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CD63 molecule

CD63, ME491
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. The use of alternate polyadenylation sites has been found for this gene. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, P-selectin, IgE, HAD, Tetraspanin
Papers using CD63 antibodies
Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis.
Srivastava Rakesh K., In PLoS ONE, 2009
... Polyclonal antibodies to AnxA2, AnxA6, EEA1, CD71, LAMP1, HSP90, and CD63 were purchased from Santa Cruz Biotechnology Inc ...
A six-color polychromatic flow cytometry to evaluate human basophil activation
Bellavite Paolo et al., In Clinical and Molecular Allergy : CMA, 2007
... , clone 2D1) and anti-CD63-FITC (isotype IgG1, clone H5C6) were purchased from Becton Dickinson Pharmingen USA ...
Bioavailability of quercetin from berries and the diet
Bellavite Paolo et al., In Clinical and Molecular Allergy : CMA, 2005
... clone NP4D6), CD63-FITC (isotype IgG1 clone MEM-259) were purchased from Biolegend, San Diego CA, USA ...
CellProfiler: image analysis software for identifying and quantifying cell phenotypes.
Saks Valdur, In PLoS ONE, 2005
... Rat anti-CD63/lamp-3 (R5G2) was from MBL International (Woburn, MA, USA) ...
Induction of p38 mitogen-activated protein kinase reduces early endosome autoantigen 1 (EEA1) recruitment to phagosomal membranes
Puertollano Rosa et al., In Traffic (Copenhagen, Denmark), 2002
... Minneapolis, MN, USA), mouse monoclonal to α-adaptin (AP-6; Affinity Bioreagents, Golden, CO, USA), mouse monoclonal anti-CD63 (H5C6; BD Pharmigen, San Jose, CA, USA), mouse phosphotyrosine antibody (clone 4G10; Upstate Biotechnology, Lake Placid, NY, USA), rabbit anti-GFP (MBL International, Woburn, MA, USA), ...
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Papers on CD63
Targeting of Neutrophil Lewis X Blocks Transepithelial Migration and Increases Phagocytosis and Degranulation.
Parkos et al., Atlanta, United States. In Am J Pathol, Feb 2016
There was increased surface expression of Le(x) on PMN after TEM, and blockade of terminal Le(x) regulated post-migratory PMN functions, increasing PMN phagocytosis and the surface mobilization of azurophilic (CD63, myeloperoxidase, and neutrophil elastase) and specific (CD66b and lactoferrin) granule markers.
Exosomal transfer of functional small RNAs mediates cancer-stroma communication in human endometrium.
Kyo et al., Kanazawa, Japan. In Cancer Med, Jan 2016
The isolated fibroblasts were cultured in conditioned media from CD63-GFP-expressing Ishikawa cells, and we found that GFP-positive exosomes were transferred from Ishikawa cells to the fibroblasts.
Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals.
Bond et al., In J Vis Exp, Dec 2015
Exosomes were identified on the basis of exosome markers acetylcholinesterase (AChE), and the CD9, CD63, and CD45 antigens.
Tumor-derived exosomes in cancer progression and treatment failure.
Feng et al., Nanjing, China. In Oncotarget, Dec 2015
Exosomes have diameter within the range of 30-100nm and spherical to cup-shaped nanoparticles with specific surface molecular characteristics, such as CD9 and CD63.
Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods.
Giricz et al., Budapest, Hungary. In Plos One, 2014
Furthermore, with this method only a minor fraction of total exosomes could be isolated from blood as deduced from the constant amount of exosomal markers CD63 and TSG101 detected after serial UC of rat blood plasma samples.
CD81-receptor associations--impact for hepatitis C virus entry and antiviral therapies.
Baumert et al., Strasbourg, France. In Viruses, 2014
HCV entry into hepatocytes is a complex process that requires the coordinated interaction of viral and host factors for the initiation of infection, including CD81, scavenger receptor BI, claudin-1, occludin, membrane-bound host cell kinases, Niemann-Pick C1 Like 1, Harvey rat sarcoma viral oncogene homolog (HRas), CD63 and transferrin receptor 1. Furthermore, recent data in HCV model systems have demonstrated that targeting critical components of tetraspanins and associated cell membrane proteins open new avenues to prevent and treat viral infection.
Exosomes: a novel pathway of local and distant intercellular communication that facilitates the growth and metastasis of neoplastic lesions.
Grizzle et al., Birmingham, United States. In Am J Pathol, 2014
A subgroup of such microvesicles is called exosomes and is described in blood as 30 to 100 nm in diameter and as spherical to cup-shaped nanoparticles with specific surface molecular characteristics (eg, expression of the tetraspanins CD9, CD81, and CD63).
Mast cells and basophils are essential for allergies: mechanisms of allergic inflammation and a proposed procedure for diagnosis.
Yang et al., Jinzhou, China. In Acta Pharmacol Sin, 2013
The identification of surface membrane activation markers of mast cells and basophils (CD203c, CCR3, CD63, etc) has led to development of the basophil activation test (BAT), an in vitro specific allergen challenge test (SACT).
Update on the performance and application of basophil activation tests.
Saini et al., Baltimore, United States. In Curr Allergy Asthma Rep, 2013
Though no standardized technique currently exists, recent advances have improved the performance of this assay, including identification of new basophil-specific markers and comparisons of the expression of CD63 to CD203c during activation.
Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model.
Verma et al., Los Angeles, United States. In Nat Cell Biol, 2012
Activation of the Erk signalling pathway and cell proliferation requires Timp-1 and its receptor CD63.
Activation of peripheral-blood granulocytes is strongly correlated with patient outcome after immunotherapy with anti-GD2 monoclonal antibody and granulocyte-macrophage colony-stimulating factor.
Cheung et al., New York City, United States. In J Clin Oncol, 2012
Samples were analyzed by flow cytometry for CD11a, CD63, CD87, and CD11b and its activation epitope CBRM1/5.
The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis.
Raposo et al., Paris, France. In Dev Cell, 2011
Loss of CD63 is associated impairment of amyloidogenesis and downstream melanosome morphogenesis.
CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin.
Cutler et al., London, United Kingdom. In Blood, 2011
Loss of CD63 has a similar phenotype to loss of P-selectin itself, thus CD63 is an essential cofactor to P-selectin.
The role of tetraspanin CD63 in antigen presentation via MHC class II.
Berditchevski et al., Birmingham, United Kingdom. In Eur J Immunol, 2011
shRNA knockdown in B lymphoblastoid cell line results to increased CD4(+) T-cell recognition
LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation.
Pegtel et al., Amsterdam, Netherlands. In Embo J, 2011
C-terminal modifications that retain LMP1 in Golgi compartments preclude assembly within CD63-enriched domains and/or exosomal discharge leading to NF-kappaB overstimulation.
Down-regulation of TM4SF is associated with the metastatic potential of gastric carcinoma TM4SF members in gastric carcinoma.
Hoang-Vu et al., Wenzhou, China. In World J Surg Oncol, 2010
decreased levels of CD63 were associated with distant and lymph node metastasis status and does play a direct role in human gastric carcinogenesis.
Intercellular transfer to signalling endosomes regulates an ex vivo bone marrow niche.
Lippincott-Schwartz et al., Bethesda, United States. In Nat Cell Biol, 2009
HPCs made prolonged contact with the osteoblast surface through a specialized membrane domain enriched in prominin 1, CD63 and rhodamine PE.
Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells.
Abraham et al., Durham, United States. In Nat Med, 2007
We report that type 1 fimbriated uropathogenic Escherichia coli (UPEC) circumvents the bladder barrier by harboring in these Rab27b/CD63-positive and cAMP-regulatable fusiform vesicles within bladder epithelial cells (BECs).
Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse.
Griffiths et al., Oxford, United Kingdom. In Nat Immunol, 2003
Although the lysosomal protein CD63 was mislocalized to the plasma membrane, perforin and granzymes were correctly localized to the lytic granules in AP-3-deficient CTLs.
More papers using CD63 antibodies
Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes
Mekada Eisuke et al., In The Journal of Cell Biology, 2001
... Mouse anti-CD9 mAbs (BU16 and MM2/57), anti-CD81 mAb (JS64), and anti-CD63 mAb (AHN-16) were purchased from Biodesign, Biosource International, Immunotech, and ...
Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties
Rooijakkers Suzan H M et al., In The EMBO Journal, 1996
... CD44 (515, BD), CD47 (B6H12, BD), CD49b (12F1, BD), CD54 (HA58, BD), CD58 (1C3, BD), CD63 (CLB-gran/12, ImmunoTech), CD87 (VIM5, BD), CD88 (S5/1, Biolegend), CD89 (Mip8a, Abd-Serotec), CD114 ...
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