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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 12 Nov 2015.

CD47 molecule

This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: thrombospondin-1, B it, CAN, V1a, CD45
Papers using CD47 antibodies
Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation.
Ferreira Sergio T., In PLoS ONE, 2004
... Anti-CD47 antibody B6H12 was purchased from Abcam (Cambridge, UK) ...
Shiga toxin-2 induces neutrophilia and neutrophil activation in a murine model of hemolytic uremic syndrome.
Ratner Adam J., In PLoS ONE, 1999
... Rat anti-mouse CD47 affinity purified mAb (clone miap301) was obtained from BD Biosciences (San Diego, CA) ...
Papers on CD47
CD47-retargeted oncolytic adenovirus armed with melanoma differentiation-associated gene-7/interleukin-24 suppresses in vivo leukemia cell growth.
Luo et al., Hangzhou, China. In Oncotarget, 07 Dec 2015
We report here a novel oncolytic adenovirus vector redirected to CD47+ leukemia cells though carrying a sCAR-4N1 expression cassette in the viral genome, forming Ad.4N1, in which 4N1 represents the C-terminal CD47-binding domain of thrombospondin-1.
Cleavage of signal regulatory protein alpha (SIRPα) enhances inflammatory signaling.
Mallampalli et al., Pittsburgh, United States. In J Biol Chem, 03 Dec 2015
SIRPα ligation by a broadly expressed transmembrane protein CD47 results in phosphorylation of the cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs), resulting in the inhibition of NF-κB signaling in macrophages.
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells.
Semenza et al., Xi'an, China. In Proc Natl Acad Sci U S A, 28 Nov 2015
UNASSIGNED: Increased expression of CD47 has been reported to enable cancer cells to evade phagocytosis by macrophages and to promote the cancer stem cell phenotype, but the molecular mechanisms regulating CD47 expression have not been determined.
miR-192 suppresses leptomeningeal dissemination of medulloblastoma by modulating cell proliferation and anchoring through the regulation of DHFR, integrins, and CD47.
Kim et al., Seoul, South Korea. In Oncotarget, 25 Nov 2015
miR-192 decreased cellular anchoring via the repression of ITGAV, ITGB1, ITGB3, and CD47.
Red Blood Cell Membrane as a Biomimetic Nanocoating for Prolonged Circulation Time and Reduced Accelerated Blood Clearance.
Zhao et al., Wuhan, China. In Small, 21 Nov 2015
Biomimetic RBC membrane-coated Fe3 O4 nanoparticles (Fe3 O4 @RBC NPs) rely on CD47, which is a "don't eat me" marker on the RBC surface, to escape immune clearance through interactions with the signal regulatory protein-alpha (SIRP-α) receptor.
Loss of CD47 Makes Dendritic Cells See Red.
van Bruggen et al., Amsterdam, Netherlands. In Immunity, 20 Nov 2015
Cyster and colleagues now demonstrate that the "self" molecule CD47 on erythrocytes critically restricts splenic DC activation.
Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses.
Cyster et al., San Francisco, United States. In Immunity, 20 Nov 2015
Removal of the SIRPα ligand, CD47, from self-RBCs was sufficient to convert them into an adjuvant for adaptive immune responses.
Evolution of normal and neoplastic tissue stem cells: progress after Robert Hooke.
Weissman, Stanford, United States. In Philos Trans R Soc Lond B Biol Sci, 19 Nov 2015
All leukaemia and cancer cells escape being removed by scavenger macrophages by expressing the 'don't eat me' signal CD47.
CD47 blockade triggers T cell-mediated destruction of immunogenic tumors.
Xu et al., Beijing, China. In Nat Med, 31 Oct 2015
Macrophage phagocytosis of tumor cells mediated by CD47-specific blocking antibodies has been proposed to be the major effector mechanism in xenograft models.
The immunomodulatory oligodendrocyte.
Schaeren-Wiemers et al., Basel, Switzerland. In Brain Res, 27 Oct 2015
CD200, CD47) as well as extracellular matrix proteins (e.g.
Current Status of Hepatocyte Xenotransplantation.
Bühler et al., Genève, Switzerland. In Int J Surg, 08 Oct 2015
In this review we present an overview of the innate immune barriers in hepatocyte xenotransplantation, including the role of complement and natural antibodies; the role of phagocytic cells and ligands like CD47 in the regulation of phagocytic cells; and the role of Natural Killer cells.
Macrophage engulfment of a cell or nanoparticle is regulated by unavoidable opsonization, a species-specific 'Marker of Self' CD47, and target physical properties.
Discher et al., Philadelphia, United States. In Curr Opin Immunol, Aug 2015
'Marker of Self' CD47 signals into a macrophage to inhibit the acto-myosin cytoskeleton that makes engulfment efficient.
Alternative 3' UTRs act as scaffolds to regulate membrane protein localization.
Mayr et al., New York City, United States. In Nature, Jul 2015
The long 3' UTR of CD47 enables efficient cell surface expression of CD47 protein, whereas the short 3' UTR primarily localizes CD47 protein to the endoplasmic reticulum.
Targeting the innate immune system as immunotherapy for acute myeloid leukemia.
Kline et al., Chicago, United States. In Front Oncol, Dec 2014
Promising immune targets include the toll-like receptors, calreticulin/CD47, the stimulator of interferon genes pathway, and signal transducer and activator of transcription 3 (STAT3).
FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS.
Issazadeh-Navikas et al., Copenhagen, Denmark. In Nat Med, Mar 2014
FoxA1(+) Treg cells develop primarily in the central nervous system in response to autoimmune inflammation, have a distinct transcriptional profile and are CD4(+)FoxA1(+)CD47(+)CD69(+)PD-L1(hi)FoxP3(-).
Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo.
Luscinskas et al., Boston, United States. In J Immunol, 2012
Engagement of endothelial CD47 by its ligands triggers outside-in signals in endothelium, facilitating leukocyte transendothelial migration at sites of inflammation.
Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice.
Steinman et al., Stanford, United States. In J Exp Med, 2012
Data show that CD47(-/-) mice are refractory to experimental autoimmune encephalomyelitis (EAE).
Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein α (SIRPα), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein β (SIRPβ).
Parkos et al., Atlanta, United States. In J Biol Chem, 2012
Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein alpha (SIRPalpha), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein beta (SIRPbeta).
CD47(high) expression on CD4 effectors identifies functional long-lived memory T cell progenitors.
Sarfati et al., Montréal, Canada. In J Immunol, 2012
CD47(high) status on CD4 T cells identifies functional long-lived memory T cell progenitors.
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.
Weissman et al., Stanford, United States. In Proc Natl Acad Sci U S A, 2012
data,show that CD47 is a commonly expressed molecule on all cancers, its function to block phagocytosis is known, and blockade of its function leads to tumor cell phagocytosis and elimination
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