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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CD46 molecule, complement regulatory protein

The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: CD55, CAN, CD59, SLAM, HAD
Papers on CD46
Inhibition of complement component C5 prevents clotting in an ex vivo model of xenogeneic activation of coagulation.
Tiede et al., Hannover, Germany. In Xenotransplantation, Feb 2016
METHODS: A microfluidic flow chamber was used to study platelet activation and thrombus formation of human platelet-rich plasma (PRP) upon perfusion over wild-type (WT) or α-1,3- galactosyltransferase knockout (GTKO) and human CD46 (hCD46) transgenic porcine aortic endothelial cells (PAEC).
TNF Regulates Essential Alternative Complement Pathway Components and Impairs Activation of Protein C in Human Glomerular Endothelial Cells.
Moake et al., Houston, United States. In J Immunol, Feb 2016
We investigated gene expression of the surface complement regulatory proteins (CD55, CD59, CD46, and CD141 [thrombomodulin]) and AP components in human glomerular microvascular endothelial cells (GMVECs) and in HUVECs, a frequently used investigational model of endothelial cells.
CD46 Activation Regulates miR-150-Mediated Control of GLUT1 Expression and Cytokine Secretion in Human CD4+ T Cells.
Blom et al., Malmö, Sweden. In J Immunol, Feb 2016
UNASSIGNED: CD46 is a cell surface complement inhibitor widely expressed in human tissues, in contrast to mice, where expression is limited to the testes.
Susceptibility of KSHV-infected PEL cell lines to the human complement system.
Lee et al., Taejŏn, South Korea. In J Microbiol Biotechnol, Jan 2016
Interestingly, two widely used PEL cell lines, BCP-1 and BCBL-1, showed different susceptibility to the complement system, which may be due to CD46 expression on their cell membranes.
Functional analysis of membrane-bound complement regulatory protein on T-cell immune response in ginbuna crucian carp.
Nakao et al., Fukuoka, Japan. In Mol Immunol, Jan 2016
Membrane-bound complement regulatory protein CD46, a costimulatory protein for T cells, is a key molecule for T-cell immunomodulation.
The immunomodulatory oligodendrocyte.
Schaeren-Wiemers et al., Basel, Switzerland. In Brain Res, Oct 2015
CD46, CD55, CD59), tetraspanins (e.g.
Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses.
Kemper et al., Basel, Switzerland. In Immunity, Jul 2015
Here we found that in activated human T cells, autocrine stimulation of the complement receptor CD46, and specifically its intracellular domain CYT-1, was required for induction of the amino acid (AA) transporter LAT1 and enhanced expression of the glucose transporter GLUT1.
Common variants associated with general and MMR vaccine-related febrile seizures.
Hviid et al., Copenhagen, Denmark. In Nat Genet, 2014
Two loci were distinctly associated with MMR-related febrile seizures, harboring the interferon-stimulated gene IFI44L (rs273259: P = 5.9 × 10(-12) versus controls, P = 1.2 × 10(-9) versus MMR-unrelated febrile seizures) and the measles virus receptor CD46 (rs1318653: P = 9.6 × 10(-11) versus controls, P = 1.6 × 10(-9) versus MMR-unrelated febrile seizures).
Xenotransplantation of Cells, Tissues, Organs and the German Research Foundation Transregio Collaborative Research Centre 127.
Abicht et al., München, Germany. In Adv Exp Med Biol, 2014
These include genetic modification of the donor animals to knock out genes responsible for xenoreactive surface epitopes and to express multiple xenoprotective molecules such as the human complement regulators CD46, 55, 59, thrombomodulin and others.
Complement regulator CD46: genetic variants and disease associations.
Atkinson et al., Saint Louis, United States. In Hum Genomics, 2014
Membrane cofactor protein (MCP; CD46) is an ubiquitously expressed complement regulatory protein that protects host cells from injury by complement.
Recent developments in animal models for human herpesvirus 6A and 6B.
Lusso et al., France. In Curr Opin Virol, 2014
Neuroinflammatory signs were observed in infected marmosets and CD46-transgenic mice; although viral replication was not prominent, persistence of viral DNA and specific immunologic responses were detected, suggesting an immune-mediated pathogenic mechanism.
Complement modulation of T cell immune responses during homeostasis and disease.
Tenner et al., Irvine, United States. In J Leukoc Biol, 2014
Here, we will review recent data demonstrating the influence of complement proteins C1q, C3b/iC3b, C3a (and C3aR), and C5a (and C5aR) and complement regulators DAF (CD55) and CD46 (MCP) on T cell function during homeostasis and disease.
The CD46-Jagged1 interaction is critical for human TH1 immunity.
Kemper et al., London, United Kingdom. In Nat Immunol, 2012
CD46 is a complement regulator with important roles related to the immune response.
Virion-associated complement regulator CD55 is more potent than CD46 in mediating resistance of mumps virus and vesicular stomatitis virus to neutralization.
Parks et al., Winston-Salem, United States. In J Virol, 2012
mumps virus (MuV) and vesicular stomatitis virus (VSV) assemble to include CD46 and CD55, two host cell regulators which inhibit propagation of complement pathways through distinct mechanisms.
Prostaglandin E2 affects T cell responses through modulation of CD46 expression.
Astier et al., Edinburgh, United Kingdom. In J Immunol, 2012
Prostaglandin (PG)E2 has a novel role in CD46 functions, which might at least partly explain the diverse roles of PGE2 in T cell functions.
CD46 measles virus receptor polymorphisms influence receptor protein expression and primary measles vaccine responses in naive Australian children.
Richmond et al., Perth, Australia. In Clin Vaccine Immunol, 2012
Three CD46 variants (rs7144, rs11118580, and rs2724384) were significantly associated with measles virus-specific IgG levels (P = 0.008, P = 0.026, and P = 0.018, respectively).
Expression and significance of leukocyte membrane cofactor protein transcript in systemic lupus erythematosus.
Das et al., New Delhi, India. In Lupus, 2012
in systemic lupus erythematosus, the expression of leukocyte MCP at the mRNA level is closely related to disease activity
HBXIP upregulates CD46, CD55 and CD59 through ERK1/2/NF-κB signaling to protect breast cancer cells from complement attack.
Ye et al., Tianjin, China. In Febs Lett, 2012
Data suggest that HBXIP upregulates CD46, CD55 and CD59 through p-ERK1/2/NF-kappaB signaling to protect breast cancer from complement-dependent cytotoxicity.
Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14.
Lieber et al., Seattle, United States. In Nat Med, 2011
This opening improves access to receptors, for example, CD46 and Her2/neu, that are trapped in intercellular junctions.
The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis.
Arnberg et al., Umeå, Sweden. In Nat Med, 2011
Whereas most other adenoviruses infect cells by engaging CD46 or the coxsackie and adenovirus receptor (CAR), Ad37 binds previously unknown sialic acid-containing cell surface molecules.
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