Regulatory T cells in cardiovascular diseases.
Jinan, China. In Nat Rev Cardiol, 03 Dec 2015
The role of CD4(+)CD25(+)FOXP3(+) regulatory T (TREG) cells in the modulation of inflammation and immunity has received increasing attention.
Endophilin marks and controls a clathrin-independent endocytic pathway.
Cambridge, United Kingdom. In Nature, Feb 2015
This pathway mediates the ligand-triggered uptake of several G-protein-coupled receptors such as α2a- and β1-adrenergic, dopaminergic D3 and D4 receptors and muscarinic acetylcholine receptor 4, the receptor tyrosine kinases EGFR, HGFR, VEGFR, PDGFR, NGFR and IGF1R, as well as interleukin-2 receptor.
FOXP3(+) Treg Cells and Gender Bias in Autoimmune Diseases.
Shanghai, China. In Front Immunol, Dec 2014
CD4(+)CD25(+) regulatory T (Treg) cells play a pivotal role in the maintenance of immune homeostasis, where the X-linked master transcription factor forkhead box P3 (FOXP3) determines Treg cell development and function.
[Immunological Aspects in Oncology--Circulating γδ T Cells].
In Klin Onkol, Dec 2014
Detailed immunophenotyping was also conducted describing representation of memory subsets (using CD45RO and CD27 markers) and presence of surface markers HLADr, CD69, CD25, CD28, CCR7, CTLA 4, ICOS, PD 1L and PD 1 between γδ T cells of the controls and breast carcinoma patients.
A modified γ-retrovirus vector for X-linked severe combined immunodeficiency.
More papers using
London, United Kingdom. In N Engl J Med, Nov 2014
BACKGROUND: In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus-based γ-retrovirus vector expressing interleukin-2 receptor γ-chain (γc) complementary DNA successfully restored immunity in most patients but resulted in vector-induced leukemia through enhancer-mediated mutagenesis in 25% of patients.