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Ectonucleoside triphosphate diphosphohydrolase 6

CD39L2, NTPDase6, ENTPD6
ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which is characteristic of NTPases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD39, PCPH, CAN, ACID, ATPase
Papers on CD39L2
Biochemical characterization of Arabidopsis APYRASE family reveals their roles in regulating endomembrane NDP/NMP homoeostasis.
Heazlewood et al., Melbourne, Australia. In Biochem J, Dec 2015
Interestingly, complementation of the mutant yeast using well characterized human apyrases could only be accomplished by using a functional ER endo-apyrase (NTPDase6), but not the ecto-apyrase (NTPDase1).
Yeast model identifies ENTPD6 as a potential non-obstructive azoospermia pathogenic gene.
Li et al., Beijing, China. In Sci Rep, 2014
These yeast data suggest that ENTPD6 may be a novel meiosis-associated NOA-related gene, and the yeast model provides a good approach to analyze GWAS results of NOA.
Hair cell specific NTPDase6 immunolocalisation in vestibular end organs: potential role of purinergic signaling in vestibular sensory transduction.
Vlajkovic et al., Auckland, New Zealand. In J Vestib Res, 2011
This report demonstrates selective expression of NTPDase6 by rat vestibular hair cells.
Gene set analysis of purine and pyrimidine antimetabolites cancer therapies.
Weinshilboum et al., Rochester, United States. In Pharmacogenet Genomics, 2011
All four genes selected from the pyrimidine gene sets (PSME3, CANT1, ENTPD6, ADRM1) were validated, but only one (PDE4D) was validated for the thiopurine gene sets.
Ectonucleoside triphosphate diphosphohydrolase 6 expression in testis and testicular cancer and its implication in cisplatin resistance.
Naito et al., Fukuoka, Japan. In Oncol Rep, 2011
After screening, we selected the ENTPD6 among these 19 genes.
Phosphatase-coupled universal kinase assay and kinetics for first-order-rate coupling reaction.
Wu, Minneapolis, United States. In Plos One, 2010
In this assay, CD39L2, a nucleotidase, is added into a kinase reaction to hydrolyze ADP to AMP and phosphate.
Distribution of NTPDase5 and NTPDase6 and the regulation of P2Y receptor signalling in the rat cochlea.
Vlajkovic et al., In Purinergic Signal, 2010
This study investigated the distribution of NTPDase5 and NTPDase6, two intracellular members of the E-NTPDase family, and linked this to regulation of P2 receptor signalling in the adult rat cochlea.
Developmentally regulated expression of ectonucleotidases NTPDase5 and NTPDase6 and UDP-responsive P2Y receptors in the rat cochlea.
Vlajkovic et al., Auckland, New Zealand. In Histochem Cell Biol, 2010
This study reports the changes in expression of NTPDase5 and NTPDase6 in the developing rat cochlea.
A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS).
Bergman et al., Charlottesville, United States. In Diabetologia, 2009
One region resides in a gene desert between PXT1 and KCTD20 on 6p21, while the region on 20p11 has several viable candidate genes (ENTPD6, PYGB, GINS1 and RP4-691N24.1).
Identification of cellular genes affecting the infectivity of foot-and-mouth disease virus.
Cohen et al., New York City, United States. In J Virol, 2009
The role of one such EST, that of ectonucleoside triphosphate diphosphohydrolase 6 (NTPDase6; also known as CD39L2), a membrane-associated ectonucleoside triphosphate diphosphohydrolase that previously was not suspected of involvement in the propagation of viral pathogens and which we now show is required for normal synthesis of FMDV RNA and proteins, is described in this report.
Localization of plasma membrane bound NTPDases in the murine reproductive tract.
Sévigny et al., Québec, Canada. In Histochem Cell Biol, 2009
In addition, NTPDase6 was putatively detected in Golgi-phase acrosome vesicles of round spermatids.
The single NTPase gene of Drosophila melanogaster encodes an intracellular nucleoside triphosphate diphosphohydrolase 6 (NTPDase6).
Knowles, San Diego, United States. In Arch Biochem Biophys, 2009
I report here the cloning and characterization of a nucleoside triphosphate diphosphohydrolase 6 (NTPDase6) encoded by the single Dmel/NTPase gene of Drosophila melanogaster.
E-NTPDases and ecto-5'-nucleotidase expression profile in rat heart left ventricle and the extracellular nucleotide hydrolysis by their nerve terminal endings.
Sarkis et al., Porto Alegre, Brazil. In Life Sci, 2008
RT-PCR analysis from left ventricle tissue demonstrate different levels of expression of Entpd1 (Cd39), Entpd2 (Cd39L1), Entpd3 (Cd39L3), Entpd5 (Cd39L4) Entpd6, (Cd39L2) and 5'-NT/CD73.
Bacterial expression, characterization, and disulfide bond determination of soluble human NTPDase6 (CD39L2) nucleotidase: implications for structure and function.
Kirley et al., Cincinnati, United States. In Biochemistry, 2003
A secondary structural model of NTPDase-6 is proposed based on disulfide architecture (four conserved cysteine residues Cys249-Cys280 and Cys340-Cys354, circular dichroism data, and regions of conservation among all NTPDases.
Sequencing, functional expression and characterization of rat NTPDase6, a nucleoside diphosphatase and novel member of the ecto-nucleoside triphosphate diphosphohydrolase family.
Zimmermann et al., Frankfurt am Main, Germany. In Biochem J, 2000
We have isolated and characterized the cDNA encoding nucleoside triphosphate diphosphohydrolase 6 (NTPDase6), a novel member of the ecto-nucleoside triphosphate diphosphohydrolase family.
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