Langerhans cell origin and regulation.
Newcastle upon Tyne, United Kingdom. In Curr Opin Hematol, Jan 2016
Human CD1c dendritic cells have Langerhans cell potential in vitro, raising the possibility that dendritic cell progenitors provide the second wave.
Lipid and small-molecule display by CD1 and MR1.
Boston, United States. In Nat Rev Immunol, Oct 2015
The use of tetramers of human CD1a, CD1b, CD1c or MR1 proteins now allows detailed analysis of the human T cell repertoire, which has revealed new invariant TCRs that bind CD1b molecules and are different from those that define natural killer T cells and mucosal-associated invariant T cells.
Biology of CD1- and MR1-restricted T cells.
Oxford, United Kingdom. In Annu Rev Immunol, 2013
In this review, we describe the most recent events in the field, with particular emphasis on (a) structural and functional aspects of lipid presentation by CD1 molecules, (b) the development of CD1d-restricted invariant natural killer T (iNKT) cells and transcription factors required for their differentiation, (c) the ability of iNKT cells to modulate innate and adaptive immune responses through their cross talk with lymphoid and myeloid cells, and (d) MR1-restricted and group I (CD1a, CD1b, and CD1c)-restricted T cells.