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CD247 molecule

CD3zeta
The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Interleukin-2, CD4, CD8, ZAP-70
Papers on CD3zeta
A signaling-enhanced chimeric receptor to activate the ICOS pathway in T cells.
New
Gupta et al., Thousand Oaks, United States. In J Immunol Methods, Sep 2015
Here we describe a genetically engineered human T cell line that expresses a chimeric receptor (ICOS-CD3) consisting of full-length human ICOS fused at its C-terminal end to the cytoplasmic domain of human CD3 zeta.
Tumor-Targeted Human T Cells Expressing CD28-Based Chimeric Antigen Receptors Circumvent CTLA-4 Inhibition.
Sadelain et al., New York City, United States. In Plos One, 2014
We investigated whether T cells expressing an anti-CD19, CD3 zeta and CD28-based CAR (19-28z) displayed the same proliferation and anti-tumor abilities than T cells expressing a CD3 zeta-based CAR (19z1) costimulated through the CD80/CD28, ligand/receptor pathway.
Comprehensive Survey of miRNA-mRNA Interactions Reveals That Ccr7 and Cd247 (CD3 zeta) are Posttranscriptionally Controlled in Pancreas Infiltrating T Lymphocytes of Non-Obese Diabetic (NOD) Mice.
Passos et al., Ribeirão Preto, Brazil. In Plos One, 2014
The interactions between miR-202-3p and the Ccr7 chemokine receptor mRNA or Cd247 (Cd3 zeta chain) mRNA found in PILs are highlighted because these interactions can contribute to a better understanding of how the lack of immune homeostasis and the emergence of autoimmunity (e.g., T1D) can be associated with the decreased activity of Ccr7 or Cd247, as previously observed in NOD mice.
Potential therapeutic strategy for gastric cancer peritoneal metastasis by NKG2D ligands-specific T cells.
Shi et al., Jinan, China. In Onco Targets Ther, 2014
The purpose of this study was to construct a chimeric receptor linking the extracellular domain of NKG2D to the CD28 and CD3zeta chain intracellular domains to target gastric cancers that expressed NKG2D ligands.
Serine Arginine-Rich Splicing Factor 1 (SRSF1) Contributes to the Transcriptional Activation of CD3ζ in Human T Cells.
Tsokos et al., Boston, United States. In Plos One, 2014
T lymphocytes from many patients with systemic lupus erythematosus (SLE) express decreased levels of the T cell receptor (TCR)-associated CD3 zeta (ζ) signaling chain, a feature directly linked to their abnormal phenotype and function.
CD247 variants and single-nucleotide polymorphisms observed in systemic lupus erythematosus patients.
Review
Suzuki et al., Tokyo, Japan. In Rheumatology (oxford), 2013
SLE is associated with a deficiency in cluster of differentiation 247 (CD247, also known as CD3 zeta chain), a component of the T-cell receptor (TCR)-CD3 complex.
CD3ζ-chain expression of human T lymphocytes is regulated by TNF via Src-like adaptor protein-dependent proteasomal degradation.
GeneRIF
Nagy et al., Budapest, Hungary. In J Immunol, 2012
These data provide evidence for src-like adaptor protein-dependent regulation of CD3 zeta-chain in the fine control of TCR signaling.
Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap.
GeneRIF
Thomson et al., Manchester, United Kingdom. In Ann Rheum Dis, 2012
A novel juvenile idiopathic arthritis susceptibility locus was identified, CD247.
Mechanistic insight into pertussis toxin and lectin signaling using T cells engineered to express a CD8α/CD3ζ chimeric receptor.
GeneRIF
Miller et al., Cincinnati, United States. In Biochemistry, 2012
It was shown that CD8alpha/CD3zeta rescues pertussis toxin-induced signaling events lacking in TCR null cells, indicating that CD8alpha/CD3zeta can substitute for TCR and supports the hypothesis that pertussis toxin stimulates signaling via receptor cross-linking.
Altered expression of the TCR signaling related genes CD3 and FcεRIγ in patients with aplastic anemia.
GeneRIF
Li et al., Guangzhou, China. In J Hematol Oncol, 2011
Altered expression of the TCR signaling related genes CD3 and FcepsilonRIgamma in patients with aplastic anemia.
CD3Z genetic polymorphism in immune response to hepatitis B vaccination in two independent Chinese populations.
GeneRIF
Li et al., Beijing, China. In Plos One, 2011
The rs12133337 polymorphism in the CD3Z gene might affect the immune response to hepatitis B vaccination, and a lower BMI might increase the contribution of the polymorphism to immunity to hepatitis B vaccination.
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia.
Impact
June et al., Philadelphia, United States. In N Engl J Med, 2011
We designed a lentiviral vector expressing a chimeric antigen receptor with specificity for the B-cell antigen CD19, coupled with CD137 (a costimulatory receptor in T cells [4-1BB]) and CD3-zeta (a signal-transduction component of the T-cell antigen receptor) signaling domains.
The genetics of systemic sclerosis.
Review
Agarwal, Houston, United States. In Discov Med, 2010
More recently a genome-wide association study has been performed and identified CD247 (CD3-zeta) as a novel genetic risk factor for the susceptibility to SSc.
Building better chimeric antigen receptors for adoptive T cell therapy.
Review
Gilham et al., Manchester, United Kingdom. In Curr Gene Ther, 2010
The archetypal CAR consists of a single-chain antibody fragment, specific to a tumour-associated antigen, fused to a component of the T-cell receptor complex (typically CD3zeta) which on antigen binding primes the engrafted T-cell for anti-tumour activity.
Systems biology of lupus: mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment.
Review
Perl, Syracuse, United States. In Autoimmunity, 2010
mTOR controls the expression T-cell receptor-associated signaling proteins CD4 and CD3zeta through increased expression of the endosome recycling regulator Rab5 and HRES-1/Rab4 genes, enhances Ca2+ fluxing and skews the expression of tyrosine kinases both in T and B cells, and blocks the expression of Foxp3 and the generation of regulatory T cells.
DiD-Labeled anti-EpCAM-directed NK-92-scFv(MOC31) zeta cells
Review
Leung, Bethesda, United States. In Unknown Journal, 2009
Tavri et al. (16) have generated NK-92 cells transduced with a humanized single-chain Fv antibody fragment (scFv) of EpCAM antibody MOC31 fused with CD3 zeta chain and tagged with 1,1’-dioctadecyl-3,3,3’,3’-tetramethylindodicarbocyanine (DiD) (DiD-NK-92-scFv(MOC31) zeta cells) for noninvasive NIR imaging of EpCAM expression in prostate tumor cells in rats.
A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta-chain degradation.
Impact
Wang et al., Yokohama, Japan. In Immunity, 2008
We demonstrate that the lysosomal protein LAPTM5 negatively regulated surface TCR expression by specifically interacting with the invariant signal-transducing CD3zeta chain and promoting its degradation without affecting other CD3 proteins, CD3epsilon, CD3delta, or CD3gamma.
Three phase II cytokine working group trials of gp100 (210M) peptide plus high-dose interleukin-2 in patients with HLA-A2-positive advanced melanoma.
Impact
Ernstoff et al., Nashville, United States. In J Clin Oncol, 2008
Immune studies including assays of CD3-zeta expression and numbers of CD4(+)/CD25(+)/FoxP3(+) regulatory T cells, CD15(+)/CD11b(+)/CD14(-) immature myeloid-derived cells, and CD8(+)gp100 tetramer-positive cells in the blood did not correlate with clinical benefit.
The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes.
Impact
Malissen et al., Marseille, France. In Nat Immunol, 2008
In contrast, in preselection CD4+CD8+ thymocytes, the CD3epsilon PRS acted together with the adaptor protein SLAP to promote CD3zeta degradation, thereby contributing to downregulation of TCR expression on the cell surface.
Activating and inhibitory functions of DAP12.
Review
Impact
Colonna et al., Saint Louis, United States. In Nat Rev Immunol, 2007
This model extends from previous studies of inhibitory signalling mediated by other adaptors, such as the Fc-receptor gamma-chain and CD3zeta, and provides a potential mechanism for the conflicting phenotypes observed in studies of DAP12-deficient mice.
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