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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Jul 2015.

CD47 molecule

CD47
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: thrombospondin-1, B it, CAN, V1a, CD45
Papers using CD47 antibodies
Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation.
Supplier
Ferreira Sergio T., In PLoS ONE, 2004
... Anti-CD47 antibody B6H12 was purchased from Abcam (Cambridge, UK) ...
Shiga toxin-2 induces neutrophilia and neutrophil activation in a murine model of hemolytic uremic syndrome.
Supplier
Ratner Adam J., In PLoS ONE, 1999
... Rat anti-mouse CD47 affinity purified mAb (clone miap301) was obtained from BD Biosciences (San Diego, CA) ...
Papers on CD47
Molecular Pathways: Activating T Cells After Cancer Cell Phagocytosis from Blockade of CD47 "Don't Eat Me" Signals.
New
Weissman et al., Stanford, United States. In Clin Cancer Res, 26 Jul 2015
Our laboratory has identified CD47 as an important "don't eat me" signal expressed on malignant cells.
Alternative 3' UTRs act as scaffolds to regulate membrane protein localization.
New
Impact
Mayr et al., New York City, United States. In Nature, 18 Jul 2015
The long 3' UTR of CD47 enables efficient cell surface expression of CD47 protein, whereas the short 3' UTR primarily localizes CD47 protein to the endoplasmic reticulum.
CD47 deficiency ameliorates autoimmune nephritis in Fas(lpr) mice by suppressing IgG autoantibody production.
New
Liu et al., Nanjing, China. In J Pathol, 12 Jul 2015
UNASSIGNED: CD47, a self-recognition marker, plays an important role in both innate and adaptive immune response.
CD47 blockade inhibits tumor progression human osteosarcoma in xenograft models.
New
Wang et al., Hangzhou, China. In Oncotarget, 08 Jul 2015
In this study, we explored the use of antibodies that block CD47 with a tumor growth suppressive effect on osteosarcoma.
SIRP/CD47 signaling in neurological disorders.
Review
New
Hu et al., Pittsburgh, United States. In Brain Res, Apr 2015
This review will focus on the signal regulatory protein (SIRP) and its ligand CD47, two surface receptors expressed on microglia and other cells in the central nervous system (CNS) such as neurons.
The story of CD4+ CD28- T cells revisited: solved or still ongoing?
Review
New
Schirmer et al., Innsbruck, Austria. In J Immunol Res, Dec 2014
As an alternative costimulatory signal instead of CD28, not only natural killer cell receptors and Toll-like receptors, but also CD47, CTLA-4, OX40, and 4-1BB have to be considered.
Crosstalk between red blood cells and the immune system and its impact on atherosclerosis.
Review
New
Riganò et al., Roma, Italy. In Biomed Res Int, Dec 2014
This review reports current knowledge on the impact of oxidative stress in RBC modifications with the surface appearance of senescent signals characterized by reduced expression of CD47 and glycophorin A and higher externalization of phosphatidylserine.
Targeting the innate immune system as immunotherapy for acute myeloid leukemia.
Review
New
Kline et al., Chicago, United States. In Front Oncol, Dec 2014
Promising immune targets include the toll-like receptors, calreticulin/CD47, the stimulator of interferon genes pathway, and signal transducer and activator of transcription 3 (STAT3).
Ara-C and anti-CD47 antibody combination therapy eliminates acute monocytic leukemia THP-1 cells in vivo and in vitro.
New
Sheng et al., Zhengzhou, China. In Genet Mol Res, Dec 2014
In this study, we examined the prognostic significance of cluster differentiation 47 (CD47) and identified the appropriate target for eliminating LSCs.
FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS.
New
Impact
Issazadeh-Navikas et al., Copenhagen, Denmark. In Nat Med, Mar 2014
FoxA1(+) Treg cells develop primarily in the central nervous system in response to autoimmune inflammation, have a distinct transcriptional profile and are CD4(+)FoxA1(+)CD47(+)CD69(+)PD-L1(hi)FoxP3(-).
The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and therapeutic target.
Review
Impact
Van den Berg et al., Oxford, United Kingdom. In Annu Rev Immunol, 2013
CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory immunoreceptor SIRPα (also termed CD172a or SHPS-1).
Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow.
Review
Isenberg et al., Pittsburgh, United States. In Front Physiol, 2013
Here we review molecular mechanisms that modulate sGC activity while emphasizing a novel biochemical pathway in which binding of the matricellular protein thrombospondin-1 (TSP1) to the cell surface receptor CD47 causes inhibition of sGC.
Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies.
Impact
Garcia et al., Stanford, United States. In Science, 2013
CD47 is an antiphagocytic signal that cancer cells employ to inhibit macrophage-mediated destruction.
Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay.
Impact
Trumpp et al., Heidelberg, Germany. In Nat Biotechnol, 2013
These MIC-containing CTC populations expressed EPCAM, CD44, CD47 and MET.
Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo.
GeneRIF
Luscinskas et al., Boston, United States. In J Immunol, 2012
Engagement of endothelial CD47 by its ligands triggers outside-in signals in endothelium, facilitating leukocyte transendothelial migration at sites of inflammation.
Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice.
GeneRIF
Steinman et al., Stanford, United States. In J Exp Med, 2012
Data show that CD47(-/-) mice are refractory to experimental autoimmune encephalomyelitis (EAE).
OS045. Multi-dimensional protein identification technology analysis of syncytiotrophoblast vesicles released from perfused preeclampsia placentas.
Redman et al., Oxford, United Kingdom. In Pregnancy Hypertens, 2012
Preliminary analysis indicates the presence of alarmins (HSP70, and galectin 3), exosomal proteins (CD63,CD9,CD81), immunoregulatory molecules (CD26,CD200,CD47,Galectin 1), complement and complement regulatory molecules (C1q,C3,CD55,CD59 and vitronectin), amino acid transporters (CD98) and anti-angiogenic molecules (endoglin).
Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein α (SIRPα), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein β (SIRPβ).
GeneRIF
Parkos et al., Atlanta, United States. In J Biol Chem, 2012
Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein alpha (SIRPalpha), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein beta (SIRPbeta).
CD47(high) expression on CD4 effectors identifies functional long-lived memory T cell progenitors.
GeneRIF
Sarfati et al., Montréal, Canada. In J Immunol, 2012
CD47(high) status on CD4 T cells identifies functional long-lived memory T cell progenitors.
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.
GeneRIF
Weissman et al., Stanford, United States. In Proc Natl Acad Sci U S A, 2012
data,show that CD47 is a commonly expressed molecule on all cancers, its function to block phagocytosis is known, and blockade of its function leads to tumor cell phagocytosis and elimination
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