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CD55 molecule, decay accelerating factor for complement

CD55, DAF
This gene encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also known as the decay-accelerating factor (DAF); binding of DAF to complement proteins accelerates their decay, disrupting the cascade and preventing damage to host cells. Antigens present on the DAF glycoprotein constitute the Cromer blood group system (CROM). Two alternatively spliced transcripts encoding different proteins have been identified. The predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. Additional, alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin, CAN, CD59, V1a, caspase-3
Papers using CD55 antibodies
Plant stomata: a checkpoint of host immunity and pathogen virulence
Supplier
Raghavendra Agepati S. et al., In Journal of Experimental Botany, 2009
... DAF-2DA was from Calbiochem (Rockland, MA) ...
Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone
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Zou Ming-Hui et al., In Journal of Cellular and Molecular Medicine, 2007
... Recombinant eNOS and 4, 5-diaminofluorescein (DAF-2) were obtained from Cayman Chemical (Ann Arbor, MI, ...
Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress.
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Gartel Andrei L., In PLoS ONE, 2007
... (ImmunoTools, Friesoythe, Germany), Cell Death Detection Kit (Roche, Penzberg, Germany) and 4,5 diaminofluorescein -2 diacetate (DAF-2DA, Cayman Chemicals, Ann Arbor, MI, ...
A computer-based, image-analysis method to quantify HIV-1 infection in a single-cycle infectious center assay.
Supplier
Hope Thomas J., In PLoS Pathogens, 2005
... antibody isotype control, a goat, anti-mouse IgG antibody conjugated to allophycocyanin (APC) and a FITC-conjugated antibody to CD55/DAF were obtained from BioLegend (San Diego, CA) ...
ChIPOTle: a user-friendly tool for the analysis of ChIP-chip data
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Brunet Anne et al., In Nature, 2004
... Genes that act downstream of DAF-16 to influence the lifespan of ...
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Papers on CD55
The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators.
New
Impact
Murphy et al., Princeton, United States. In Nature, Feb 2016
It primarily does so through the activity of the DAF-16 transcription factor (forkhead box O (FOXO) homologue), whose global targets were identified in Caenorhabditis elegans using whole-worm transcriptional analyses more than a decade ago.
Stimulation of calcium-sensing receptors induces endothelium-dependent vasorelaxations via nitric oxide production and activation of IKCa channels.
New
Albert et al., London, United Kingdom. In Vascul Pharmacol, Feb 2016
[Ca(2+)]o-induced relaxations were reduced by inhibitors of endothelial NO synthase, guanylate cyclase, and protein kinase G. CaSR activation also induced NO production in freshly isolated endothelial cells (ECs) in experiments using the fluorescent NO indicator DAF-FM.
Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic Acid.
New
Lok et al., Dallas, United States. In Plos Pathog, Jan 2016
In the free-living nematode Caenorhabditis elegans, analogous determination between dauer arrest and reproductive growth is governed by dafachronic acids (DAs), a class of steroid hormones that are ligands for the nuclear hormone receptor DAF-12.
Mutation of C. elegans demethylase spr-5 extends transgenerational longevity.
New
Shi et al., Boston, United States. In Cell Res, Jan 2016
We further show that this trans-generational lifespan extension is dependent on a hormonal signaling pathway involving the steroid dafachronic acid, an activator of the nuclear receptor DAF-12.
A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans.
New
de Magalhães et al., Liverpool, United Kingdom. In Aging Cell, Jan 2016
We also treated daf-16 worms with rapamycin, allantoin or trichostatin A, and a lifespan extension was observed, suggesting that these drugs act via DAF-16-independent mechanisms, as would be expected from CR mimetics.
Human articular chondrocytes with higher aldehyde dehydrogenase activity have stronger expression of COL2A1 and SOX9.
New
Christian et al., Vilnius, Lithuania. In Osteoarthritis Cartilage, Jan 2016
Markers CD54 and CD55 were significantly stronger expressed, while CD47, CD140b, CD146 and CD166 were depleted in ALDH-expressing (ALDH(pos)) cells.
Caenorhabditis elegans DAF-16/FOXO transcription factor and its mammalian homologs associate with age-related disease.
Review
New
Kammenga et al., Wageningen, Netherlands. In Exp Gerontol, Dec 2015
The insulin/IGF-1 signaling pathway is evolutionarily conserved and its function is mediated largely by FOXO transcription factors.
Complement in hemolytic anemia.
Review
New
Brodsky, Baltimore, United States. In Blood, Dec 2015
Paroxysmal nocturnal hemoglobinuria (PNH) cells are susceptible to hemolysis because of a loss of the complement regulatory proteins CD59 and CD55.
Structural insights on complement activation.
Review
New
Llorca et al., Madrid, Spain. In Febs J, Oct 2015
In addition, the displacement of the TED and its interaction with the macroglobulin 1 (MG1) domain generates an extended surface in C3b where the complement regulators factor H (FH), decay accelerating factor (DAF), membrane cofactor protein (MCP) and complement receptor 1 (CR1) can bind, mediating accelerated decay of the AP C3-convertase and proteolytic inactivation of C3b.
The immunomodulatory oligodendrocyte.
Review
New
Schaeren-Wiemers et al., Basel, Switzerland. In Brain Res, Oct 2015
CD46, CD55, CD59), tetraspanins (e.g.
The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity.
New
Impact
Dillin et al., Los Angeles, United States. In Cell Metab, Aug 2015
Here we identify the deubiquitylating enzyme MATH-33 as an essential DAF-16 regulator in IIS, which stabilizes active DAF-16 protein levels and, as a consequence, influences DAF-16 functions, such as metabolism, stress response, and longevity in C. elegans.
A Hispanic female patient with heartburn: A rare presentation of Paroxysmal Nocturnal Hemoglobinuria.
Review
New
Cáceres-Pérkins et al., In Bol Asoc Med P R, Jul 2015
Peripheral blood flow cytometry assays revealed diminished expression of CD55 and CD59 on the erythrocytes, granulocytes and monocytes.'
Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion.
New
Impact
Duraisingh et al., Boston, United States. In Science, Jun 2015
We found that CD55 is an essential host factor for P. falciparum invasion.
Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity.
New
Impact
Blackwell et al., Boston, United States. In Nature, Apr 2015
Reduced insulin/IGF-1 signalling (rIIS) extends lifespan across the evolutionary spectrum, and in juvenile Caenorhabditis elegans also allows the transcription factor DAF-16/FOXO to induce development into dauer, a diapause that withstands harsh conditions.
The FOXO transcription factor DAF-16 bypasses ire-1 requirement to promote endoplasmic reticulum homeostasis.
Impact
Henis-Korenblit et al., In Cell Metab, 2014
We show that activation of the Caenorhabditis elegans transcription factor DAF-16 and its human homolog FOXO3 restore secretory protein metabolism when the UPR is dysfunctional.We show that DAF-16 establishes alternative ER-associated degradation systems that degrade misfolded proteins independently of the ER stress sensor ire-1 and the ER-associated E3 ubiquitin ligase complex sel-11/sel-1.
Virion-associated complement regulator CD55 is more potent than CD46 in mediating resistance of mumps virus and vesicular stomatitis virus to neutralization.
GeneRIF
Parks et al., Winston-Salem, United States. In J Virol, 2012
mumps virus (MuV) and vesicular stomatitis virus (VSV) assemble to include CD46 and CD55, two host cell regulators which inhibit propagation of complement pathways through distinct mechanisms.
A functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza A virus infection.
GeneRIF
Yuen et al., Hong Kong, Hong Kong. In J Infect Dis, 2012
In conclusion, CD55 polymorphisms are associated with severe 2009 pandemic H1N1 influenza A virus infection.
A single amino acid substitution controls DAF-dependent phenotype of echovirus 11 in rhabdomyosarcoma cells.
GeneRIF
Sokolova et al., Yekaterinburg, Russia. In Virus Res, 2012
It was shown that a single amino acid substitution in the capsid protein VP2 of Echovirus 11 could control the expression of the DAF-dependent phenotype.
Immunohistochemical expression and prognostic value of CD97 and its ligand CD55 in primary gallbladder carcinoma.
GeneRIF
Zhang et al., Nanjing, China. In J Biomed Biotechnol, 2011
CD97 and CD55 showed high expression at the invasive front of gallbladder carcinoma. CD97 and CD55 expression was associated with high histologic grade, advanced pathologic T stage, clinical stage and positive venous/lymphatic invasion.
Triggering of the dsRNA sensors TLR3, MDA5, and RIG-I induces CD55 expression in synovial fibroblasts.
GeneRIF
Hamann et al., Amsterdam, Netherlands. In Plos One, 2011
Triggering of the dsRNA sensors TLR3, MDA5, and RIG-I induces CD55 expression in synovial fibroblasts.
More papers using CD55 antibodies
The BCL2 family: regulators of the cellular life-or-death switch
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Chung Jing-Gung et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2001
... ), Fluo-3/AM, and 4-amino-5-methylamino-2′,7′-difluorofluorescein diacetate (DAF-FM) were obtained from the Molecular Probes/Life Technologies (Eugene, OR, USA) ...
The significance of digital gene expression profiles.
Supplier
Carlow Clotilde K. S., In PLoS ONE, 1996
... -DAF-16 DBD) was affinity-purified by Ni-NTA resin (Qiagen, Valencia, CA) ...
Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.
Supplier
Wang Haibin, In PLoS ONE, 1988
... NOC-18 and DAF FM were from Cayman.
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