Blood-brain barrier damage in vascular dementia.
Japan. In Neuropathology, Dec 2015
In addition, mRNA expression of osteopontin, matrix metalloproteinase-13 (MMP-13), and CD36 was increased in vessels showing BBB damage in hypertensive SHRSP.
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages.
Saint Louis, United States. In Nat Immunol, 2014
We found that the uptake of triacylglycerol substrates via the scavenger receptor CD36 and their subsequent lipolysis by lysosomal acid lipase (LAL) was important for the engagement of elevated oxidative phosphorylation, enhanced spare respiratory capacity (SRC), prolonged survival and expression of genes that together define M2 activation.
Aquaporins: important but elusive drug targets.
More papers using
San Francisco, United States. In Nat Rev Drug Discov, 2014
Moreover, loss-of-function mutations in human AQPs cause congenital cataracts (AQP0) and nephrogenic diabetes insipidus (AQP2), and autoantibodies against AQP4 cause the autoimmune demyelinating disease neuromyelitis optica.