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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Mar 2014.

CD47 molecule

This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: thrombospondin-1, B it, CAN, V1a, CD45
Papers using CD47 antibodies
Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation.
Ferreira Sergio T., In PLoS ONE, 2004
... Anti-CD47 antibody B6H12 was purchased from Abcam (Cambridge, UK) ...
Shiga toxin-2 induces neutrophilia and neutrophil activation in a murine model of hemolytic uremic syndrome.
Ratner Adam J., In PLoS ONE, 1999
... Rat anti-mouse CD47 affinity purified mAb (clone miap301) was obtained from BD Biosciences (San Diego, CA) ...
Papers on CD47
Immune escape and survival mechanisms in circulating tumor cells of colorectal cancer.
Koch et al., Dresden, Germany. In Cancer Res, 15 Apr 2014
Gene expression analyses revealed both a pronounced upregulation of CD47 as a potential immune-escape mechanism and a significant downregulation of several other pathways, suggesting a dormant state of viable CTC.
Expression and prognostic significance of cancer stem cell markers CD24 and CD44 in urothelial bladder cancer xenografts and patients undergoing radical cystectomy.
Sprick et al., Heidelberg, Germany. In Urol Oncol, 12 Apr 2014
OBJECTIVES: To evaluate CD24/CD44/CD47 cancer stem cell marker expressions in bladder cancer (BCa) and provide data on their prognostic significance for clinical outcome in patients undergoing radical cystectomy (RC).
The CD47-SIRPα signaling system: its physiological roles and therapeutic application.
Matozaki et al., Kōbe, Japan. In J Biochem, 12 Apr 2014
CD47, another immunoglobulin superfamily protein, is a ligand for SIRPα, with the two proteins constituting a cell-cell communication system (the CD47-SIRPα signaling system).
Red blood cell in vitro quality and function is maintained after S-303 pathogen inactivation treatment.
Marks et al., Sydney, Australia. In Transfusion, 11 Apr 2014
Flow cytometry analysis demonstrated similar RBC size, morphology, expression of CD47, and glycophorin A in all groups.
FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS.
Issazadeh-Navikas et al., Copenhagen, Denmark. In Nat Med, 31 Mar 2014
FoxA1(+) Treg cells develop primarily in the central nervous system in response to autoimmune inflammation, have a distinct transcriptional profile and are CD4(+)FoxA1(+)CD47(+)CD69(+)PD-L1(hi)FoxP3(-).
BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton.
Agostinis et al., Leuven, Belgium. In Cell Death Dis, Dec 2013
Remarkably, BNIP3 silencing led to a drop of the protein levels of the integrin-associated protein CD47 and its downstream signaling effectors Rac1 and Cdc42.
The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target.
van den Berg et al., Oxford, United Kingdom. In Annu Rev Immunol, Dec 2013
UNLABELLED: CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory immunoreceptor SIRPα (also termed CD172a or SHPS-1).
Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies.
Garcia et al., Stanford, United States. In Science, Aug 2013
CD47 is an antiphagocytic signal that cancer cells employ to inhibit macrophage-mediated destruction.
Engineering antiphagocytic biomimetic drug carriers.
Peng et al., United States. In Ther Deliv, Jul 2013
The 'marker-of-self' CD47 protein, which is found ubiquitously on mammalian cell surfaces, has been used for evading phagocyte clearance of drug carriers.
Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay.
Trumpp et al., Heidelberg, Germany. In Nat Biotechnol, Jun 2013
These MIC-containing CTC populations expressed EPCAM, CD44, CD47 and MET.
Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles.
Discher et al., Philadelphia, United States. In Science, Mar 2013
The membrane protein CD47 is reportedly a "marker of self" in mice that impedes phagocytosis of self by signaling through the phagocyte receptor CD172a.
Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47.
Roberts et al., Bethesda, United States. In Expert Opin Ther Targets, 2013
INTRODUCTION: CD47 is a ubiquitously expressed cell surface receptor that serves as a counter-receptor for SIRPα in recognition of self by the innate immune system.
Neuronal influence behind the central nervous system regulation of the immune cells.
Cárdenas et al., Mexico. In Front Integr Neurosci, 2012
Contact-dependent mechanisms are provided by several membrane immune modulating molecules such as Sema-7A, CD95L, CD22, CD200, CD47, NCAM, ICAM-5, and cadherins; which can inhibit the expression of microglial inflammatory cytokines, induce apoptosis or inactivate infiltrated T-cells.
Mechanisms tagging senescent red blood cells for clearance in healthy humans.
Bogdanova et al., Zürich, Switzerland. In Front Physiol, 2012
Exoplasmically accessible phosphatidylserine (PS) and the alterations in the interplay between CD47 on RBC and its receptor on macrophages, signal regulatory protein alpha (SIRPalpha protein), were also reported to induce erythrocyte clearance.
Activated CD47 regulates multiple vascular and stress responses: implications for acute kidney injury and its management.
Isenberg et al., Pittsburgh, United States. In Am J Physiol Renal Physiol, 2012
The cell surface receptor CD47 is widely expressed on vascular cells and in tissues.
Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo.
Luscinskas et al., Boston, United States. In J Immunol, 2012
Engagement of endothelial CD47 by its ligands triggers outside-in signals in endothelium, facilitating leukocyte transendothelial migration at sites of inflammation.
Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice.
Steinman et al., Stanford, United States. In J Exp Med, 2012
Data show that CD47(-/-) mice are refractory to experimental autoimmune encephalomyelitis (EAE).
Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein α (SIRPα), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein β (SIRPβ).
Parkos et al., Atlanta, United States. In J Biol Chem, 2012
Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein alpha (SIRPalpha), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein beta (SIRPbeta).
CD47(high) expression on CD4 effectors identifies functional long-lived memory T cell progenitors.
Sarfati et al., Montréal, Canada. In J Immunol, 2012
CD47(high) status on CD4 T cells identifies functional long-lived memory T cell progenitors.
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.
Weissman et al., Stanford, United States. In Proc Natl Acad Sci U S A, 2012
data,show that CD47 is a commonly expressed molecule on all cancers, its function to block phagocytosis is known, and blockade of its function leads to tumor cell phagocytosis and elimination
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