gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 Oct 2014.

CD47 molecule

CD47
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: thrombospondin-1, B it, CAN, V1a, CD45
Papers using CD47 antibodies
Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation.
Supplier
Ferreira Sergio T., In PLoS ONE, 2004
... Anti-CD47 antibody B6H12 was purchased from Abcam (Cambridge, UK) ...
Shiga toxin-2 induces neutrophilia and neutrophil activation in a murine model of hemolytic uremic syndrome.
Supplier
Ratner Adam J., In PLoS ONE, 1999
... Rat anti-mouse CD47 affinity purified mAb (clone miap301) was obtained from BD Biosciences (San Diego, CA) ...
Papers on CD47
Polymorphism in the Innate Immune Receptor SIRPα Controls CD47 Binding and Autoimmunity in the Nonobese Diabetic Mouse.
New
Danska et al., Toronto, Canada. In J Immunol, 10 Nov 2014
Compared to T1D-resistant strains, the NOD variant of SIRPα displayed greater binding to its ligand CD47, as well as enhanced T cell proliferation and diabetogenic potency.
CD47 in the tumor microenvironment limits cooperation between anti-tumor T cell immunity and radiation therapy.
New
Roberts et al., In Cancer Res, 08 Nov 2014
CD47 blockade has been found to confer radioprotection to normal tissues while enhancing tumor radiosensitivity.
Transgenic Expression of Human CD47 Markedly Increases Engraftment in a Murine Model of Pig-to-Human Hematopoietic Cell Transplantation.
New
Hawley et al., Boston, United States. In Am J Transplant, 02 Nov 2014
CD47 is a cell-surface molecule that interacts in a species-specific manner with SIRPα receptors on macrophages to inhibit phagocytosis and expression of human CD47 (hCD47) on porcine cells has been shown to inhibit phagocytosis by primate macrophages.
Co-expression of MET and CD47 is a novel prognosticator for survival of luminal breast cancer patients.
New
Trumpp et al., Heidelberg, Germany. In Oncotarget, 30 Oct 2014
We have previously shown that luminal-type circulating tumor cells (CTCs) co-expressing the tyrosine-kinase MET and CD47, a ligand involved in cancer cell evasion from macrophage scavenging, are able to initiate metastasis in xenografts.
Signal Regulatory Protein alpha (SIRPα) regulates the homeostasis of CD103(+) CD11b(+) DCs in the intestinal lamina propria.
New
Mowat et al., Glasgow, United Kingdom. In Eur J Immunol, 19 Oct 2014
UNLABELLED: Signal regulatory protein alpha (SIRPα/CD172a) is a conserved transmembrane protein thought to play an inhibitory role in immune function by binding the ubiquitous ligand CD47.
FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS.
New
Impact
Issazadeh-Navikas et al., Copenhagen, Denmark. In Nat Med, Mar 2014
FoxA1(+) Treg cells develop primarily in the central nervous system in response to autoimmune inflammation, have a distinct transcriptional profile and are CD4(+)FoxA1(+)CD47(+)CD69(+)PD-L1(hi)FoxP3(-).
Thrombospondin-1 and CD47 regulation of cardiac, pulmonary and vascular responses in health and disease.
Review
New
Isenberg et al., Pittsburgh, United States. In Matrix Biol, Feb 2014
It is now apparent that the secreted protein thrombospondin-1 (TSP1), that is upregulated in cardiovascular disease and animal models of the same, on activating cell surface receptor CD47, redundantly inhibits NO production and NO signaling.
The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and therapeutic target.
New
Impact
Van den Berg et al., Oxford, United Kingdom. In Annu Rev Immunol, Dec 2013
CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory immunoreceptor SIRPα (also termed CD172a or SHPS-1).
[Role of CD47 in hematologic malignancies].
Review
New
Zhao et al., Cangzhou, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, Dec 2013
CD47 is a ubiquitously expressed transmembrane glycoprotein on surface of many cells.
Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow.
Review
New
Isenberg et al., Pittsburgh, United States. In Front Physiol, Dec 2013
Here we review molecular mechanisms that modulate sGC activity while emphasizing a novel biochemical pathway in which binding of the matricellular protein thrombospondin-1 (TSP1) to the cell surface receptor CD47 causes inhibition of sGC.
Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies.
New
Impact
Garcia et al., Stanford, United States. In Science, Aug 2013
CD47 is an antiphagocytic signal that cancer cells employ to inhibit macrophage-mediated destruction.
Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay.
New
Impact
Trumpp et al., Heidelberg, Germany. In Nat Biotechnol, Jun 2013
These MIC-containing CTC populations expressed EPCAM, CD44, CD47 and MET.
Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles.
New
Impact
Discher et al., Philadelphia, United States. In Science, Mar 2013
The membrane protein CD47 is reportedly a "marker of self" in mice that impedes phagocytosis of self by signaling through the phagocyte receptor CD172a.
Mechanisms tagging senescent red blood cells for clearance in healthy humans.
Review
Bogdanova et al., Zürich, Switzerland. In Front Physiol, 2012
Exoplasmically accessible phosphatidylserine (PS) and the alterations in the interplay between CD47 on RBC and its receptor on macrophages, signal regulatory protein alpha (SIRPalpha protein), were also reported to induce erythrocyte clearance.
Neuronal influence behind the central nervous system regulation of the immune cells.
Review
Cárdenas et al., Mexico. In Front Integr Neurosci, 2012
Contact-dependent mechanisms are provided by several membrane immune modulating molecules such as Sema-7A, CD95L, CD22, CD200, CD47, NCAM, ICAM-5, and cadherins; which can inhibit the expression of microglial inflammatory cytokines, induce apoptosis or inactivate infiltrated T-cells.
Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo.
GeneRIF
Luscinskas et al., Boston, United States. In J Immunol, 2012
Engagement of endothelial CD47 by its ligands triggers outside-in signals in endothelium, facilitating leukocyte transendothelial migration at sites of inflammation.
Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice.
GeneRIF
Steinman et al., Stanford, United States. In J Exp Med, 2012
Data show that CD47(-/-) mice are refractory to experimental autoimmune encephalomyelitis (EAE).
Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein α (SIRPα), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein β (SIRPβ).
GeneRIF
Parkos et al., Atlanta, United States. In J Biol Chem, 2012
Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein alpha (SIRPalpha), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein beta (SIRPbeta).
CD47(high) expression on CD4 effectors identifies functional long-lived memory T cell progenitors.
GeneRIF
Sarfati et al., Montréal, Canada. In J Immunol, 2012
CD47(high) status on CD4 T cells identifies functional long-lived memory T cell progenitors.
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.
GeneRIF
Weissman et al., Stanford, United States. In Proc Natl Acad Sci U S A, 2012
data,show that CD47 is a commonly expressed molecule on all cancers, its function to block phagocytosis is known, and blockade of its function leads to tumor cell phagocytosis and elimination
share on facebooktweetadd +1mail to friends