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CD47 molecule

CD47
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: thrombospondin-1, B it, CAN, V1a, CD45
Papers using CD47 antibodies
Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation.
Supplier
Ferreira Sergio T., In PLoS ONE, 2004
... Anti-CD47 antibody B6H12 was purchased from Abcam (Cambridge, UK) ...
Shiga toxin-2 induces neutrophilia and neutrophil activation in a murine model of hemolytic uremic syndrome.
Supplier
Ratner Adam J., In PLoS ONE, 1999
... Rat anti-mouse CD47 affinity purified mAb (clone miap301) was obtained from BD Biosciences (San Diego, CA) ...
Papers on CD47
CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans.
New
Susin et al., Paris, France. In Plos Med, 31 Mar 2015
The objective of our work was to identify potential approaches that might overcome CLL drug refractoriness by examining the pro-apoptotic potential of targeting the cell surface receptor CD47 with serum-stable agonist peptides.
CD47 signaling pathways controlling cellular differentiation and responses to stress.
New
Roberts et al., Bethesda, United States. In Crit Rev Biochem Mol Biol, 24 Mar 2015
UNASSIGNED: Abstract CD47 is a widely expressed integral membrane protein that serves as the counter-receptor for the inhibitory phagocyte receptor signal-regulatory protein-α (SIRPα) and as a signaling receptor for the secreted matricellular protein thrombospondin-1.
CD47 regulates the phagocytic clearance and replication of the Plasmodium yoelii malaria parasite.
New
Kumar et al., Silver Spring, United States. In Proc Natl Acad Sci U S A, 23 Mar 2015
CD47 is a marker of self on most cells, including RBC, which, in conjunction with signal regulatory protein alpha (expressed on macrophages), prevents the clearance of cells by the immune system.
Antibody mediated therapy targeting CD47 inhibits tumor progression of hepatocellular carcinoma.
New
Chapman et al., Saint Louis, United States. In Cancer Lett, 23 Mar 2015
In this study, we used xenograft tumor models to investigate the use of antibodies that block CD47 and inhibit HCC tumor growth.
Inhibition of CD47 effectively targets pancreatic cancer stem cells via dual mechanism.
New
Heeschen et al., Madrid, Spain. In Clin Cancer Res, 23 Mar 2015
The "don't eat me" signal CD47 on cancer cells communicates to the signal regulatory protein-α on macrophages and prevents their phagocytosis.
Crosstalk between Red Blood Cells and the Immune System and Its Impact on Atherosclerosis.
Review
New
Riganò et al., Roma, Italy. In Biomed Res Int, Dec 2014
This review reports current knowledge on the impact of oxidative stress in RBC modifications with the surface appearance of senescent signals characterized by reduced expression of CD47 and glycophorin A and higher externalization of phosphatidylserine.
FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS.
New
Impact
Issazadeh-Navikas et al., Copenhagen, Denmark. In Nat Med, Mar 2014
FoxA1(+) Treg cells develop primarily in the central nervous system in response to autoimmune inflammation, have a distinct transcriptional profile and are CD4(+)FoxA1(+)CD47(+)CD69(+)PD-L1(hi)FoxP3(-).
The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and therapeutic target.
Review
Impact
Van den Berg et al., Oxford, United Kingdom. In Annu Rev Immunol, 2013
CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory immunoreceptor SIRPα (also termed CD172a or SHPS-1).
Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow.
Review
Isenberg et al., Pittsburgh, United States. In Front Physiol, 2013
Here we review molecular mechanisms that modulate sGC activity while emphasizing a novel biochemical pathway in which binding of the matricellular protein thrombospondin-1 (TSP1) to the cell surface receptor CD47 causes inhibition of sGC.
Monoclonal antibodies against human cancer stem cells.
Review
Naujokat, Heidelberg, Germany. In Immunotherapy, 2013
Various cell surface and transmembrane proteins expressed by CSCs, including CD44, CD47, CD123, EpCAM (CD326), CD133, IGF receptor I, and proteins of the Notch and Wnt signaling pathways have been identified.
[Role of CD47 in hematologic malignancies].
Review
Zhao et al., Cangzhou, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2013
CD47 is a ubiquitously expressed transmembrane glycoprotein on surface of many cells.
Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies.
Impact
Garcia et al., Stanford, United States. In Science, 2013
CD47 is an antiphagocytic signal that cancer cells employ to inhibit macrophage-mediated destruction.
Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay.
Impact
Trumpp et al., Heidelberg, Germany. In Nat Biotechnol, 2013
These MIC-containing CTC populations expressed EPCAM, CD44, CD47 and MET.
Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles.
Impact
Discher et al., Philadelphia, United States. In Science, 2013
The membrane protein CD47 is reportedly a "marker of self" in mice that impedes phagocytosis of self by signaling through the phagocyte receptor CD172a.
Mechanisms tagging senescent red blood cells for clearance in healthy humans.
Review
Bogdanova et al., Zürich, Switzerland. In Front Physiol, 2012
Exoplasmically accessible phosphatidylserine (PS) and the alterations in the interplay between CD47 on RBC and its receptor on macrophages, signal regulatory protein alpha (SIRPalpha protein), were also reported to induce erythrocyte clearance.
Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo.
GeneRIF
Luscinskas et al., Boston, United States. In J Immunol, 2012
Engagement of endothelial CD47 by its ligands triggers outside-in signals in endothelium, facilitating leukocyte transendothelial migration at sites of inflammation.
Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice.
GeneRIF
Steinman et al., Stanford, United States. In J Exp Med, 2012
Data show that CD47(-/-) mice are refractory to experimental autoimmune encephalomyelitis (EAE).
Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein α (SIRPα), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein β (SIRPβ).
GeneRIF
Parkos et al., Atlanta, United States. In J Biol Chem, 2012
Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein alpha (SIRPalpha), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein beta (SIRPbeta).
CD47(high) expression on CD4 effectors identifies functional long-lived memory T cell progenitors.
GeneRIF
Sarfati et al., Montréal, Canada. In J Immunol, 2012
CD47(high) status on CD4 T cells identifies functional long-lived memory T cell progenitors.
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.
GeneRIF
Weissman et al., Stanford, United States. In Proc Natl Acad Sci U S A, 2012
data,show that CD47 is a commonly expressed molecule on all cancers, its function to block phagocytosis is known, and blockade of its function leads to tumor cell phagocytosis and elimination
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