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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

CD58 molecule

CD58, LFA-3
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: Intercellular Adhesion Molecule-1, CD2, CD11b, CAN, CD80
Papers using CD58 antibodies
DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
Supplier
Marovich Mary A. et al., In The Journal of Experimental Medicine, 2001
... anti–DC-SIGN2 (clone 120612), anti–L-SIGN (clone 120604; R&D Systems), anti-CD11a (lymphocyte function–associated antigen 1, LFA-1), anti-CD58 (LFA-3), anti-CD74 (invariant chain), and matched isotype controls (Becton Dickinson).
Papers on CD58
Discovery of signature genes in gastric cancer associated with prognosis.
New
Ma et al., In Neoplasma, Feb 2016
A total of 17 genes were identified as signature genes, such as DAB2, ALDH2, CD58, CITED2, BNIP3L, SLC43A2, FAU and COL5A1.Many signature genes associated with prognosis of GC were identified in present study, some of which have been implicated in the pathogenesis of GC.
Molecular Pathology of Adult T-Cell Leukemia/Lymphoma.
Review
New
Ohshima, Kurume, Japan. In Oncology, Nov 2015
Furthermore, we found that genomic alteration of CD58, which is implicated in immune escape, is more frequently observed in acute than in chronic ATLL.
A poxviral-based cancer vaccine the transcription factor twist inhibits primary tumor growth and metastases in a model of metastatic breast cancer and improves survival in a spontaneous prostate cancer model.
New
Hodge et al., Bethesda, United States. In Oncotarget, Oct 2015
An alternative therapeutic strategy is a vaccine comprised of a Modified vaccinia Ankara (MVA), incorporating the Twist transgene and a TRIad of COstimulatory Molecules (B7-1, ICAM-1, LFA-3; TRICOM).
Ultrastructural study of cultured ovine bone marrow-derived mesenchymal stromal cells.
New
Resta et al., Bari, Italy. In Ann Anat, Sep 2015
Flow cytometry displayed that all oBM-MSCs lacked expression of CD31, CD34, CD45, HLA-DR whereas they expressed CD44, CD58, HLAI and a minor subset of the cell population (12%) exhibited CD90.
[Expression of CD58 in childhood B-lineage acute lymphoblastic leukemia and its feasibility in minimal residual disease detection].
New
Luo et al., Zhengzhou, China. In Zhongguo Dang Dai Er Ke Za Zhi, Aug 2015
OBJECTIVE: To measure the expression of lymphocyte function-associated antigen-3 (CD58) in childhood B-lineage acute lymphoblastic leukemia (B-ALL) and to explore the feasibility of CD58 as an indicator for minimal residual disease (MRD) detection in childhood B-ALL.
Diffuse large B-cell lymphoma classification system that associates normal B-cell subset phenotypes with prognosis.
New
Impact
Johnsen et al., Odense, Denmark. In J Clin Oncol, May 2015
The centroblast subtype had a complex genotype, whereas the centrocyte subtype had high TP53 mutation and insertion/deletion frequencies and expressed LMO2, CD58, and stromal-1-signature and major histocompatibility complex class II-signature genes, which are known to have a positive impact on prognosis.
Susceptibility variants in the CD58 gene locus point to a role of microRNA-548ac in the pathogenesis of multiple sclerosis.
Review
Zettl et al., Rostock, Germany. In Mutat Res Rev Mutat Res, 2015
Single nucleotide polymorphisms (SNPs) within the first intron of CD58 have been independently confirmed to be related to the risk of MS.
Effect of luteolin on gene expression in mouse H22 hepatoma cells.
Ren et al., Hohhot, China. In Genet Mol Res, 2014
The purpose of our study was to observe the effects of luteolin on the expression of the genes ICAM-1, LFA-3, and PCNA in H22 hepatoma tissue.
Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas.
Impact
Ferrando et al., New York City, United States. In Nat Genet, 2014
In addition, we describe new and recurrent, albeit less frequent, genetic defects including mutations in FYN, ATM, B2M and CD58 implicating SRC signaling, impaired DNA damage response and escape from immune surveillance mechanisms in the pathogenesis of PTCL.
Decoding multiple sclerosis: an update on genomics and future directions.
Review
Oksenberg, San Francisco, United States. In Expert Rev Neurother, 2013
Follow-up experiments refined some of the association signals (IL2RA and CD58), identified gene-gene interactions (HLA-DRB1/EVI5) and revealed mechanistic insights into the functional consequences of the identified gene variants, most notably an increase in the soluble to membrane-bound ratio for IL-7, IL-2 and TNF receptors and a tyrosine-protein kinase 2-mediated immune deviation.
Modulating T-cell costimulation as new immunosuppressive concept in organ transplantation.
Review
Wekerle et al., Vienna, Austria. In Curr Opin Organ Transplant, 2012
RECENT FINDINGS: Here we focus on the clinically relevant costimulatory pathways CD28:CD80/86, CD40:CD154 (CD40L), CD2:LFA-3 and ICAM:LFA-1.
Combined genetic inactivation of β2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma.
Impact
GeneRIF
Dalla-Favera et al., New York City, United States. In Cancer Cell, 2012
In 21 percent of diffuse large B cell lymphoma cases, lesions involve the CD58 gene, which encodes a molecule involved in T and natural killer cell-mediated responses
Lack of association between CD58 genetic variations and aspirin-exacerbated respiratory disease in a Korean population.
GeneRIF
Shin et al., Seoul, South Korea. In J Asthma, 2011
Seven selected CD58 single-nucleotide polymorphisms were found to not affect aspirin-exacerbated respiratory disease susceptibility in a Korean population.
Recent advances in immunosuppressive therapy for prevention of renal allograft rejection.
Review
Brennan et al., Durham, United States. In Curr Opin Organ Transplant, 2011
Targets of T-cell-mediated activation include antibodies and fusion proteins interfering with LFA-1/ICAM-1, CD2/LFA-3, CD40/CD154, and CD28/B7.1 and B7.2 interactions.
Association study of ITGAM, ITGAX, and CD58 autoimmune risk loci in systemic sclerosis: results from 2 large European Caucasian cohorts.
GeneRIF
Allanore et al., Paris, France. In J Rheumatol, 2011
Two large cohorts of systemic sclerosis (SSc) patients of European Caucasian ancestry do not support the implication of ITGAM, ITGAX, and CD58 genes in the genetic susceptibility of SSc, although they were identified as autoimmune disease risk genes.
The genetics of multiple sclerosis: an update 2010.
Review
GeneRIF
Akkad et al., Bochum, Germany. In Mol Cell Probes, 2010
Studies indicate that SNP in IL7RA, IL2RA, CD58 and CLEC16A genes has been consistently associated with MS.
Modulated expression of adhesion molecules and galectin-1: role during mesenchymal stromal cell immunoregulatory functions.
GeneRIF
Lagneaux et al., Brussels, Belgium. In Exp Hematol, 2010
Data show that coculture with activated T cells upregulated expression of CD54 and CD58 and secretion of galectin-1 by MSCs.
Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer.
Impact
Godfrey et al., Mountain View, United States. In J Clin Oncol, 2010
PROSTVAC-VF comprises two recombinant viral vectors, each encoding transgenes for PSA, and three immune costimulatory molecules (B7.1, ICAM-1, and LFA-3).
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
Impact
GeneRIF
Plenge et al., Boston, United States. In Nat Genet, 2009
Genetic variants at CD58, is associated with rheumatoid arthritis risk
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