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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Interleukin 2 receptor, alpha

CD25, IL-2R, interleukin-2 receptor
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: CD4, Foxp3, Interleukin-2, CAN, IL-10
Papers using CD25 antibodies
Increased T regulatory cells lead to development of Th2 immune response in male SJL mice
Deth Richard et al., In Autism Research and Treatment, 2010
... All antibodies except for anti-CD25 mAb were from BD Biosciences (San Jose, CA) ...
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells.
Unutmaz Derya, In PLoS ONE, 2010
... Directly conjugated mAbs against CD4-APC, CD8-APC, CD3-PerCP, CD25-PE (all from BD Biosciences, Oxford, UK), ...
Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression.
Wu Yuntao, In PLoS ONE, 2008
... Fluorophore-conjugated CXCR4 (12GS), CCR5 (T21/8), CD25 (BC96), and CD45RO were purchased from Biolegend.
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo.
Ahuja Sunil K., In PLoS ONE, 2005
... T cells were then stained with CD4-FITC and CD25-PE (both from BD Biosciences, USA), and their purity ...
CD25+CD4+ Regulatory T Cells from the Peripheral Blood of Asymptomatic HIV-infected Individuals Regulate CD4+ and CD8+ HIV-specific T Cell Immune Responses In Vitro and Are Associated with Favorable Clinical Markers of Disease Status
Fauci Anthony S. et al., In The Journal of Experimental Medicine, 2001
... cells using anti-CD25–coupled immunomagentic beads (Miltenyi Biotec) to obtain CD25-depleted PBMCs or exposed to a cocktail of immunomagnetic beads (StemCell Technologies Inc.) to obtain CD4 ...
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Papers on CD25
Elevated Levels of Serum IL-12 and IL-18 are Associated with Lower Frequencies of CD4(+)CD25 (high)FOXP3 (+) Regulatory T cells in Young Patients with Type 1 Diabetes.
Myśliwska et al., Gdańsk, Poland. In Inflammation, 31 Oct 2014
Serum levels of IL-12 and IL-18 were measured by ELISA, and the peripheral blood CD4(+)CD25(high) FOXP3(+) regulatory T cell frequencies were analyzed by flow cytometry.
Oral delivery of glutamic acid decarboxylase (GAD)-65 and IL10 by Lactococcus lactis reverses diabetes in recent-onset NOD mice.
Mathieu et al., Leuven, Belgium. In Diabetes, Aug 2014
Combination therapy did not eliminate pathogenic effector T cells, but increased the presence of functional CD4(+)Foxp3(+)CD25(+) regulatory T cells.
Preclinical characterization of AMG 330, a CD3/CD33-bispecific T-cell-engaging antibody with potential for treatment of acute myelogenous leukemia.
Rattel et al., München, Germany. In Mol Cancer Ther, Jun 2014
In the presence of AML cells, AMG 330 specifically induced expression of CD69 and CD25 as well as release of IFN-γ, TNF, interleukin (IL)-2, IL-10, and IL-6.
Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.
Farrar et al., Minneapolis, United States. In Nat Immunol, May 2014
Conversely, TNFRSF agonists enhanced the differentiation of Treg cell progenitors by augmenting responsiveness of the interleukin 2 receptor (IL-2R) and transcription factor STAT5. Costimulation with the ligand of GITR elicited dose-dependent enrichment for cells of lower TCR affinity in the Treg cell repertoire.
Increasing the biological activity of IL-2 and IL-15 through complexing with anti-IL-2 mAbs and IL-15Rα-Fc chimera.
Kovar et al., Praha, Czech Republic. In Immunol Lett, May 2014
However, the expression pattern and physiological role of IL-2 and IL-15 private receptor α chains CD25 and IL-15Rα, respectively, are strikingly different.
Regulatory T cells, maternal-foetal immune tolerance and recurrent miscarriage: New therapeutic challenging opportunities.
Gris et al., Spain. In Med Clin (barc), Apr 2014
It has been showed that pregnancy selectively stimulates the accumulation of maternal Foxp3(+)CD4(+)CD25(+) (Foxp3Tregs) cells with foetal specificity.
A161: Novel 3-Dimensional Explant Method Facilitates the Study of Lymphocyte Populations in the Synovium and Reveals a Large Population of Resident Memory T cells in Rheumatoid Arthritis.
Fuhlbrigge et al., Boston, United States. In Arthritis Rheumatol, Mar 2014
In the CD4+ subset, interferon gamma expression was common (39.5 ± 9.0%), IL-17(+) expression was rare (range: 0.1 to 3.4%), and T regulatory cells (CD4(+) CD25(+) Foxp3(+) ) were present (8.9 ± 3.2%).
A119: deep sequencing analysis of the T regulatory and T effector repertoire in juvenile idiopathic arthritis.
Notarangelo et al., Boston, United States. In Arthritis Rheumatol, Mar 2014
Tregs (CD4(+) CD25(+) CD127(low) ) and Teffs (CD4(+) CD25(-) ) were sorted by flow cytometry.
Regulatory T cell proliferative potential is impaired in human autoimmune disease.
Matarese et al., Napoli, Italy. In Nat Med, Jan 2014
Human CD4(+)CD25(high)CD127(-)FoxP3(+) regulatory T (Treg) cells suppress immune responses in vitro and in vivo.
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.
Takayanagi et al., Tokyo, Japan. In Nat Med, Jan 2014
Under arthritic conditions, CD25(lo)Foxp3(+)CD4(+) T cells lose Foxp3 expression (herein called exFoxp3 cells) and undergo transdifferentiation into TH17 cells.
Regulatory T cells as adjuvant target for enhancing the viral disease vaccine efficacy.
Bayry, Paris, France. In Virusdisease, Jan 2014
CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) are critical for immune homeostasis and tolerance.
Complexity of Interferon-γ Interactions with HSV-1.
Bigley, Dayton, United States. In Front Immunol, Dec 2013
Both M2 microglia and CD4(+)CD25(+)Foxp3(+) Treg cells produce IL-10.
Regulatory dendritic cells for immunotherapy in immunologic diseases.
Dawicki et al., Saskatoon, Canada. In Front Immunol, Dec 2013
For example, while many, if not most, types of induced regulatory dendritic cells lead CD4(+) naïve or Teff cells to adopt a CD25(+)Foxp3(+) Treg phenotype, exposure of Langerhans cells or dermal dendritic cells to vitamin D leads in one case to the downstream induction of CD25(+)Foxp3(+) regulatory T cell responses, while in the other to Foxp3(-) type 1 regulatory T cells (Tr1) responses.
Epigenetic modifications induced by Blimp-1 Regulate CD8⁺ T cell memory progression during acute virus infection.
Berg et al., Worcester, United States. In Immunity, Nov 2013
We found that increased proliferation and survival of Blimp-1-deficient CD8⁺ T cells resulted from sustained expression of CD25 and CD27 and persistent cytokine responsiveness.
Urinary-cell mRNA profile and acute cellular rejection in kidney allografts.
Clinical Trials in Organ Transplantation 04 (CTOT-04) Study Investigators et al., New York City, United States. In N Engl J Med, Aug 2013
It also distinguished patients who received anti-interleukin-2 receptor antibodies from those who received T-cell-depleting antibodies (P<0.001) and was diagnostic of acute cellular rejection in both groups.
Cell surface expression of CD25 antigen (surface IL-2 receptor α-chain) is not a prognostic marker in chronic lymphocytic leukemia: results of a retrospective study of 281 patients.
Israeli CLL Study Group et al., Jerusalem, Israel. In Ann Hematol, 2012
There is no correlation between CD25 expression on the surface of chronic lymphocytic leukemia (CLL) cells and time to first treatment or overall survival; CD25 expression does not appear to be a prognostic factor in CLL.
Foxp3+CD25(high) CD4+ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity.
Gomes et al., Belo Horizonte, Brazil. In Immunobiology, 2012
Data indicate that the frequency of Foxp3(+)CD25(high) CD4(+)-T cells is augmented and correlated with the maintenance of a better cardiac function in indeterminate (IND) Chagas disease.
Inhibition of allogenic T-cell cytotoxicity by hepatic stellate cell via CD4⁺ CD25⁺ Foxp3⁺ regulatory T cells in vitro.
Lee et al., Taiwan. In Transplant Proc, 2012
Hepatic stellate cells seem to act as liver-resident antigen-presenting cells instructing the generation of CD4/CD25/Foxp3(+) regulatory T cells.
The interleukin-2 receptor α chain (CD25) plays an important role in regulating monocyte-derived CD40 expression during anti-porcine cellular responses.
Xu et al., Jinan, China. In Transplant Proc, 2012
CD25 plays an important role in regulating monocyte-derived CD40 expression during anti-porcine cellular responses.
Soluble cytokine receptors (sIL-2Rα, sIL-2Rβ) induce subunit-specific behavioral responses and accumulate in the cerebral cortex and basal forebrain.
Siegel et al., Newark, United States. In Plos One, 2011
sIL-2Ralpha and sIL-2Rbeta induce marked subunit- and soluble cytokine receptor-specific behavioral disturbances
More papers using CD25 antibodies
Phenotype, Localization, and Mechanism of Suppression of CD4+CD25+ Human Thymocytes
Romagnani Sergio et al., In The Journal of Experimental Medicine, 2000
... The goat anti–mouse IgG and anti-CD25 Abs conjugated with magnetic beads were obtained from Miltenyi Biotec.
Human foamy virus capsid formation requires an interaction domain in the N terminus of Gag
Young John A. T, In PLoS Pathogens, 2000
anti-CD14 (Clone TUK4, Miltenyi Biotec), Phycoerythrin-conjugated anti-CD25 (clone 4E3, Miltenyi Biotec), and anti HLA-DR (L243, ...
Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding.
Douek Danny C., In PLoS Pathogens, 1999
... Naïve cells were subsequently purified by staining with CD45RO-FITC and CD25-PE (BD Pharmingen, San Jose, CA) followed by sorting on a FACSAria (Becton Dickinson, San Jose, CA) ...
Naturally anergic and suppressive CD25+CD4+ T cells as a functionally and phenotypically distinct immunoregulatory T cell population
Roncarolo Maria-Grazia et al., In The Journal of Experimental Medicine, 1999
... cells were stained with PE-coupled anti-CD25 mAbs and purified after the addition of anti-PE–coupled magnetic beads (Miltenyi Biotec).
Failure of B-cell differentiation in mice lacking the transcription factor EBF
Winkler Thomas H. et al., In The Journal of Experimental Medicine, 1994
... –hu-CD25 and Production of Transgenic Mice.
A common factor regulates both Th1- and Th2-specific cytokine gene expression
Joshi Beenu et al., In Lipids in Health and Disease, 1993
anti-human CD25-PECy5, were from Becton Dickinson,USA ...
The Genetical Interpretation of Statistics of the Third Degree in the Study of Quantitative Inheritance.
Desrosiers Ronald C., In PLoS Pathogens, 1931
... cells were further isolated with CD25 magnetic beads and two passages on MS columns (Miltenyi Biotec, Bergisch-Gladbach, Germany) ...
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