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CD3e molecule, epsilon

CD3epsilon, CD3E
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, CAN, CD8, Interleukin-2, HAD
Papers using CD3epsilon antibodies
Requirement for the NF-κB Family Member RelA in the Development of Secondary Lymphoid Organs
Supplier
Baltimore David et al., In The Journal of Experimental Medicine, 1995
... 1 h at 37°C with one of the following primary reagents: anti-B220-biotin (1:100; RA3–6B2; BD PharMingen), anti-CD3e-biotin (1:50; 145–2C11; BD PharMingen), anti-CR-1-biotin (8C12; BD PharMingen), PNA-biotin (1:50; Vector Laboratories), MOMA-1 (1:10; Serotec), anti-CD45.2-biotin
Papers on CD3epsilon
Chromatin decondensation and T cell hyperresponsiveness in diabetes-associated hyperglycemia.
New
Kornfeld et al., Worcester, United States. In J Immunol, 01 Dec 2014
Purified T cells from chronically hyperglycemic (HG) mice produced higher levels of Th1, Th2, and Th17 cytokines and proliferated more than T cells from normoglycemic controls after anti-CD3e or Ag stimulation.
Towards neuroimmunotherapy for cancer: the neurotransmitters glutamate, dopamine and GnRH-II augment substantially the ability of T cells of few head and neck cancer patients to perform spontaneous migration, chemotactic migration and migration towards the autologous tumor, and also elevate markedly the expression of CD3zeta and CD3epsilon TCR-associated chains.
New
Levite et al., Mons, Belgium. In J Neural Transm, Aug 2014
In this study we asked if Glutamate, Dopamine or GnRH-II can augment the spontaneous migration, chemotactic migration and towards autologous HNC migration, and also increase CD3zeta and CD3epsilon expression, of peripheral T cells purified from the blood of five HNC patients.
Interaction network analysis revealed biomarkers in myocardial infarction.
New
Dong et al., Harbin, China. In Mol Biol Rep, Aug 2014
In the interaction network, LCK, CD247, CD3D, FYN, HLA-DRA, IL2, CD8A CD3E, CD4, CD3G had high degree, among which CD3E, CD4, CD3G were DEGs while others were linker genes screened from Global Network database.
A Mouse Strain Defective in Both T Cells and NK Cells Has Enhanced Sensitivity to Tumor Induction by Plasmid DNA Expressing Both Activated H-Ras and c-Myc.
New
Peden et al., Boston, United States. In Plos One, Dec 2013
In this paper, we demonstrate that the newborn CD3 epsilon transgenic mouse, which is defective in both T-cell and NK-cell functions, can detect the oncogenic activity of 25 ng of the circular form of pMSV-T24-H-ras/MSV-c-myc.
Generation and characterization of a JAK2V617F-containing erythroleukemia cell line.
New
Zhao et al., Oklahoma City, United States. In Plos One, Dec 2013
J53Z1 cells were stained positive for surface markers CD71 and CD117 but negative for Sca-1, TER-119, CD11b, Gr-1, F4/80, CD11c, CD317, CD4, CD8a, CD3e, B220, CD19, CD41, CD42d, NK-1.1, and FceR1.
Altered expression of the TCR signaling related genes CD3 and FcεRIγ in patients with aplastic anemia.
GeneRIF
Li et al., Guangzhou, China. In J Hematol Oncol, 2011
Altered expression of the TCR signaling related genes CD3 and FcepsilonRIgamma in patients with aplastic anemia.
Change in expression pattern of TCR-CD3 complex in patients with multiple myeloma.
GeneRIF
Schmidt et al., Guangzhou, China. In Hematology, 2011
Data show that the expression pattern of the four CD3 chains was epsilon>zeta>delta>gamma in peripheral blood mononuclear cells from MM, while a gamma>epsilon>zeta>delta expression pattern was found in healthy controls.
The expression pattern of CD3 chain genes in fetal/maternal interface.
GeneRIF
Li et al., Guangzhou, China. In Hematology, 2011
Study characterized the expression pattern of CD3-gamma, -delta, -epsilon and -zeta chain genes from placenta, which contributes to further understanding of the features of T-cell immune status in placenta.
Tumor site immune markers associated with risk for subsequent basal cell carcinomas.
GeneRIF
Kiecolt-Glaser et al., Columbus, United States. In Plos One, 2010
Results show that levels of CD3epsilon, CD25, CD68, and ICAM-1 mRNA in BCC biopsies may predict risk for new basal cell carcinomas.
Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.
Review
Call et al., Boston, United States. In Cold Spring Harb Perspect Biol, 2010
The intrinsic binding of the cytoplasmic domains of the CD3epsilon and zeta chains to the inner leaflet of the plasma membrane represents a novel mechanism for control of receptor activation: Insertion of critical CD3epsilon tyrosines into the hydrophobic membrane core prevents their phosphorylation before receptor engagement.
Identification of the transgenic integration site in immunodeficient tgε26 human CD3ε transgenic mice.
GeneRIF
Takahama et al., Tokushima, Japan. In Plos One, 2009
analysis of the transgenic integration site in immunodeficient tgepsilon26 human CD3epsilon transgenic mice
Nasal natural killer (NK)/T-cell lymphoma: clinical, histological, virological, and genetic features.
Review
Ishii et al., Asahikawa, Japan. In Int J Clin Oncol, 2009
Surface antigens and the NK-cell marker, CD56, as well as pan-T antigen CD2, cytoplasmic CD3 (CD3epsilon), and CD45 are expressed in the lymphoma cells.
Anti-CD3 recombinant diphtheria immunotoxin therapy of cutaneous T cell lymphoma.
Review
Woo et al., Temple, United States. In Curr Drug Targets, 2009
The recombinant CD3 immunotoxin, A-dmDT(390)-bisFv(UCHT1), composed of the catalytic and translocation domains of diphtheria toxin fused to two single chain Fv fragments of an anti-CD3epsilon monoclonal antibody was administered to five patients with cutaneous T cell lymphoma (CTCL) by eight 15 min intravenous infusions over four days.
Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif.
Impact
Wucherpfennig et al., Boston, United States. In Cell, 2008
Live-cell imaging studies showed a close interaction of the CD3epsilon cytoplasmic domain of the T cell receptor (TCR) with the plasma membrane through fluorescence resonance energy transfer between a C-terminal fluorescent protein and a membrane fluorophore.
A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta-chain degradation.
Impact
Wang et al., Yokohama, Japan. In Immunity, 2008
We demonstrate that the lysosomal protein LAPTM5 negatively regulated surface TCR expression by specifically interacting with the invariant signal-transducing CD3zeta chain and promoting its degradation without affecting other CD3 proteins, CD3epsilon, CD3delta, or CD3gamma.
The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes.
Impact
Malissen et al., Marseille, France. In Nat Immunol, 2008
Antigen recognition by T cell antigen receptors (TCRs) is thought to 'unmask' a proline-rich sequence (PRS) present in the CD3epsilon cytosolic segment, which allows it to trigger T cell activation.
Intravascular cytotoxic T-cell lymphoma: A case report and review of the literature.
Review
Miller et al., Boston, United States. In J Am Acad Dermatol, 2008
A 62-year-old male presented with erythematous patches and plaques on the lower extremities, and a biopsy revealed IVL with an activated cytotoxic phenotype (CD56(+), perforin+, granzyme B+, TIA-1+, CD3epsilon(+), CD20(-), CD4(-), CD8(-), CD5(-), and T-cell receptor [TCR] betaF1(-)), consistent with either NK-cell or T-cell origin.
Human monoclonal antibodies from transgenic mice.
Review
Lonberg, Milpitas, United States. In Handb Exp Pharmacol, 2007
Since the 1986 regulatory approval of muromonomab-CD3, a mouse monoclonal antibody (MAb) directed against the T cell CD3epsilon antigen, MAbs have become an increasingly important class of therapeutic compounds in a variety of disease areas ranging from cancer and autoimmune indications to infectious and cardiac diseases.
Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex.
Impact
Weiss et al., San Francisco, United States. In Nat Immunol, 2006
SLAP and c-Cbl were found to interact, and their expression together downregulated CD3epsilon.
Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development.
Impact
Saito et al., Yokohama, Japan. In Nat Immunol, 2006
Dimerization but not raft localization of CD3epsilon was sufficient to simulate pre-TCR function and promote beta-selection.
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