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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Fc receptor, IgG, low affinity IIb

CD32, FcgammaRIIa, FcgammaRIIB, Fc gamma RII
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: CD16, CD64, CAN, V1a, HAD
Papers using CD32 antibodies
Differential targeting of secretory lysosomes and recycling endosomes in mast cells revealed by patterned antigen arrays.
Supplier
Maridonneau-Parini Isabelle et al., In Frontiers in Immunology, 2006
... Anti-CD16/CD32 monoclonal antibodies were from Immunostep (clone 2.4G2, Caltag medsystems, ...
CD91a receptor for heat shock protein gp96
Supplier
Henson Peter M. et al., In The Journal of Experimental Medicine, 1999
... Monoclonal anti-CR1 (anti-CD35), anti-mannose receptor, anti-CD32 (BD PharMingen); monoclonal anti-CR3 (Dako); chicken polyclonal anti-CRT antibodies ...
Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells
Supplier
Dimmeler Stefanie et al., In The Journal of Experimental Medicine, 1997
... After blocking with purified anti–mouse CD16/CD32 (FcγIII/II receptor) antibodies (1:100; BD Biosciences), washed cells were incubated ...
Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties
Supplier
Rooijakkers Suzan H M et al., In The EMBO Journal, 1996
... antibody screening assay on neutrophils was performed using commercial fluorophore-conjugated antibodies: Phycoerythrin (PE)-conjugated antibodies recognizing CD32 (7.3, Fitzgerald), CD35 (E11, BD), CD44 ...
Papers on CD32
Validation of research trajectory 1 of an Exposome framework: Exposure to benzo(a)pyrene confers enhanced susceptibility to bacterial infection.
New
Hood et al., Nashville, United States. In Environ Res, Feb 2016
FcγRIIa (CD32a), a member of the Fc family of immunoreceptors with low affinity for immunoglobulin G, has been reported to bind preferentially to IgG within lipid rafts.
Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs.
New
Liu et al., Hangzhou, China. In J Biol Chem, Jan 2016
In addition to increased gene expressions of α-smooth muscle actin and collagen 1α1, suggesting myofibroblast differentiation, TERC deficiency also leads to marked cellular infiltrations of a mononuclear cell population positive for the leukocyte common antigen CD45, low-affinity Fc receptor CD16/CD32, and pattern recognition receptor CD11b in the lungs.
Successful en bloc venous resection with reconstruction and subsequent radiotherapy for 2 consecutive recurrences of intravenous leiomyoma-a case report.
New
Zhou et al., Jinan, China. In Bmc Cancer, Dec 2015
On Immunohistochemical staining, the tumor cells were positive for CD32, CD34, Vimentin and smooth muscle actin.
Triple costimulation via CD80, 4-1BB, and CD83 ligand elicits the long-term growth of Vγ9Vδ2 T cells in low levels of IL-2.
New
Kim et al., Seoul, South Korea. In J Leukoc Biol, Dec 2015
To understand the roles of costimulatory signals in activation and expansion ex vivo, Vγ9Vδ2 T cells were grown with artificial APCs that express CD83, 4-1BB ligand, and/or CD32, which allowed a loading of αCD3 and αCD28 antibodies.
Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model.
New
Venero et al., Stockholm, Sweden. In Aging (albany Ny), Sep 2015
In contrast, CD16/CD32 expression, a microglial pro-inflammatory marker, was found to be negatively affected upon CASP8 deletion.
DNA-Containing Immunocomplexes Promote Inflammasome Assembly and Release of Pyrogenic Cytokines by CD14+ CD16+ CD64high CD32low Inflammatory Monocytes from Malaria Patients.
Gazzinelli et al., Belo Horizonte, Brazil. In Mbio, 2014
The main source of IC-induced proinflammatory cytokines (i.e., tumor necrosis factor alpha [TNF-α] and interleukin-1β [IL-1β])in peripheral blood mononuclear cells from acute malaria patients was found to be a CD14(+) CD16 (FcγRIIIA)(+) CD64 (FcγRI)(high) CD32 (FcγRIIB)(low) monocyte subset.
Polymorphisms of protein tyrosine phosphatase CD148 influence FcγRIIA-dependent platelet activation and the risk of heparin-induced thrombocytopenia.
GeneRIF
Gruel et al., Tours, France. In Blood, 2012
Polymorphisms of protein tyrosine phosphatase CD148 influence FcgammaRIIA-dependent platelet activation and the risk of heparin-induced thrombocytopenia.
Regulatory dendritic cells program B cells to differentiate into CD19hiFcγIIbhi regulatory B cells through IFN-β and CD40L.
GeneRIF
Cao et al., Shanghai, China. In Blood, 2012
We report that regulatory dendritic cells can induce splenic B cells to differentiate into a distinct subtype of IL-10-producing regulatory B cells with unique phenotype CD19(hi)FcgammaIIb(hi).
IgG opsonization of bacteria promotes Th17 responses via synergy between TLRs and FcγRIIa in human dendritic cells.
GeneRIF
de Jong et al., Amsterdam, Netherlands. In Blood, 2012
These data identified cross-talk between TLRs and FcgammaRIIa as a novel mechanism by which dendritic cells promote protective effector Th17-cell responses against bacteria.
Role of activating FcγR gene polymorphisms in Kawasaki disease susceptibility and intravenous immunoglobulin response.
GeneRIF
Portman et al., Birmingham, United States. In Circ Cardiovasc Genet, 2012
A common variation in FCGR2A is associated with increased KD susceptibility.
ABCB1, FCGR2A, and FCGR3A polymorphisms in patients with HER2-positive metastatic breast cancer who were treated with first-line taxane plus trastuzumab chemotherapy.
GeneRIF
Bang et al., Seoul, South Korea. In Oncology, 2011
FCGR2A polymorphisms are not associated with response to therapy in HER2-positive metastatic breast cancer.
Monoclonal antibody therapy directed against human acute myeloid leukemia stem cells.
Review
Majeti, Palo Alto, United States. In Oncogene, 2011
In recent years, a number of such antigens have been identified, including CD123, CD44, CLL-1, CD96, CD47, CD32, and CD25.
Advances in the understanding of the Fc gamma receptors-mediated autoantibodies uptake.
Review
D'Amore et al., Bari, Italy. In Clin Exp Med, 2011
In humans, three different types of FcγRs, belonging to the Ig gene superfamily, have been identified; FcγRI (cluster of differentiation (CD64), FcγRII (CD32) and FcγRIII (CD16).
A novel role for the IgG Fc glycan: the anti-inflammatory activity of sialylated IgG Fcs.
Review
Ravetch et al., New York City, United States. In J Clin Immunol, 2010
This leads to upregulated surface expression of the inhibitory FcR, FcgammaRIIb, on inflammatory cells, thereby attenuating autoantibody-initiated inflammation.
Mechanisms of IVIG efficacy in chronic inflammatory demyelinating polyneuropathy.
Review
Lünemann et al., Marburg an der Lahn, Germany. In J Clin Immunol, 2010
Studies in animal models of autoimmune diseases indicated that the inhibitory Fc-gamma receptor FcgammaRIIB, expressed on myeloid cells and B cells, is required for the anti-inflammatory activity of IVIG.
FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications.
Review
Impact
Clatworthy et al., Cambridge, United Kingdom. In Nat Rev Immunol, 2010
FcgammaRIIB is the only inhibitory Fc receptor.
Immunoglobulin G Fc receptor FcgammaRIIIa 158 V/F polymorphism correlates with rituximab-induced neutropenia after autologous transplantation in patients with non-Hodgkin's lymphoma.
Impact
Horning et al., Stanford, United States. In J Clin Oncol, 2010
PATIENTS AND METHODS: Genomic DNA was used for FcgammaRIIIa V/F or the FcgammaRIIa H/R genotyping.
Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan.
Impact
GeneRIF
Boissière-Michot et al., Montpellier, France. In J Clin Oncol, 2009
Combined FCGR2A/FCGR3A polymorphisms are prognostic factors for disease profression in metastatis colorectal cancer patients treated with cetuximab plus irinotecan.
Structural recognition and functional activation of FcgammaR by innate pentraxins.
Impact
Sun et al., Rockville, United States. In Nature, 2009
The complex structure between human SAP and FcgammaRIIa reveals a diagonally bound receptor on each SAP pentamer with both D1 and D2 domains of the receptor contacting the ridge helices from two SAP subunits.
Human neutrophil Fcgamma receptors initiate and play specialized nonredundant roles in antibody-mediated inflammatory diseases.
Impact
Mayadas et al., Boston, United States. In Immunity, 2008
Here we demonstrate that neutrophil-selective transgenic expression of the two uniquely human neutrophil Fc gamma receptors (FcgammaRs), FcgammaRIIA and FcgammaRIIIB, in Fcgamma-chain-deficient mice restored susceptibility to progressive glomerulonephritis and the cutaneous RPA reaction.
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