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CD3g molecule, gamma

CD3 gamma, CD3G
The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, T3D, CD3epsilon, CD4, CD8
Papers on CD3 gamma
Epigenetic profiling in CD4+ and CD8+ T cells from Graves' disease patients reveals changes in genes associated with T cell receptor signaling.
New
Peterson et al., Tartu, Estonia. In J Autoimmun, Nov 2015
Among the hypermethylated CpG sites, we specifically found enrichment of genes involved in T cell signaling (CD247, LCK, ZAP70, CD3D, CD3E, CD3G, CTLA4 and CD8A) and decreased expression of CD3 gene family members.
In vivo immunotoxicity of perfluorooctane sulfonate in BALB/c mice: Identification of T-cell receptor and calcium-mediated signaling pathway disruption through gene expression profiling of the spleen.
New
Zhang et al., Beijing, China. In Chem Biol Interact, Nov 2015
Western blot analysis confirmed that the expressions of CAMK4, THEMIS, and CD3G, which were involved in the upregulated pathways, were induced upon PFOS exposure.
Characterisation of lymphocyte subpopulations in infantile haemangioma.
New
Tan et al., Wellington, New Zealand. In J Clin Pathol, Oct 2015
The presence of mRNA corresponding to CD45, CD3G, CD20 and Thy-1 was confirmed by reverse transcriptase-polymerase chain reaction in snap-frozen IH tissues.
Experimental hyperglycemia induces an increase of monocyte and T-lymphocyte content in adipose tissue of healthy obese women.
Rossmeislová et al., Praha, Czech Republic. In Plos One, 2014
Further, HG promoted an increase of mRNA levels of immune response markers (CCL2, TLR4, TNFα) and lymphocyte markers (CD3g, CD4, CD8a, TBX21, GATA3, FoxP3) in SAAT (p<0.05 and 0.01).
The expression of B & T cell activation markers in children's tonsils following live attenuated influenza vaccine.
Brokstad et al., Bergen, Norway. In Hum Vaccin Immunother, 2014
We observed that at d 3-4 post vaccination, 6 genes were down-regulated, namely APC, CD3G, FASLG, IL7, CD8A and TLR1.
A functional insertion/deletion polymorphism in the proximal promoter of CD3G is associated with susceptibility for hepatocellular carcinoma in Chinese population.
GeneRIF
Gao et al., Suzhou, China. In Dna Cell Biol, 2012
roles of CD3G polymorphisms in predisposition for HCC
[Expression and clinical significance of CD3, CD4 and COX-2 in non-small cell lung cancer].
GeneRIF
Jiao et al., Beijing, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012
Data show that the expressions of CD3, CD4 were significantly associated with overall survival(OS) of non-small cell lung cancer (NSCLC) patients.
Altered expression of the TCR signaling related genes CD3 and FcεRIγ in patients with aplastic anemia.
GeneRIF
Li et al., Guangzhou, China. In J Hematol Oncol, 2011
Altered expression of the TCR signaling related genes CD3 and FcepsilonRIgamma in patients with aplastic anemia.
Epidermal CCR6+ γδ T cells are major producers of IL-22 and IL-17 in a murine model of psoriasiform dermatitis.
GeneRIF
Hwang et al., Milwaukee, United States. In J Immunol, 2011
A transgenic T cell receptor gammadelta-low expressing subset of T cells accumulates in mouse epidermis after IL-23 injections.
CD3γ-independent pathways in TCR-mediated signaling in mature T and iNKT lymphocytes.
GeneRIF
Recio et al., Madrid, Spain. In Cell Immunol, 2010
Data show that TCRzeta phosphorylation signal pathways were affected in CD3gamma(-/-) primary and HVS-transformed T cells.
Hierarchical role of CD3 chains in thymocyte development.
Review
Dave, Montréal, Canada. In Immunol Rev, 2009
Invariant CD3gamma, delta, epsilon, and zeta polypeptides are central to the function of these two receptor complexes.
A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta-chain degradation.
Impact
Wang et al., Yokohama, Japan. In Immunity, 2008
We demonstrate that the lysosomal protein LAPTM5 negatively regulated surface TCR expression by specifically interacting with the invariant signal-transducing CD3zeta chain and promoting its degradation without affecting other CD3 proteins, CD3epsilon, CD3delta, or CD3gamma.
[Expression anomalies of the CD3-TCR complex expression and immunodeficiencies].
Review
Fischer et al., Montréal, Canada. In Med Sci (paris), 2007
The main differences observed involve the respective roles of the CD3gamma chain as well as the CD3delta, whose functions seem to be reciprocal between the two species.
CD3 deficiencies.
Review
Le Deist et al., Paris, France. In Curr Opin Allergy Clin Immunol, 2005
These results contrast with the partial T-cell immunodeficiency caused by a deficiency in CD3G.
CD3 delta immunodeficiency.
Review
Roifman, Toronto, Canada. In Curr Opin Allergy Clin Immunol, 2004
SUMMARY: Unlike patients with CD3 gamma or CD3 epsilon deficiency who have a milder condition, patients with CD3 delta deficiency present with severe lethal susceptibility to infections during early infancy.
TCR trafficking in resting and stimulated T cells.
Review
Geisler, Copenhagen, Denmark. In Crit Rev Immunol, 2003
Constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif in the TCR subunit CD3g and might play a role in quality control of the TCR.
Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer.
Impact
Reinherz et al., Boston, United States. In Cell, 2001
CD3 epsilon and CD3 gamma are integral components of both the TCR and pre-TCR.
Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells.
Impact
Kruisbeek et al., Amsterdam, Netherlands. In Immunity, 1999
Signaling through the pre-TCR is essential for early T cell development and is severely impaired in mice lacking the CD3 gamma chain of the pre-TCR.
Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.
Impact
Alt et al., Boston, United States. In Science, 1993
RAG-2-/- mice have small numbers of TCR-CD4-CD8-(double negative, DN) thymocytes that express CD3 gamma delta epsilon and zeta proteins intracellularly.
Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency.
Impact
Lisowska-Grospierre et al., Paris, France. In Nat Genet, 1993
The T-cell receptor (TCR) is composed of two glycoproteins (alpha and beta or gamma and delta) associated with four invariant polypeptides (CD3-gamma, delta, epsilon and zeta).
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