Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia.
Philadelphia, United States. In N Engl J Med, 2011
We designed a lentiviral vector expressing a chimeric antigen receptor with specificity for the B-cell antigen CD19, coupled with CD137 (a costimulatory receptor in T cells [4-1BB]) and CD3-zeta (a signal-transduction component of the T-cell antigen receptor) signaling domains.
The genetics of systemic sclerosis.
Houston, United States. In Discov Med, 2010
More recently a genome-wide association study has been performed and identified CD247 (CD3-zeta) as a novel genetic risk factor for the susceptibility to SSc.
Building better chimeric antigen receptors for adoptive T cell therapy.
Manchester, United Kingdom. In Curr Gene Ther, 2010
The archetypal CAR consists of a single-chain antibody fragment, specific to a tumour-associated antigen, fused to a component of the T-cell receptor complex (typically CD3zeta) which on antigen binding primes the engrafted T-cell for anti-tumour activity.
DiD-Labeled anti-EpCAM-directed NK-92-scFv(MOC31) zeta cells
Bethesda, United States. In Unknown Journal, 2009
Tavri et al. (16) have generated NK-92 cells transduced with a humanized single-chain Fv antibody fragment (scFv) of EpCAM antibody MOC31 fused with CD3 zeta chain and tagged with 1,1’-dioctadecyl-3,3,3’,3’-tetramethylindodicarbocyanine (DiD) (DiD-NK-92-scFv(MOC31) zeta cells) for noninvasive NIR imaging of EpCAM expression in prostate tumor cells in rats.
Activating and inhibitory functions of DAP12.
Saint Louis, United States. In Nat Rev Immunol, 2007
This model extends from previous studies of inhibitory signalling mediated by other adaptors, such as the Fc-receptor gamma-chain and CD3zeta, and provides a potential mechanism for the conflicting phenotypes observed in studies of DAP12-deficient mice.