Lipid and small-molecule display by CD1 and MR1.
Boston, United States. In Nat Rev Immunol, Oct 2015
The use of tetramers of human CD1a, CD1b, CD1c or MR1 proteins now allows detailed analysis of the human T cell repertoire, which has revealed new invariant TCRs that bind CD1b molecules and are different from those that define natural killer T cells and mucosal-associated invariant T cells.
Human T cells use CD1 and MR1 to recognize lipids and small molecules.
Boston, United States. In Curr Opin Chem Biol, 2014
Moving beyond in vitro studies, the recent development of human CD1a, CD1b, CD1c and MR1 tetramers allows direct and specific enumeration of lipid-reactive and small molecule-reactive T cells, providing a new approach to study of T cell-mediated diseases.
Biology of CD1- and MR1-restricted T cells.
Oxford, United Kingdom. In Annu Rev Immunol, 2013
In this review, we describe the most recent events in the field, with particular emphasis on (a) structural and functional aspects of lipid presentation by CD1 molecules, (b) the development of CD1d-restricted invariant natural killer T (iNKT) cells and transcription factors required for their differentiation, (c) the ability of iNKT cells to modulate innate and adaptive immune responses through their cross talk with lymphoid and myeloid cells, and (d) MR1-restricted and group I (CD1a, CD1b, and CD1c)-restricted T cells.