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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CD1c molecule

CD1c, r-7, BDCA-1
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD1, CAN, MHC, CD4, CD11c
Papers using CD1c antibodies
Randomized phase II trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer
de Vries I. Jolanda M. et al., In Cancer Immunology, Immunotherapy, 2007
... were purified by positive isolation using anti-BDCA-4-conjugated magnetic microbeads, and BDCA-1 mDCs were purified using anti-CD1c-conjugated microbeads (both Miltenyi Biotec, Bergisch-Gladbach, Germany) after B cell ...
Regulation of phagosome maturation by signals from toll-like receptors.
Rodrigues Mauricio Martins, In PLoS ONE, 2003
... Antibodies against CD1c (M241) were purchased from Ancell, BDCA-2 (AC144), and BDCA-4 ...
The germless theory of allergic disease: revisiting the hygiene hypothesis
Jong Yuh-Jyh et al., In Environmental Health Perspectives, 2000
... mononuclear cells (PBMCs) were isolated, and circulating mDCs were magnetically sorted using blood DC antigen (BDCA-1) cell isolation kits (Miltenyi Biotec, Bergisch Gladbach, Germany), following ...
Papers on CD1c
Human autoreactive T cells recognize CD1b and phospholipids.
Moody et al., Utrecht, Netherlands. In Proc Natl Acad Sci U S A, Feb 2016
In contrast with the common detection of T cells that recognize MHC, CD1a, CD1c, or CD1d proteins, CD1b autoreactive T cells have been difficult to isolate in humans.
Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers.
Adams et al., Toronto, Canada. In J Immunol, Feb 2016
Dissection of TCR interactions with CD1c carrying foreign Ags, permissive ligands, and nonpermissive lipid ligands clarifies the molecular basis of the frequently observed but poorly understood phenomenon of mixed self- and foreign Ag reactivity in the CD1 system.
The Notch Ligand DLL4 Defines a Capability of Human Dendritic Cells in Regulating Th1 and Th17 Differentiation.
Zhang et al., Shanghai, China. In J Immunol, Jan 2016
CD1c(+) DCs and plasmacytoid DCs (pDCs) from the peripheral blood (PB) of healthy donors did not express DLL4.
Intragraft Blood Dendritic Cell Antigen-1-Positive Myeloid Dendritic Cells Increase during BK Polyomavirus-Associated Nephropathy.
Florquin et al., Amsterdam, Netherlands. In J Am Soc Nephrol, Jan 2016
Adjustment for confounders in various multivariable models revealed more blood dendritic cell antigen-1(+) (BDCA-1(+)) myeloid dendritic cells (mDCs) present during BKPyVAN (odds ratio, 2.31; 95% confidence interval, 1.03 to 5.16; P=0.04) than during TCMR.
Profiling of primary peripheral blood- and monocyte-derived dendritic cells using monoclonal antibodies from the HLDA10 Workshop in Wollongong, Australia.
Bühring et al., Tübingen, Germany. In Clin Transl Immunology, Nov 2015
Mainly three phenotypically and functionally distinct DC subsets are described in the human peripheral blood (PB): plasmacytoid DCs (pDCs), which express the key marker CD303 (BDCA-2), and two myeloid DC subsets (CD1c(+) DC (mDC1) and CD141(+) DC (mDC2)), which express the key markers CD1c (BDCA-1) and CD141 (BDCA-3), respectively.
Lipid and small-molecule display by CD1 and MR1.
Moody et al., Boston, United States. In Nat Rev Immunol, Oct 2015
The use of tetramers of human CD1a, CD1b, CD1c or MR1 proteins now allows detailed analysis of the human T cell repertoire, which has revealed new invariant TCRs that bind CD1b molecules and are different from those that define natural killer T cells and mucosal-associated invariant T cells.
Donor Unrestricted T Cells: A Shared Human T Cell Response.
Moody et al., Utrecht, Netherlands. In J Immunol, Oct 2015
However, other T cells can be considered "donor unrestricted" because their targets, CD1a, CD1b, CD1c, CD1d, or MR1, are expressed in a similar form among all humans.
The immunology of the porcine skin and its value as a model for human skin.
Ricklin et al., Switzerland. In Mol Immunol, Jul 2015
The equivalent of the human CD141(+) DC subset is CD1a(-)CD4(-)CD172a(-)CADM1(high), that of the CD1c(+) subset is CD1a(+)CD4(-)CD172a(+)CADM1(+/low), and porcine plasmacytoid dendritic cells are CD1a(-)CD4(+)CD172a(+)CADM1(-).
Mycolic acid-specific T cells protect against Mycobacterium tuberculosis infection in a humanized transgenic mouse model.
Wang et al., Chicago, United States. In Elife, 2014
Group 1 CD1 molecules, CD1a, CD1b and CD1c, present lipid antigens from Mycobacterium tuberculosis (Mtb) to T cells.
Role of Group 1 CD1-Restricted T Cells in Infectious Disease.
Wang et al., Chicago, United States. In Front Immunol, 2014
Group 1 CD1 (CD1a, CD1b, and CD1c)-restricted T cells have been implicated to play critical roles in a variety of autoimmune and infectious diseases.
Human T cells use CD1 and MR1 to recognize lipids and small molecules.
Moody et al., Boston, United States. In Curr Opin Chem Biol, 2014
Moving beyond in vitro studies, the recent development of human CD1a, CD1b, CD1c and MR1 tetramers allows direct and specific enumeration of lipid-reactive and small molecule-reactive T cells, providing a new approach to study of T cell-mediated diseases.
Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice.
Butcher et al., Stanford, United States. In Nat Immunol, 2014
CD103(+)Sirpα(+) DCs aligned with human blood CD1c(+) DCs and mouse intestinal CD103(+)CD11b(+) DCs and supported the induction of regulatory T cells.
Biology of CD1- and MR1-restricted T cells.
Cerundolo et al., Oxford, United Kingdom. In Annu Rev Immunol, 2013
In this review, we describe the most recent events in the field, with particular emphasis on (a) structural and functional aspects of lipid presentation by CD1 molecules, (b) the development of CD1d-restricted invariant natural killer T (iNKT) cells and transcription factors required for their differentiation, (c) the ability of iNKT cells to modulate innate and adaptive immune responses through their cross talk with lymphoid and myeloid cells, and (d) MR1-restricted and group I (CD1a, CD1b, and CD1c)-restricted T cells.
Human CD1c+ dendritic cells drive the differentiation of CD103+ CD8+ mucosal effector T cells via the cytokine TGF-β.
Palucka et al., Dallas, United States. In Immunity, 2013
Here, we analyzed, by using lung tissues from humans and humanized mice, the role of human CD1c(+) and CD141(+) DCs in determining the type of CD8(+) T cell immunity generated to live-attenuated influenza virus (LAIV) vaccine.
Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells.
Ginhoux et al., Newcastle upon Tyne, United Kingdom. In Immunity, 2012
Here, we identified a CD141(hi) DC present in human interstitial dermis, liver, and lung that was distinct from the majority of CD1c(+) and CD14(+) tissue DCs and superior at cross-presenting soluble antigens.
Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coli.
Radford et al., South Brisbane, Australia. In Eur J Immunol, 2012
Escherichia coli-activated CD1c(+) dendritic cells suppressed T-cell proliferation in an IL-10-dependent manner
Identification of self-lipids presented by CD1c and CD1d proteins.
Xu et al., Oxford, United Kingdom. In J Biol Chem, 2011
Identification of self-lipids presented by CD1c and CD1d proteins.
CD1d and CD1c expression in human B cells is regulated by activation and retinoic acid receptor signaling.
van den Elzen et al., Vancouver, Canada. In J Immunol, 2011
both CD1d and CD1c are upregulated by retinoic acid receptor alpha signaling in human B cells
Immunohistochemical characterisation of dendritic cells in human atherosclerotic lesions: possible pitfalls.
Bult et al., Antwerp, Belgium. In Pathology, 2011
Accumulation of BDCA-1 and BDCA-2 around neovessels showed that mDCs and pDCs are recruited to advanced arteriosclerotic plaques.
Expression of dendritic cell markers CD11c/BDCA-1 and CD123/BDCA-2 in coronary artery disease upon activation in whole blood.
Bult et al., Antwerp, Belgium. In J Immunol Methods, 2010
Expression of dendritic cell markers CD11c/BDCA-1 and CD123/BDCA-2 in coronary artery disease upon activation in whole blood.
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