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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 04 Oct 2015.

Interleukin 2 receptor, alpha

CD25, IL-2R, interleukin-2 receptor
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: CD4, Foxp3, Interleukin-2, CAN, CD8
Papers using CD25 antibodies
Increased T regulatory cells lead to development of Th2 immune response in male SJL mice
Deth Richard et al., In Autism Research and Treatment, 2010
... All antibodies except for anti-CD25 mAb were from BD Biosciences (San Jose, CA) ...
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells.
Unutmaz Derya, In PLoS ONE, 2010
... Directly conjugated mAbs against CD4-APC, CD8-APC, CD3-PerCP, CD25-PE (all from BD Biosciences, Oxford, UK), ...
Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression.
Wu Yuntao, In PLoS ONE, 2008
... Fluorophore-conjugated CXCR4 (12GS), CCR5 (T21/8), CD25 (BC96), and CD45RO were purchased from Biolegend.
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo.
Ahuja Sunil K., In PLoS ONE, 2005
... T cells were then stained with CD4-FITC and CD25-PE (both from BD Biosciences, USA), and their purity ...
CD25+CD4+ Regulatory T Cells from the Peripheral Blood of Asymptomatic HIV-infected Individuals Regulate CD4+ and CD8+ HIV-specific T Cell Immune Responses In Vitro and Are Associated with Favorable Clinical Markers of Disease Status
Fauci Anthony S. et al., In The Journal of Experimental Medicine, 2001
... cells using anti-CD25–coupled immunomagentic beads (Miltenyi Biotec) to obtain CD25-depleted PBMCs or exposed to a cocktail of immunomagnetic beads (StemCell Technologies Inc.) to obtain CD4 ...
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Papers on CD25
Implication of B lymphocytes in the pathogenesis of ANCA-associated vasculitides.
Mouthon et al., Paris, France. In Autoimmun Rev, 30 Nov 2015
Perturbations of B-cell homeostasis have been identified in AAV with increased expression of CD38 and decreased expression of CD5 in active phase, contrasting with increased expression of CD25 and CD86 in remission state.
Origin and functions of pro-inflammatory cytokine producing Foxp3(+) regulatory T cells.
Zhu et al., Cleveland, United States. In Cytokine, 30 Nov 2015
CD4(+)CD25(+)Foxp3(+) regulatory cells (Tregs) are a special lineage of cells central in the maintenance of immune homeostasis, and are targeted for human immunotherapy.
Regulatory B Cells with a Partial Defect in CD40 Signaling and Overexpressing Granzyme B Transfer Allograft Tolerance in Rodents.
Chiffoleau et al., Nantes, France. In J Immunol, 02 Nov 2015
Regulatory B cells were not required for induction of tolerance and appeared following Foxp3(+)CD4(+)CD25(+) regulatory T cells, suggesting cooperation with regulatory T cells for their expansion.
The Timing of Stimulation and IL-2 Signaling Regulate Secondary CD8 T Cell Responses.
Badovinac et al., Iowa City, United States. In Plos Pathog, 31 Oct 2015
The timing of stimulation of 1° M CD8 T cells also impacted the duration of expression of the high-affinity IL-2 receptor (CD25) on 2° effector CD8 T cells and their sensitivity to IL-2 signaling.
Characteristics of the peripheral T cell immune response of patients at different stages of vascular cognitive impairment.
Benyan et al., Hangzhou, China. In Immunol Lett, 30 Oct 2015
Peripheral CD8(+)T, CD4(+)CD25(+) Treg, CD4(+)IL-17(+) Th17 cells proportion, and IL-1β, IL-2, IL-6, IFN-γ levels, and neuropsychological function were assessed.
Immune modulation of T regulatory cells and IgE responses in horses vaccinated with West Nile virus vaccine combined with a CpG ODN.
Gershwin et al., Davis, United States. In Vaccine, 27 Oct 2015
Multicolor flow cytometry was used to evaluate expression of CD4, CD25, and intracellular Foxp3 on PBMCs.
IL-27 and TGFβ mediated expansion of Th1 and adaptive regulatory T cells expressing IL-10 correlates with bacterial burden and disease severity in pulmonary tuberculosis.
Babu et al., Chennai, India. In Immun Inflamm Dis, 30 Sep 2015
We first demonstrate that TB antigens induce an expansion of IL-10 expressing Th1 (IL-10(+), IFNγ(+), T-bet(+)), Th2 (IL-10(+), IL-4(+), GATA-3(+)), Th9 (IL-10(+), IL-9(+), IL-4(-)), Th17 (IL-10(+), IL-17(+), IFNγ(-)), and natural and adaptive regulatory T cells [nTregs; IL-10(+), CD4(+), CD25(+), Foxp3(+) and aTregs; IL-10 single(+), CD4(+), CD25(-), Foxp3(-)] in PTB and LTB individuals, with frequencies being significantly higher in the former.
Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms.
Garcia et al., Stanford, United States. In Immunity, Jun 2015
IL-2 signals via interleukin-2 receptor-β (IL-2Rβ):IL-2Rγ heterodimers on cells expressing high (regulatory T cells, Treg) or low (effector cells) amounts of IL-2Rα (CD25).
Systemic mastocytosis in adults: 2015 update on diagnosis, risk stratification, and management.
Pardanani, Rochester, United States. In Am J Hematol, Mar 2015
Minor diagnostic criteria include elevated serum tryptase level, abnormal MC expression of CD25 and/or CD2, and presence of KITD816V.
Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability.
Turka et al., Boston, United States. In Nat Immunol, Feb 2015
Diminished control of PI(3)K activity in Treg cells led to reduced expression of the interleukin-2 (IL-2) receptor α subunit CD25, accumulation of Foxp3(+)CD25(-) cells and, ultimately, loss of expression of the transcription factor Foxp3 in these cells.
Endophilin marks and controls a clathrin-independent endocytic pathway.
McMahon et al., Cambridge, United Kingdom. In Nature, Feb 2015
This pathway mediates the ligand-triggered uptake of several G-protein-coupled receptors such as α2a- and β1-adrenergic, dopaminergic D3 and D4 receptors and muscarinic acetylcholine receptor 4, the receptor tyrosine kinases EGFR, HGFR, VEGFR, PDGFR, NGFR and IGF1R, as well as interleukin-2 receptor.
Glucocorticoid-induced tumour necrosis factor receptor-related protein: a key marker of functional regulatory T cells.
Riccardi et al., Perugia, Italy. In J Immunol Res, Dec 2014
Furthermore, some Treg subsets including Tr1 cells express either low or no classical Treg markers (e.g., FoxP3 and CD25) and do express GITR.
A modified γ-retrovirus vector for X-linked severe combined immunodeficiency.
Thrasher et al., London, United Kingdom. In N Engl J Med, Nov 2014
BACKGROUND: In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus-based γ-retrovirus vector expressing interleukin-2 receptor γ-chain (γc) complementary DNA successfully restored immunity in most patients but resulted in vector-induced leukemia through enhancer-mediated mutagenesis in 25% of patients.
CD8αα⁺ innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity.
Olivares-Villagómez et al., Nashville, United States. In Immunity, Oct 2014
Development of iCD8α cells depends on expression of interleukin-2 receptor γ chain (IL-2Rγc), IL-15, and the major histocompatibility complex (MHC) class Ib protein H2-T3, also known as the thymus leukemia antigen or TL.
[Mastocytosis. Review of the literature and description of clinical cases].
Obukhova et al., In Ter Arkh, 2013
Abnormal mast cells are characterized by the atypical morphology and pathological expression of CD25 and CD2 antigens.
Cell surface expression of CD25 antigen (surface IL-2 receptor α-chain) is not a prognostic marker in chronic lymphocytic leukemia: results of a retrospective study of 281 patients.
Israeli CLL Study Group et al., Jerusalem, Israel. In Ann Hematol, 2012
There is no correlation between CD25 expression on the surface of chronic lymphocytic leukemia (CLL) cells and time to first treatment or overall survival; CD25 expression does not appear to be a prognostic factor in CLL.
Foxp3+CD25(high) CD4+ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity.
Gomes et al., Belo Horizonte, Brazil. In Immunobiology, 2012
Data indicate that the frequency of Foxp3(+)CD25(high) CD4(+)-T cells is augmented and correlated with the maintenance of a better cardiac function in indeterminate (IND) Chagas disease.
Inhibition of allogenic T-cell cytotoxicity by hepatic stellate cell via CD4⁺ CD25⁺ Foxp3⁺ regulatory T cells in vitro.
Lee et al., Taiwan. In Transplant Proc, 2012
Hepatic stellate cells seem to act as liver-resident antigen-presenting cells instructing the generation of CD4/CD25/Foxp3(+) regulatory T cells.
The interleukin-2 receptor α chain (CD25) plays an important role in regulating monocyte-derived CD40 expression during anti-porcine cellular responses.
Xu et al., Jinan, China. In Transplant Proc, 2012
CD25 plays an important role in regulating monocyte-derived CD40 expression during anti-porcine cellular responses.
Soluble cytokine receptors (sIL-2Rα, sIL-2Rβ) induce subunit-specific behavioral responses and accumulate in the cerebral cortex and basal forebrain.
Siegel et al., Newark, United States. In Plos One, 2011
sIL-2Ralpha and sIL-2Rbeta induce marked subunit- and soluble cytokine receptor-specific behavioral disturbances
More papers using CD25 antibodies
Phenotype, Localization, and Mechanism of Suppression of CD4+CD25+ Human Thymocytes
Romagnani Sergio et al., In The Journal of Experimental Medicine, 2000
... The goat anti–mouse IgG and anti-CD25 Abs conjugated with magnetic beads were obtained from Miltenyi Biotec.
Human foamy virus capsid formation requires an interaction domain in the N terminus of Gag
Young John A. T, In PLoS Pathogens, 2000
anti-CD14 (Clone TUK4, Miltenyi Biotec), Phycoerythrin-conjugated anti-CD25 (clone 4E3, Miltenyi Biotec), and anti HLA-DR (L243, ...
Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding.
Douek Danny C., In PLoS Pathogens, 1999
... Naïve cells were subsequently purified by staining with CD45RO-FITC and CD25-PE (BD Pharmingen, San Jose, CA) followed by sorting on a FACSAria (Becton Dickinson, San Jose, CA) ...
Naturally anergic and suppressive CD25+CD4+ T cells as a functionally and phenotypically distinct immunoregulatory T cell population
Roncarolo Maria-Grazia et al., In The Journal of Experimental Medicine, 1999
... cells were stained with PE-coupled anti-CD25 mAbs and purified after the addition of anti-PE–coupled magnetic beads (Miltenyi Biotec).
Failure of B-cell differentiation in mice lacking the transcription factor EBF
Winkler Thomas H. et al., In The Journal of Experimental Medicine, 1994
... –hu-CD25 and Production of Transgenic Mice.
A common factor regulates both Th1- and Th2-specific cytokine gene expression
Joshi Beenu et al., In Lipids in Health and Disease, 1993
anti-human CD25-PECy5, were from Becton Dickinson,USA ...
The Genetical Interpretation of Statistics of the Third Degree in the Study of Quantitative Inheritance.
Desrosiers Ronald C., In PLoS Pathogens, 1931
... cells were further isolated with CD25 magnetic beads and two passages on MS columns (Miltenyi Biotec, Bergisch-Gladbach, Germany) ...
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