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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CD28 molecule

The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: CD4, CD8, CAN, HAD, Interleukin-2
Papers using CD28 antibodies
Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis.
Ryffel Bernhard, In PLoS ONE, 2009
... Monoclonal antibodies to murine CD3 (2C11) and CD28 (37.51) were purchased from eBioscience and BD Biosciences, respectively ...
Identification of IL-17-producing FOXP3+ regulatory T cells in humans
Salh Baljinder et al., In BMC Immunology, 2008
... integrin antibody, alpha 5 integrin si-RNA, and ILK antibody from Santa Cruz (Santa Cruz, CA); anti-CD3, anti-CD28 antibody from BD Biosciences.
Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival.
Kanellopoulos Jean, In PLoS ONE, 2008
... Cells were activated with a mixture of soluble anti-CD3ε (HIT3a, BD Biosciences) and anti-CD28 (BD Biosciences), or with 20–40 ...
Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression.
Wu Yuntao, In PLoS ONE, 2008
... The purified monoclonal antibodies (mAbs) 〈CD2 (OKT3) and 〈CD28 (28.2) were purchased from eBioscience.
Perturbation of T-cell development by insertional mutation of a PrP transgene
Stüve Olaf et al., In Brain, 2008
... Hamster anti-mouse CD3 (145-2C11) and hamster anti-mouse CD28 (37.51) monoclonal antibodies were purchased from BD Biosciences.
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Papers on CD28
Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation.
Lombardi et al., London, United Kingdom. In Oncotarget, Feb 2016
This is the first report of the manufacture of clinical grade Tregs from prospective liver transplant recipients via a CliniMACS-based GMP isolation technique and expanded using anti-CD3/CD28 beads, IL-2 and rapamycin.
Immunomodulatory potential of Rhein, an anthraquinone moiety of Cassia occidentalis seeds.
Das et al., Lucknow, India. In Toxicol Lett, Feb 2016
Lymphocyte receptor expression analysis revealed that Rhein exposure significantly down regulate the expression of CD3e, CD4, CD8, CD28, CD69 molecules in T-cells.
Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-κB, NFAT and AP-1.
Steinberger et al., Vienna, Austria. In J Immunol Methods, Feb 2016
Ligation of the TCR complex induced moderate reporter activity, which was strongly enhanced upon coengagement of the costimulatory receptors CD2 or CD28.
Dietary supplementation with purified citrus limonin glucoside does not alter ex vivo functions of circulating T lymphocytes or monocytes in overweight/obese human adults.
Kelley et al., Davis, United States. In Nutr Res, Jan 2016
Peripheral blood mononuclear cells were isolated and activated with CD3 plus CD28 antibodies (T-lymphocyte activation) or lipopolysaccharide (monocyte activation).
Using GWAS to identify genetic predisposition in hepatic autoimmunity.
Hirschfield et al., Birmingham, United Kingdom. In J Autoimmun, Jan 2016
Potential functional implications of key findings are discussed including the IL-12/STAT4 pathway in PBC and the CD28/IL-2 pathway in PSC.
T cells from patients with Candida sepsis display a suppressive immunophenotype.
Hotchkiss et al., Saint Louis, United States. In Crit Care, Dec 2015
Compared to control patients, CD8 T cells from patients with Candidemia had evidence of cellular activation as indicated by increased CD69 expression while CD4 T cells had decreased expression of the major positive co-stimulatory molecule CD28.
Integrated molecular analysis of adult T cell leukemia/lymphoma.
Ogawa et al., Kyoto, Japan. In Nat Genet, Nov 2015
Other notable features include a predominance of activating mutations (in PLCG1, PRKCB, CARD11, VAV1, IRF4, FYN, CCR4 and CCR7) and gene fusions (CTLA4-CD28 and ICOS-CD28).
Current status of pig kidney xenotransplantation.
Kobayashi et al., Pittsburgh, United States. In Int J Surg, Nov 2015
An anti-CD40 mAb-based regimen is proving equally successful, but blockade of the CD28/B7 pathway is inadequate.
TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation.
Li et al., Guangzhou, China. In Nat Immunol, Nov 2015
We found that the kinase PKC-θ was sumoylated upon costimulation with antigen or via the TCR plus the coreceptor CD28, with Lys325 and Lys506 being the main sumoylation sites.
Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells.
Sadelain et al., New York City, United States. In Cancer Cell, Nov 2015
Using an in vivo "stress test" to challenge CD19-targeted T cells, we studied the functionality and persistence imparted by seven different CAR structures providing CD28 and/or 4-1BB costimulation.
Shifting the Evolving CAR T Cell Platform into Higher Gear.
Bluestone et al., San Francisco, United States. In Cancer Cell, Nov 2015
In this issue of Cancer Cell, Zhao and colleagues test various chimeric antigen receptor (CAR) T cells to show that CD28-CD3ζ CAR T cells that constitutively express 4-1BBL promote T cell expansion and tumor eradication while reducing exhaustion.
Agonists of Co-stimulation in Cancer Immunotherapy Directed Against CD137, OX40, GITR, CD27, CD28, and ICOS.
Melero et al., Pamplona, Spain. In Semin Oncol, Aug 2015
Co-stimulatory receptors include surface moieties that are constitutively expressed on resting lymphocytes such as CD28 or CD27 and others whose expression is induced upon recent previous antigen priming, ie, CD137, GITR, OX40, and ICOS.
Antagonism of aminoacid transport in primary CD4 T cells by HIV-1 Vpu.
Lehner et al., Manchester, United Kingdom. In Lancet, Mar 2015
TOV3 was highly expressed in primary human CD4 T cells, and depletion of TOV3 by RNA interference markedly impaired the mitogenic response to CD3/CD28 stimulation.
Co-Stimulatory Blockade of the CD28/CD80-86/CTLA-4 Balance in Transplantation: Impact on Memory T Cells?
Vanhove et al., Nantes, France. In Front Immunol, 2014
CD28 and CTLA-4 are prototypal co-stimulatory and co-inhibitory cell surface signaling molecules interacting with CD80/86, known to be critical for immune response initiation and regulation, respectively.
[Immunological Aspects in Oncology--Circulating γδ T Cells].
Dubská et al., In Klin Onkol, 2014
Detailed immunophenotyping was also conducted describing representation of memory subsets (using CD45RO and CD27 markers) and presence of surface markers HLADr, CD69, CD25, CD28, CCR7, CTLA 4, ICOS, PD 1L and PD 1 between γδ T cells of the controls and breast carcinoma patients.
Association of genetic variation in co-stimulatory molecule genes with outcome of liver transplant in Iranian patients.
Nikeghbalian et al., Shīrāz, Iran. In Gene, 2012
Genetic variation in CD28 gene is associated with acute rejection of liver transplantation.
B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production.
Silva-Santos et al., Lisbon, Portugal. In J Immunol, 2012
B7 costimulatory antigen and CD28 interactions promote proliferation and survival of activated murine gammadelta T cells following Plasmodium infection.
Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity.
Lew et al., Australia. In Eur J Immunol, 2012
Direct CD28 costimulation of CD8-positive T-lymphocytes is critial in their priming during primary influenza infection.
AP-1 is involved in ICOS gene expression downstream of TCR/CD28 and cytokine receptor signaling.
Abe et al., Noda, Japan. In Eur J Immunol, 2012
Results indicate AP-1 transcription factors are involved in ICOS gene expression downstream of both TCR/CD28 signaling and cytokine receptor signaling.
CD40, CD45 CTLA-4 levels are elevated in healthy older adults.
Terzioglu et al., Antalya, Turkey. In Clin Lab, 2011
CTLA-4 expression levels were higher in older subjects, with no difference in CD28 expression levels between younger/older individuals.
More papers using CD28 antibodies
Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation.
Matloubian Mehrdad, In PLoS ONE, 2007
... The indicated CD28, B7, and RAG2-GFP transgenic mice were bred onto ...
Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cells.
Zimmer Jacques, In PLoS ONE, 2007
anti-CD4-APC, anti-CD4-FITC, and anti-CD28 (Biolegend, San Diego, CA, USA); ...
Hydrogen peroxide induces the production of tumor necrosis factor-α in RAW 264.7 macrophage cells via activation of p38 and stress-activated protein kinase
Mizuno Masashi et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... antibody and antimouse CD28 antibody were purchased from Biolegend (San Diego, USA) ...
Cell type-specific functions of Rho GTPases revealed by gene targeting in mice.
Unutmaz Derya, In PLoS ONE, 2006
... cells were incubated with anti-mouse CD3ε mAb (2c11, BD Pharmingen, San Diego, CA) and anti-mouse CD28 mAb (37.51, eBioscience, San Diego, CA) (both ...
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors
Marrack Philippa, In PLoS Biology, 2006
... Purified CD3ɛ (145–2C11) and CD28 (37.51) antibodies (eBioscience) were used at indicated ...
Nanostructures and molecular force bases of a highly sensitive capacitive immunosensor.
Unutmaz Derya, In PLoS ONE, 2004
... Anti-CD3-coated or anti-CD3/anti-CD28-coated 96-well plates were from BD Biosciences.
Inhibitors of mitogen-activated protein kinases differentially regulate costimulated T cell cytokine production and mouse airway eosinophilia
Pahl Andreas et al., In BMC Immunology, 2004
... Purified anti-human CD3 and purified anti-human CD28 were obtained from PharMingen Becton Dickinson Company (Heidelberg, Germany) ...
Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator.
Unutmaz Derya, In PLoS ONE, 2004
... activation was performed using soluble 1 µg/ml anti CD3 (clone OKT3) antibody (ebioscience) and 2 µg/ml anti CD28 (clone 28.2) antibody (ebioscience).
Delivery of bioactive molecules into the cell: the Trojan horse approach
Kabouridis Panagiotis S. et al., In Febs Letters, 2003
... combination of mAbs were used; anti-human CD3 (clone HIT3a)/CD28 (clone CD28.2), and anti-mouse CD3 (clone 145-2C11)/CD28 (clone 37.51) from eBioscience (San Diego, CA) ...
The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL–C3G-mediated activation of Rap1
Billadeau Daniel D. et al., In The Journal of Cell Biology, 2003
... The OKT3 mAb antibody was obtained from the Mayo Pharmacy and the anti-CD28 mAb was purchased from BD Biosciences.
Experimental autoimmune uveoretinitis in the rat and mouse.
Pablo Villoslada, In PLoS ONE, 2002
... Anti-CD3 and anti-CD28 antibodies were purchased from eBioscience (San Diego, CA, USA) ...
Differential Regulation of TCR-mediated Gene Transcription by Vav Family Members
Billadeau Daniel D. et al., In The Journal of Experimental Medicine, 2002
... The anti-CD28 mAb was purchased from BD Biosciences, and the antiphosphotyrosine mAb ...
Combined Deficiency of p50 and cRel in CD4+ T Cells Reveals an Essential Requirement for Nuclear Factor κB in Regulating Mature T Cell Survival and In Vivo Function
Beg Amer A. et al., In The Journal of Experimental Medicine, 2001
... T cells were activated by culture in the presence of 1 μg/ml plate-bound αCD3 and 1 μg/ml αCD28 (BD Biosciences) monoclonal antibodies ...
Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis.
Papavasiliou Nina, In PLoS ONE, 2001
... and stimulated with plate-bound anti-CD3 mAb (clone OKT3; kindly provided by Janssen-Cilag, Neuss, Germany) and anti-CD28 mAb (ANC28.1/5D10;
Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis
Khoury Samia J. et al., In The Journal of Experimental Medicine, 2001
... Female WT or CD28-deficient C57BL/6 mice, and WT or DO-11.10
CD28 Costimulation Is Required for In Vivo Induction of Peripheral Tolerance in CD8 T Cells
Hodes Richard J. et al., In The Journal of Experimental Medicine, 2000
... CD28WT H-Y mice were bred with mice deficient in CD28 (CD28KO; The Jackson Laboratory) to establish TCR transgenic RAG-2–deficient CD28-deficient (CD28KO H-Y) ...
Replication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase.
Arendt Christopher, In PLoS ONE, 2000
... T cells were activated using anti-CD3/CD28 coated beads (Dynabeads, Invitrogen) and cultured in RPMI media (Life Technologies) with 10% fetal calf ...
Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding.
Douek Danny C., In PLoS Pathogens, 1999
... Culture Collection, Manassas, Virginia, United States) in RPMI with 10% FBS supplemented with 1 µg/ml soluble anti-CD28 antibodies (BD Biosciences Pharmingen) and 50 U/mL ...
Transforming Growth Factor β Blocks Tec Kinase Phosphorylation, Ca2+ Influx, and NFATc Translocation Causing Inhibition of T Cell Differentiation
Ray Anuradha et al., In The Journal of Experimental Medicine, 1998
... Anti-CD28 (37.51), anti-CD3ɛ (145–2C11) were purchased from BD Biosciences.
Inflammation and Alzheimer's disease pathogenesis.
Breithaupt T B et al., In BMC Immunology, 1995
... Louis, Mo.), fetal calf serum from Harlan Bioproducts (Madison, Wis.), anti-CD28 and anti-CD3 (4E) from Research Diagnostics (Flanders, N.J.) ...
Topological Requirements and Signaling Properties of T Cell–activating, Anti-CD28 Antibody Superagonists
Hünig Thomas et al., In The Journal of Experimental Medicine, 1995
... Anti–mouse CD28 (clone 37.51; reference 16), mouse anti–phosphotyrosine (clone 4G10), and mouse anti–human CD3 (clone UCHT1) was purchased from BD Biosciences.
GATA-3 in Human T Cell Helper Type 2 Development
Schulze-Koops Hendrik et al., In The Journal of Experimental Medicine, 1990
... anti-CD4 (Sigma-Aldrich); anti-CD19 and FITC-labeled anti–HLA-DR (DakoCytomation); PE-labeled anti–IL-4 (MP4-25D2), FITC-labeled anti–IFN-γ (4S.B3), and anti-CD28 (CD28.2;
Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo
Mascaró Cristina et al., In Molecular Therapy. Nucleic Acids, 1989
... Beadlyte 7-plex human T receptor signaling kit (Millipore) after 10-minute stimulation with 1 µg/ml CD3 and 0.5 µg/ml CD28 mAb (BD Biosciences).
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