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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Dipeptidyl-peptidase 4

CD26, dipeptidyl peptidase IV, DPP IV
The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DSP, Glucagon, E4, Insulin, CAN
Papers on CD26
Enzymatic generation of whey protein hydrolysates under pH-controlled and non pH-controlled conditions: Impact on physicochemical and bioactive properties.
FitzGerald et al., Limerick, Ireland. In Food Chem, Jun 2016
In contrast, there was no significant effect of pH regulation on dipeptidyl peptidase IV (DPP-IV) properties.
Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity.
Watt et al., London, United Kingdom. In Cell Rep, Feb 2016
However, each tumor had a distinct stromal signature in terms of immune cell infiltrate and expression of CD26 and CD44.
Dipeptidyl Peptidase IV-Inhibitory Peptides Derived from Silver Carp (Hypophthalmichthys molitrix Val.) Proteins.
Chen et al., In J Agric Food Chem, Feb 2016
UNASSIGNED: The dipeptidyl peptidase IV (DPP-IV)-inhibitory bioactivity of silver carp proteins (SCPs) hydrolysates were investigated, and their containing efficacious DPP-IV-inhibitory peptides were explored by in silico hydrolysis analysis, peptides separation combined with LC-MS/MS identification and chemical synthesis.
CD26/dipeptidylpeptidase IV-chemokine interactions: double-edged regulation of inflammation and tumor biology.
Struyf et al., Leuven, Belgium. In J Leukoc Biol, Feb 2016
CD26/dipeptidylpeptidase IV, ubiquitously expressed in tissues and blood, removes NH2-terminal dipeptides from proteins with a penultimate Pro or Ala.
Unravelling the immunological roles of dipeptidyl peptidase 4 (DPP4) activity and/or structure homolog (DASH) proteins.
von Hörsten et al., Stuttgart, Germany. In Clin Exp Immunol, Jan 2016
UNASSIGNED: Dipeptidyl peptidase 4 (CD26, DPP4) is a multifunctional protein involved in T-cell activation by co-stimulation via its association with ADA, Caveolin-1, CARMA-1, CD45, M6P/IGFII-R and CXC-R4.
Cellular and molecular mechanisms in graft-versus-host disease.
Wei et al., Hefei, China. In J Leukoc Biol, Jan 2016
Accumulation of CD26 T cells in graft-versus-host disease target organs was found.
GLP-1 mimetic drugs and the risk of exocrine pancreatic disease: Cell and animal studies.
Williams, Ann Arbor, United States. In Pancreatology, Jan 2016
It is released in response to the presence of nutrients in the small intestine and stimulates vagal afferent nerve endings as well as entering the blood where it is rapidly degraded by dipeptidyl peptidase IV.
[Short bowel syndrome and intestinal failure - new developments].
Lamprecht, Rostock, Germany. In Dtsch Med Wochenschr, Dec 2015
Teduglutide, a DPP-IV resistant GLP2 analogue, is available a pharmacologic treatment, which stimulates intestinal absorption and can facilitate infusion free days.
CD26 costimulatory blockade improves lung allograft rejection and is associated with enhanced interleukin-10 expression.
Jungraithmayr et al., Zürich, Switzerland. In J Heart Lung Transplant, Dec 2015
BACKGROUND: The ectoenzyme CD26/dipeptidyl peptidase 4 (DPP4) has costimulatory activity that contributes to T cell activation and proliferation.
Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy.
Albert et al., Paris, France. In Nat Immunol, Aug 2015
Here we show that in vivo post-translational processing of chemokines by dipeptidylpeptidase 4 (DPP4, also known as CD26) limits lymphocyte migration to sites of inflammation and tumors.
Skin fibrosis. Identification and isolation of a dermal lineage with intrinsic fibrogenic potential.
Longaker et al., Stanford, United States. In Science, May 2015
Using flow cytometry, we identify CD26/DPP4 as a surface marker that allows isolation of this lineage.
Mutation screening for thalassaemia in the Jino ethnic minority population of Yunnan Province, Southwest China.
Jia et al., Shanghai, China. In Bmj Open, 2014
and CD26 (HbE or HBB:c.79G>A).
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26.
Gao et al., Beijing, China. In Nature, 2013
CD26 (also known as dipeptidyl peptidase 4, DPP4) was recently identified as the cellular receptor for MERS-CoV.
Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC.
Haagmans et al., Rotterdam, Netherlands. In Nature, 2013
Here we identify dipeptidyl peptidase 4 (DPP4; also known as CD26) as a functional receptor for hCoV-EMC.
Dipeptidyl peptidase-4 expression is reduced in Crohn's disease.
McLaughlin et al., Manchester, United Kingdom. In Regul Pept, 2012
DP4 is reduced in tissue and plasma in active Crohn's disease.
Compartment- and malignance-dependent up-regulation of γ-glutamyltranspeptidase and dipetidylpeptidase-IV activity in human brain gliomas.
Šedo et al., Praha, Czech Republic. In Histol Histopathol, 2012
we report on up-regulation of dipeptidylpeptidase-IV in human brain gliomas
Association between HbA1c and dipeptidyl peptidase IV activity in type 2 diabetes mellitus.
Moretto et al., In Clin Chim Acta, 2012
an association between HbA1c and dipeptidyl peptidase IV activity in type 2 diabetes mellitus
Human Th17 cells express high levels of enzymatically active dipeptidylpeptidase IV (CD26).
Thimme et al., Freiburg, Germany. In J Immunol, 2012
Analysis of CD26 expression on different CD4+ T helper subsets shows that CD26 expression is highest on CD4+ T cells producing type 17 cytokines compared with T helper type (Th)1, Th2, and regulatory T cells.
Plasma seprase and DPP4 levels as markers of disease and prognosis in cancer.
Chen et al., Stony Brook, United States. In Dis Markers, 2011
Higher plasma DPP4 was associated with better survival in all cancer types
A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer.
Wong et al., Hong Kong, Hong Kong. In Cell Stem Cell, 2010
CD26-expression cells are responsible for tumor growth, metastasis and chemoresistance in colorectal cancer
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