Identification of CD112R as a novel checkpoint for human T cells.
Hangzhou, China. In J Exp Med, Feb 2016
UNASSIGNED: T cell immunoglobulin and ITIM domain (TIGIT) and CD226 emerge as a novel T cell cosignaling pathway in which CD226 and TIGIT serve as costimulatory and coinhibitory receptors, respectively, for the ligands CD155 and CD112.
Recurrent activating mutations of CD28 in peripheral T-cell lymphomas.
Xi'an, China. In Leukemia, Jan 2016
We found increased transcription of the CD28-responsive genes CD226 and TNFA in cells expressing the T195P mutant in response to CD3 and CD86 co-stimulation and increased downstream activation of NF-κB by both D124V and T195P mutants, suggesting a potential therapeutic target in CD28-mutated PTCLs.Leukemia accepted article preview online, 31 December 2015.