thus potentially serving as regulatory NK (NK(reg)) cells.
Elevated T cell receptor signaling identifies a thymic precursor to the TCRαβ(+)CD4(-)CD8β(-) intraepithelial lymphocyte lineage.
Impact
Bendelac et al., Chicago, United States. In Immunity, 2014
By cloning and expressing several TCRs isolated from unconventional iIELs, we identified immature CD4(lo)CD8(lo)(DP(lo))CD69(hi)PD-1(hi) thymocytes as the earliest postsignaling precursors for these cells.
Activation states of blood eosinophils in asthma.
Review
Johansson, Madison, United States. In Clin Exp Allergy, 2014
A number of eosinophil surface proteins, including CD69, L-selectin, intercellular adhesion molecule-1 (ICAM-1, CD54), CD44, P-selectin glycoprotein ligand-1 (PSGL-1, CD162), cytokine receptors, Fc receptors, integrins including αM integrin (CD11b), and activated conformations of Fc receptors and integrins, have been proposed to report cell activation.
FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS.
Impact
Issazadeh-Navikas et al., Copenhagen, Denmark. In Nat Med, 2014
FoxA1(+) Treg cells develop primarily in the central nervous system in response to autoimmune inflammation, have a distinct transcriptional profile and are CD4(+)FoxA1(+)CD47(+)CD69(+)PD-L1(hi)FoxP3(-).
Transforming growth factor-β signaling controls the formation and maintenance of gut-resident memory T cells by regulating migration and retention.
Impact
Bevan et al., Seattle, United States. In Immunity, 2013
During the maintenance phase, TGF-β was required for the retention of intestinal Trm cells at least in part through the induction of integrins αEβ7 and α1, as well as CD69.
CD301b⁺ dermal dendritic cells drive T helper 2 cell-mediated immunity.
Impact
Iwasaki et al., New Haven, United States. In Immunity, 2013
Transient depletion of CD301b⁺ DCs resulted in less effective accumulation and decreased expression of CD69 by polyclonal CD4⁺ T cells in the lymph node.
Mechanism of T cell regulation by microRNAs.
Review
Jiang et al., Changzhou, China. In Cancer Biol Med, 2013
For instance, miR-181 family members function in progression by targeting Bcl2 and CD69, among others.
Evidence for an intronic cis-regulatory element within CD69 gene.
GeneRIF
Lauzurica et al., Madrid, Spain. In Genes Immun, 2012
Intron I acts as an important regulatory element of CD69 expression.
Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity.
GeneRIF
Weigert et al., Frankfurt am Main, Germany. In Eur J Immunol, 2012
Priming with apoptotic debris prevented DCs from establishing cytotoxicity toward live human tumor cells by inducing a Treg-cell population, defined by coexpression of CD39 and CD69
Type II membrane protein CD69 regulates the formation of resting T-helper memory.
GeneRIF
Nakayama et al., Chiba, Japan. In Proc Natl Acad Sci U S A, 2012
Data show that CD69 is critical for the generation and maintenance of professional memory T-helper (Th) lymphocytes, which can efficiently help humoral immunity in the late phase.
CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential.
GeneRIF
Niess et al., Ulm, Germany. In J Immunol, 2012
data presented indicated that the activation Ag CD69 plays a role in regulating mucosal immune responses in the intestine
Activated CD69+ T cells foster immune privilege by regulating IDO expression in tumor-associated macrophages.
GeneRIF
Zheng et al., Guangzhou, China. In J Immunol, 2012
T cells isolated from the hepatocellular carcinoma tissues expressed significantly more CD69 molecules than did those on paired circulating and nontumor-infiltrating T cells; these tumor-derived CD69(+) T cells could induce considerable IDO in monocytes
More papers using CD69 antibodies
Centromeric Repositioning of Coreceptor Loci Predicts Their Stable Silencing and the CD4/CD8 Lineage Choice
Supplier
Brown Karen E. et al., In The Journal of Experimental Medicine, 1999
... Thymocytes were stained with CD4-PE/Cy5, CD8a-PE (Caltag Laboratories), and in some experiments CD69-FITC (BD Biosciences), and sorted on a FACS ...
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