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CD47 molecule

This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: thrombospondin-1, B it, CAN, V1a, CD45
Papers using CD47 antibodies
Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation.
Ferreira Sergio T., In PLoS ONE, 2004
... Anti-CD47 antibody B6H12 was purchased from Abcam (Cambridge, UK) ...
Shiga toxin-2 induces neutrophilia and neutrophil activation in a murine model of hemolytic uremic syndrome.
Ratner Adam J., In PLoS ONE, 1999
... Rat anti-mouse CD47 affinity purified mAb (clone miap301) was obtained from BD Biosciences (San Diego, CA) ...
Papers on CD47
Storage of RBCs results in an increased susceptibility for complement-mediated degradation.
Salama et al., Berlin, Germany. In Transfus Med, 10 Jan 2015
STUDY DESIGN AND METHODS: We investigated the surface expression of CD35, CD55, CD59 and CD47, as well as deposition of C3d, using flow cytometry over a storage period of up to 42 days on a weekly basis.
CD47 Blockade Reduces Ischemia Reperfusion Injury and Improves Survival in a Rat Liver Transplantation Model.
Chapman et al., Saint Louis, United States. In Liver Transpl, 06 Jan 2015
We investigated whether blocking the CD47/TSP-1 inhibitory action on NO signaling using a monoclonal antibody specific to CD47 (CD47mAb400) reduces IRI in liver grafts.
Plasmodium falciparum avoids change in erythrocytic surface expression of phagocytosis markers during inhibition of nitric oxide synthase activity.
Kurtzhals et al., Copenhagen, Denmark. In Mol Biochem Parasitol, 29 Dec 2014
We investigated if inhibiting the P. falciparum NOS with specific and unspecific NOS inhibitors led to a decrease in intraerythrocytic NO accumulation and if this was associated with a change in surface expression of the phagocytosis markers CD47 and phosphatidyl serine.
Cell rigidity and shape override CD47's 'Self' signaling in phagocytosis by hyperactivating Myosin-II.
Discher et al., Philadelphia, United States. In Blood, 19 Dec 2014
UNLABELLED: A macrophage engulfs another cell or foreign particle in an adhesive process that often activates Myosin-II, unless the macrophage also engages 'Marker of Self' CD47 that inhibits Myosin.
Antigen-induced regulation of T cell motility, interaction with antigen-presenting cells and activation through endogenous thrombospondin-1 and its receptors.
Sundqvist et al., Huddinge, Sweden. In Immunology, 12 Dec 2014
Here we show that the T cell receptor (TCR) and CD28 regulate T cell motility, contact with antigen-presenting cells and activation through endogenous thrombospondin-1 (TSP-1) and its receptors low density lipoprotein receptor-related protein 1 (LRP1), calreticulin and CD47.
CD47 does not mediate amyloid-β(1-42) protofibril-stimulated microglial cytokine release.
Nichols et al., Saint Louis, United States. In Biochem Biophys Res Commun, 22 Nov 2014
One receptor potentially involved in Aβ recognition and the ensuing microglia proinflammatory response is CD47.
FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS.
Issazadeh-Navikas et al., Copenhagen, Denmark. In Nat Med, Mar 2014
FoxA1(+) Treg cells develop primarily in the central nervous system in response to autoimmune inflammation, have a distinct transcriptional profile and are CD4(+)FoxA1(+)CD47(+)CD69(+)PD-L1(hi)FoxP3(-).
[Role of CD47 in hematologic malignancies].
Zhao et al., Cangzhou, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, Dec 2013
CD47 is a ubiquitously expressed transmembrane glycoprotein on surface of many cells.
The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and therapeutic target.
Van den Berg et al., Oxford, United Kingdom. In Annu Rev Immunol, Dec 2013
CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory immunoreceptor SIRPα (also termed CD172a or SHPS-1).
Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow.
Isenberg et al., Pittsburgh, United States. In Front Physiol, Dec 2013
Here we review molecular mechanisms that modulate sGC activity while emphasizing a novel biochemical pathway in which binding of the matricellular protein thrombospondin-1 (TSP1) to the cell surface receptor CD47 causes inhibition of sGC.
Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies.
Garcia et al., Stanford, United States. In Science, Aug 2013
CD47 is an antiphagocytic signal that cancer cells employ to inhibit macrophage-mediated destruction.
Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay.
Trumpp et al., Heidelberg, Germany. In Nat Biotechnol, Jun 2013
These MIC-containing CTC populations expressed EPCAM, CD44, CD47 and MET.
Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles.
Discher et al., Philadelphia, United States. In Science, Mar 2013
The membrane protein CD47 is reportedly a "marker of self" in mice that impedes phagocytosis of self by signaling through the phagocyte receptor CD172a.
Mechanisms tagging senescent red blood cells for clearance in healthy humans.
Bogdanova et al., Zürich, Switzerland. In Front Physiol, 2012
Exoplasmically accessible phosphatidylserine (PS) and the alterations in the interplay between CD47 on RBC and its receptor on macrophages, signal regulatory protein alpha (SIRPalpha protein), were also reported to induce erythrocyte clearance.
Neuronal influence behind the central nervous system regulation of the immune cells.
Cárdenas et al., Mexico. In Front Integr Neurosci, 2012
Contact-dependent mechanisms are provided by several membrane immune modulating molecules such as Sema-7A, CD95L, CD22, CD200, CD47, NCAM, ICAM-5, and cadherins; which can inhibit the expression of microglial inflammatory cytokines, induce apoptosis or inactivate infiltrated T-cells.
Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo.
Luscinskas et al., Boston, United States. In J Immunol, 2012
Engagement of endothelial CD47 by its ligands triggers outside-in signals in endothelium, facilitating leukocyte transendothelial migration at sites of inflammation.
Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice.
Steinman et al., Stanford, United States. In J Exp Med, 2012
Data show that CD47(-/-) mice are refractory to experimental autoimmune encephalomyelitis (EAE).
Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein α (SIRPα), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein β (SIRPβ).
Parkos et al., Atlanta, United States. In J Biol Chem, 2012
Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein alpha (SIRPalpha), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein beta (SIRPbeta).
CD47(high) expression on CD4 effectors identifies functional long-lived memory T cell progenitors.
Sarfati et al., Montréal, Canada. In J Immunol, 2012
CD47(high) status on CD4 T cells identifies functional long-lived memory T cell progenitors.
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.
Weissman et al., Stanford, United States. In Proc Natl Acad Sci U S A, 2012
data,show that CD47 is a commonly expressed molecule on all cancers, its function to block phagocytosis is known, and blockade of its function leads to tumor cell phagocytosis and elimination
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