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CD53 molecule

CD53, OX-44, CD53 antigen
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD63, CD81, CD37, Tetraspanin, KAI1
Papers on CD53
Analysis of differences in the molecular mechanism of rheumatoid arthritis and osteoarthritis based on integration of gene expression profiles.
Cao et al., Guangzhou, China. In Immunol Lett, Dec 2015
C-ETS-1 could interact with matrix metallopeptidase 1 (MMP1) and CD53 while P53 could interact with epidermal growth factor receptor (EGFR) and dual specificity phosphatase 1 (DUSP1).
Down-regulation of CD53 expression in Epinephelus coioides under LPS, Poly (I:C), and cytokine stimulation.
Lin et al., Tainan City, Taiwan. In Fish Shellfish Immunol, Dec 2015
Members of the tetraspanin family include CD9, CD37, CD63, and CD53, and others.
CD34 defines an osteoprogenitor cell population in mouse bone marrow stromal cells.
Kassem et al., Odense, Denmark. In Stem Cell Res, Nov 2015
Among these, we identified osteoprogenitor-associated CD markers expressed only in mBMSC(Bone): CD34, CD54, CD73, CD132, CD200, CD227 and adipoprogenitor-associated CD markers expressed only in mBMSC(Adipo): CD53, CD80, CD134, CD141 and CD212.
Multispectral imaging reveals the tissue distribution of tetraspanins in human lymphoid organs.
van Spriel et al., Nijmegen, Netherlands. In Histochem Cell Biol, Aug 2015
Tetraspanins CD37 and CD53 are four-transmembrane proteins involved in cellular and humoral immune responses.
Combined use of biomarkers for distinguishing between bacterial and viral etiologies in pediatric lower respiratory tract infections.
Wang et al., China. In Infect Dis (lond), May 2015
The AUC of CRP combined with CD53 (0.963, 95% confidence interval (CI) 0.921-1.002)
Identify the signature genes for diagnose of uveal melanoma by weight gene co-expression network analysis.
Zhang et al., China. In Int J Ophthalmol, 2014
The hub gene RPS15A, PTGDS, CD53 and MSI2 might play a vital role in progress of uveal melanoma.
PAHO'S Strategy for Universal Access to Health and Universal Health Coverage: implications for health services and hospitals in LAC.
Fabrega et al., In World Hosp Health Serv, 2014
The Directing Council of the Pan American Health Organization (PAHO) recently approved resolution CD53.R14, titled Strategy for Universal Access to Health and Universal Health Coverage.
Tetraspanins as therapeutic targets in hematological malignancy: a concise review.
Muthusamy et al., Columbus, United States. In Front Physiol, 2014
There are a select few, such as CD37 and CD53, which are restricted to hematopoietic lineages.
The tetraspanin web revisited by super-resolution microscopy.
van Spriel et al., Nijmegen, Netherlands. In Sci Rep, 2014
We demonstrate that tetraspanins form individual nanoclusters smaller than 120 nm and quantified that a single tetraspanin CD53 cluster contains less than ten CD53 molecules.
The Temporal Pattern of Changes in Serum Biomarker Levels Reveals Complex and Dynamically Changing Pathologies after Exposure to a Single Low-Intensity Blast in Mice.
Agoston et al., Bethesda, United States. In Front Neurol, 2014
We then determined the serum levels of biomarkers related to metabolism (4-HNE, HIF-1α, ceruloplasmin), vascular function (AQP1, AQP4, VEGF, vWF, Flk-1), inflammation (OPN, CINC1, fibrinogen, MIP-1a, OX-44, p38, MMP-8, MCP-1 CCR5, CRP, galectin-1), cell adhesion and the extracellular matrix (integrin α6, TIMP1, TIMP4, Ncad, connexin-43), and axonal (NF-H, Tau), neuronal (NSE, CK-BB) and glial damage (GFAP, S100β, MBP) at various post-injury time points.
Genetic association study of coronary collateral circulation in patients with coronary artery disease using 22 single nucleotide polymorphisms corresponding to 10 genes involved in postischemic neovascularization.
de Anta et al., Barcelona, Spain. In Bmc Cardiovasc Disord, 2014
RESULTS: Statistical analysis showed that the HIF1A rs11549465 and rs2057482; VEGFA rs2010963, rs1570360, rs699947, rs3025039 and rs833061; KDR rs1870377, rs2305948 and rs2071559; CCL2 rs1024611, rs1024610, rs2857657 and rs2857654; NOS3 rs1799983; ICAM1 rs5498 and rs3093030; TGFB1 rs1800469; CD53 rs6679497; POSTN rs3829365 and rs1028728; and LGALS2 rs7291467 polymorphisms, as well as their haplotype combinations, were not associated with CCC (p < 0.05).
A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels.
Slagboom et al., Leiden, Netherlands. In Eur J Hum Genet, 2010
SNP rs6679497 in gene CD53 showed significant association with TNFalpha levels (P=0.001); no association of this SNP was observed with osteoarthritis
Asymmetric cell divisions of human hematopoietic stem and progenitor cells meet endosomes.
Beckmann et al., Düsseldorf, Germany. In Cell Cycle, 2007
Remarkably, three of these proteins, the tetraspanins CD53 and CD63, and the transferrin receptor are endosome-associated proteins.
Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients.
Lawrence et al., Albany, United States. In J Leukoc Biol, 2007
The paradox is that lymphocytes from RA patients are believed to resist apoptosis, and we suggest that the elevated expression of CD53, which results from the increased oxidative stress, may protect against apoptosis.
The effects of intensive, moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 (ICAM-1), CD18 (beta2 integrin) and CD53.
Guy et al., Edinburgh, United Kingdom. In Eur J Appl Physiol, 2006
Analysis of lymphocyte subsets showed that the total number of CD3+, CD4+, CD8+ and CD56+ lymphocytes increased after the intensive protocol before falling below pre-exercise values at 1 h post-exercise.
LPS-induced CD53 expression: a protection mechanism against oxidative and radiation stress.
Paik et al., Taejŏn, South Korea. In Mol Cells, 2004
CD53 has a role in macrophage protection against LPS-induced oxidative stress and UVB irradiation
Induction of DNA synthesis by ligation of the CD53 tetraspanin antigen in primary cultures of mesangial cells.
Lazo et al., Salamanca, Spain. In Kidney Int, 2003
First identification of a tetraspanin protein in mesangial cells. CD53 antigen delivers a signal that initiates DNA synthesis.
CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system.
Maecker et al., Stanford, United States. In Annu Rev Immunol, 1997
The tetraspanin superfamily (or TM4SF) includes CD81, CD9, CD37, CD53, CD63, CD82, CD151, and an increasing number of additional proteins.
The tetraspanin superfamily: molecular facilitators.
Levy et al., Stanford, United States. In Faseb J, 1997
A brief overview indicates that some tetraspanins are found in virtually all tissues (CD81, CD82, CD9, CD63), whereas others are highly restricted, such as CD37 (B cells) or CD53 (lymphoid and myeloid cells).
New CD from the B cell section of the Fifth International Workshop on Human Leukocyte Differentiation Antigens.
Tedder et al., Durham, United States. In Leuk Lymphoma, 1993
CD81 (TAPA-1) and CD82 (R2) are new members of the tetra-spans family of transmembrane proteins, which include CD9, CD37, CD53 and CD63.
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