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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2015.

CD47 molecule

This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: thrombospondin-1, B it, CAN, V1a, HAD
Papers using CD47 antibodies
Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation.
Ferreira Sergio T., In PLoS ONE, 2004
... Anti-CD47 antibody B6H12 was purchased from Abcam (Cambridge, UK) ...
Shiga toxin-2 induces neutrophilia and neutrophil activation in a murine model of hemolytic uremic syndrome.
Ratner Adam J., In PLoS ONE, 1999
... Rat anti-mouse CD47 affinity purified mAb (clone miap301) was obtained from BD Biosciences (San Diego, CA) ...
Papers on CD47
Evolution of normal and neoplastic tissue stem cells: progress after Robert Hooke.
Weissman, Stanford, United States. In Philos Trans R Soc Lond B Biol Sci, 19 Nov 2015
All leukaemia and cancer cells escape being removed by scavenger macrophages by expressing the 'don't eat me' signal CD47.
SIRP/CD47 signaling in neurological disorders.
Hu et al., Pittsburgh, United States. In Brain Res, 14 Nov 2015
This review will focus on the signal regulatory protein (SIRP) and its ligand CD47, two surface receptors expressed on microglia and other cells in the central nervous system (CNS) such as neurons.
The immunomodulatory oligodendrocyte.
Schaeren-Wiemers et al., Basel, Switzerland. In Brain Res, 27 Oct 2015
CD200, CD47) as well as extracellular matrix proteins (e.g.
The Antitumor Activity of CD47 Blockade Depends on T-cell Activation.
In Cancer Discov, 10 Oct 2015
UNASSIGNED: CD8(+) T cells are required for anti-CD47-induced regression of syngeneic tumor models.
Current Status of Hepatocyte Xenotransplantation.
Bühler et al., Genève, Switzerland. In Int J Surg, 08 Oct 2015
In this review we present an overview of the innate immune barriers in hepatocyte xenotransplantation, including the role of complement and natural antibodies; the role of phagocytic cells and ligands like CD47 in the regulation of phagocytic cells; and the role of Natural Killer cells.
CD47 blockade triggers T cell-mediated destruction of immunogenic tumors.
Xu et al., Beijing, China. In Nat Med, 01 Oct 2015
UNASSIGNED: Macrophage phagocytosis of tumor cells mediated by CD47-specific blocking antibodies has been proposed to be the major effector mechanism in xenograft models.
Macrophage engulfment of a cell or nanoparticle is regulated by unavoidable opsonization, a species-specific 'Marker of Self' CD47, and target physical properties.
Discher et al., Philadelphia, United States. In Curr Opin Immunol, Aug 2015
'Marker of Self' CD47 signals into a macrophage to inhibit the acto-myosin cytoskeleton that makes engulfment efficient.
Alternative 3' UTRs act as scaffolds to regulate membrane protein localization.
Mayr et al., New York City, United States. In Nature, Jul 2015
The long 3' UTR of CD47 enables efficient cell surface expression of CD47 protein, whereas the short 3' UTR primarily localizes CD47 protein to the endoplasmic reticulum.
Targeting the innate immune system as immunotherapy for acute myeloid leukemia.
Kline et al., Chicago, United States. In Front Oncol, Dec 2014
Promising immune targets include the toll-like receptors, calreticulin/CD47, the stimulator of interferon genes pathway, and signal transducer and activator of transcription 3 (STAT3).
The story of CD4+ CD28- T cells revisited: solved or still ongoing?
Schirmer et al., Innsbruck, Austria. In J Immunol Res, Dec 2014
As an alternative costimulatory signal instead of CD28, not only natural killer cell receptors and Toll-like receptors, but also CD47, CTLA-4, OX40, and 4-1BB have to be considered.
Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential.
Majeti et al., Stanford, United States. In Plos One, Dec 2014
CD47 is a widely expressed cell surface protein that functions as a regulator of phagocytosis mediated by cells of the innate immune system, such as macrophages and dendritic cells.
Primary Cutaneous Peripheral T-Cell Lymphoma Not Otherwise Specified: A Rapidly Progressive Variant of Cutaneous T-Cell Lymphoma.
Donato et al., Reading, United States. In Case Rep Oncol Med, Dec 2014
Biopsy results demonstrated CD4 positivity, consistent with Mycosis Fungoides with coexpression of CD5, CD47, and CD7.
FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS.
Issazadeh-Navikas et al., Copenhagen, Denmark. In Nat Med, Mar 2014
FoxA1(+) Treg cells develop primarily in the central nervous system in response to autoimmune inflammation, have a distinct transcriptional profile and are CD4(+)FoxA1(+)CD47(+)CD69(+)PD-L1(hi)FoxP3(-).
The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and therapeutic target.
Van den Berg et al., Oxford, United Kingdom. In Annu Rev Immunol, 2013
CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory immunoreceptor SIRPα (also termed CD172a or SHPS-1).
Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies.
Garcia et al., Stanford, United States. In Science, 2013
CD47 is an antiphagocytic signal that cancer cells employ to inhibit macrophage-mediated destruction.
Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo.
Luscinskas et al., Boston, United States. In J Immunol, 2012
Engagement of endothelial CD47 by its ligands triggers outside-in signals in endothelium, facilitating leukocyte transendothelial migration at sites of inflammation.
Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice.
Steinman et al., Stanford, United States. In J Exp Med, 2012
Data show that CD47(-/-) mice are refractory to experimental autoimmune encephalomyelitis (EAE).
Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein α (SIRPα), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein β (SIRPβ).
Parkos et al., Atlanta, United States. In J Biol Chem, 2012
Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein alpha (SIRPalpha), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein beta (SIRPbeta).
CD47(high) expression on CD4 effectors identifies functional long-lived memory T cell progenitors.
Sarfati et al., Montréal, Canada. In J Immunol, 2012
CD47(high) status on CD4 T cells identifies functional long-lived memory T cell progenitors.
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.
Weissman et al., Stanford, United States. In Proc Natl Acad Sci U S A, 2012
data,show that CD47 is a commonly expressed molecule on all cancers, its function to block phagocytosis is known, and blockade of its function leads to tumor cell phagocytosis and elimination
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