Histopathologic and immunophenotypical criteria for the diagnosis of Sézary syndrome in differentiation from other erythrodermic skin diseases: An EORTC Cutaneous Lymphoma Task Force Study of 97 cases.
Mannheim, Germany. In Br J Dermatol, 09 May 2015
Evaluation criteria were: epidermal and dermal changes, morphology of the infiltrate, immunohistochemical analysis of marker loss (CD2, CD3, CD4, CD5 and CD7), bystander infiltrate by stainings for CD8, FOXP3 and CD25 and expression of Ki-67, CD30, PD-1 and MUM-1.
Endophilin marks and controls a clathrin-independent endocytic pathway.
Cambridge, United Kingdom. In Nature, Feb 2015
This pathway mediates the ligand-triggered uptake of several G-protein-coupled receptors such as α2a- and β1-adrenergic, dopaminergic D3 and D4 receptors and muscarinic acetylcholine receptor 4, the receptor tyrosine kinases EGFR, HGFR, VEGFR, PDGFR, NGFR and IGF1R, as well as interleukin-2 receptor.
Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation.
Lisbon, Portugal. In Front Immunol, Dec 2014
Some of the key players are the costimulatory receptors CD27 and CD28, which differentially impact on pro-inflammatory subsets of γδ T-cells; the cytokine receptors IL-2R, IL-7R, and IL-15R, which drive functional differentiation and expansion of γδ T-cells; the NK receptor NKG2D and its contribution to γδ T-cell cytotoxicity; and the inhibitory receptors PD-1 and BTLA that control γδ T-cell homeostasis.
A modified γ-retrovirus vector for X-linked severe combined immunodeficiency.
London, United Kingdom. In N Engl J Med, Nov 2014
BACKGROUND: In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus-based γ-retrovirus vector expressing interleukin-2 receptor γ-chain (γc) complementary DNA successfully restored immunity in most patients but resulted in vector-induced leukemia through enhancer-mediated mutagenesis in 25% of patients.
Utilizing regulatory T cells against rheumatoid arthritis.
More papers using
United States. In Front Oncol, 2013
CD4(+)CD25(+) Treg cells are well-known suppressive cells, which express the transcription factor Foxp3, are indispensable for the maintenance of immune self-tolerance and homeostasis by suppressing aberrant or excessive immune response.