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CD59 molecule, complement regulatory protein

CD59, MINI, protectin
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD55, CAN, HAD, CD46, ACID
Papers on CD59
Increased levels of CSF CD59 in neuromyelitis optica and multiple sclerosis.
Kuwabara et al., Chiba, Japan. In Clin Chim Acta, Mar 2016
We determined whether CSF CD59, which is a complement regulator and C5b-9 formation inhibitor, is involved in the pathogenesis of NMO and MS.
Cell type-specific modulation of lipid mediator's formation in murine adipose tissue by omega-3 fatty acids.
Kopecky et al., Praha, Czech Republic. In Biochem Biophys Res Commun, Feb 2016
Our results demonstrate selective increase in levels of anti-inflammatory lipid mediators in WAT in response to omega-3, reflecting either their association with adipocytes (endocannabinoid-related N-docosahexaenoylethanolamine) or with stromal vascular cells (pro-resolving lipid mediator protectin D1).
Increased internalization of complement inhibitor CD59 may contribute to endothelial inflammation in obstructive sleep apnea.
Jelic et al., New York City, United States. In Sci Transl Med, Feb 2016
The target of a differentially bound peptide on ECs collected from OSA patients was identified as CD59, a major complement inhibitor that protects ECs from the membrane attack complex (MAC).
DNA methylation and the social gradient of osteoporotic fracture: A conceptual model.
Williams et al., Geelong, Australia. In Bone, Jan 2016
MINI ABSTRACT: Our conceptual model proposes how DNA methylation might underpin the social gradient in osteoporotic fracture.
Urinary alpha-1 antitrypsin and CD59 glycoprotein predict albuminuria development in hypertensive patients under chronic renin-angiotensin system suppression.
Alvarez-Llamas et al., Madrid, Spain. In Cardiovasc Diabetol, Dec 2015
RESULTS: CD59 glycoprotein and alpha-1 antitrypsin (AAT) resulted already altered in patients developing albuminuria de novo, with a similar response in those with maintained albuminuria.
Complement in hemolytic anemia.
Brodsky, Baltimore, United States. In Blood, Dec 2015
Paroxysmal nocturnal hemoglobinuria (PNH) cells are susceptible to hemolysis because of a loss of the complement regulatory proteins CD59 and CD55.
The immunomodulatory oligodendrocyte.
Schaeren-Wiemers et al., Basel, Switzerland. In Brain Res, Oct 2015
CD46, CD55, CD59), tetraspanins (e.g.
A Hispanic female patient with heartburn: A rare presentation of Paroxysmal Nocturnal Hemoglobinuria.
Cáceres-Pérkins et al., In Bol Asoc Med P R, Jul 2015
Peripheral blood flow cytometry assays revealed diminished expression of CD55 and CD59 on the erythrocytes, granulocytes and monocytes.'
Role of complement and complement regulatory proteins in the complications of diabetes.
Halperin et al., Boston, United States. In Endocr Rev, Jun 2015
In this article, we summarize the body of evidence that supports a role for the complement system and complement regulatory proteins in the pathogenesis of diabetic vascular complications, with specific emphasis on the role of the membrane attack complex (MAC) and of CD59, an extracellular cell membrane-anchored inhibitor of MAC formation that is inactivated by nonenzymatic glycation.
Congenital CD59 Deficiency.
Schrezenmeier et al., Ulm, Germany. In Hematol Oncol Clin North Am, Jun 2015
The severe clinical symptoms of inherited CD59 deficiency confirm the importance of CD59 as essential complement regulatory protein for protection of cells against complement attack, in particular protection of hematopoietic cells and human neuronal tissue.
Pro-resolving lipid mediators are leads for resolution physiology.
Serhan, Boston, United States. In Nature, 2014
Advances in our understanding of the mechanisms that bring about the resolution of acute inflammation have uncovered a new genus of pro-resolving lipid mediators that include the lipoxin, resolvin, protectin and maresin families, collectively called specialized pro-resolving mediators.
Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis.
Marette et al., Québec, Canada. In Nat Med, 2014
Herein we show that protectin DX (PDX) exerts an unanticipated glucoregulatory activity that is distinct from its anti-inflammatory actions.
Investigating structure-activity relationship and mechanism of action of antitubercular 1-(4-chlorophenyl)-4-(4-hydroxy-3-methoxy-5-nitrobenzylidene) pyrazolidine-3,5-dione [CD59].
Sriram et al., Hyderābād, India. In Int J Mycobacteriol, 2014
BACKGROUND AND OBJECTIVES: The objective of this study is to synthesize and evaluate 1-(4-chlorophenyl)-4-(4-hydroxy-3-methoxy-5-nitrobenzylidene) pyrazolidine-3,5-dione (CD59) analogues to establish structure-activity relationship and mechanism of action.
The complement inhibitor CD59 regulates insulin secretion by modulating exocytotic events.
Renström et al., Malmö, Sweden. In Cell Metab, 2014
Complement proteins are a component of innate immunity and kill non-self cells by perforating the plasma membrane, a reaction prevented by CD59.
The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza.
Imai et al., Akita, Japan. In Cell, 2013
Using mediator lipidomics and bioactive lipid screen, we report that the omega-3 polyunsaturated fatty acid (PUFA)-derived lipid mediator protectin D1 (PD1) markedly attenuated influenza virus replication via RNA export machinery.
HBXIP upregulates CD46, CD55 and CD59 through ERK1/2/NF-κB signaling to protect breast cancer cells from complement attack.
Ye et al., Tianjin, China. In Febs Lett, 2012
Data suggest that HBXIP upregulates CD46, CD55 and CD59 through p-ERK1/2/NF-kappaB signaling to protect breast cancer from complement-dependent cytotoxicity.
DAF/CD55 and Protectin/CD59 modulate adaptive immunity and disease outcome in experimental autoimmune myasthenia gravis.
Xuebin et al., Saint Louis, United States. In J Neuroimmunol, 2012
Actively immunized experimental autoimmune myasthenia gravis mice deficient in either CD55 or CD59 showed significant differences in adaptive immune responses and worsened disease outcome associated with increased levels of serum cytokines, modified production of acetylcholine receptor antibodies, and more complement deposition at the neuromuscular junction.
Post-transcriptional CD59 gene silencing by siRNAs induces enhanced human T lymphocyte response to tumor cell lysate-loaded DCs.
Wang et al., Qingdao, China. In Cell Immunol, 2011
findings demonstrated that decreased CD59 expression on T cells significantly enhanced activation and proliferation of CD4( ) T cells and CD8( ) T cells; data support that CD59 down-regulates antigen-specific activation of T lymphocytes in a ligand-dependent manner
Both freshly prepared and frozen-stored amniotic membrane cells express the complement inhibitor CD59.
Németh et al., Budapest, Hungary. In Scientificworldjournal, 2011
CD59 was expressed both on freshly prepared and frozen-stored samples. Higher level of CD59 was detected on ICAM1+ mesenchymal cells than on nanog+ epithelial cells.
The effects of CD59 gene as a target gene on breast cancer cells.
Xu et al., Qingdao, China. In Cell Immunol, 2010
Overexpression of CD59 promoted the proliferation of MCF-7 breast cancer cells and inhibited anti-apoptotic Bcl-2 expression making CD59 a promising target in the gene therapy of breast cancer.
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