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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 04 Mar 2015.

Interleukin 2 receptor, alpha

CD25, IL-2R, interleukin-2 receptor
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: CD4, Foxp3, Interleukin-2, CAN, CD8
Papers using CD25 antibodies
Increased T regulatory cells lead to development of Th2 immune response in male SJL mice
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Deth Richard et al., In Autism Research and Treatment, 2010
... All antibodies except for anti-CD25 mAb were from BD Biosciences (San Jose, CA) ...
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells.
Supplier
Unutmaz Derya, In PLoS ONE, 2010
... Directly conjugated mAbs against CD4-APC, CD8-APC, CD3-PerCP, CD25-PE (all from BD Biosciences, Oxford, UK), ...
Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression.
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Wu Yuntao, In PLoS ONE, 2008
... Fluorophore-conjugated CXCR4 (12GS), CCR5 (T21/8), CD25 (BC96), and CD45RO were purchased from Biolegend.
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo.
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Ahuja Sunil K., In PLoS ONE, 2005
... T cells were then stained with CD4-FITC and CD25-PE (both from BD Biosciences, USA), and their purity ...
CD25+CD4+ Regulatory T Cells from the Peripheral Blood of Asymptomatic HIV-infected Individuals Regulate CD4+ and CD8+ HIV-specific T Cell Immune Responses In Vitro and Are Associated with Favorable Clinical Markers of Disease Status
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Fauci Anthony S. et al., In The Journal of Experimental Medicine, 2001
... cells using anti-CD25–coupled immunomagentic beads (Miltenyi Biotec) to obtain CD25-depleted PBMCs or exposed to a cocktail of immunomagnetic beads (StemCell Technologies Inc.) to obtain CD4 ...
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Papers on CD25
Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution.
New
Wittrup et al., Cambridge, United States. In Proc Natl Acad Sci U S A, 02 Apr 2015
Examination of cell subset biodistribution showed that the immunocytokine associated mainly with IL-2R-expressing innate immune cells, with more bound immunocytokine present in systemic organs than the tumor microenvironment.
Elevated lymphocyte count at time of acute myeloid leukemia diagnosis is associated with shorter remission.
New
Estey et al., In Leuk Lymphoma, 01 Apr 2015
Flow cytometry showed low frequency of natural killer (NK) cells and high frequency of CD4+ T cells (which includes the subset of T regulatory cells; CD4(+)CD25(+)Foxp3(+) cells) in the high ALC group.
CD39(+) regulatory T cells attenuate allergic airway inflammation.
New
Yang et al., Wuhan, China. In Clin Exp Allergy, 26 Mar 2015
In vitro suppression assay suggested that CD39(+) Tregs have more potent suppressive effect on cytokines secretion from CD4(+) CD25(-) responder T cells and the inhibitory effects were reduced by addition of adenosine A2A receptor antagonist.
MicroRNA 26a modulates regulatory T cells expansion and attenuates renal ischemia-reperfusion injury.
New
Gou et al., Chongqing, China. In Mol Immunol, 26 Mar 2015
The promoted renal function after IRI induced by Mir-26a overexpression was abrogated by depletion of tregs with anti-CD25 antibodies.
Generation, cryopreservation, function and in vivo persistence of ex vivo expanded cynomolgus monkey regulatory T cells.
New
Thomson et al., Pittsburgh, United States. In Cell Immunol, 14 Mar 2015
The expanded Treg maintained their expression of Treg signature markers, CD25, CD27, CD39, Foxp3, Helios, and CTLA-4, as well as CXCR3, which plays an important role in T cell migration to sites of inflammation.
Translational research and biomarkers in neonatal sepsis.
Review
New
Speeckaert et al., Gent, Belgium. In Clin Chim Acta, 04 Mar 2015
Soluble interleukin-2 receptor has been used to identify bacteremia, whereas low plasma RANTES concentrations are characteristic for septicemia.
Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability.
New
Impact
Turka et al., Boston, United States. In Nat Immunol, 28 Feb 2015
Diminished control of PI(3)K activity in Treg cells led to reduced expression of the interleukin-2 (IL-2) receptor α subunit CD25, accumulation of Foxp3(+)CD25(-) cells and, ultimately, loss of expression of the transcription factor Foxp3 in these cells.
Markers of acute rejection and graft acceptance in liver transplantation.
Review
New
Burra et al., Padova, Italy. In World J Gastroenterol, 28 Feb 2015
Amongst these, NK cell-related molecules seem to be the most valid marker of graft acceptance, whereas the role CD4(+)CD25(+)Foxp3(+) T cells has still to be properly defined.
Endophilin marks and controls a clathrin-independent endocytic pathway.
New
Impact
McMahon et al., Cambridge, United Kingdom. In Nature, 22 Feb 2015
This pathway mediates the ligand-triggered uptake of several G-protein-coupled receptors such as α2a- and β1-adrenergic, dopaminergic D3 and D4 receptors and muscarinic acetylcholine receptor 4, the receptor tyrosine kinases EGFR, HGFR, VEGFR, PDGFR, NGFR and IGF1R, as well as interleukin-2 receptor.
Epigenetic enzymes are the therapeutic targets for CD4(+)CD25(+/high)Foxp3(+) regulatory T cells.
Review
New
Yang et al., Amman, Jordan. In Transl Res, Jan 2015
CD4(+)CD25(+/high)Foxp3(+) regulatory T (Treg) cells are a subset of CD4(+) T cells that play an essential role in maintaining peripheral immune tolerance.
Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation.
Review
New
Silva-Santos et al., Lisbon, Portugal. In Front Immunol, Dec 2014
Some of the key players are the costimulatory receptors CD27 and CD28, which differentially impact on pro-inflammatory subsets of γδ T-cells; the cytokine receptors IL-2R, IL-7R, and IL-15R, which drive functional differentiation and expansion of γδ T-cells; the NK receptor NKG2D and its contribution to γδ T-cell cytotoxicity; and the inhibitory receptors PD-1 and BTLA that control γδ T-cell homeostasis.
A modified γ-retrovirus vector for X-linked severe combined immunodeficiency.
New
Impact
Thrasher et al., London, United Kingdom. In N Engl J Med, Nov 2014
BACKGROUND: In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus-based γ-retrovirus vector expressing interleukin-2 receptor γ-chain (γc) complementary DNA successfully restored immunity in most patients but resulted in vector-induced leukemia through enhancer-mediated mutagenesis in 25% of patients.
CD8αα⁺ innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity.
New
Impact
Olivares-Villagómez et al., Nashville, United States. In Immunity, Oct 2014
Development of iCD8α cells depends on expression of interleukin-2 receptor γ chain (IL-2Rγc), IL-15, and the major histocompatibility complex (MHC) class Ib protein H2-T3, also known as the thymus leukemia antigen or TL.
Epitope-specific regulation of memory programming by differential duration of antigen presentation to influenza-specific CD8(+) T cells.
New
Impact
Randall et al., Birmingham, United States. In Immunity, Aug 2014
As a consequence, they maintained CD25 expression and responded to interleukin-2 (IL-2) and CD27, which together programmed their robust secondary proliferative capacity and interferon-γ (IFN-γ)-producing ability.
Utilizing regulatory T cells against rheumatoid arthritis.
Review
Song et al., United States. In Front Oncol, 2013
CD4(+)CD25(+) Treg cells are well-known suppressive cells, which express the transcription factor Foxp3, are indispensable for the maintenance of immune self-tolerance and homeostasis by suppressing aberrant or excessive immune response.
Cell surface expression of CD25 antigen (surface IL-2 receptor α-chain) is not a prognostic marker in chronic lymphocytic leukemia: results of a retrospective study of 281 patients.
GeneRIF
Israeli CLL Study Group et al., Jerusalem, Israel. In Ann Hematol, 2012
There is no correlation between CD25 expression on the surface of chronic lymphocytic leukemia (CLL) cells and time to first treatment or overall survival; CD25 expression does not appear to be a prognostic factor in CLL.
Foxp3+CD25(high) CD4+ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity.
GeneRIF
Gomes et al., Belo Horizonte, Brazil. In Immunobiology, 2012
Data indicate that the frequency of Foxp3(+)CD25(high) CD4(+)-T cells is augmented and correlated with the maintenance of a better cardiac function in indeterminate (IND) Chagas disease.
Inhibition of allogenic T-cell cytotoxicity by hepatic stellate cell via CD4⁺ CD25⁺ Foxp3⁺ regulatory T cells in vitro.
GeneRIF
Lee et al., Taiwan. In Transplant Proc, 2012
Hepatic stellate cells seem to act as liver-resident antigen-presenting cells instructing the generation of CD4/CD25/Foxp3(+) regulatory T cells.
The interleukin-2 receptor α chain (CD25) plays an important role in regulating monocyte-derived CD40 expression during anti-porcine cellular responses.
GeneRIF
Xu et al., Jinan, China. In Transplant Proc, 2012
CD25 plays an important role in regulating monocyte-derived CD40 expression during anti-porcine cellular responses.
Soluble cytokine receptors (sIL-2Rα, sIL-2Rβ) induce subunit-specific behavioral responses and accumulate in the cerebral cortex and basal forebrain.
GeneRIF
Siegel et al., Newark, United States. In Plos One, 2011
sIL-2Ralpha and sIL-2Rbeta induce marked subunit- and soluble cytokine receptor-specific behavioral disturbances
More papers using CD25 antibodies
Phenotype, Localization, and Mechanism of Suppression of CD4+CD25+ Human Thymocytes
Supplier
Romagnani Sergio et al., In The Journal of Experimental Medicine, 2000
... The goat anti–mouse IgG and anti-CD25 Abs conjugated with magnetic beads were obtained from Miltenyi Biotec.
Human foamy virus capsid formation requires an interaction domain in the N terminus of Gag
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Young John A. T, In PLoS Pathogens, 2000
anti-CD14 (Clone TUK4, Miltenyi Biotec), Phycoerythrin-conjugated anti-CD25 (clone 4E3, Miltenyi Biotec), and anti HLA-DR (L243, ...
Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding.
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Douek Danny C., In PLoS Pathogens, 1999
... Naïve cells were subsequently purified by staining with CD45RO-FITC and CD25-PE (BD Pharmingen, San Jose, CA) followed by sorting on a FACSAria (Becton Dickinson, San Jose, CA) ...
Naturally anergic and suppressive CD25+CD4+ T cells as a functionally and phenotypically distinct immunoregulatory T cell population
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Roncarolo Maria-Grazia et al., In The Journal of Experimental Medicine, 1999
... cells were stained with PE-coupled anti-CD25 mAbs and purified after the addition of anti-PE–coupled magnetic beads (Miltenyi Biotec).
Failure of B-cell differentiation in mice lacking the transcription factor EBF
Supplier
Winkler Thomas H. et al., In The Journal of Experimental Medicine, 1994
... –hu-CD25 and Production of Transgenic Mice.
A common factor regulates both Th1- and Th2-specific cytokine gene expression
Supplier
Joshi Beenu et al., In Lipids in Health and Disease, 1993
anti-human CD25-PECy5, were from Becton Dickinson,USA ...
The Genetical Interpretation of Statistics of the Third Degree in the Study of Quantitative Inheritance.
Supplier
Desrosiers Ronald C., In PLoS Pathogens, 1931
... cells were further isolated with CD25 magnetic beads and two passages on MS columns (Miltenyi Biotec, Bergisch-Gladbach, Germany) ...
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