gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Fc fragment of IgG, high affinity Ia, receptor

CD64, FcgammaRI, Fc gamma receptor, IgG Fc receptor, FcRI
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD32, CD16, CAN, HAD, CD14
Papers on CD64
Biotinylation of the Fcγ receptor ectodomains by mammalian cell co-transfection: application to the development of a surface plasmon resonance-based assay.
New
Durocher et al., Montréal, Canada. In J Mol Recognit, Feb 2016
Finally, biotin-tagged FcγRs produced with the in-cell approach are successfully applied to the development of SPR-based assays to evaluate the impact of the glycosylation pattern of monoclonal antibodies on their interaction with CD16a and CD64.
Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses.
New
Mehandru et al., New York City, United States. In J Exp Med, Feb 2016
Compared with lung DCs (LDC), lung CD64(+) macrophages had decreased expression of B cell activation genes and induced significantly less IgA production.
Fully-human MAP-fusion protein selectively targets and eliminates proliferating CD64(+) M1 macrophages.
New
Thepen et al., Aachen, Germany. In Immunol Cell Biol, Feb 2016
Here, we describe a new fully-human CFP called H22(scFv)-MAP which specifically targets CD64(+) cells.
Utility of immune response-derived biomarkers in the differential diagnosis of inflammatory disorders.
Review
New
Kullberg et al., Nijmegen, Netherlands. In J Infect, Jan 2016
CD64 expression on neutrophils can discriminate between non-infectious systemic inflammation and sepsis, and limited evidence suggests the same for decoy receptor 3. PCT is useful for both diagnosing bacterial infection complicating influenza and guiding antibiotic treatment in lower respiratory tract infections in general.
High-Affinity Fc Receptor Expression Indicates Relative Immaturity in Human Monocytes.
New
Clanchy, Melbourne, Australia. In J Interferon Cytokine Res, Jan 2016
As CD14(hi)CD64(hi) monocytes have higher proliferative potential than CD14(hi)CD64(lo) monocytes, the surface marker profile on 4 subsets defined by CD14 and CD64 was measured.
Laparoscopically assisted colorectal surgery provides better short-term clinical and inflammatory outcomes compared to open colorectal surgery.
New
Ihan et al., Ljubljana, Slovenia. In Arch Med Sci, Jan 2016
CD64 expression and cytokine expression were also determined.
The many faces of FcγRI: implications for therapeutic antibody function.
Review
New
Feldman et al., Silver Spring, United States. In Immunol Rev, Nov 2015
Fcγ receptor I (FcγRI or CD64) is the sole human Fc receptor with high affinity for monovalent IgG.
Fc receptor inside-out signaling and possible impact on antibody therapy.
Review
New
Leusen et al., Utrecht, Netherlands. In Immunol Rev, Nov 2015
This regulatory mechanism has been described for FcγRI (CD64), FcγRIIa (CD32a), and FcαRI (CD89) and is also well-known for integrins.
[LABORATORY MARKERS FOR EARLY DIAGNOSIS OF NEONATAL SEPSIS].
Review
New
Shishkina et al., In Anesteziol Reanimatol, May 2015
We notified the newest methods in sepsis diagnosis such as plasma amyloid A, DAMP molecules, cell surface markers CD64, CD11b, and inter-a inhibitor proteins.
Effective Biomarkers for Diagnosis of Neonatal Sepsis.
Review
Bhandari, New Haven, United States. In J Pediatric Infect Dis Soc, 2014
The diagnostic utility of the following biomarkers seems to be most practical in the early (interleukin [IL]-6, IL-8, tumor necrosis factor-alpha, neutrophil CD64), mid (procalcitonin) and late (C-reactive protein) phases of neonatal sepsis.
A role for the ITAM signaling module in specifying cytokine-receptor functions.
Impact
Medzhitov et al., New Haven, United States. In Nat Immunol, 2014
Through the use of the receptor for interferon-γ (IFN-γR) and the ITAM adaptor Fcγ as an example, we found that IFN-γ modified responses of the phagocytic antibody receptor FcγRI (CD64) to specify cell-autonomous antimicrobial functions.
Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin.
Impact
Henri et al., Marseille, France. In Immunity, 2013
By combining CD64 and CCR2 staining, we successfully identified each of these cell types and studied their origin, transcriptomic signatures, and migratory and T cell stimulatory properties.
IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses.
Impact
Ginhoux et al., Singapore, Singapore. In Immunity, 2013
Here, we showed that murine lung and gut lamina propria CD11b+ DC populations were comprised of two subsets: FLT3- and IRF4-dependent CD24(+)CD64(-) DCs and contaminating CSF-1R-dependent CD24(-)CD64(+) macrophages.
Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen.
Impact
Lambrecht et al., Gent, Belgium. In Immunity, 2013
By using CD64 and MAR-1 staining, we reliably separated CD11b(+) monocyte-derived DCs (moDCs) from conventional DCs (cDCs) and studied antigen uptake, migration, and presentation assays of lung and lymph node (LN) DCs in response to inhaled house dust mite (HDM).
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages.
Impact
Immunological Genome Consortium et al., New York City, United States. In Nat Immunol, 2012
Nonetheless, well-characterized surface markers, including MerTK and FcγR1 (CD64), along with a cluster of previously unidentified transcripts, were distinctly and universally associated with mature tissue macrophages.
MicroRNA-127 inhibits lung inflammation by targeting IgG Fcγ receptor I.
GeneRIF
Jiang et al., Durham, United States. In J Immunol, 2012
IgG FcgammaRI (CD64) is a target of miR-127, as evidenced by reduced CD64 protein expression in macrophages overexpressing miR-127.
Serine phosphorylation of FcγRI cytoplasmic domain directs lipid raft localization and interaction with protein 4.1G.
GeneRIF
Kimberly et al., Birmingham, United States. In J Leukoc Biol, 2012
A phosphoserine-dependent tethering role for protein 4.1G in lipid rafts provides insight into the unique phosphoserine-based regulation of FcgammaRI receptor signaling.
Crystal structure of Fcγ receptor I and its implication in high affinity γ-immunoglobulin binding.
GeneRIF
Sun et al., Rockville, United States. In J Biol Chem, 2011
a molecular mechanism for the high affinity IgG recognition by FcgammaRI
Coupling of Fcγ receptor I to Fcγ receptor IIb by SRC kinase mediates C-reactive protein impairment of endothelial function.
GeneRIF
Shaul et al., Dallas, United States. In Circ Res, 2011
CRP antagonism of eNOS is mediated by coupling of FcgammaRI to FcgammaRIIB by Src kinase and activation of inositol 5'-phosphatase 1, and consistent with this mechanism, both FcgammaRI and FcgammaRIIB are required for CRP to blunt endothelial repair in vivo.
Neutrophil CD64 as a sepsis biomarker.
Review
GeneRIF
Hoffmann, Wiesbaden, Germany. In Biochem Med (zagreb), 2010
Neutrophil CD64 appears to be a better diagnostic test than traditional hematological assays.
share on facebooktweetadd +1mail to friends