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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CD2 molecule

CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010] (from NCBI)
Top mentioned proteins: CD4, CD8, CAN, HAD, CD7
Papers using CD2 antibodies
Matrix-assisted laser desorption/ionization-tandem mass spectrometry with high resolution and sensitivity for identification and characterization of proteins.
Lewinsohn David M., In PLoS Pathogens, 2001
... ) using the following antibodies: anti-CD14-FITC (DAKO, Glastrup, Denmark), anti-CD3-PE (BD Biosciences, Franklin Lakes, USA), anti-CD2-PE (BD Biosciences), mouse IgG1-FITC Isotype control ...
De novo CD5+ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients
Stein Harald et al., In Virchows Archiv, 2001
... CD2AB75Citrate1:50NovocastraCD3F7.2.38Citrate1:100Dako ...
Isolation of mouse small intestinal intraepithelial lymphocytes, Peyer’s patch, and lamina propria cells
Siegel Richard M. et al., In Mucosal immunology, 2000
... Improved version of a human CD2 minigene based vector for T cell- specific expression in transgenic mice ...
The [beta]-catenin-TCF-1 pathway ensures CD4+CD8+ thymocyte survival.
Alberola-Ila Jose, In PLoS ONE, 2000
... CkbTg mice were generated by over-expression of Ckb under control of the human CD2 promoter and locus control region in the transgenic expression vector p29△2 (gift ...
Different initiation of pre-TCR and γδ TCR signalling
Cantrell Doreen A. et al., In The Journal of Experimental Medicine, 1999
... L61 Rac-1 and CD2 C3 transgenic mice, and Vav-1 ...
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Papers on CD2
Effect of yeast-derived products and distillers dried grains with solubles (DDGS) on antibody-mediated immune response and gene expression of pattern recognition receptors and cytokines in broiler chickens immunized with T-cell dependent antigens.
Slominski et al., Winnipeg, Canada. In Poult Sci, Feb 2016
UNASSIGNED: This study evaluated the effect of yeast-derived products on innate and antibody mediated immune response in broiler chickens following immunization with sheep red blood cells (SRBC) and bovine serum albumin (BSA).
Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-κB, NFAT and AP-1.
Steinberger et al., Vienna, Austria. In J Immunol Methods, Feb 2016
Ligation of the TCR complex induced moderate reporter activity, which was strongly enhanced upon coengagement of the costimulatory receptors CD2 or CD28.
Stepwise discriminant function analysis for rapid identification of acute promyelocytic leukemia from acute myeloid leukemia with multiparameter flow cytometry.
Fu et al., Wuhan, China. In Int J Hematol, Feb 2016
The weighed discriminant function reveals seven differentially expressed variables (CD2/CD9/CD11b/CD13/CD34/HLA-DR/CD117), which predict a molecular result for APL characterization with an accuracy that approaches 99 % (99.6 and 98.8 % for AML samples in training and test sets, respectively).
Primary hepatic Epstein-Barr virus-associated CD30-positive peripheral T-cell lymphoma of cytotoxic phenotype.
Qing et al., Torrance, United States. In Exp Mol Pathol, Feb 2016
By immunohistochemistry, the lymphoma cells expressed CD2, CD3, CD8, CD30, CD43, CD45, granzyme B, TIA-1, and negative for CD4, CD5, CD7, CD56, βF1, ALK-1, and B-cell markers.
When to Treat Adults Like Children: Optimizing Therapy for Lymphoblastic Lymphoma in Young Adults.
Advani et al., Cleveland, United States. In J Clin Oncol, Jan 2016
The lymphoblasts were examined by flow cytometry and immunohistochemistry and expressed the T-cell markers CD2, CD3, CD4, and terminal deoxynucleotidyl transferase.
Identification of sheep red blood cell (SRBC) surface immune-responsive peptides detected by antisera from SRBC-immunized rats.
Takeyoshi et al., Japan. In J Toxicol Sci, Dec 2015
To identify the sheep red blood cell (SRBC) surface immune-responsive peptides, immuno-reactive fraction of SRBC was detected by SDS-PAGE and western blot analysis with antisera from SRBC-immunized rats.
The Comparison of the Immunologic Properties of Stem Cells Isolated from Human Exfoliated Deciduous Teeth, Dental Pulp, and Dental Follicles.
Akkoc et al., İstanbul, Turkey. In Stem Cells Int, Dec 2015
Lymphocytes were cocultured with stem cells in the presence and absence of IFN-γ and stimulated with anti-CD2, anti-CD3, and anti-CD28 for 3 days.
Molecular Pathology of Adult T-Cell Leukemia/Lymphoma.
Ohshima, Kurume, Japan. In Oncology, Nov 2015
ATLL cells express CD2, CD3, CD5, CD4, and CD25, as well as CCR4 and FoxP3 of the regulatory T-cell marker.
Clinical consequences of circulating CD28-negative T cells for solid organ transplantation.
Betjes, Rotterdam, Netherlands. In Transpl Int, Sep 2015
CD28neg T cells depend on IL-15 for their proliferation, and they have increased the expression of specific costimulatory molecules, such as NK receptors, TNF-alpha receptor family members, and the adhesion/costimulatory molecule CD2.
T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection.
Smith et al., Cambridge, United Kingdom. In Nature, Aug 2015
We can reproduce the exhaustion signature by modifying the balance of persistent stimulation of T-cell antigen receptors and specific CD2-induced co-stimulation provided to human CD8 T cells in vitro, suggesting that each process plays a role in dictating outcome in autoimmune disease.
Primary Esophageal Extranasal NK/T Cell Lymphoma With Biphasic Morphology: A Case Report and Literature Review.
Chen et al., Birmingham, United States. In Medicine (baltimore), Jul 2015
Immunohistochemical studies confirmed that both underlying atypical cells and superficial small lymphocytes were neoplastic, sharing an identical immunophenotype: positive for CD2, CD3, CD43, CD8, CD56, TIA-1 and granzyme B. Epstein-Barr virus-encoded small RNAs were found in both cells.
Successful long-term control of recurrent primary central nervous system anaplastic large cell lymphoma after autologous hematopoietic stem cell transplantation with concurrent whole brain and spinal cord radiotherapy.
Kobayashi et al., Nagano, Japan. In Rinsho Ketsueki, 2014
Cerebrospinal fluid (CSF) cytology showed large atypical cells expressing CD2, cytoplasmic CD3, CD7, CD13 and CD30.
Capping protein regulators fine-tune actin assembly dynamics.
Cooper et al., Saint Louis, United States. In Nat Rev Mol Cell Biol, 2014
These proteins, including CARMIL (capping protein, ARP2/3 and myosin I linker), CD2AP (CD2-associated protein) and the WASH (WASP and SCAR homologue) complex subunit FAM21, recruit CP to specific subcellular locations and modulate its actin-capping activity via allosteric effects.
Immunophenotyping in systemic mastocytosis diagnosis: 'CD25 positive' alone is more informative than the 'CD25 and/or CD2' WHO criterion.
Escribano et al., Toledo, Spain. In Mod Pathol, 2012
CD2 expression does not contribute to improve the diagnosis of systemic mastocytosis when compared with aberrant CD25 expression alone.
Down-regulation of the cavin family proteins in breast cancer.
Cong et al., Beijing, China. In J Cell Biochem, 2012
The cavin family protein Polymerase 1 and transcript release factor, SRBC and serum deprivation response protein were down regulated in breast cancer cell lines and breast tumor tissue.
Epigenetic alteration of PRKCDBP in colorectal cancers and its implication in tumor cell resistance to TNFα-induced apoptosis.
Chi et al., Seoul, South Korea. In Clin Cancer Res, 2012
Data indicate that PRKCDBP expression was hardly detectable in 29 of 80 (36%) primary tumors and 11 of 19 (58%) cell lines.
Leukemic priming of resting NK cells is killer Ig-like receptor independent but requires CD15-mediated CD2 ligation and natural cytotoxicity receptors.
Lowdell et al., London, United Kingdom. In J Immunol, 2012
CD2-mediated priming of resting natural killer (NK) cells is unaffected by their degree of functional maturation.
T cell-signaling network analysis reveals distinct differences between CD28 and CD2 costimulation responses in various subsets and in the MAPK pathway between resting and activated regulatory T cells.
Torgersen et al., Oslo, Norway. In J Immunol, 2011
CD2 signals more strongly to S6-ribosomal protein, whereas CD28 costimulation specifically induces signaling necessary for proper NF-kappaB activation.
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
Plenge et al., Boston, United States. In Nat Genet, 2009
Genetic variants at CD2 are associated with rheumatoid arthritis risk
Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegans.
Sengupta et al., Waltham, United States. In Science, 2009
The SRBC-64 and SRBC-66 GPCRs are members of the large Caenorhabditis-specific SRBC subfamily and are expressed in the ASK chemosensory neurons, which are required for pheromone-induced dauer formation.
More papers using CD2 antibodies
Human and murine granzyme B exhibit divergent substrate preferences
Martin Seamus J. et al., In The Journal of Cell Biology, 1999
... caspase-8 (Oncogene); anti–mouse caspase-8, (Alexis); anti–α-tubulin and anti-actin (ICN, UK); anti-p23 (Affinity BioReagents); anti-nucleophosmin (Invitrogen); anti–CD2-associated protein (Santa Cruz Biotechnology, Inc.); anti-DFF45/ICAD (Calbiochem and ...
Identifying DNA and protein patterns with statistically significant alignments of multiple sequences
Murphy Kenneth M. et al., In Nature, 1998
... Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice ...
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