Complement in hemolytic anemia.
Baltimore, United States. In Blood, Dec 2015
Paroxysmal nocturnal hemoglobinuria (PNH) cells are susceptible to hemolysis because of a loss of the complement regulatory proteins CD59 and CD55.
Role of complement and complement regulatory proteins in the complications of diabetes.
Boston, United States. In Endocr Rev, Jun 2015
In this article, we summarize the body of evidence that supports a role for the complement system and complement regulatory proteins in the pathogenesis of diabetic vascular complications, with specific emphasis on the role of the membrane attack complex (MAC) and of CD59, an extracellular cell membrane-anchored inhibitor of MAC formation that is inactivated by nonenzymatic glycation.
Congenital CD59 Deficiency.
Ulm, Germany. In Hematol Oncol Clin North Am, Jun 2015
The severe clinical symptoms of inherited CD59 deficiency confirm the importance of CD59 as essential complement regulatory protein for protection of cells against complement attack, in particular protection of hematopoietic cells and human neuronal tissue.
Pro-resolving lipid mediators are leads for resolution physiology.
Boston, United States. In Nature, 2014
Advances in our understanding of the mechanisms that bring about the resolution of acute inflammation have uncovered a new genus of pro-resolving lipid mediators that include the lipoxin, resolvin, protectin and maresin families, collectively called specialized pro-resolving mediators.