Short-range cytokine gradients to mimic paracrine cell interactions in vitro.
Leipzig, Germany. In J Control Release, Feb 2016
Directed chemotactic migration of cells from a hematopoietic cell line (FDCPmix) and primary murine HSPC (Sca-1(+) CD150(+) CD48(-)) toward the SDF-1-laden microparticles proved functional short-range gradients in a two-dimensional and three-dimensional setting over time periods of many hours.
Molecular targets on mast cells and basophils for novel therapies.
Kuopio, Finland. In J Allergy Clin Immunol, 2014
Surface-activating receptors, such as CD48 and thymic stromal lymphopoietin receptors, as well as inhibitory receptors, such as CD300a, FcγRIIb, and endocannabinoid receptors, hold promising therapeutic possibilities based on preclinical studies.
Paris, France. In Blood Cells Mol Dis, 2013
They undergo maturation into adult HSCs in the aorta or in the fetal liver accompanied by the expression of MHC class I, CD45, CD150, Sca-1 and the absence of CD48.
CD48: A co-stimulatory receptor of immunity.
Jerusalem, Israel. In Int J Biochem Cell Biol, 2011
Stimulation of CD48 induces rearrangement of signaling factors in lipid rafts, Lck-kinase activity, and tyrosine phosphorylation.
Onchocerciasis in the Americas: from arrival to (near) elimination.
United States. In Parasit Vectors, 2010
Once endemic to six countries in the Americas (Brazil, Colombia, Ecuador, Guatemala, Mexico and Venezuela), onchocerciasis is on track for interruption of transmission in the Americas by 2012, in line with Pan American Health Organization resolution CD48.R12.
Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells.
Boston, United States. In Nat Biotechnol, 2009
Mathematical modeling of H2B-GFP dilution in HSCs, identified with a stringent marker combination (L(-)K(+)S(+)CD48(-)CD150(+)), revealed unexpected heterogeneity in their proliferation rates and showed that approximately 20% of HSCs divide at an extremely low rate (< or =0.8-1.8% per day).