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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ectonucleoside triphosphate diphosphohydrolase 1

CD39, NTPDase, NTPDase1, ATPDase
has apyrase activity; may inactivate signaling mediated by extracellular nucleotides [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: 5'-nucleotidase, CAN, V1a, CD4, ATPase
Papers using CD39 antibodies
CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype
Supplier
Fearon Douglas T. et al., In The Journal of Experimental Medicine, 1995
... Claire Hivroz, Paris, France), anti-CD5 (Coulter Corp., Hialeh, Florida), anti-CD39 (Serotec Ltd., Oxford, UK) and anti-IgD (DAKO, Bucks, UK) IgG1 mAbs ...
Papers on CD39
Regulatory T cells from colon cancer patients express CD39 and inhibit transendothelial effector T cell migration by an adenosine-dependent mechanism.
New
Quiding-Järbrink et al., Göteborg, Sweden. In Cancer Immunol Res, Feb 2016
Our results showed that circulating Treg from cancer patients expressed high levels of CD39, an ectoenzyme mediating hydrolysis of ATP to AMP, as a rate-determining first step in the generation of immunosuppressive adenosine.
γδ T Cells Protect the Liver and Lungs of Mice from Autoimmunity Induced by Scurfy Lymphocytes.
New
Shevach et al., Bethesda, United States. In J Immunol, Feb 2016
The activated γδ T cells expressed high levels of CD39 and NKG2D on their cell surface.
Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic mice.
New
Hamilton-Williams et al., Brisbane, Australia. In Immunol Cell Biol, Feb 2016
NOD Treg cells were reduced in frequency specifically in the lymph nodes and expressed lower levels of CD25 and CD39/CD73 immunosuppressive molecules.
Ectonucleotidase activity and immunosuppression in astrocyte-CD4 T cell bidirectional signaling.
New
Grassi et al., Rozzano, Italy. In Oncotarget, Feb 2016
Here we show that astrocytes promote the expression and enzymatic activity of CD39 and CD73 ectonucleotidases in recently activated CD4 cells by a contact dependent mechanism that is independent of T cell receptor interaction with class II major histocompatibility complex (MHC).
Purinergic signaling in scarring.
Review
New
Cronstein et al., Ferrara, Italy. In Faseb J, Jan 2016
Regulation of this process is maintained by nucleoside and nucleotide transporters, as well as the ectonucleotidases ectonucleoside triphosphate diphosphohydrolase [ENTPD; cluster of differentiation (CD)39] and ecto-5'-nucleotidase (5'-NT; CD73), among others.
Hypoxia-induced inflammation and purinergic signaling in cross clamping the human aorta.
New
Hakovirta et al., Turku, Finland. In Springerplus, Dec 2015
Using Biorad Multipex™ 21- and 27-panels 48 different cytokines, chemokines and growth factors were analyzed, in addition to circulating levels of ATP, ADP, CD39, CD73 and HIF-1α, and compared between the groups.
CD73 and CD39 ectonucleotidases in T cell differentiation: Beyond immunosuppression.
Review
New
Sauma et al., Santiago, Chile. In Febs Lett, Dec 2015
CD39 and CD73 are two ectonucleotidases that cooperate in the generation of extracellular adenosine through ATP hydrolysis, thus tilting the balance towards immunosuppressive microenvironments.
Beyond ecto-nucleotidase: CD39 defines human Th17 cells with CD161.
Review
New
Robson et al., Nanchang, China. In Purinergic Signal, Sep 2015
CD39/ENTPD1 is a prototypic member of the ectonucleoside triphosphate diphosphohydrolase (ENTPDase) family on cell surface.
Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.
New
Impact
Quintana et al., Boston, United States. In Nat Med, Jun 2015
Conversely, CD39 promotes Tr1 cell differentiation by depleting eATP.
Adenosine receptor signaling: a key to opening the blood-brain door.
Review
Kim et al., Ithaca, United States. In Fluids Barriers Cns, 2014
Extracellular adenosine, which is efficiently generated through the catabolism of ATP via the CD39/CD73 ecto-nucleotidase axis, promotes BBB permeability by signaling through A1 and A2A ARs expressed on BBB cells.
Autoimmune Hepatitis: Clinical Review with Insights into the Purinergic Mechanism of Disease.
Review
Robson et al., Farmington, United States. In J Clin Transl Hepatol, 2013
We focus on regulatory T cell impairments as a consequence of changes in CD39 ectonucleotidase expression and altered purinergic signaling.
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
Impact
Quintana et al., Boston, United States. In Nat Immunol, 2013
The effects of IL-27 were mediated at least in part through induction of the immunoregulatory molecule CD39 in DCs.
Overexpression of CD39 in mouse airways promotes bacteria-induced inflammation.
GeneRIF
Oury et al., Liège, Belgium. In J Immunol, 2012
a chronic increase of epithelial CD39 expression and activity promotes airway inflammation in response to bacterial challenge
Defective renal water handling in transgenic mice over-expressing human CD39/NTPDase1.
GeneRIF
Kishore et al., Salt Lake City, United States. In Am J Physiol Renal Physiol, 2012
heightened nucleotide scavenging by increased levels of CD39 altered the release of endogenous argipressin in response to dehydration
Ectonucleotide triphosphate diphosphohydrolase-1 (CD39) mediates resistance to occlusive arterial thrombus formation after vascular injury in mice.
GeneRIF
Gumina et al., Columbus, United States. In Am J Pathol, 2012
Ectonucleotide triphosphate diphosphohydrolase-1 (CD39) mediates resistance to occlusive arterial thrombus formation after vascular injury.
Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression.
Impact
GeneRIF
Ghiringhelli et al., Dijon, France. In Immunity, 2012
Stat3 supported whereas Gfi-1 repressed CD39 and CD73 expression by binding to their promoters.
Resident cardiac immune cells and expression of the ectonucleotidase enzymes CD39 and CD73 after ischemic injury.
GeneRIF
Schrader et al., Düsseldorf, Germany. In Plos One, 2011
Study suggests that extracellular ATP formed during I/R is preferentially degraded by CD39 present on myeloid cells, while the formation of immunosuppressive adenosine is mainly catalysed by CD73 present on granulocytes and lymphoid cells.
Increased NTPDase activity in lymphocytes during experimental sepsis.
GeneRIF
Leal et al., Santa Maria, Brazil. In Scientificworldjournal, 2011
NTPDase activity is increased in lymphocytes during experimental sepsis
Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells.
Impact
Quintana et al., Boston, United States. In Nat Immunol, 2010
We found that AhR activation promoted the differentiation of CD4(+)Foxp3(-) T cells, which produce IL-10 and control responder T cells through granzyme B. However, activation of AhR in the presence of transforming growth factor-beta1 induced Foxp3(+) iT(reg) cells, which suppress responder T cells through the ectonucleoside triphosphate diphosphohydrolase CD39.
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance.
Impact
Ravichandran et al., Charlottesville, United States. In Nature, 2009
Enzymatic removal of ATP and UTP (by apyrase or the expression of ectopic CD39) abrogated the ability of apoptotic cell supernatants to recruit monocytes in vitro and in vivo.
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