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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Aug 2015.

CD4 molecule

CD4
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: CD8, HAD, CAN, AGE, CD25
Papers using CD4 antibodies
Morphofunctional fundamentals for peptide regulation of aging
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Kvetnoy I. M. et al., In Journal of Amino Acids, 2010
... and the monoclonal antibodies to CD4, marked with phycoerytherin (Becton Dickinson, USA) ...
Dietary sulfur amino acid effects on fasting plasma cysteine/cystine redox potential in humans
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James S. Jill et al., In Autism Research and Treatment, 2010
... Human Monocyte Isolation Kit II and Human CD4 T cell Isolation Kit II were purchased from Miltenyi Biotec (Bergisch-Gladbach, Germany) ...
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
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Brooks David G. et al., In The Journal of Experimental Medicine, 2009
... LCMV-specific CD4 TCR transgenic ...
Primary Malignant Giant-Cell Tumor of Bone Has High Survival Rate
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Gitelis Steven et al., In Diagnostic Pathology, 2009
... following antibodies were used on Ventana Benchmark and the manufacturer's solution CC1 for antigen retrieval.: CD4 (Biocare Medical, Concord, CA) 1:10 dilution, ...
The HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G/F.
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Vij Neeraj, In PLoS ONE, 2009
... astrocytic cell line, SVGA-LTR GFP or -LTR-gag-GFP RRE reporter cells, 293 HEK cells, and Magi (CD4/CCR5) cells [47] were all maintained in DMEM (Gibco BRL life technologies, NY, USA) containing 10% ...
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Papers on CD4
Stromal infiltration of CD8 T cells is associated with improved clinical outcome in HPV-positive oropharyngeal squamous carcinoma.
New
West et al., Manchester, United Kingdom. In Br J Cancer, 27 Sep 2015
One hundred and thirty-nine samples with concordant HPV detection were analysed for CD3, CD4, CD8 and FoxP3 expression in tumour and stromal regions using multiplexIHC and multispectral image analysis.
A Retrospective Analysis of 7 Human Immunodeficiency Virus-Negative Infants Infected by Penicillium marneffei.
New
Liu et al., Nanning, China. In Medicine (baltimore), 31 Aug 2015
The lymphocyte and CD4 T-cell counts were normal.
Diabetes in patients with HIV: patient characteristics, management and screening.
New
van Crevel et al., Nijmegen, Netherlands. In Neth J Med, 31 Aug 2015
Patients with coexisting diabetes were older, had a longer duration of HIV, lower CD4 cell counts and higher body mass index (BMI), and were more likely to use aspirin, statins and antihypertensive medication than those without diabetes (all p < 0.05).
Barrier Epithelial Cells and the Control of Type 2 Immunity.
Review
New
Impact
Lambrecht et al., Gent, Belgium. In Immunity, 21 Aug 2015
Type-2-cell-mediated immunity, rich in eosinophils, basophils, mast cells, CD4(+) T helper 2 (Th2) cells, and type 2 innate lymphoid cells (ILC2s), protects the host from helminth infection but also drives chronic allergic diseases like asthma and atopic dermatitis.
Phenotype and function of tissue-resident unconventional Foxp3-expressing CD4(+) regulatory T cells.
Review
New
Zhang et al., Zhengzhou, China. In Cell Immunol, 29 Jul 2015
Tissue-resident Treg cells, which are largely Foxp3-expressing CD4(+) Treg cells, are distinct from one another and conventional Treg cells, and have tissue-specific phenotype and function.
Antagonism of aminoacid transport in primary CD4 T cells by HIV-1 Vpu.
New
Impact
Lehner et al., Manchester, United Kingdom. In Lancet, Mar 2015
TOV3 was highly expressed in primary human CD4 T cells, and depletion of TOV3 by RNA interference markedly impaired the mitogenic response to CD3/CD28 stimulation.
Role of retinoic acid in the stability of the T-helper-type 1 lineage and implications for autoimmunity.
New
Impact
Noelle et al., New York City, United States. In Lancet, Mar 2015
BACKGROUND: CD4 T cells with features of both T-helper-type 1 (Th1) and 17 (Th17) cells have been implicated in several autoimmune diseases suggesting that plasticity among CD4 T-cell lineages is potentially pathogenic.
A role for helminth parasites in achieving immunological tolerance in transplantation.
New
Impact
Maizels et al., Edinburgh, United Kingdom. In Lancet, Mar 2015
FINDINGS: Flow cytometric analysis showed a 41·7% increase in the mean percentage of CD4+CD25+Foxp3+ regulatory T cells (of total CD4 cells) from a baseline of 8·1% (95% CI 7·4-8·8) in untreated mice to 11·5% (8·8-14·2) in the treatment group (p=0·0085).
Targeting indirect pathway CD4 T-cell alloresponses in the prevention of chronic transplant rejection.
New
Impact
Pettigrew et al., Cambridge, United Kingdom. In Lancet, Mar 2015
Indirect CD4 T-cell allorecognition of mismatched donor MHC class I and II, and of H-Y minor histocompatibility antigen was assessed by quantifying proliferation of adoptively transferred monoclonal T-cell receptor transgenic T cells (TCR75, Tea, Mar).
Recipient natural killer cell allorecognition of passenger donor lymphocytes and its effect on adaptive alloimmunity after transplantation.
New
Impact
Pettigrew et al., Cambridge, United Kingdom. In Lancet, Mar 2015
We have previously described how graft-versus-host (GVH) allorecognition by passenger CD4 T cells within MHC class II-mismatched bm12 heart grafts provokes antinuclear humoral autoimmunity in C57BL/6 recipient mice.
Immune Evasion Strategies of Trypanosoma cruzi.
Review
New
Morrot et al., Rio de Janeiro, Brazil. In J Immunol Res, Dec 2014
These receptors also induce suppression of CD4(+) T cells responses, and we presented evidence that the sialylation of parasite-derived mucins is required for the inhibitory effects on CD4 T cells.
The Emerging Role of miRNAs in HTLV-1 Infection and ATLL Pathogenesis.
Review
New
Nicot et al., Kansas City, United States. In Viruses, Dec 2014
Human T-cell leukemia virus (HTLV)-1 is a human retrovirus and the etiological agent of adult T-cell leukemia/lymphoma (ATLL), a fatal malignancy of CD4/CD25+ T lymphocytes.
Follicular Helper CD4+ T Cells in Human Neuroautoimmune Diseases and Their Animal Models.
Review
New
Jin et al., Jilin, China. In Mediators Inflamm, Dec 2014
Follicular helper CD4(+) T (TFH) cells play a fundamental role in humoral immunity deriving from their ability to provide help for germinal center (GC) formation, B cell differentiation into plasma cells and memory cells, and antibody production in secondary lymphoid tissues.
Simultaneous hepatectomy and splenectomy versus hepatectomy alone for hepatocellular carcinoma complicated by hypersplenism: a meta-analysis.
New
Yan et al., Wuhan, China. In Onco Targets Ther, Dec 2014
P=0.003), and CD4/CD8 ratio (MD 0.69, 95% CI 0.61-0.77,
The Role of Sexually Transmitted Infections in HIV-1 Progression: A Comprehensive Review of the Literature.
Crum-Cianflone et al., Bethesda, United States. In J Sex Transm Dis, 2012
Regarding the effect of STIs on HIV-1 progression, the most studied interrelationship has been with HIV-1/HSV-2 coinfection, with recent studies showing that antiherpetic medications slow the time to CD4 <200 cells/µL and antiretroviral therapy among coinfected patients.
Recombinatorial biases and convergent recombination determine interindividual TCRβ sharing in murine thymocytes.
GeneRIF
Han et al., Xiamen, China. In J Immunol, 2012
Thymic selection does not appear to play an important role in CD4+CD8+ T cell receptor (TCR)beta repertoire overlap between individuals.
CD4+ T cell-dependent IFN-γ production by CD8+ effector T cells in Mycobacterium tuberculosis infection.
GeneRIF
Ernst et al., New York City, United States. In J Immunol, 2012
CD4-positive cell deficiency impairs IFN-gamma production by CD8-positive effector cells at the site of Mycobacterium tuberculosis infection in mice.
Lineage-specific differences between human and simian immunodeficiency virus regulation of gp120 trimer association and CD4 binding.
GeneRIF
Sodroski et al., Boston, United States. In J Virol, 2012
The N/C termini and the inner domain beta-sandwich and layer 2 support the noncovalent association of gp120 trimer with the CD4.
Intrinsic impairment of CD4(+)CD25(+) regulatory T cells in acquired aplastic anemia.
GeneRIF
Zheng et al., Tianjin, China. In Blood, 2012
The study provides evidence for impairment of CD4(+)CD25(+) regulatory T cells -including decreased frequencies in peripheral blood and bone marrow in patients with in acquired aplastic anemia.
Foxp3+CD25(high) CD4+ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity.
GeneRIF
Gomes et al., Belo Horizonte, Brazil. In Immunobiology, 2012
Data indicate that the frequency of Foxp3(+)CD25(high) CD4(+)-T cells is augmented and correlated with the maintenance of a better cardiac function in indeterminate (IND) Chagas disease.
More papers using CD4 antibodies
CD4+ T lymphocytes mediate acute pulmonary ischemia-reperfusion injury.
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Wherry E. John, In PLoS Pathogens, 2008
... fl/fl mice to CD4-cre transgenic mice ...
A novel regulatory B-cell population in sheep Peyer's patches spontaneously secretes IL-10 and downregulates TLR9-induced IFNalpha responses.
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Tailleux Ludovic, In PLoS ONE, 2008
... rat anti CD8α clone YTS105.18 and hamster anti-CD11c clone HL3 were purchased from Serotec, rat anti-CD4 clone YTS191.1.2
Human immunodeficiency virus: 25 years of diagnostic and therapeutic strategies and their impact on hepatitis B and C virus
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Gürtler Lutz G. et al., In Medical Microbiology and Immunology, 2008
... CD4 cells were measured by FACS analysis (Becton–Dickinson, Heidelberg, Germany).RNA was extracted from EDTA-plasma according to the recommendation of the manufacturer (Qiagen, Hilden, Germany) ...
Improved expression and reactivity of transduced tumor-specific TCRs in human lymphocytes by specific silencing of endogenous TCR
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Hooijberg Erik et al., In Journal of Translational Medicine, 2008
... For this purpose, total PBMC were stained with anti-CD4 Ab and microbead-conjugated anti-mouse IgG Abs (Miltenyi Biotec), followed by MACS sorting ...
Neuromodulatory activities of CD4+CD25+ regulatory T cells in a murine model of HIV-1-associated neurodegeneration
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Unutmaz Derya, In PLoS ONE, 2008
... cell population by negative selection (CD4 separation kit, Miltenyi Biotec), as described above ...
Visualizing antigen specific CD4+ T cells using MHC class II tetramers
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Nepom G T et al., In Genes and Immunity, 2008
... In the first step CD4+ T cells were separated from all non-CD4 cells using CD4+ T cell isolation kit (Miltenyi Biotec, Auburn, CA, USA).
Interaction of human PD-L1 and B7-1
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Ohashi Kazuhiko et al., In Veterinary Research, 2007
... Separation System (BD Biosciences, Franklin Lakes, NJ, USA) and the following antibodies: CACT138A (mouse anti-bovine CD4: VMRD, WA, USA), IL-A51 (mouse ...
CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells.
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Zimmer Jacques, In PLoS ONE, 2007
... OT II OVA CD4 transgenic mice were kindly provided ...
SERS-Based Detection in an Optofluidic Ring Resonator Platform
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Fan Xudong et al., In Sensors (Basel, Switzerland), 2006
... CD4 mouse monoclonal IgG antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) and ...
KLRG1 binds cadherins and preferentially associates with SHIP-1
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Rishi Arun, In PLoS ONE, 2006
... Anti-CD3 and anti-CD4 (clones OKT3 and OKT4; eBioscience, San Diego, CA) stimulation ...
Semen-derived amyloid fibrils drastically enhance HIV infection.
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KewalRamani Vineet N., In PLoS ONE, 2006
... to the manufacturer's guidelines for phycoerythrin (PE)-conjugated anti-CD8 (clone DK25; BD Pharmingen), fluorescein isothiocyanate (FITC)-conjugated anti-CD4 (clone L200; Dako), peridinin-chlorophyll-Cychrome (PerCP-Cy5.5)-conjugated
Treatment Outcomes of Patients with HIV and Tuberculosis
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Risbud A.R. et al., In The Indian Journal of Medical Research, 2006
... To determine the degree of immune-suppression in the enrolled patients, the CD4 counts were estimated in freshly collected blood in EDTA containing vacutainer tubes (Becton Dickinson, Franklin Lakes, NJ, USA) ...
Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells.
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Emerman Michael, In PLoS Pathogens, 2006
... 293T-4X4 and 293T CXCR4 were generated using lentiviral transduction of 293T with lentiviruses coding for CD4 and/or CXCR4 molecules and magnetic sorting (Miltenyi Biotec).
An anti-CD45RO/RB monoclonal antibody modulates T cell responses via induction of apoptosis and generation of regulatory T cells.
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Rénia Laurent, In PLoS ONE, 2004
... Leukocytes were labelled with a combination of antimurine CD4-allophycocyanin (rat IgG2a, clone RM4-5, BD Biosciences), CD19-PE-Cyanin7 (rat IgG2a, clone ...
Cytotoxic T-cell non-Hodgkin's lymphoma of the thyroid gland
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Lee Young-Don et al., In Journal of Korean Medical Science, 2004
... by avidin-biotin-peroxidase complex methods using antibodies against CD3 (Dako, Glostrup, Denmark, prediluted), CD20 (Dako, prediluted), CD4 (Dako, prediluted), CD8 (Dako, prediluted), ...
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
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Behar Samuel M. et al., In The Journal of Experimental Medicine, 2004
... Kuchroo), goat F(ab’)2 anti–human Ig (2012–01; SouthernBiotech), CD11b microbeads (Miltenyi Biotec), CD4 microbeads (Miltenyi Biotec), human IgG1κ (I5154; Sigma-Aldrich), ...
Extrapulmonary tuberculosis
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Gulati Vinay et al., In Clinical and Developmental Immunology, 2003
... CD4 count and HIV viral load were estimated using flow-cytometry (Becton Dickinson, USA) and Amplicor HIV-1 ...
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.
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Alberola-Ila Jose, In PLoS ONE, 2003
... stained with the following antibodies, all conjugated to PE-Cy5: CD3ε (145-2C11, BioLegend, San Diego, CA), CD4 (RM4-5, eBioscience, San Diego, CA), CD8α ...
Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer
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Nakajima Y et al., In British Journal of Cancer, 2002
... The sections were then incubated overnight at 4°C with anti-human CD45RO (UHL1, monoclonal mouse; DAKO), CD4 (1 : 40) (4B12, monoclonal mouse; DAKO), and CD8 (C8/144B, monoclonal ...
The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation
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Jameson Stephen C. et al., In The Journal of Experimental Medicine, 2002
... thank Alfred Singer and Tom McCaughtry (National Institutes of Health) for generously providing cells from E8I-CD4 transgenic mice, and also Hidde ...
IL-7 Promotes the Transition of CD4 Effectors to Persistent Memory Cells
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Swain Susan L. et al., In The Journal of Experimental Medicine, 2002
... We used naive CD4 T cells from AND mice transgenic (Tg) for a TCR specific ...
The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility
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Lüscher Bernhard et al., In The Journal of Cell Biology, 2002
... α-tubulin acetylation in cells, HEK293 cells were cotransfected with plasmids expressing SIRT2 and the human CD4 antigen with a truncated cytoplasmic domain (pMACS4.1;
Phosphoinositide regulation of the actin cytoskeleton
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Yin Helen L. et al., In The Journal of Cell Biology, 2002
allophycocyanin (APC)–anti-CD4, and anti-FcγRIIB/III mAb 2.4G2 (BD Biosciences); anti-pERK (Cell Signaling Technology); ...
A DNA vector-based RNAi technology to suppress gene expression in mammalian cells.
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Unutmaz Derya, In PLoS ONE, 2001
... mice with CD4-Cre transgenic mice, in which the ...
Costimulation via OX40L Expressed by B Cells Is Sufficient to Determine the Extent of Primary CD4 Cell Expansion and Th2 Cytokine Secretion In Vivo
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Bradley Linda M. et al., In The Journal of Experimental Medicine, 2001
... OT-II TCR (vα2, vβ5) CD4 transgenic mice that respond to ...
Interleukin 1 Receptor Dependence of Serum Transferred Arthritis Can be Circumvented by Toll-like Receptor 4 Signaling
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Corr Maripat et al., In The Journal of Experimental Medicine, 2001
... TCR were identified at 2–3 wk of age by cytofluorometry of peripheral blood lymphocytes using anti-CD4 PE (Caltag) and anti-Vβ6 FITC (BD Biosciences) labeled antibodies ...
A Bayesian framework for the analysis of microarray expression data: regularized t-test and statistical inferences of gene changes.
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Kosik Kenneth S et al., In Genome Biology, 2000
... Naïve CD4 cells were purified from spleen and lymph nodes of Tcrα-/- DO11 TCR transgenic mice by magnetic bead ...
Homeostatic Competition Among T Cells Revealed by Conditional Inactivation of the Mouse Cd4 Gene
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Killeen Nigel et al., In The Journal of Experimental Medicine, 2000
... Cd4 mutation.The generation of dLck-hcre transgenic mice expressing a codon optimized ...
Human foamy virus capsid formation requires an interaction domain in the N terminus of Gag
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Young John A. T, In PLoS Pathogens, 2000
... CD4-positive T cells were negatively selected using the CD4-positive T Cell Isolation Kit II (Miltenyi Biotec, ...
CD1d-expressing Dendritic Cells but Not Thymic Epithelial Cells Can Mediate Negative Selection of NKT Cells
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Wang Chyung-Ru et al., In The Journal of Experimental Medicine, 1999
and NK1.1 (PK136); Cy-Chrome-conjugated mAbs specific for TCRβ (H57–597), and CD4 (RM4–5; BD Biosciences).
Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells
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Stockinger Brigitta et al., In The Journal of Experimental Medicine, 1999
... CD4 overexpression in A18 TCR-transgenic mice (4A18 mice) was ...
Highly resolved chemical imaging of living cells by using synchrotron infrared microspectrometry
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Ko Fu-Hsiang et al., In International Journal of Nanomedicine, 1997
... Anti-human CD4 (14-0049) and biotinylated anti-human CD3 (13-0038) antibodies were purchased from eBioscience, Inc (San Diego, CA) ...
Platelet-derived endothelial cell growth factor/thymidine phosphorylase immunohistochemical expression in lymphoid tissue and lymphoid malignancies
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Hou J. Steve et al., In Advances in Hematology, 1996
... antibodies used in this study were TP (1 : 1000; Novus Biologicals, Littleton, Colo), CD3 (1 : 100; Dako), CD4 (1 : 10; Dako), CD68 (1 : 2000; Dako), and ...
Transcription factors of the NFAT familyregulation and function
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Paul William E. et al., In The Journal of Experimental Medicine, 1996
... T cells were purified by positive selection (through an automatic MACS machine) using anti–mouse CD4 (L3T4) MicroBeads (Miltenyi Biotec).
Transgenic expression of CD95 ligand on islet β cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts
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Ricciardi-Castagnoli Paola et al., In The Journal of Experimental Medicine, 1996
... purified from TCR-OVA DO11.10 transgenic mice, bred in BALB/c background, by positive selection with an anti-CD4 antibody coupled to magnetic microbeads, using MiniMacS Separating columns (all from Miltenyi Biotec).
Prevalence of intestinal parasites in adult patients with enteropathic. AIDS in North-eastern Tanzania.
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Wiwanitkit Viroj, In BMC Gastroenterology, 1995
... The CD4 count determination in this study was performed by automated flow cytometry analyzer, FACS Calibur (Becton Dickinson).
Identification of a major co-receptor for primary isolates of HIV-1
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Liu Yong-Jun et al., In The Journal of Experimental Medicine, 1995
... Dickinson) and CD45RA-Tricolor (MEM 56; Caltag), and in addition, different PE-conjugated antibodies: anti–HLA-DR (Becton Dickinson), CD4 (Leu-3a; Becton Dickinson), and IL-3Rα (9F5l; BD ...
Interleukin 7 Regulates the Survival and Generation of Memory CD4 Cells
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Bradley Linda M. et al., In The Journal of Experimental Medicine, 1994
... OT-II TCR (vα2 and vβ5) CD4 transgenic mice that respond to ...
Existence of a soluble form of CD50 (intercellular adhesion molecule-3) produced upon human lymphocyte activation. Present in normal human serum and levels are increased in the serum of systemic lupus erythematosus patients
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Blanco Julià et al., In Retrovirology, 1994
... Whole CD4 T cells, memory CD4 T cells (CD45RO+) and naïve CD4 T cells (CD45RA+) were purified by negative immunomagnetic selection using the appropriate cocktails of antibodies (Miltenyi Biotec SL, Madrid, Spain) ...
A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development
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Perlmutter Roger M. et al., In The Journal of Experimental Medicine, 1993
... The 727 CD4 transgenic mouse line has previously ...
Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus–seropositive individuals
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Reiner Steven L. et al., In The Journal of Experimental Medicine, 1992
... CD4° mice and CD4 transgenic mice were also bred ...
Intestinal Epithelial Cells Synthesize Glucocorticoids and Regulate T Cell Activation
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Brunner Thomas et al., In The Journal of Experimental Medicine, 1990
... Anti–CD69-FITC, anti–TCRβ-FITC, anti–CD8α-Cy-chrome, anti–CD8β-PE, anti–CD4-PE, and anti–αEβ7-PE were obtained from BD Biosciences.
Gamma delta beta-thalassemia due to a de novo mutation deleting the 5′ beta-globin gene activation-region hypersensitive sites
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Nakano Hideki et al., In The Journal of Experimental Medicine, 1988
... , biotinylated anti-B220, biotinylated anti-CD3, biotinylated anti–I-Ad, FITC-conjugated anti–I-Ad, PE-conjugated anti–I-Ad, and anti-CD4 (PharMingen); NLDC-145 and MOMA-1 (Bachem).
Precise gene fusion by PCR.
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Kanellopoulos Jean, In PLoS ONE, 1988
... T cells were negatively isolated using magnetic beads (CD4 isolation kit II, Miltenyi Biotec, Auburn, CA, purification >90%) ...
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