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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 11 Dec 2014.

Interleukin 2 receptor, alpha

CD25, IL-2R, interleukin-2 receptor
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: CD4, Foxp3, Interleukin-2, CAN, CD8
Papers using CD25 antibodies
Increased T regulatory cells lead to development of Th2 immune response in male SJL mice
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Deth Richard et al., In Autism Research and Treatment, 2010
... All antibodies except for anti-CD25 mAb were from BD Biosciences (San Jose, CA) ...
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells.
Supplier
Unutmaz Derya, In PLoS ONE, 2010
... Directly conjugated mAbs against CD4-APC, CD8-APC, CD3-PerCP, CD25-PE (all from BD Biosciences, Oxford, UK), ...
Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression.
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Wu Yuntao, In PLoS ONE, 2008
... Fluorophore-conjugated CXCR4 (12GS), CCR5 (T21/8), CD25 (BC96), and CD45RO were purchased from Biolegend.
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo.
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Ahuja Sunil K., In PLoS ONE, 2005
... T cells were then stained with CD4-FITC and CD25-PE (both from BD Biosciences, USA), and their purity ...
CD25+CD4+ Regulatory T Cells from the Peripheral Blood of Asymptomatic HIV-infected Individuals Regulate CD4+ and CD8+ HIV-specific T Cell Immune Responses In Vitro and Are Associated with Favorable Clinical Markers of Disease Status
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Fauci Anthony S. et al., In The Journal of Experimental Medicine, 2001
... cells using anti-CD25–coupled immunomagentic beads (Miltenyi Biotec) to obtain CD25-depleted PBMCs or exposed to a cocktail of immunomagnetic beads (StemCell Technologies Inc.) to obtain CD4 ...
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Papers on CD25
Profound loss of intestinal Tregs in acutely SIV-infected neonatal macaques.
New
Veazey et al., United States. In J Leukoc Biol, 09 Jan 2015
Large numbers of FoxP3(+) T cells were found in all tissues in newborn macaques, which coexpressed high levels of CD25 and CD4, indicating that they were Tregs.
Foxp3-mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells.
New
Shevach et al., Bethesda, United States. In J Leukoc Biol, 09 Jan 2015
UNLABELLED: CD4(+)CD25(+)Foxp3(+) Tregs have a diminished capacity to activate the PI3K/Akt pathway.
Bone marrow mesenchymal stem cells suppressing activation of allogeneic cytokine-induced killer/natural killer cells either by direct or indirect interaction.
New
Wei et al., Guangzhou, China. In Cell Biol Int, 09 Jan 2015
MSC can also depress the expression of CD69 on these killer cells, as well as increased the ratio of CD4(+) CD25(+) CD127(low) T regulatory (Treg) cells in the CIK/NK cell culture system.
Autologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patients.
New
Malmegrim et al., Ribeirão Preto, Brazil. In Bone Marrow Transplant, 08 Jan 2015
AHSCT increased CD4(+)CD25(hi)FoxP3(+) regulatory T-cell counts and expression of CTLA-4 and GITR (glucocorticoid-induced TNFR) on CD4(+)CD25(hi) T cells.
Regulatory T-cells in autoimmune diseases: Challenges, controversies and-yet-unanswered questions.
Review
New
Longhi et al., London, United Kingdom. In Autoimmun Rev, 16 Nov 2014
Markers commonly used to define human Tregs in the research setting include high expression of CD25, FOXP3 positivity and low expression/negativity for CD127.
A modified γ-retrovirus vector for X-linked severe combined immunodeficiency.
New
Impact
Thrasher et al., London, United Kingdom. In N Engl J Med, 09 Nov 2014
BACKGROUND: In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus-based γ-retrovirus vector expressing interleukin-2 receptor γ-chain (γc) complementary DNA successfully restored immunity in most patients but resulted in vector-induced leukemia through enhancer-mediated mutagenesis in 25% of patients.
CD8αα⁺ innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity.
New
Impact
Olivares-Villagómez et al., Nashville, United States. In Immunity, Oct 2014
Development of iCD8α cells depends on expression of interleukin-2 receptor γ chain (IL-2Rγc), IL-15, and the major histocompatibility complex (MHC) class Ib protein H2-T3, also known as the thymus leukemia antigen or TL.
TREG-cell therapies for autoimmune rheumatic diseases.
Review
New
Sakaguchi et al., Paris, France. In Nat Rev Rheumatol, Sep 2014
Naturally occurring Foxp3(+)CD25(+)CD4(+) regulatory T (TREG) cells maintain immunological self-tolerance and prevent a variety of autoimmune diseases, including rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus.
Epigenetic enzymes are the therapeutic targets for CD4(+)CD25(+/high)Foxp3(+) regulatory T cells.
Review
New
Yang et al., Amman, Jordan. In Transl Res, Sep 2014
UNLABELLED: CD4(+)CD25(+/high)Foxp3(+) regulatory T (Treg) cells are a subset of CD4(+) T cells that play an essential role in maintaining peripheral immune tolerance.
Epitope-specific regulation of memory programming by differential duration of antigen presentation to influenza-specific CD8(+) T cells.
New
Impact
Randall et al., Birmingham, United States. In Immunity, Aug 2014
As a consequence, they maintained CD25 expression and responded to interleukin-2 (IL-2) and CD27, which together programmed their robust secondary proliferative capacity and interferon-γ (IFN-γ)-producing ability.
Lung microbiota promotes tolerance to allergens in neonates via PD-L1.
New
Impact
Marsland et al., Lausanne, Switzerland. In Nat Med, Jun 2014
Immediately following birth, neonatal mice were prone to develop exaggerated airway eosinophilia, release type 2 helper T cell cytokines and exhibit airway hyper-responsiveness following exposure to house dust mite allergens, even though their lungs harbored high numbers of natural CD4(+)Foxp3(+)CD25(+)Helios(+) regulatory T (Treg) cells.
Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.
New
Impact
Farrar et al., Minneapolis, United States. In Nat Immunol, May 2014
Conversely, TNFRSF agonists enhanced the differentiation of Treg cell progenitors by augmenting responsiveness of the interleukin 2 receptor (IL-2R) and transcription factor STAT5. Costimulation with the ligand of GITR elicited dose-dependent enrichment for cells of lower TCR affinity in the Treg cell repertoire.
Utilizing regulatory T cells against rheumatoid arthritis.
Review
New
Song et al., United States. In Front Oncol, Dec 2013
CD4(+)CD25(+) Treg cells are well-known suppressive cells, which express the transcription factor Foxp3, are indispensable for the maintenance of immune self-tolerance and homeostasis by suppressing aberrant or excessive immune response.
The unique neonatal NK cells: a critical component required for neonatal autoimmune disease induction by maternal autoantibody.
Review
New
Tung et al., Charlottesville, United States. In Front Immunol, Dec 2013
Resistance to nAOD in older mice results from the emergence of the Ly49C/I(+) NK cells that regulate effector NK cells and from CD25(+) regulatory T cell control.
[Cytogenetic and immunological characteristics of stimulated human peripheral blood lymphocytes are connected with cell proliferation rates].
New
In Radiats Biol Radioecol, Nov 2013
It has been determined that after stimulation the level of marker-positive cells (CD25, CD69 and Ki67) is closely related to PI and is greater in the populations with lower proliferation rates.
Cell surface expression of CD25 antigen (surface IL-2 receptor α-chain) is not a prognostic marker in chronic lymphocytic leukemia: results of a retrospective study of 281 patients.
GeneRIF
Israeli CLL Study Group et al., Jerusalem, Israel. In Ann Hematol, 2012
There is no correlation between CD25 expression on the surface of chronic lymphocytic leukemia (CLL) cells and time to first treatment or overall survival; CD25 expression does not appear to be a prognostic factor in CLL.
Foxp3+CD25(high) CD4+ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity.
GeneRIF
Gomes et al., Belo Horizonte, Brazil. In Immunobiology, 2012
Data indicate that the frequency of Foxp3(+)CD25(high) CD4(+)-T cells is augmented and correlated with the maintenance of a better cardiac function in indeterminate (IND) Chagas disease.
Inhibition of allogenic T-cell cytotoxicity by hepatic stellate cell via CD4⁺ CD25⁺ Foxp3⁺ regulatory T cells in vitro.
GeneRIF
Lee et al., Taiwan. In Transplant Proc, 2012
Hepatic stellate cells seem to act as liver-resident antigen-presenting cells instructing the generation of CD4/CD25/Foxp3(+) regulatory T cells.
The interleukin-2 receptor α chain (CD25) plays an important role in regulating monocyte-derived CD40 expression during anti-porcine cellular responses.
GeneRIF
Xu et al., Jinan, China. In Transplant Proc, 2012
CD25 plays an important role in regulating monocyte-derived CD40 expression during anti-porcine cellular responses.
Soluble cytokine receptors (sIL-2Rα, sIL-2Rβ) induce subunit-specific behavioral responses and accumulate in the cerebral cortex and basal forebrain.
GeneRIF
Siegel et al., Newark, United States. In Plos One, 2011
sIL-2Ralpha and sIL-2Rbeta induce marked subunit- and soluble cytokine receptor-specific behavioral disturbances
More papers using CD25 antibodies
Phenotype, Localization, and Mechanism of Suppression of CD4+CD25+ Human Thymocytes
Supplier
Romagnani Sergio et al., In The Journal of Experimental Medicine, 2000
... The goat anti–mouse IgG and anti-CD25 Abs conjugated with magnetic beads were obtained from Miltenyi Biotec.
Human foamy virus capsid formation requires an interaction domain in the N terminus of Gag
Supplier
Young John A. T, In PLoS Pathogens, 2000
anti-CD14 (Clone TUK4, Miltenyi Biotec), Phycoerythrin-conjugated anti-CD25 (clone 4E3, Miltenyi Biotec), and anti HLA-DR (L243, ...
Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding.
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Douek Danny C., In PLoS Pathogens, 1999
... Naïve cells were subsequently purified by staining with CD45RO-FITC and CD25-PE (BD Pharmingen, San Jose, CA) followed by sorting on a FACSAria (Becton Dickinson, San Jose, CA) ...
Naturally anergic and suppressive CD25+CD4+ T cells as a functionally and phenotypically distinct immunoregulatory T cell population
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Roncarolo Maria-Grazia et al., In The Journal of Experimental Medicine, 1999
... cells were stained with PE-coupled anti-CD25 mAbs and purified after the addition of anti-PE–coupled magnetic beads (Miltenyi Biotec).
Failure of B-cell differentiation in mice lacking the transcription factor EBF
Supplier
Winkler Thomas H. et al., In The Journal of Experimental Medicine, 1994
... –hu-CD25 and Production of Transgenic Mice.
A common factor regulates both Th1- and Th2-specific cytokine gene expression
Supplier
Joshi Beenu et al., In Lipids in Health and Disease, 1993
anti-human CD25-PECy5, were from Becton Dickinson,USA ...
The Genetical Interpretation of Statistics of the Third Degree in the Study of Quantitative Inheritance.
Supplier
Desrosiers Ronald C., In PLoS Pathogens, 1931
... cells were further isolated with CD25 magnetic beads and two passages on MS columns (Miltenyi Biotec, Bergisch-Gladbach, Germany) ...
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