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CD48 molecule

CD48, Blast-1
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: CD2, CAN, Nail, SLAM, CD58
Papers on CD48
Hoxa cluster genes determine the proliferative activity of adult mouse hematopoietic stem and progenitor cells.
Bijl et al., Montréal, Canada. In Blood, Feb 2016
Comparative RNA sequencing analyses of Hoxa(-/-) and WT hematopoietic stem cells (CD150(+)/CD48(-)/Lineage(-)/c-kit(+)/Sca-1(+)) identified a large number of differentially expressed genes, three of which (Nr4a3, Col1a1, and Hnf4a) showed >10-fold reduced levels.
Short-range cytokine gradients to mimic paracrine cell interactions in vitro.
Pompe et al., Leipzig, Germany. In J Control Release, Feb 2016
Directed chemotactic migration of cells from a hematopoietic cell line (FDCPmix) and primary murine HSPC (Sca-1(+) CD150(+) CD48(-)) toward the SDF-1-laden microparticles proved functional short-range gradients in a two-dimensional and three-dimensional setting over time periods of many hours.
Mutation analysis with random DNA identifiers (MARDI) catalogs Pig-a mutations in heterogeneous pools of CD48-deficient T cells derived from DMBA-treated rats.
Dobrovolsky et al., Mexico. In Environ Mol Mutagen, Jan 2016
When applied to the Pig-a cDNA analysis of heterogeneous pools of CD48-deficient T cells derived from DMBA-treated rats, MARDI detected nearly all Pig-a mutations that were previously identified by conventional clone-by-clone analysis and discovered many additional ones consistent with DMBA exposure: mostly A to T transversions, with the mutated A located on the non-transcribed DNA strand.
CD252 regulates mast cell-mediated, CD1d-restricted NKT-cell activation in mice.
Bulfone-Paus et al., Germany. In Eur J Immunol, Dec 2015
Moreover, the co-stimulatory molecules CD48, CD137L, CD252, CD274 and CD275 affected MC-induced IFN-γ release and iNKT-cell proliferation.
Stroma-Derived Connective Tissue Growth Factor Maintains Cell Cycle Progression and Repopulation Activity of Hematopoietic Stem Cells In Vitro.
Oostendorp et al., München, Germany. In Stem Cell Reports, Dec 2015
Further experiments demonstrated that CD34(-) CD48(-) CD150(+) LSK (CD34(-) SLAM) cell numbers from shCtgf co-cultures increase in G0 and senescence and show delayed time to first cell division.
Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells.
Nahrendorf et al., Boston, United States. In Cell Stem Cell, Jun 2015
Here, we identify a CCR2(+)CD150(+)CD48(-) LSK hematopoietic subset as the most upstream contributor to emergency myelopoiesis after ischemic organ injury.
Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia.
Levine et al., New York City, United States. In Cancer Cell, May 2015
Multipotent Tet2(-/-);Flt3(ITD) progenitors (LSK CD48(+)CD150(-)) propagate disease in secondary recipients and were refractory to standard AML chemotherapy and FLT3-targeted therapy.
Mast cells' integrated actions with eosinophils and fibroblasts in allergic inflammation: implications for therapy.
Levi-Schaffer et al., Jerusalem, Israel. In Adv Immunol, 2014
One of the salient features of the AEU is the CD48/2B4 receptor/ligand binding complex.
Molecular targets on mast cells and basophils for novel therapies.
Maurer et al., Kuopio, Finland. In J Allergy Clin Immunol, 2014
Surface-activating receptors, such as CD48 and thymic stromal lymphopoietin receptors, as well as inhibitory receptors, such as CD300a, FcγRIIb, and endocannabinoid receptors, hold promising therapeutic possibilities based on preclinical studies.
Embryonic hematopoiesis.
Cumano et al., Paris, France. In Blood Cells Mol Dis, 2013
They undergo maturation into adult HSCs in the aorta or in the fetal liver accompanied by the expression of MHC class I, CD45, CD150, Sca-1 and the absence of CD48.
SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors.
Morrison et al., Dallas, United States. In Cell Stem Cell, 2013
Here we show that four SLAM family markers, CD150, CD48, CD229, and CD244, can distinguish HSCs and MPPs from restricted progenitors and subdivide them into a hierarchy of functionally distinct subpopulations with stepwise changes in cell-cycle status, self-renewal, and reconstituting potential.
No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia.
Børglum et al., Aalborg, Denmark. In Psychiatr Genet, 2012
replication study of association of 2 SNPs in HERV-K18 and 19 tagSNPs in CD48 with schizophrenia (SZ)and type 2 diabetes (T2D) in patients with SZ in 2 Danish samples; no association was found with SZ or with T2D among individuals with SZ for any of the SNPs
Mast cells as critical effectors of host immune defense against Gram-negative bacteria.
Matsuguchi, Kagoshima, Japan. In Curr Med Chem, 2011
The former includes Toll-like receptors (TLRs), CD48, and nucleotide-binding oligomerization (NOD) proteins, while the latter includes Fcγ receptors (FcγRs) and complement receptors.
Ox-LDL can enhance the interaction of mice natural killer cells and dendritic cells via the CD48-2B4 pathway.
Zhu et al., Hangzhou, China. In Heart Vessels, 2011
Ox-LDL significantly promoted the interaction of natural killer cells and dendritic cells via CD48-2B4 contact-dependent mechanisms.
The SLAM family member CD48 (Slamf2) protects lupus-prone mice from autoimmune nephritis.
Paul et al., Boston, United States. In J Autoimmun, 2011
B6-specific background genes modulate the effect of CD48 on lupus nephritis in a recessive manner
CD48 on hematopoietic progenitors regulates stem cells and suppresses tumor formation.
Goodell et al., Houston, United States. In Blood, 2011
CD48 plays a vital role as an environmental sensor for regulating hematopoietic stem cells and progenitor cell numbers and inhibiting tumor development
CD48: A co-stimulatory receptor of immunity.
Levi-Schaffer et al., Jerusalem, Israel. In Int J Biochem Cell Biol, 2011
Stimulation of CD48 induces rearrangement of signaling factors in lipid rafts, Lck-kinase activity, and tyrosine phosphorylation.
Onchocerciasis in the Americas: from arrival to (near) elimination.
Sauerbrey et al., United States. In Parasit Vectors, 2010
Once endemic to six countries in the Americas (Brazil, Colombia, Ecuador, Guatemala, Mexico and Venezuela), onchocerciasis is on track for interruption of transmission in the Americas by 2012, in line with Pan American Health Organization resolution CD48.R12.
Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells.
Hock et al., Boston, United States. In Nat Biotechnol, 2009
Mathematical modeling of H2B-GFP dilution in HSCs, identified with a stringent marker combination (L(-)K(+)S(+)CD48(-)CD150(+)), revealed unexpected heterogeneity in their proliferation rates and showed that approximately 20% of HSCs divide at an extremely low rate (< or =0.8-1.8% per day).
Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors.
Clarke et al., Ann Arbor, United States. In Nature, 2008
This increase is associated with the acquisition of long-term reconstitution capacity by cells of the phenotype c-kit+Sca-1+Flt3+CD150-CD48-Lin-, which defines multipotent progenitors in wild-type mice.
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