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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CD200 molecule

CD200, NQO2, OX2, quinone reductase 2
The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, oxidoreductase, CD45, HAD
Papers on CD200
CD200 expression in human cultured bone marrow mesenchymal stem cells is induced by pro-osteogenic and pro-inflammatory cues.
Deschaseaux et al., Tours, France. In J Cell Mol Med, Feb 2016
In this study such a heterogeneity was reflected by the CD200 protein.
Serum-derived exosomes from mice with highly metastatic breast cancer transfer increased metastatic capacity to a poorly metastatic tumor.
Zhu et al., Toronto, Canada. In Cancer Med, Feb 2016
UNASSIGNED: Altered interaction between CD200 and CD200R represents an example of "checkpoint blockade" disrupting an effective, tumor-directed, host response in murine breast cancer cells.
Immunophenotype of normal vs. myeloma plasma cells: Toward antibody panel specifications for MRD detection in multiple myeloma.
Orfao et al., Salamanca, Spain. In Cytometry B Clin Cytom, Jan 2016
Among the later markers, CD19, CD45, CD27, and CD81, together with CD56, CD117, CD200, and CD307, have emerged as particularly informative; however, no single marker provides enough specificity for clear discrimination between clonal PCs and normal PCs.
Orexins excite ventrolateral geniculate nucleus neurons predominantly via OX2 receptors.
Lewandowski et al., Kraków, Poland. In Neuropharmacology, Jan 2016
Orexin A/hypocretin-1 (OXA) and orexin B/hypocretin-2 (OXB) bind to two metabotropic receptors, named the OX1 and OX2 receptors.
Differential effects of intra-accumbal orexin-1 and -2 receptor antagonists on the expression and extinction of morphine-induced conditioned place preference in rats.
Haghparast et al., Tehrān, Iran. In Pharmacol Biochem Behav, Jan 2016
In this study, an attempt was made to determine the effects of intra-accumbal administration of SB334867 as an orexin-1 receptor (OX1R) antagonist and TCS OX2 29 as an orexin-2 receptor (OX2R) antagonist in the expression and maintenance of morphine-induced conditioned place preference (CPP) in rats.
Hairy cell leukaemia-variant: Disease features and treatment.
Campo et al., Barcelona, Spain. In Best Pract Res Clin Haematol, Dec 2015
The immunophenotype is that of a clonal B-cell CD11c and CD103 positive but, unlike classical HCL, CD25, CD123 and CD200 negative.
The immunomodulatory oligodendrocyte.
Schaeren-Wiemers et al., Basel, Switzerland. In Brain Res, Oct 2015
CD200, CD47) as well as extracellular matrix proteins (e.g.
Macrophage adaptation in airway inflammatory resolution.
Hussell et al., Manchester, United Kingdom. In Eur Respir Rev, Sep 2015
Granulocyte-macrophage colony-stimulating factor, interleukin-10, transforming growth factor-β, surfactant proteins and signalling via the CD200 receptor, for example, all raise the threshold above which airway macrophages can be activated.
Early reprogramming regulators identified by prospective isolation and mass cytometry.
Wernig et al., Stanford, United States. In Nature, Jun 2015
Instead, in a systematic functional surface marker screen, we find that early reprogramming-prone cells express a unique set of surface markers, including CD73, CD49d and CD200, that are absent in both fibroblasts and iPS cells.
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant.
Rosenbaum et al., Dallas, United States. In Nature, Apr 2015
The human OX2 receptor (OX2R) belongs to the β branch of the rhodopsin family of GPCRs, and can bind to diverse compounds including the native agonist peptides orexin-A and orexin-B and the potent therapeutic inhibitor suvorexant.
CD200 Expression on Plasma Cell Myeloma Cells is Associated with the Efficacies of Bortezomib, Lenalidomide and Thalidomide.
Takimoto et al., In J Clin Exp Hematop, 2014
The aim of this study was to determine the diagnostic and prognostic significance of CD200 expression in newly diagnosed PCM.
An overview of the effects of anti-IgE therapies.
Yalcin, Taipei, Taiwan. In Med Sci Monit, 2013
Information on the use of omalizumab in treatment of asthma and other allergic diseases has improved our understanding that treatment acts on many levels, including regulating levels of inflammatory proteins, including cytokines (copper-containing alpha- 2-glycoprotein, total antioxidant capacity, MDA, NO, H2O2, CXCL8, IL-10, TGF-β, GMCSF, IL-17, IL-1β), MPV, Hs-CRP, eosinophil cationic peptide, vitamin-D (25(OH)D), homocysteine (Hcy), OX-2, d- dimer, albumin, and sApo-2L.
Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells.
Tonks et al., In Leukemia, 2012
Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells.
Persistence of gene expression profile in CD200 transgenic skin allografts is associated with graft survival on retransplantation to normal recipients.
Gorczynski et al., Toronto, Canada. In Transplantation, 2012
a local (to the grafted tissue) tolerance mechanism initiated after CD200/CD200R engagement in primary graft recipients can lead to prolonged survival of grafts on transfer to secondary control nontransgenic recipients.
The expressions of CD200 and CD200R molecules on myeloid and lymphoid dendritic cells in pre-eclampsia and normal pregnancy.
Oleszczuk et al., Lublin, Poland. In Am J Reprod Immunol, 2012
Decreased expression of CD200 on CD1c+ myeloid dendritic cells was observed in the third trimester of normal pregnancy suggesting that tolerogenic properties of dendritic cells decrease before delivery; higher expression was observed during preeclampsia
Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells.
Zamoyska et al., Edinburgh, United Kingdom. In Plos One, 2011
these results indicate a role of CD200R:CD200 in T cell responses to helminths which has diagnostic and prognostic relevance as a marker of infection for chronic schistosomiasis in mouse and man.
Downregulation of quinone reductase 2 attenuates vascular smooth muscle cells proliferation and neointimal formation in balloon injured rat carotid artery.
Cao et al., Nanjing, China. In Cell Physiol Biochem, 2011
Downregulation of NQO2 significantly suppresses vascular smooth muscle cell proliferation and progression of neointimal formation after vascular injury.
An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells.
Drukker et al., Stanford, United States. In Nat Biotechnol, 2011
To ensure complete removal of teratoma-forming cells, we identified additional pluripotency surface markers (PSMs) exhibiting a large dynamic expression range during differentiation: CD9, CD30, CD50, CD90 and CD200.
Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells.
Bang et al., San Diego, United States. In Nat Biotechnol, 2011
We show enrichment of pancreatic endoderm cells using CD142 and of endocrine cells using CD200 and CD318.
Orexin receptors: pharmacology and therapeutic opportunities.
Winrow et al., Boston, United States. In Annu Rev Pharmacol Toxicol, 2010
Orexin-A and -B (also known as hypocretin-1 and -2) are neuropeptides produced in the lateral hypothalamus that promote many aspects of arousal through the OX1 and OX2 receptors.
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