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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Hemoglobin, alpha 1

CD31, HbA1, PECAM-1
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, CD34, vascular endothelial growth factor, HAD, CD45
Papers using CD31 antibodies
The prognostic value of histological tumor necrosis in solid organ malignant disease: a systematic review
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Liu Shuang et al., In Theranostics, 2010
... antibody (1:100, BD Biosciences, San Jose, CA) and rat anti-CD31 antibody (1:100, BD Biosciences) for 1 h at room ...
Integrin targeted delivery of radiotherapeutics
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Liu Shuang et al., In Theranostics, 2010
... antibody (1:100, Santa Cruz) and CD31 antibody (1:100, BD Biosciences) for 1 h at room ...
Methods for evaluating endothelial function: a position statement from the European Society of Cardiology Working Group on Peripheral Circulation.
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Madeddu Paolo, In PLoS ONE, 2010
... For the detection of EMP, PPP was incubated at 4°C for 20 minutes with CD31-PE (BD Biosciences, Erembodegem Belgium) and CD42b-FITC ...
Gene expression prowles during activation of cultured rat hepatic stellate cells by tumoral hepatocytes and fetal bovine serum
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Dupuy Evelyne et al., In Gastroenterology Research and Practice, 2009
... (Abcam, Cambridge, UK); rat antimouse CD31, (Pharmingen Becton Dickinson, Le Pont de Claix, ...
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Papers on CD31
Localized signals that regulate transendothelial migration.
Review
New
Muller, United States. In Curr Opin Immunol, Feb 2016
The adhesion molecules, PECAM (CD31) and CD99 that regulate two major steps in TEM, do so by regulating specific signals.
Mesenchymal Stem Cells Alleviate LPS-Induced Acute Lung Injury in Mice by MiR-142a-5p-Controlled Pulmonary Endothelial Cell Autophagy.
New
You et al., Taizhou, China. In Cell Physiol Biochem, Feb 2016
Mouse PECs were isolated by flow cytometry based on CD31 expression and then analyzed for autophagy-associated factors LC3 and Beclin-1 by Western blot.
Association of synovial inflammation and inflammatory mediators with glenohumeral rotator cuff pathology.
New
Sokolove et al., Stanford, United States. In J Shoulder Elbow Surg, Feb 2016
Cryosections were stained and examined under light microscopy and confocal fluorescent microscopy for anti-cluster CD45 (common leukocyte antigen), anti-CD31 (endothelial), and anti-CD68 (macrophage) cell surface markers.
Dynamics of circulating microparticles in chronic kidney disease and transplantation: Is it really reliable marker?
Review
New
Unsur et al., Kayseri, Turkey. In World J Transplant, Jan 2016
EMPs having CD144, CD 146, CD31(+)/CD41(-), CD51 and CD105 may be used to evaluate the vascular endothelial cell damage and determine asymptomatic patients who might be at higher risk of developing cardiovascular disease in CKD and renal transplant.
Myocarditis in patients with subarachnoid hemorrhage: A histopathologic study.
New
Niessen et al., Amsterdam, Netherlands. In J Crit Care, Jan 2016
CD31 was used to identify putative thrombi.
Hepatocyte Growth Factor Effects on Mesenchymal Stem Cells Derived from Human Arteries: A Novel Strategy to Accelerate Vascular Ulcer Wound Healing.
New
Pasquinelli et al., Bologna, Italy. In Stem Cells Int, Dec 2015
HGF/SF did not increase hVW-MSC proliferation, whereas it enhanced the cell migration, the formation of capillary-like structures, and the expression of angiogenic markers (vWF, CD31, and KDR).
Human endothelial and foetal femur-derived stem cell co-cultures modulate osteogenesis and angiogenesis.
New
Oreffo et al., Southampton, United Kingdom. In Stem Cell Res Ther, Dec 2015
An ex vivo organotypic embryonic chick (E11) femur culture model was used to determine the osteogenic effects of VEGF as determined using micro-computed tomography (μCT) and Alcian blue/Sirius red histochemistry and immunocytochemistry for expression of CD31.
[Pleural epithelioid hemangioendothelioma: a case report and review of the literature].
Review
New
Mengzhao et al., In Zhonghua Jie He He Hu Xi Za Zhi, Mar 2015
Biopsy of the pleura showed epithelioid tumor cells, and immunohistochemistry was positive for CD31, CD34 and vimentin.
Biomarkers of cancer angioprevention for clinical studies.
Review
Noonan et al., Reggio nell'Emilia, Italy. In Ecancermedicalscience, 2014
Here we discuss the importance of angioprevention and the potential use of VEGF, PlGF, CD31, Ang and Tie, circulating vascular cell precursors, and microRNA as potential biomarkers.
Cryptococcal infection of the femoral bone similar with pathologic features of vascular tumors: a case report and review of literature.
Review
Jiang et al., Guangzhou, China. In Int J Clin Exp Pathol, 2014
By immunohistochemistry (IHC), only CD31 and CD68 were positive, while CK, CK8/18, EMA, P63, CK7, CK20, PSAP, PSA, CD34 negative.
PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis.
Impact
Cao et al., Baltimore, United States. In Nat Med, 2014
A recent study showed that a specific vessel subtype, strongly positive for CD31 and endomucin (CD31(hi)Emcn(hi)), couples angiogenesis and osteogenesis.
Endothelial cell expression of haemoglobin α regulates nitric oxide signalling.
Impact
Isakson et al., Charlottesville, United States. In Nature, 2012
Here we report a new model for the regulation of NO signalling by demonstrating that haemoglobin (Hb) α (encoded by the HBA1 and HBA2 genes in humans) is expressed in human and mouse arterial endothelial cells and enriched at the myoendothelial junction, where it regulates the effects of NO on vascular reactivity.
Crosstalk between reticular adherens junctions and platelet endothelial cell adhesion molecule-1 regulates endothelial barrier function.
GeneRIF
Millán et al., Madrid, Spain. In Arterioscler Thromb Vasc Biol, 2012
reticular adherens junctions act coordinately with PECAM-1 to maintain endothelial barrier function in regions of low actomyosin-mediated tension.
Effects of sevelamer on HbA1c, inflammation, and advanced glycation end products in diabetic kidney disease.
GeneRIF
Striker et al., New York City, United States. In Clin J Am Soc Nephrol, 2012
Sevelamer carbonate significantly reduces HbA1c in diabetics with early kidney disease.
A molecular tool to assess the pathological relevance of alpha-globin DNA variants.
GeneRIF
Ghassemifar et al., Australia. In Pathology, 2012
We confirm in silico predictions of the consequences of the HBA1:c.301-3C>G mutation, proving aberrant RNA splicing and the production of a truncated alpha-globin protein.
Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.
GeneRIF
Sessa et al., New Haven, United States. In Circ Res, 2012
We show that knockdown of ZDHHC21 leads to reduced levels of platelet endothelial cell adhesion molecule-1 at the cell surface.
Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks.
Impact
Immunological Genome Project Consortium et al., Boston, United States. In Nat Immunol, 2012
Poorly studied podoplanin (gp38)-negative CD31(-) LNSCs showed similarities to FRCs but lacked expression of interleukin 7 (IL-7) and were identified as myofibroblastic pericytes that expressed integrin α(7).
Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans.
Impact
Tesselaar et al., Utrecht, Netherlands. In Immunity, 2012
By combining in vivo kinetic labeling using deuterated water, thymectomy experiments, analysis of T cell receptor excision circles and CD31 expression, and mathematical modeling, we have quantified the contribution of thymus output and peripheral naive T cell division to the maintenance of T cells in mice and men.
Race-ethnic differences in the association of genetic loci with HbA1c levels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III).
GeneRIF
MAGIC Investigators et al., Boston, United States. In Bmc Med Genet, 2011
An 11-HbA1c loci risk allele frequencies associated SNP genotype score was subtly different by race-ethnicity and was associated with increase in HbA1c in non-Hispanic white and Mexican American but not non-Hispanic black; no mortality association.
Biologic correlation of 2-[18F]-fluoro-2-deoxy-D-glucose uptake on positron emission tomography in thymic epithelial tumors.
Impact
Yamamoto et al., Shizuoka, Japan. In J Clin Oncol, 2010
Tumor sections were stained by immunohistochemistry for glucose transporter 1 (GLUT1), glucose transporter 3 (GLUT3), hypoxia-inducible factor-1 alpha (HIF-1alpha), vascular endothelial growth factor (VEGF), microvessels (CD31 and CD34), cell cycle control marker (p53), and apoptosis marker (bcl-2).
More papers using CD31 antibodies
Saturated fatty acids enhance osteoclast survival
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Park Jung Han Yoon et al., In Breast Cancer Research : BCR, 2009
... UK); antibodies against cyclin-dependent kinase (CDK)2, CDK4, vascular endothelial cell growth factor (VEGF)-A, VEGF-C, and CD31 from Santa Cruz Biotechnology (Santa Cruz, CA, USA); ...
An orally available small molecule inhibitor of c-Met, PF-2341066, reduces tumor burden in a pre-clinical model of ovarian cancer metastasis.
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Lengyel E et al., In Oncogene, 2009
... -integrin, CD31 and protein A/G agarose beads were from Santa Cruz Biotechnology, Inc (Santa Cruz, CA) ...
Dynamic effect of di-2-(ethylhexyl) phthalate on testicular toxicity: epigenetic changes and their impact on gene expression.
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Boekelheide Kim et al., In Environmental Health Perspectives, 2009
... and processed for horseradish avidin-biotin immunoperoxidase staining (SP-2001; Vector Laboratories, Burlingame, CA) using a mouse monoclonal CD31 anti-human antibody (Dako Cytomation, Carpinteria, CA) ...
CLEC-2 activates Syk through dimerization
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Heemskerk Johan W. M. et al., In Cellular and Molecular Life Sciences, 2009
... Microbeads coated with human anti-CD31 mAb and MS columns were a kind gift from Miltenyi Biotec.
Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.
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Okamoto Shu-ichi, In PLoS ONE, 2008
... Antibodies utilized in this study were: PECAM/CD31 (Santa Cruz Biotechnology, Santa Cruz, CA), GFAP ...
Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.
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McCubrey James, In PLoS ONE, 2008
... FITC-conjugated mouse monoclonal anti-PIM (HPI, Inc), anti-CD45 (Cell Signaling Technology), anti-CD22 (Novocastra), anti-CXCR4 (Abcam), anti-SDF-1α, anti-CD31 (Santa Cruz Biotechnology) and anti-CAIX (Novus Biologicals) ...
Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR
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Bouloumié Anne et al., In Diabetes, 2008
... Antibodies for immunofluorescence were from Dakocytomation (Denmark, CD31), Epitomics (CD34), Zymed (Invitrogen, France, ...
Assessment of microvessel density and carbonic anhydrase-9 (CA-9) expression in rectal cancer
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van Kempen Léon C. L. T. et al., In Virchows Archiv, 2008
... antigen retrieval step and preincubation with normal serum was followed by incubation with monoclonal mouse-anti CD31 (Dako, clone JC70A, 1:20) overnight ...
Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation.
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Gaetano Carlo, In PLoS ONE, 2008
... AADC and NOS3 proteins were produced from Millipore and Santa Cruz biotechnology (CA, USA), the anti-CD31 antibody from BD Biosciences (Le Pont de Claix, ...
Contractile smooth muscle cells derived from hair-follicle stem cells.
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Emanueli Costanza, In PLoS ONE, 2007
... rabbit anti-RGS5 antibody was from Invitrogen, calponin1 antibody was from Epitomics (Burlingame, USA), CD34 and CD31 antibodies was from Dako (Hamburg, Germany) ...
Class 1A PI3K regulates vessel integrity during development and tumorigenesis
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Ridley Anne J. et al., In The Journal of Cell Biology, 2007
... from Millipore; VE-cadherin–Y685 was purchased from ECM Biosciences; ICAM-1 was obtained from R&D systems; and PECAM-1 was obtained from Dako.
Stem Cell Marker CD133 Affects Clinical Outcome in Glioma Patients.
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Aboody Karen S., In PLoS ONE, 2007
... PE-conjugated anti-CD133 and APC-conjugated anti-CD31 mAbs were purchased from Miltenyi Biotec (Bergisch Gladbach, Germany) and ...
Correlation between ECT2 gene expression and methylation change of ECT2 promoter region in pancreatic cancer
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Fields Alan P. et al., In Oncogene, 2007
... Antibodies used: Ect2, RhoA and CD31/Pecam-1 (Santa Cruz Biotechnology, Santa Cruz, CA); PKCι, ...
To reg or not to reg: that is the question in COPD.
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Idzko Marco, In PLoS ONE, 2007
... antibodies were used: polyclonal rabbit anti-human NG2 (Millipore), monoclonal mouse anti-human-Nestin (R&D), monoclonal mouse anti-human CD31 (DAKO), monoclonal mouse anti-human CD146 ...
Follicular dendritic cell sarcoma in the lymph nodes of the neck
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Adam Patrick et al., In Diagnostic Pathology, 2006
... CD31DAKO ...
Kallikrein-binding protein inhibits growth of gastric carcinoma by reducing vascular endothelial growth factor production and angiogenesis
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Madeddu P et al., In British Journal of Cancer, 2006
... m) were incubated overnight with monoclonal antibodies antihuman hK1 (1 : 100, R&D) and CD31 (1 : 40, DAKO) or Isolectin B4 (1 : 100, ...
RGS18 Acts as a Negative Regulator of Osteoclastogenesis by Modulating Acid-Sensing OGR1/NFAT Signaling Pathway.
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Aziz Syed A., In PLoS ONE, 2006
... Anti-CD31 was from RDI (Fitzgerald, Concord, USA) ...
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
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Dormond Olivier et al., In Molecular Cancer, 2005
... Antibody against CD31 was purchased from BD Biosciences.
Systemic inhibition of tumor growth by soluble Flk-1 gene therapy combined with cisplatin
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Huang Y et al., In Cancer Gene Therapy, 2005
... Mouse monoclonal antibody for CD31 and LSAB kit were purchased from Dako (Copenhagen, Denmark) ...
A simple and fast densitometric method for the analysis of tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta and in the ventral tegmental area
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Mohanraj Rajesh, In PLoS ONE, 2004
... Santa Cruz, CA, USA), (p-)SAPK/JNK, (p-)ERK1/2, (p-)p-38, MMP-7 (Cell signaling technology, Danvers, MA,USA), VEGF, and CD31 (ABcam, Cambridge, MA , USA) were ...
Tumor-associated macrophages: the double-edged sword in cancer progression
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Xu Haiyan et al., In Theranostics, 2004
... sections of tumor tissue were also stained for CD31 antigen with a primary rabbit polyclonal antibody CD31 (Beijing Biosynthesis and Biotechnique Co., LTD ...
Clinical and pharmacokinetic study of TNP-470, an angiogenesis inhibitor, in combination with paclitaxel and carboplatin in patients with solid tumors.
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Kolb Martin R. J., In PLoS ONE, 2003
... A goat antibody directed against CD31 (PECAM-1, cat# M-20) was from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Endothelial signaling during development.
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Deli Maria A., In PLoS ONE, 2002
... Monoclonal mouse anti-human CD34, mouse anti-human platelet endothelial cell adhesion molecule (PECAM-1), and peroxidase-conjugated secondary antibodies were all purchased from DAKO A/S (Glostrup, DK) ...
Inhibition of hypoxia inducible factor 1 alpha causes oxygen-independent cytotoxicity and induces p53 independent apoptosis in glioblastoma cells
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Djonov Valentin et al., In Breast Cancer Research, 2002
... 8654) for 10 min, sections were incubated with the first antibody diluted in TBS: mouse anti-CD31, 1:20 (JC/70A, M-0823; Dako, Glostrup, Denmark) (for details, ...
Trichoblastoma, basal cell carcinoma, and follicular differentiation: what should we trust?
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Bröcker Eva-B. et al., In Journal of Skin Cancer, 2002
... Serial sections were stained with H&E and CD31 (Clone JC70A, Dako Denmark, dilution 1 : 30) following ...
Gastrointestinal stromal tumors: chemotherapy and imatinib
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K. Breuhahn et al., In Rare Tumors, 2001
... tyrosine kinase 1 (FLT3, 1:100, Abcam, Cambridge, UK), as well as CD31 (1:25, Dako) and MIB1 (1:200, Dako), ...
Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice
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Tsukita Shoichiro et al., In The Journal of Cell Biology, 2001
... Rat anti–PECAM-1 mAb (BD Biosciences), rat anti–mouse ZO-1 mAb ...
Osteoblast expression of vascular endothelial growth factor is modulated by the extracellular microenvironment
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Yang Bai et al., In BioMedical Engineering OnLine, 2000
... CD31 and von-Willebrand factors staining were performed using the ImmunoCruz Staining System (Santa Cruz Biotechnology, Inc., Santa Cruz, CA, ...
Transdifferentiation of polymorphonuclear neutrophils: acquisition of CD83 and other functional characteristics of dendritic cells
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Foster Thomas H. et al., In Theranostics, 2000
... AlexaFluor647- or AlexaFluor488-conjugated anti-CD31 antibody (clone MEC13.3,
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
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Duffield Jeremy Stuart, In PLoS ONE, 2000
... Anti-CD31 antibody for immunoperoxidase studies was from Abcam (Cambridge, MA) ...
Cellular in vivo assay of calpain activity using a fluorescent substrate. Application to study of anoxic liver injury.
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Morty Rory Edward, In PLoS ONE, 1999
... CD31 (PECAM-1) antibody was from BD Biosciences Pharmingen (San Diego, CA) ...
MT1-MMP–dependent neovessel formation within the confines of the three-dimensional extracellular matrix
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Weiss Stephen J. et al., In The Journal of Cell Biology, 1999
... in culture, the collagen gel–embedded fragments were fixed, the endothelial cells were immunostained with anti–mouse CD31 antibody (BD Biosciences) followed with Alexa Fluor ...
Prox1 function is required for the development of the murine lymphatic system
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Maurer Dieter et al., In The Journal of Experimental Medicine, 1998
... Primary nonconjugated mouse mAbs used were anti–VE-cadherin (Immunotech), -CD31 (Ancell), -CD44 (Bender MedSystems), -CD45 ...
Differential binding characteristics and cellular inhibition by soluble VEGF receptors 1 and 2
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Huang Ying et al., In BMC Cancer, 1997
... Mouse monoclonal antibody for CD31 and LSAB kit were purchased from Dako (Denmark) ...
An entire functional mammary gland may comprise the progeny from a single cell.
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Najbauer Joseph, In PLoS ONE, 1997
... Fluorescent conjugated rat monoclonal antibodies against CD49f (GoH3), CD24 (M1/69), CD45 (30-F11), and CD31 (MEC 13.3) were purchased from BD Biosciences (San Jose, CA) ...
Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats
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McCullough Louise D et al., In Experimental & Translational Stroke Medicine, 1996
... cohort, mice were sacrificed 30 minutes after stroke; then brains were perfused and stained with CD31(eBioscience, San Diego, CA) and ...
Regulation of growth and prostatic marker expression by activin A in an androgen-sensitive prostate cancer cell line LNCAP
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Nishio K et al., In British Journal of Cancer, 1996
... -actin (Santa Cruz Biotechnology, Santa Cruz, CA, USA); and a mouse anti-CD31 monoclonal antibody (BD Biosciences, San Jose, CA, USA) ...
PECAM-1 (CD31) regulates a hydrogen peroxide–activated nonselective cation channel in endothelial cells
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Kotlikoff Michael I. et al., In The Journal of Cell Biology, 1996
... Newman (Blood Center of Southeastern Wisconsin, Milwaukee, WI); PCD, a rabbit polyclonal antibody directed against the PECAM-1 cytoplasmic domain; Sc-18 (Santa Cruz Biotechnology), a rabbit polyclonal antibody found ...
Interstitial fluid pressure, perfusion rate and oxygen tension in human melanoma xenografts
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Hill Richard P et al., In BMC Cancer, 1995
... CD31 (MMTV-PyMT transgenic n = 3, MMTV-PyMT orthotopic ...
The sialomucin CD34 is expressed on hematopoietic cells and blood vessels during murine development
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Augustin Hellmut G. et al., In The Journal of Cell Biology, 1994
... The monoclonal mouse anti-CD31 antibody and the monoclonal mouse anti-BrdU antibody were from Dako (Glostrup, Denmark) ...
Active immunotherapy of cancer with a nonreplicating recombinant fowlpox virus encoding a model tumor-associated antigen.
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Platten Michael, In PLoS ONE, 1994
... (normal cells) were isolated from BALB/c mice using magnetic dynabeads (Invitrogen, Karlsruhe, Germany) coated with CD31 antibody (BD Biosciences; Heidelberg, Germany) according to ...
Interaction of human malignant melanoma (ST-ML-12) tumor spheroids with endothelial cell monolayers. Damage to endothelium by oxygen-derived free radicals.
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Gullberg Donald, In PLoS ONE, 1991
... anti-human tenascin, polyclonal rabbit anti-human CD34, polyclonal rabbit anti-human pan-laminin (Abcam, UK), monoclonal mouse anti-human CD31, monoclonal mouse anti-human collagen-IV (Dako, Ely, UK) and polyclonal ...
Glutahione replenishment capacity is lower in isolated perivenous than in periportal hepatocytes
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Afford Simon C. et al., In Febs Letters, 1987
... 4% goat serum (Sigma) before the addition of mouse anti-human mAb (IgG Isotype-matched control (Invitrogen) CD31 (Dako), cytokeratin 19 (Dako), cytokeratin ...
A rapid method of total lipid extraction and purification.
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Holowka David, In PLoS ONE, 1958
... Antibodies against CD31 were from BD Biosciences (MEC 13.3) and Spring ...
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