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CD68 molecule

CD68
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, CD163, CD8, S-100
Papers using CD68 antibodies
Enzymatic-nonenzymatic cellular antioxidant defence systems response and immunohistochemical detection of MDMA, VMAT2, HSP70, and apoptosis as biomarkers for MDMA (Ecstasy) neurotoxicity
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Fineschi Vittorio et al., In Diagnostic Pathology, 2009
... CD68 (Serotec, United Kingdom)5 min Proteolytic Enzyme (Dako, Copenhagen, Denmark), 20°C.
Cell death
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Shintaku Masayuki, In Virchows Archiv, 2008
... against the following substances were employed: LC3 (polyclonal; Medical & Biological Laboratories, Nagoya, Japan; 1:1,000), CD68 (clone KP1, Dako; 1:100), and S-100 protein ...
Quantifying the role of aberrant somatic hypermutation in transformation of follicular lymphoma
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Delabie Jan et al., In Journal of Hematopathology, 2007
... CD68 (PG-M1)DAKO Cytomation, Denmark A/S ...
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
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Prassl Ruth et al., In International Journal of Nanomedicine, 2006
An Alexa Fluor 488-prelabeled rat anti-mouse CD68 antibody was used as a macrophage marker, and nonspecific rat anti-human IgG2a was used as the negative control (AbD Serotec, Dusseldorf, Germany) ...
Follicular dendritic cell sarcoma in the lymph nodes of the neck
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Adam Patrick et al., In Diagnostic Pathology, 2006
... CD68 (PG-M1)DAKO ...
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Papers on CD68
Immunogenicity, inflammation and lipid accumulation in cynomolgus monkeys infused with a lipidated Tetranectin-ApoA-I fusion protein.
New
Atzpodien et al., Basel, Switzerland. In Toxicol Sci, Feb 2016
Expected dose-dependent increases in serum lipids were accompanied by vacuolated monocytes/macrophages in multiple organs, which in the glomeruli were shown to be CD68-positive, contain lipid and co-localized with granular IgG deposits.
Association of synovial inflammation and inflammatory mediators with glenohumeral rotator cuff pathology.
New
Sokolove et al., Stanford, United States. In J Shoulder Elbow Surg, Feb 2016
Cryosections were stained and examined under light microscopy and confocal fluorescent microscopy for anti-cluster CD45 (common leukocyte antigen), anti-CD31 (endothelial), and anti-CD68 (macrophage) cell surface markers.
Myocarditis in patients with subarachnoid hemorrhage: A histopathologic study.
New
Niessen et al., Amsterdam, Netherlands. In J Crit Care, Jan 2016
Myocardium of 25 patients who died of SAH and 18 controls was stained with antibodies identifying macrophages (CD68), lymphocytes (CD45), and neutrophil granulocytes (myeloperoxidase).
Maggot debridement therapy promotes diabetic foot wound healing by up-regulating endothelial cell activity.
New
Wang et al., Nanjing, China. In J Diabetes Complications, Dec 2015
Moreover, significant elevation in CD34 and CD68 levels was also observed in treated wounds.
Palmar and plantar lichen planus: a case report and review of the literature.
Review
New
Pereyo et al., Atlanta, United States. In An Bras Dermatol, May 2015
Immunohistochemical staining revealed positivity within the epidermis and/or lichenoid infiltrate with CD3, CD8, CD45, CD68, myeloid histiod antigen, BCL2, p27, p53, HLA-DPDQDR, metallothionein and tissue inhibitor of metalloproteinases 1.
An unusual tumour of the lung.
Review
New
Sellami-Boudawara et al., In Pathologica, Mar 2015
The neoplastic mast cells stained strongly with tryptase, CD117, CD68 and CD45, CD14 and CD33; whereas the undifferentiated cells lacked all these markers and expressed EMA and cytokeratin.
Can macrophages within the microenvironment of locally invasive rectal cancers predict response to radiotherapy?
New
Impact
Jayne et al., Leeds, United Kingdom. In Lancet, Mar 2015
Dual-staining immunohistochemistry was performed with CD68 as macrophage marker, HLA-DR as M1 marker, and CD163 as M2 marker.
Potential for monocyte recruitment by IgE immunotherapy for cancer in a rat model of tumour metastasis.
New
Impact
Karagiannis et al., London, United Kingdom. In Lancet, Mar 2015
We measured significant CD68-positive (CD68+) macrophage infiltration of tumours after MOv18 IgE treatment (mean ratio of CD68+ cells in tumour vs periphery 3·6 [0·5] for MOv18 IgE-treated tumours vs 2·3 [0·3] for MOv18 IgG-treated tumours; p=0·03).
[CEREBRAL MICROGLIA AND MICROGLIAL MARKERS].
Review
Kirik et al., In Morfologiia, 2014
the main attention is focused on microglial markers--the proteins (Iba-1, CD11b, CD68, HLA-DR, and some others) expressed by normal microgliocytes and those activated by the effects of damaging factors.
A rare case of pulmonary sclerosing hemagioma with lymph node metastasis and review of the literature.
Review
Zhang et al., Hangzhou, China. In Int J Clin Exp Pathol, 2014
Immunohistochemistry (IHC) revealed that both surface-lining cuboidal and polygonal cells expressed EMA and thyroid transcription factor 1 (TTF-1), but were negative for CD34, VIII factor, CD68 and Claratinin.
Cryptococcal infection of the femoral bone similar with pathologic features of vascular tumors: a case report and review of literature.
Review
Jiang et al., Guangzhou, China. In Int J Clin Exp Pathol, 2014
By immunohistochemistry (IHC), only CD31 and CD68 were positive, while CK, CK8/18, EMA, P63, CK7, CK20, PSAP, PSA, CD34 negative.
Oxidative Stress Is Associated with Neuroinflammation in Animal Models of HIV-1 Tat Neurotoxicity.
Strayer et al., Philadelphia, United States. In Antioxidants (basel), 2013
Administration of Tat in the CP induced an increase in numbers of Iba-1- and CD68-positive cells, as well as an infiltration of astrocytes.
Gene expression-based model using formalin-fixed paraffin-embedded biopsies predicts overall survival in advanced-stage classical Hodgkin lymphoma.
Impact
Gascoyne et al., Vancouver, Canada. In J Clin Oncol, 2013
The predictor was superior to the International Prognostic Score and CD68 immunohistochemistry in multivariate analyses.
Expression of FOXP3, CD68, and CD20 at diagnosis in the microenvironment of classical Hodgkin lymphoma is predictive of outcome.
Impact
Gribben et al., London, United Kingdom. In J Clin Oncol, 2013
We aimed to overcome these limitations by validating recently identified microenvironment biomarkers (CD68, FOXP3, and CD20) in a new patient cohort with a greater extent of tissue and by using rigorous statistical methodology.
Low macrophage accumulation in skeletal muscle of obese type 2 diabetics and elderly subjects.
GeneRIF
Ravussin et al., Baton Rouge, United States. In Obesity (silver Spring), 2012
elderly subjects had twofold higher CD68 and CD206 gene expression (both P < 0.002) than young participants. In both studies, CD68(+) muscle macrophages were not associated with BMI.
CD68 and CD163 as prognostic factors for Korean patients with Hodgkin lymphoma.
GeneRIF
Huh et al., Seoul, South Korea. In Eur J Haematol, 2012
CD68 and CD163 are prognostic factors for Korean patients with Hodgkin lymphoma
CD163 versus CD68 in tumor associated macrophages of classical Hodgkin lymphoma.
GeneRIF
Ibrahim et al., New York City, United States. In Diagn Pathol, 2011
CD163 staining is lower than CD68, with less non-specific staining of background inflammatory cells and Hodgkin cells, therefore is a better marker for Hodgkin lymphoma associated macrophages.
Immunohistochemical expression of anti-CD68 antibody in atherosclerotic plaque.
GeneRIF
Foia et al., Jászvásár, Romania. In Rom J Morphol Embryol, 2011
CD68 may have a role in atherosclerotic plaque
Statins promote the regression of atherosclerosis via activation of the CCR7-dependent emigration pathway in macrophages.
GeneRIF
Garabedian et al., New York City, United States. In Plos One, 2010
Statins promote the beneficial remodeling of plaques in diseased mouse arteries through the stimulation of the CCR7 / CD68 emigration pathway in macrophages
Macrophage markers in serum and tumor have prognostic impact in American Joint Committee on Cancer stage I/II melanoma.
Impact
GeneRIF
Steiniche et al., Århus, Denmark. In J Clin Oncol, 2009
Results show that both serum levels of sCD163 and the presence of CD68(+) macrophage infiltration at the tumor invasive front are independent predictors of survival in AJCC stage I/II melanoma.
More papers using CD68 antibodies
Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas
Supplier
Kirchmair Rudolf, In PLoS ONE, 2003
... and the following antibodies; CD68, Dako M0876; MMP-1, Millipore MAB3307; ...
De novo CD5+ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients
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Stein Harald et al., In Virchows Archiv, 2001
... CD68PG-M1Citrate1:50Dako ...
Neuron count reevaluation in the myenteric plexus of chagasic megacolon after morphometric neuron analysis
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Adad Sheila Jorge et al., In Journal of Tropical Medicine, 2000
... Immunohistochemistry (polymers technique) was performed for anti-CD20 (DAKO, dilution 1 : 600, clone: L26, Carpinteria, CA), anti-CD68 (DAKO, dilution 1 : 1000, clone: KP1, ...
IL-6 switches the differentiation of monocytes from dendritic cells to macrophages
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Moser Bernhard et al., In The Journal of Experimental Medicine, 1999
... antibodies were from Miltenyi Biotec, and anti-CD3 and S-100 rabbit IgG, and anti-CD20 (L26) and anti-CD68 (PG-M1) mouse monoclonal antibodies were from Dako.
Calreticulin: one protein, one gene, many functions
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Mangge Harald et al., In Biologics : Targets & Therapy, 1998
... AlexaFluor488-prelabeled rat antimouse CD31 and rat antimouse CD68 antibodies were used as endothelial cell and macrophage markers, respectively (AbD Serotec, Dusseldorf, Germany) ...
Sphingosine kinase. Assay and product analysis.
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Combs Colin, In PLoS ONE, 1997
... double-immunostainings were performed by incubating sections with mouse anti-GFAP (1∶200; Chemicon, Temicula, CA) or mouse anti-CD68 (1∶250; Dako, Glostrup, Denmark) with either ...
Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms.
Supplier
Seifert H. Steven, In PLoS Pathogens, 1997
... The rat monoclonal anti-CD68 monoclonal antibody FA-11 was obtained from AbD Serotec (Kidlington, UK) ...
Platelet-derived endothelial cell growth factor/thymidine phosphorylase immunohistochemical expression in lymphoid tissue and lymphoid malignancies
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Hou J. Steve et al., In Advances in Hematology, 1996
... this study were TP (1 : 1000; Novus Biologicals, Littleton, Colo), CD3 (1 : 100; Dako), CD4 (1 : 10; Dako), CD68 (1 : 2000; Dako), and CD21 (1 : 50; Vector, ...
Effect of hypertension and cardiac hypertrophy on coronary artery morphology in sudden cardiac death
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Burke Allen et al., In Pathology Research International, 1995
... Macrophages were identified by CD68, KP-1 clone (Dako, Carpinteria, dilution 1:50), and ...
(-)deprenyl increases activities of superoxide dismutase and catalase in certain brain regions in old male mice
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Hammond Robert R et al., In Journal of Neuroinflammation, 1993
... Monoclonal anti-CD68 antibody was from Dako (Mississauga, ON, Canada) ...
A radioautographic study of the hepatic uptake of circulating carcinoembryonic antigen by the mouse
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Reitsma Pieter H., In PLoS ONE, 1976
... (Invitrogen) of goat anti-rabbit IgG (H+L) as secondary antibody (green) and with monoclonal rat anti-mouse CD68 (AbD Serotec, Oxford, UK) followed by ...
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