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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Mar 2015.

CD4 molecule

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: CD8, HAD, CAN, AGE, Foxp3
Papers using CD4 antibodies
Morphofunctional fundamentals for peptide regulation of aging
Kvetnoy I. M. et al., In Journal of Amino Acids, 2010
... and the monoclonal antibodies to CD4, marked with phycoerytherin (Becton Dickinson, USA) ...
Dietary sulfur amino acid effects on fasting plasma cysteine/cystine redox potential in humans
James S. Jill et al., In Autism Research and Treatment, 2010
... Human Monocyte Isolation Kit II and Human CD4 T cell Isolation Kit II were purchased from Miltenyi Biotec (Bergisch-Gladbach, Germany) ...
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
Brooks David G. et al., In The Journal of Experimental Medicine, 2009
... LCMV-specific CD4 TCR transgenic ...
Primary Malignant Giant-Cell Tumor of Bone Has High Survival Rate
Gitelis Steven et al., In Diagnostic Pathology, 2009
... following antibodies were used on Ventana Benchmark and the manufacturer's solution CC1 for antigen retrieval.: CD4 (Biocare Medical, Concord, CA) 1:10 dilution, ...
The HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G/F.
Vij Neeraj, In PLoS ONE, 2009
... astrocytic cell line, SVGA-LTR GFP or -LTR-gag-GFP RRE reporter cells, 293 HEK cells, and Magi (CD4/CCR5) cells [47] were all maintained in DMEM (Gibco BRL life technologies, NY, USA) containing 10% ...
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Papers on CD4
Influence of lifelong cumulative HIV viremia on long-term recovery of CD4+ cell count and CD4+/CD8+ ratio among patients on combination antiretroviral therapy.
ANRS PRIMO Cohort et al., Paris, France. In Aids, 13 Apr 2015
RESULTS: At the last visit on treatment, median CD4 cell count was 645 cells/μl in the early/intermittent treatment group (median time from infection 9.5 years, 4.8 years of continuous treatment since last resumption), and 654 cells/μl in the deferred/continuous treatment group (median time from infection 6.1 years, 3.0 years of continuous treatment).
Up-regulation of Tim-3 on T cells during acute simian immunodeficiency virus infection and on antigen specific responders.
Villinger et al., Atlanta, United States. In Aids, 13 Apr 2015
However, TIM-3 expression was transiently up-regulated on both CD4 and CD8 T cells during acute SIV infection, correlating with plasma viral loads, CD4 cell counts, and Ki67 expression up to 6 weeks postinfection and returned to baseline values by 8 weeks postinfection.
Tapping CD4 T Cells for Cancer Immunotherapy: The Choice of Personalized Genomics.
Zanetti, San Diego, United States. In J Immunol, 01 Apr 2015
However, CD4 T cells also play a central role.
Safety and immunogenicity of an investigational 4-component Staphylococcus aureus vaccine with or without AS03B adjuvant: Results of a randomized phase I trial.
Boutriau et al., Brussels, Belgium. In Hum Vaccin Immunother, 25 Mar 2015
Humoral and antigen-specific CD4(+)/CD8(+) T-cell immunity were assessed from Day (D) 0 to D540 post-vaccination.
Exosomes and their roles in immune regulation and cancer.
Chen et al., Australia. In Semin Cell Dev Biol, 24 Mar 2015
Indeed, tumour- and immune cell-derived exosomes have been shown to carry tumour antigens and promote immunity, leading to eradication of established tumours by CD8(+) T cells and CD4(+) T cells, as well as directly suppressing tumour growth and resistance to malignant tumour development.
Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease.
Lord et al., Jerusalem, Israel. In Gut, 24 Mar 2015
METHODS: To define the optimum population for Treg cell therapy in CD, CD4(+)CD25(+)CD127(lo)CD45RA(+) and CD4(+)CD25(+)CD127(lo)CD45RA(-) Treg subsets were isolated from patients' blood and expanded in vitro using a workflow that can be readily transferred to a good manufacturing practice background.
Virologic Response Following Combined Ledipasvir and Sofosbuvir Administration in Patients With HCV Genotype 1 and HIV Co-infection.
Kottilil et al., Frankfurt am Main, Germany. In Jama, 23 Mar 2015
Patients included those receiving antiretroviral therapy with HIV RNA values of 50 copies/mL or fewer and a CD4 T-lymphocyte count of 100 cells/mL or greater or patients with untreated HIV infection with a CD4 T-lymphocyte count of 500 cells/mL or greater.
Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8(+) T cells responding to infection.
Bevan et al., Seattle, United States. In Nat Immunol, 23 Mar 2015
Unlike CD103(+)CD8(+) T cells, which were TGF-β dependent and were scattered in the tissue, CD103(-)CD8(+) T cells clustered with CD4(+) T cells and CX3CR1(+) macrophages and/or dendritic cells around areas of bacterial infection.
AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges.
Farzan et al., Jupiter, United States. In Nature, 18 Mar 2015
Here we show that eCD4-Ig, a fusion of CD4-Ig with a small CCR5-mimetic sulfopeptide, binds avidly and cooperatively to the HIV-1 envelope glycoprotein (Env) and is more potent than the best bNAbs (geometric mean half-maximum inhibitory concentration (IC50) < 0.05 μg ml(-1)).
THEMIS: a critical TCR signal regulator for ligand discrimination.
Acuto et al., Singapore, Singapore. In Curr Opin Immunol, 17 Mar 2015
UNASSIGNED: Genetic approaches identified THEMIS as a critical element driving positive selection of CD4(+)CD8(+) thymocytes towards maturation.
Emerging Functions of Amphiregulin in Orchestrating Immunity, Inflammation, and Tissue Repair.
Artis et al., Newark, United States. In Immunity, 17 Mar 2015
Notably, numerous studies demonstrate that in addition to the established role of epithelial- and mesenchymal-derived AREG, multiple leukocyte populations including mast cells, basophils, group 2 innate lymphoid cells (ILC2s), and a subset of tissue-resident regulatory CD4(+) T cells can express AREG.
The Transcription Factor KLF2 Restrains CD4(+) T Follicular Helper Cell Differentiation.
Jameson et al., Minneapolis, United States. In Immunity, 17 Mar 2015
T follicular helper (Tfh) cells are essential for efficient B cell responses, yet the factors that regulate differentiation of this CD4(+) T cell subset are incompletely understood.
The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway.
Nakayama et al., Chiba, Japan. In Immunity, 17 Mar 2015
Memory CD4(+) T helper (Th) cells provide long-term protection against pathogens and are essential for the development of vaccines; however, some antigen-specific memory Th cells also drive immune-related pathology, including asthma.
A Case Report of Severe Paraquat Poisoning in an HIV-Positive Patient: An Unexpected Outcome and Inspiration.
Lu et al., Hangzhou, China. In Medicine (baltimore), 28 Feb 2015
Unfortunately, the patient was diagnosed as HIV infected, and CD4 lymphocyte count also confirmed that the patient was in a state of mild suppression of immunological function.Immediately, the patient received normative immunosuppressive therapy and hemoperfusion (HP).
Memory T follicular helper CD4 T cells.
Ahmed et al., Atlanta, United States. In Front Immunol, Dec 2014
T follicular helper (Tfh) cells are the subset of CD4 T helper cells that are required for generation and maintenance of germinal center reactions and the generation of long-lived humoral immunity.
Recombinatorial biases and convergent recombination determine interindividual TCRβ sharing in murine thymocytes.
Han et al., Xiamen, China. In J Immunol, 2012
Thymic selection does not appear to play an important role in CD4+CD8+ T cell receptor (TCR)beta repertoire overlap between individuals.
CD4+ T cell-dependent IFN-γ production by CD8+ effector T cells in Mycobacterium tuberculosis infection.
Ernst et al., New York City, United States. In J Immunol, 2012
CD4-positive cell deficiency impairs IFN-gamma production by CD8-positive effector cells at the site of Mycobacterium tuberculosis infection in mice.
Lineage-specific differences between human and simian immunodeficiency virus regulation of gp120 trimer association and CD4 binding.
Sodroski et al., Boston, United States. In J Virol, 2012
The N/C termini and the inner domain beta-sandwich and layer 2 support the noncovalent association of gp120 trimer with the CD4.
Intrinsic impairment of CD4(+)CD25(+) regulatory T cells in acquired aplastic anemia.
Zheng et al., Tianjin, China. In Blood, 2012
The study provides evidence for impairment of CD4(+)CD25(+) regulatory T cells -including decreased frequencies in peripheral blood and bone marrow in patients with in acquired aplastic anemia.
Foxp3+CD25(high) CD4+ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity.
Gomes et al., Belo Horizonte, Brazil. In Immunobiology, 2012
Data indicate that the frequency of Foxp3(+)CD25(high) CD4(+)-T cells is augmented and correlated with the maintenance of a better cardiac function in indeterminate (IND) Chagas disease.
More papers using CD4 antibodies
CD4+ T lymphocytes mediate acute pulmonary ischemia-reperfusion injury.
Wherry E. John, In PLoS Pathogens, 2008
... fl/fl mice to CD4-cre transgenic mice ...
A novel regulatory B-cell population in sheep Peyer's patches spontaneously secretes IL-10 and downregulates TLR9-induced IFNalpha responses.
Tailleux Ludovic, In PLoS ONE, 2008
... rat anti CD8α clone YTS105.18 and hamster anti-CD11c clone HL3 were purchased from Serotec, rat anti-CD4 clone YTS191.1.2
Human immunodeficiency virus: 25 years of diagnostic and therapeutic strategies and their impact on hepatitis B and C virus
Gürtler Lutz G. et al., In Medical Microbiology and Immunology, 2008
... CD4 cells were measured by FACS analysis (Becton–Dickinson, Heidelberg, Germany).RNA was extracted from EDTA-plasma according to the recommendation of the manufacturer (Qiagen, Hilden, Germany) ...
Improved expression and reactivity of transduced tumor-specific TCRs in human lymphocytes by specific silencing of endogenous TCR
Hooijberg Erik et al., In Journal of Translational Medicine, 2008
... For this purpose, total PBMC were stained with anti-CD4 Ab and microbead-conjugated anti-mouse IgG Abs (Miltenyi Biotec), followed by MACS sorting ...
Neuromodulatory activities of CD4+CD25+ regulatory T cells in a murine model of HIV-1-associated neurodegeneration
Unutmaz Derya, In PLoS ONE, 2008
... cell population by negative selection (CD4 separation kit, Miltenyi Biotec), as described above ...
Visualizing antigen specific CD4+ T cells using MHC class II tetramers
Nepom G T et al., In Genes and Immunity, 2008
... In the first step CD4+ T cells were separated from all non-CD4 cells using CD4+ T cell isolation kit (Miltenyi Biotec, Auburn, CA, USA).
Interaction of human PD-L1 and B7-1
Ohashi Kazuhiko et al., In Veterinary Research, 2007
... Separation System (BD Biosciences, Franklin Lakes, NJ, USA) and the following antibodies: CACT138A (mouse anti-bovine CD4: VMRD, WA, USA), IL-A51 (mouse ...
CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells.
Zimmer Jacques, In PLoS ONE, 2007
... OT II OVA CD4 transgenic mice were kindly provided ...
SERS-Based Detection in an Optofluidic Ring Resonator Platform
Fan Xudong et al., In Sensors (Basel, Switzerland), 2006
... CD4 mouse monoclonal IgG antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) and ...
KLRG1 binds cadherins and preferentially associates with SHIP-1
Rishi Arun, In PLoS ONE, 2006
... Anti-CD3 and anti-CD4 (clones OKT3 and OKT4; eBioscience, San Diego, CA) stimulation ...
Semen-derived amyloid fibrils drastically enhance HIV infection.
KewalRamani Vineet N., In PLoS ONE, 2006
... to the manufacturer's guidelines for phycoerythrin (PE)-conjugated anti-CD8 (clone DK25; BD Pharmingen), fluorescein isothiocyanate (FITC)-conjugated anti-CD4 (clone L200; Dako), peridinin-chlorophyll-Cychrome (PerCP-Cy5.5)-conjugated
Treatment Outcomes of Patients with HIV and Tuberculosis
Risbud A.R. et al., In The Indian Journal of Medical Research, 2006
... To determine the degree of immune-suppression in the enrolled patients, the CD4 counts were estimated in freshly collected blood in EDTA containing vacutainer tubes (Becton Dickinson, Franklin Lakes, NJ, USA) ...
Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells.
Emerman Michael, In PLoS Pathogens, 2006
... 293T-4X4 and 293T CXCR4 were generated using lentiviral transduction of 293T with lentiviruses coding for CD4 and/or CXCR4 molecules and magnetic sorting (Miltenyi Biotec).
An anti-CD45RO/RB monoclonal antibody modulates T cell responses via induction of apoptosis and generation of regulatory T cells.
Rénia Laurent, In PLoS ONE, 2004
... Leukocytes were labelled with a combination of antimurine CD4-allophycocyanin (rat IgG2a, clone RM4-5, BD Biosciences), CD19-PE-Cyanin7 (rat IgG2a, clone ...
Cytotoxic T-cell non-Hodgkin's lymphoma of the thyroid gland
Lee Young-Don et al., In Journal of Korean Medical Science, 2004
... by avidin-biotin-peroxidase complex methods using antibodies against CD3 (Dako, Glostrup, Denmark, prediluted), CD20 (Dako, prediluted), CD4 (Dako, prediluted), CD8 (Dako, prediluted), ...
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
Behar Samuel M. et al., In The Journal of Experimental Medicine, 2004
... Kuchroo), goat F(ab’)2 anti–human Ig (2012–01; SouthernBiotech), CD11b microbeads (Miltenyi Biotec), CD4 microbeads (Miltenyi Biotec), human IgG1κ (I5154; Sigma-Aldrich), ...
Extrapulmonary tuberculosis
Gulati Vinay et al., In Clinical and Developmental Immunology, 2003
... CD4 count and HIV viral load were estimated using flow-cytometry (Becton Dickinson, USA) and Amplicor HIV-1 ...
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.
Alberola-Ila Jose, In PLoS ONE, 2003
... stained with the following antibodies, all conjugated to PE-Cy5: CD3ε (145-2C11, BioLegend, San Diego, CA), CD4 (RM4-5, eBioscience, San Diego, CA), CD8α ...
Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer
Nakajima Y et al., In British Journal of Cancer, 2002
... The sections were then incubated overnight at 4°C with anti-human CD45RO (UHL1, monoclonal mouse; DAKO), CD4 (1 : 40) (4B12, monoclonal mouse; DAKO), and CD8 (C8/144B, monoclonal ...
The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation
Jameson Stephen C. et al., In The Journal of Experimental Medicine, 2002
... thank Alfred Singer and Tom McCaughtry (National Institutes of Health) for generously providing cells from E8I-CD4 transgenic mice, and also Hidde ...
IL-7 Promotes the Transition of CD4 Effectors to Persistent Memory Cells
Swain Susan L. et al., In The Journal of Experimental Medicine, 2002
... We used naive CD4 T cells from AND mice transgenic (Tg) for a TCR specific ...
The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility
Lüscher Bernhard et al., In The Journal of Cell Biology, 2002
... α-tubulin acetylation in cells, HEK293 cells were cotransfected with plasmids expressing SIRT2 and the human CD4 antigen with a truncated cytoplasmic domain (pMACS4.1;
Phosphoinositide regulation of the actin cytoskeleton
Yin Helen L. et al., In The Journal of Cell Biology, 2002
allophycocyanin (APC)–anti-CD4, and anti-FcγRIIB/III mAb 2.4G2 (BD Biosciences); anti-pERK (Cell Signaling Technology); ...
A DNA vector-based RNAi technology to suppress gene expression in mammalian cells.
Unutmaz Derya, In PLoS ONE, 2001
... mice with CD4-Cre transgenic mice, in which the ...
Costimulation via OX40L Expressed by B Cells Is Sufficient to Determine the Extent of Primary CD4 Cell Expansion and Th2 Cytokine Secretion In Vivo
Bradley Linda M. et al., In The Journal of Experimental Medicine, 2001
... OT-II TCR (vα2, vβ5) CD4 transgenic mice that respond to ...
Interleukin 1 Receptor Dependence of Serum Transferred Arthritis Can be Circumvented by Toll-like Receptor 4 Signaling
Corr Maripat et al., In The Journal of Experimental Medicine, 2001
... TCR were identified at 2–3 wk of age by cytofluorometry of peripheral blood lymphocytes using anti-CD4 PE (Caltag) and anti-Vβ6 FITC (BD Biosciences) labeled antibodies ...
A Bayesian framework for the analysis of microarray expression data: regularized t-test and statistical inferences of gene changes.
Kosik Kenneth S et al., In Genome Biology, 2000
... Naïve CD4 cells were purified from spleen and lymph nodes of Tcrα-/- DO11 TCR transgenic mice by magnetic bead ...
Homeostatic Competition Among T Cells Revealed by Conditional Inactivation of the Mouse Cd4 Gene
Killeen Nigel et al., In The Journal of Experimental Medicine, 2000
... Cd4 mutation.The generation of dLck-hcre transgenic mice expressing a codon optimized ...
Human foamy virus capsid formation requires an interaction domain in the N terminus of Gag
Young John A. T, In PLoS Pathogens, 2000
... CD4-positive T cells were negatively selected using the CD4-positive T Cell Isolation Kit II (Miltenyi Biotec, ...
CD1d-expressing Dendritic Cells but Not Thymic Epithelial Cells Can Mediate Negative Selection of NKT Cells
Wang Chyung-Ru et al., In The Journal of Experimental Medicine, 1999
and NK1.1 (PK136); Cy-Chrome-conjugated mAbs specific for TCRβ (H57–597), and CD4 (RM4–5; BD Biosciences).
Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells
Stockinger Brigitta et al., In The Journal of Experimental Medicine, 1999
... CD4 overexpression in A18 TCR-transgenic mice (4A18 mice) was ...
Highly resolved chemical imaging of living cells by using synchrotron infrared microspectrometry
Ko Fu-Hsiang et al., In International Journal of Nanomedicine, 1997
... Anti-human CD4 (14-0049) and biotinylated anti-human CD3 (13-0038) antibodies were purchased from eBioscience, Inc (San Diego, CA) ...
Platelet-derived endothelial cell growth factor/thymidine phosphorylase immunohistochemical expression in lymphoid tissue and lymphoid malignancies
Hou J. Steve et al., In Advances in Hematology, 1996
... antibodies used in this study were TP (1 : 1000; Novus Biologicals, Littleton, Colo), CD3 (1 : 100; Dako), CD4 (1 : 10; Dako), CD68 (1 : 2000; Dako), and ...
Transcription factors of the NFAT familyregulation and function
Paul William E. et al., In The Journal of Experimental Medicine, 1996
... T cells were purified by positive selection (through an automatic MACS machine) using anti–mouse CD4 (L3T4) MicroBeads (Miltenyi Biotec).
Transgenic expression of CD95 ligand on islet β cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts
Ricciardi-Castagnoli Paola et al., In The Journal of Experimental Medicine, 1996
... purified from TCR-OVA DO11.10 transgenic mice, bred in BALB/c background, by positive selection with an anti-CD4 antibody coupled to magnetic microbeads, using MiniMacS Separating columns (all from Miltenyi Biotec).
Prevalence of intestinal parasites in adult patients with enteropathic. AIDS in North-eastern Tanzania.
Wiwanitkit Viroj, In BMC Gastroenterology, 1995
... The CD4 count determination in this study was performed by automated flow cytometry analyzer, FACS Calibur (Becton Dickinson).
Identification of a major co-receptor for primary isolates of HIV-1
Liu Yong-Jun et al., In The Journal of Experimental Medicine, 1995
... Dickinson) and CD45RA-Tricolor (MEM 56; Caltag), and in addition, different PE-conjugated antibodies: anti–HLA-DR (Becton Dickinson), CD4 (Leu-3a; Becton Dickinson), and IL-3Rα (9F5l; BD ...
Interleukin 7 Regulates the Survival and Generation of Memory CD4 Cells
Bradley Linda M. et al., In The Journal of Experimental Medicine, 1994
... OT-II TCR (vα2 and vβ5) CD4 transgenic mice that respond to ...
Existence of a soluble form of CD50 (intercellular adhesion molecule-3) produced upon human lymphocyte activation. Present in normal human serum and levels are increased in the serum of systemic lupus erythematosus patients
Blanco Julià et al., In Retrovirology, 1994
... Whole CD4 T cells, memory CD4 T cells (CD45RO+) and naïve CD4 T cells (CD45RA+) were purified by negative immunomagnetic selection using the appropriate cocktails of antibodies (Miltenyi Biotec SL, Madrid, Spain) ...
A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development
Perlmutter Roger M. et al., In The Journal of Experimental Medicine, 1993
... The 727 CD4 transgenic mouse line has previously ...
Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus–seropositive individuals
Reiner Steven L. et al., In The Journal of Experimental Medicine, 1992
... CD4° mice and CD4 transgenic mice were also bred ...
Intestinal Epithelial Cells Synthesize Glucocorticoids and Regulate T Cell Activation
Brunner Thomas et al., In The Journal of Experimental Medicine, 1990
... Anti–CD69-FITC, anti–TCRβ-FITC, anti–CD8α-Cy-chrome, anti–CD8β-PE, anti–CD4-PE, and anti–αEβ7-PE were obtained from BD Biosciences.
Gamma delta beta-thalassemia due to a de novo mutation deleting the 5′ beta-globin gene activation-region hypersensitive sites
Nakano Hideki et al., In The Journal of Experimental Medicine, 1988
... , biotinylated anti-B220, biotinylated anti-CD3, biotinylated anti–I-Ad, FITC-conjugated anti–I-Ad, PE-conjugated anti–I-Ad, and anti-CD4 (PharMingen); NLDC-145 and MOMA-1 (Bachem).
Precise gene fusion by PCR.
Kanellopoulos Jean, In PLoS ONE, 1988
... T cells were negatively isolated using magnetic beads (CD4 isolation kit II, Miltenyi Biotec, Auburn, CA, purification >90%) ...
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