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Neural cell adhesion molecule 1

This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: HAD, CD4, CD8, CAN, CD16
Papers using CD56 antibodies
Mycophenolic acid response biomarkers: a cell line model system-based genome-wide screen
Mulherkar Rita et al., In The Indian Journal of Medical Research, 2010
... LCLs were incubated with primary mouse anti-CD3 (T cell marker), anti-CD19 (pan-B cell marker) and anti-CD56 (NK cell marker) antibodies (BD Pharmingen, BD Biosciences, USA) for 45 min ...
Early acquisition of neural crest competence during hESCs neuralization.
Kerkis Irina, In PLoS ONE, 2009
... cells were dissociated into single cells by incubation with Accutase (Millipore, Billerica, MA, USA), and PSA-NCAM-positive cells were isolated through magnetic separation system (Miltenyi Biotec, Bergisch Gladbach, Germany) (see ...
Follicular dendritic cell sarcoma in the lymph nodes of the neck
Adam Patrick et al., In Diagnostic Pathology, 2006
... CD56Cell Marque ...
Dendritic cells and NK cells stimulate bystander T cell activation in response to TLR agonists through secretion of IFN-alpha beta and IFN-gamma.
Zimmer Jacques, In PLoS ONE, 2004
... Partec CyFlow ML cytometer (Partec, Münster, Germany), using FITC-, PE- or APC-labeled monoclonal antibodies for CD56 and CD3 (BD Biosciences, Erembodegem, Belgium) ...
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Papers on CD56
PD-1 blockade expands intratumoral T memory cells.
Comin-Anduix et al., Denmark. In Cancer Immunol Res, Feb 2016
In peripheral blood, an unusual population of blood cells expressing CD56 were detected in two patients with regressing melanoma.
Neoplasms derived from plasmacytoid dendritic cells.
Vermi et al., Brescia, Italy. In Mod Pathol, Feb 2016
In this tumor, which is characterized by a distinctive cutaneous and bone marrow tropism, proliferating cells derive from immediate CD4(+)CD56(+) precursors of plasmacytoid dendritic cells.
Small Cell Carcinoma of the Urinary Bladder: KIT and PDGFRA Gene Mutations.
Kozacioğlu et al., İzmir, Turkey. In Rare Tumors, Jan 2016
Immunohistochemically, the tumor cells were positive for cytokeratin, chromo-granin, synaptophysin, neuron-specific enolase, CD56, CD117 and Ki67 (labeling 70%).
TG4010 immunotherapy and first-line chemotherapy for advanced non-small-cell lung cancer (TIME): results from the phase 2b part of a randomised, double-blind, placebo-controlled, phase 2b/3 trial.
Limacher et al., Strasbourg, France. In Lancet Oncol, Jan 2016
TG4010 is a modified vaccinia Ankara expressing MUC1 and interleukin 2. In a previous study, TG4010 combined with chemotherapy showed activity in non-small-cell lung cancer and the baseline value of CD16, CD56, CD69 triple-positive activated lymphocytes (TrPAL) was shown to be potentially predictive of TG4010 efficacy.
The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain.
Lichtenthaler et al., Kiel, Germany. In Prog Neurobiol, Dec 2015
Mechanistically, ADAM10 controls these functions by utilizing unique postsynaptic substrates in the central nervous system, in particular synaptic cell adhesion molecules, such as neuroligin-1, N-cadherin, NCAM, Ephrin A2 and A5.
[Primary Carcinoid Tumor of the Urinary Bladder : A Case Report and Questionnaire Survey on the Reported Cases in Japan].
Yoshida et al., Davao, Philippines. In Hinyokika Kiyo, Nov 2015
An immunohistochemical study showed the tumor cells were positively stained for chromogranin A, synaptophysin, CD56, and NSE.
L1-CAM and N-CAM: From Adhesion Proteins to Pharmacological Targets.
Meldolesi et al., Milano, Italy. In Trends Pharmacol Sci, Nov 2015
L1 cell adhesion molecule (L1-CAM) and neural cell adhesion molecule (N-CAM), key members of the immunoglobulin-like CAM (Ig-CAM) family, were first recognized to play critical roles in surface interactions of neurons, by binding with each other and with extracellular matrix (ECM) proteins.
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma.
Chen et al., Shanghai, China. In Nat Genet, Sep 2015
Natural killer/T-cell lymphoma (NKTCL) is a malignant proliferation of CD56(+) and cytoCD3(+) lymphocytes with aggressive clinical course, which is prevalent in Asian and South American populations.
Natural killer cell maturation markers in the human liver and expansion of an NKG2C+KIR+ population.
Khakoo et al., Southampton, United Kingdom. In Lancet, Mar 2015
Mononuclear cells were isolated by ficoll separation and cell surface staining performed for CD3, CD56, CD16, CD57, CD117, CD161, CD158a, CD158b, CD49a, CD49b, CXCR6, NKG2C, and NKp46.
Soma et al., In Nihon Hinyokika Gakkai Zasshi, 2015
Immunohistochemical staining was positive for CD56, synaptophysin, vimentin, GFAP, and CD99 (MIC2), but negative for AE1/AE3, OCT-4, chromogranin, INI-1, and desmin.
Effects of CD3McAb and rhIL-2 activated bone marrow on the killing and purging of leukemia cells.
Wang et al., Xi'an, China. In Genet Mol Res, 2014
Compared with bone marrow activated by rhIL-2 or CD3McAb alone, the synergistic effect of both CD3McAb+ and hIL-2 caused significant increase of CD3(+), CD8(+), CD19(+), CD25(+), CD38(+), and CD56(+) levels.
Increased CD56(+) NK cells and enhanced Th1 responses in human unexplained recurrent spontaneous abortion.
Wang et al., Guiyang, China. In Genet Mol Res, 2014
In this study, we compared the number and percentage of CD56(+) NK cells, CD4(+) T cells and CD8(+) T cells by flow cytometry in 30 URSA patients and 30 normal pregnant controls.
Flow Cytometric Analysis of T, B, and NK Cells Antigens in Patients with Mycosis Fungoides.
Tunali et al., Bursa, Turkey. In J Immunol Res, 2014
Fluorescent labeled monoclonal antibodies were used to detect cell surface antigens: T cells (CD3(+), CD4(+), CD8(+), TCRαβ (+), TCRγδ (+), CD7(+), CD4(+)CD7(+), CD4(+)CD7(-), and CD71(+)), B cells (HLA-DR(+), CD19(+), and HLA-DR(+)CD19(+)), NKT cells (CD3(+)CD16(+)CD56(+)), and NK cells (CD3(-)CD16(+)CD56(+)).
Best treatment strategies in high-risk multiple myeloma: navigating a gray area.
Anderson et al., Boston, United States. In J Clin Oncol, 2014
Bone marrow biopsy showed 60% infiltration with lambda light chain-restricted plasma cells staining positive for CD138 and CD56 and negative for CD45 by flow cytometry (Fig 1).
Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells.
Dunbar et al., Bethesda, United States. In Cell Stem Cell, 2014
Surprisingly, reconstitution of the natural killer (NK) cell lineage, and particularly the major CD16(+)/CD56(-) peripheral blood NK compartment, showed limited clonal overlap with T, B, or myeloid lineages, and therefore appears to be ontologically distinct.
Neural cell adhesion molecule modulates mesenchymal stromal cell migration via activation of MAPK/ERK signaling.
Feng et al., Singapore, Singapore. In Exp Cell Res, 2012
NCAM deficiency impairs mesenchymal stromal cell motility.
Transforming growth factor-beta1 induces microvascular abnormalities through a down-modulation of neural cell adhesion molecule in human hepatocellular carcinoma.
Alessandri et al., Brescia, Italy. In Lab Invest, 2012
TGF-beta1 contributes to HCC-induced vascular alterations by affecting the interaction between HCC-StCs and Ld-MECs through a down-modulation of NCAM expression
CD56+ T cells inhibit HIV-1 infection of macrophages.
Ho et al., Wuhan, China. In J Leukoc Biol, 2012
CD56-positive T cells have a critical role in innate defense against HIV-1 infection.
Differences of molecular expression mechanisms among neural cell adhesion molecule 1, synaptophysin, and chromogranin A in lung cancer cells.
Yazawa et al., Yokohama, Japan. In Pathol Int, 2012
NCAM1, SYPT and CGA expressions are differently regulated by neuroendocrine phenotype-specific transcription factors in lung cancer cells.
Mouse brain PSA-NCAM levels are altered by graded-controlled cortical impact injury.
McCabe et al., Bethesda, United States. In Neural Plast, 2011
alterations in PSA-NCAM levels were seen in the cerebral cortex immediately after injury, and these reductions persisted in brain regions distal to the primary injury site
More papers using CD56 antibodies
Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study
Sánchez-Madrid Francisco et al., In Arthritis Research & Therapy, 2004
... Phycoerythrin-conjugated Leu-19 (anti-CD56), Leu-19 (anti-CD56 pure) and isotype-matched controls were purchased from Becton Dickinson (Mountain View, CA, USA) ...
TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand
Liu Yong-Jun et al., In The Journal of Experimental Medicine, 2003
... mixture of mAbs against the lineage markers, CD3 (OKT3), CD14 (M5E2), CD15 (HB78), CD20 (L27), CD56 (B159), and CD235a (10F7MN), followed by using goat anti–mouse IgG-coated magnetic beads (M-450; Dynal and Miltenyi Biotec).
Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia.
Hope Thomas J., In PLoS Pathogens, 2002
... The mouse anti-human CD4, CD16, CD56, CD112 and MIC-A/MIC-B monoclonal antibodies (mAbs) were obtained from BD Biosciences ( ...
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells
Öbrink Björn et al., In The Journal of Cell Biology, 2001
... Other mouse mAbs used were anti-CD56 (T199; Dako), anti-Src (B-12; Santa Cruz ...
Janus kinase 2 is involved in stromal cell-derived factor-1alpha-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells
Burger M et al., In British Journal of Cancer, 2000
... Antibody against CD56 was obtained from AbD Serotec (Duesseldorf, Germany) ...
Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application.
Smith Kendall A et al., In Medical Immunology, 2000
... OKT3-activated PBMC were depleted of CD56, and positively selected for CD2, using antibody-conjugated magnetic beads (anti-CD56 Polysciences Inc, anti-CD2 Dynal) according ...
IL-6 switches the differentiation of monocytes from dendritic cells to macrophages
Moser Bernhard et al., In The Journal of Experimental Medicine, 1999
... MicroBead-labeled mouse anti–human CD4, CD8, CD14, CD20, and CD56 antibodies were from Miltenyi Biotec, and anti-CD3 and S-100 ...
BDCA-2, a Novel Plasmacytoid Dendritic Cell–specific Type II C-type Lectin, Mediates Antigen Capture and Is a Potent Inhibitor of Interferon α/β Induction
Schmitz Jürgen et al., In The Journal of Experimental Medicine, 1999
... using mAb against CD3 (mAb SK9, IgG2b; Becton Dickinson), CD19 (mAb 4G7, IgG1; Becton Dickinson), CD56 (mAb MY31, IgG1; Becton Dickinson), and CD14 (mAb MφP9, ...
Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells
Santoni Angela et al., In The Journal of Experimental Medicine, 1996
... The following mouse mAbs were used: anti-CD3 (Leu4), anti-CD16 (Leu11c), and anti-CD56 (Leu19) were purchased from Becton Dickinson ...
Peptidase inhibitors improve recovery of substance P and calcitonin gene-related peptide release from rat spinal cord slices
Hingtgen Cynthia M et al., In Molecular Pain, 1995
... polyclonal primary antibody, 1:300 titer, Santa Cruz Biotechnology; α-tubulin: mouse monoclonal antibody, 1:1,000 titer, Sigma; NCAM: rabbit polyclonal primary antibody, 1:500 titer, Santa Cruz Biotechnology; Integrin β-1: mouse monoclonal ...
Contact-dependent Stimulation and Inhibition of Dendritic Cells by Natural Killer Cells
Valiante Nicholas M. et al., In The Journal of Experimental Medicine, 1995
... -HLA-DR-PerCP, -CD69-FITC or -PE, -CD25-FITC, -CD3-FITC or -PE, -CD19-FITC, -CD14-FITC, -CD1a-FITC, -CD80-FITC or -PE, and -CD56-FITC or -PE (Becton Dickinson).
Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells
Rammensee Hans-Georg et al., In The Journal of Experimental Medicine, 1994
... μl MACS buffer (PBS + 0.5% BSA + 2 mM EDTA) were incubated with 20 μl CD56 MicroBeads (Miltenyi Biotec GmbH, Bergisch Gladbach, Germany) ...
Human natural killer cell receptors for HLA class I molecules: evidence that Kp43 (CD94) molecule functions as receptor for HLA-B alleles
Brooks Andrew G. et al., In The Journal of Experimental Medicine, 1993
... , San Diego, CA); Leu-19 (anti-CD56; from Becton-Dickinson, San Jose, CA); UCHT1 (anti-CD3; from DAKO, Carpinteria, CA); and fluorescein-labeled ...
Specific inhibition of GPI-anchored protein function by homing and self-association of specific GPI anchors
Stanners Clifford P. et al., In The Journal of Cell Biology, 1992
... The mAb 123C3 (Santa Cruz Biotechnology, Inc.) recognizes human NCAM, whereas antibodies H-293, H-104, and M-106 (Santa Cruz Biotechnology, Inc.) recognize the α2, ...
Early human decidual cells exhibit NK activity against the K562 cell line but not against first trimester trophoblast
Long Eric O. et al., In The Journal of Experimental Medicine, 1988
... Anti-CD3 and anti-CD56 antibodies conjugated to PE were purchased from Becton Dickinson ...
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