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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CD19 molecule

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, CAN, CD20, HAD, CD8
Papers using CD19 antibodies
Biochemical and structural characterization of the human TL1A ectodomain
Steinberger Peter et al., In Journal of Immunological Methods, 2008
... The mAbs to CD14 (MEM-18) was purchased from An der Grub (Kaumberg, Austria), CD19 mAb (BU12) from Ancell (Bayport, MN), and 41BB-L ...
Roundabout 4 is expressed on hematopoietic stem cells and potentially involved in the niche-mediated regulation of the side population phenotype
Clarkson B et al., In Blood Cancer Journal, 2008
... instances, lineage analysis of human cells was performed using anti-human Abs: FITC–CD13 (clone SJ1D1) and FITC–CD19 (clone J4.119) (BD Biosciences).
Targeting the Notch1 and mTOR pathways in a mouse T-ALL model
Wilson B S et al., In Leukemia, 2008
... were enriched by Ficoll–Paque centrifugation; for DNA/RNA preparation, B-lineage cells were isolated at 4 °C using anti-CD19 magnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany) ...
Inhibition of ABC transporters abolishes antimony resistance in Leishmania Infection.
Rich Benjamin Edward, In PLoS ONE, 2007
... Anti CD5 and CD19, F4/80 biotin conjugated mAb (murine) were obtained from eBioscience (USA) ...
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.
El-Maarri Osman, In PLoS ONE, 2006
... this set of experiments CD19+ cells were positively selected from PBMCs employing the EasySep Human CD19 Selection Kit (StemCell Technologies, Canada) according to the ...
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Papers on CD19
Immunomodulatory potential of Rhein, an anthraquinone moiety of Cassia occidentalis seeds.
Das et al., Lucknow, India. In Toxicol Lett, Feb 2016
The expression of CD19, CD28, CD40 in B-cells were also found to be significantly decreased following Rhein exposure.
Deciphering cd137 (4-1bb) signaling in T-cell costimulation for translation into successful cancer immunotherapy.
Melero et al., Pamplona, Spain. In Eur J Immunol, Feb 2016
Furthermore, the signaling cytoplasmic tail of CD137 is a key component of anti-CD19 chimeric antigen receptors (CAR) which are used to redirect T cells against leukemia and lymphoma in the clinic.
Blinatumomab: A novel, bispecific, T-cell engaging antibody.
Glode et al., Lexington, United States. In Am J Health Syst Pharm, Feb 2016
SUMMARY: Blinatumomab is a novel, bispecific, T-cell engaging antibody that targets tumor-associated antigens CD19 and CD3.
B lymphocytes in systemic sclerosis: Abnormalities and therapeutic targets.
Yoshizaki, Tokyo, Japan. In J Dermatol, Jan 2016
Recent studies show that B cells from SSc patients demonstrate an upregulated CD19 signaling pathway, which is a crucial regulator of B-cell activation, that induces SSc-specific autoantibody production in SSc.
A Phase II Study of Coltuximab Ravtansine (SAR3419) Monotherapy in Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia.
Dombret et al., Strasbourg, France. In Clin Lymphoma Myeloma Leuk, Jan 2016
We conducted a dose-escalation/expansion phase II, multicenter, single-arm study to determine the optimal dose of coltuximab ravtansine (SAR3419), an anti-CD19 antibody-drug conjugate, in this setting.
Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells.
Batista et al., Boston, United States. In Immunity, Nov 2015
Furthermore, in the absence of WIP, several receptors, namely the BCR, BAFFR, CXCR4, CXCR5, CD40, and TLR4, were impaired in promoting CD19 co-receptor activation and subsequent PI3 kinase (PI3K) signaling.
Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells.
Sadelain et al., New York City, United States. In Cancer Cell, Nov 2015
Using an in vivo "stress test" to challenge CD19-targeted T cells, we studied the functionality and persistence imparted by seven different CAR structures providing CD28 and/or 4-1BB costimulation.
Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma.
Stadtmauer et al., Philadelphia, United States. In N Engl J Med, Oct 2015
A patient with refractory multiple myeloma received an infusion of CTL019 cells, a cellular therapy consisting of autologous T cells transduced with an anti-CD19 chimeric antigen receptor, after myeloablative chemotherapy (melphalan, 140 mg per square meter of body-surface area) and autologous stem-cell transplantation.
Long-Lived Plasma Cells Are Contained within the CD19(-)CD38(hi)CD138(+) Subset in Human Bone Marrow.
Lee et al., Atlanta, United States. In Immunity, Aug 2015
Here we used CD19, CD38, and CD138 to identify four PC subsets in human bone marrow (BM).
The pharmacology of second-generation chimeric antigen receptors.
Sadelain et al., New York City, United States. In Nat Rev Drug Discov, Jul 2015
CD19-targeted CARs that incorporate CD28 or 4-1BB signalling domains are the best known to date.
Bortezomib-based treatment of acute antibody-mediated rejection: a case report.
Zhang et al., Beijing, China. In Genet Mol Res, 2014
We monitored parameters, including T lymphocyte subsets, CD139 and CD19 expression, panel reactive antibody (PRA), and serum creatinine concentration.
Bispecific antibodies and their applications.
Li et al., Beijing, China. In J Hematol Oncol, 2014
The approval of catumaxomab (anti-EpCAM and anti-CD3) and blinatumomab (anti-CD19 and anti-CD3) has become a major milestone in the development of bsAbs.
Anti-CD19 Monoclonal Antibodies: a New Approach to Lymphoma Therapy.
Davami et al., Tehrān, Iran. In Int J Mol Cell Med, 2014
CD19 is expressed on B- lineage cells and follicular dendritic cells and plays a key role in B cell malignancies and autoimmune diseases.
Flow Cytometric Analysis of T, B, and NK Cells Antigens in Patients with Mycosis Fungoides.
Tunali et al., Bursa, Turkey. In J Immunol Res, 2014
Fluorescent labeled monoclonal antibodies were used to detect cell surface antigens: T cells (CD3(+), CD4(+), CD8(+), TCRαβ (+), TCRγδ (+), CD7(+), CD4(+)CD7(+), CD4(+)CD7(-), and CD71(+)), B cells (HLA-DR(+), CD19(+), and HLA-DR(+)CD19(+)), NKT cells (CD3(+)CD16(+)CD56(+)), and NK cells (CD3(-)CD16(+)CD56(+)).
Effects of CD3McAb and rhIL-2 activated bone marrow on the killing and purging of leukemia cells.
Wang et al., Xi'an, China. In Genet Mol Res, 2014
Compared with bone marrow activated by rhIL-2 or CD3McAb alone, the synergistic effect of both CD3McAb+ and hIL-2 caused significant increase of CD3(+), CD8(+), CD19(+), CD25(+), CD38(+), and CD56(+) levels.
A c-Myc and surface CD19 signaling amplification loop promotes B cell lymphoma development and progression in mice.
Tedder et al., Durham, United States. In J Immunol, 2012
Use of c-Myc transgenic mice deficient in CD19 expression leads to identification of a c-Myc:CD19 regulatory loop that positively influences B cell transformation and lymphoma progression.
Dynamics of the splenic innate-like CD19⁺CD45Rlo cell population from adult mice in homeostatic and activated conditions.
Gaspar et al., Madrid, Spain. In J Immunol, 2012
CD19positive CD45R(lo)positive lymphocytes of embryonic origin are present in Peyer's patches and in the spleen throughout the life span of wild-type mice, beginning at postnatal day 7.
The CD19/CD81 complex physically interacts with CD38 but is not required to induce proliferation in mouse B lymphocytes.
Santos-Argumedo et al., Mexico. In Immunology, 2012
results indicate that the CD19/CD81 complex interacts with CD38 but this interaction is not required to induce proliferation in mouse B lymphocytes
Regulatory dendritic cells program B cells to differentiate into CD19hiFcγIIbhi regulatory B cells through IFN-β and CD40L.
Cao et al., Shanghai, China. In Blood, 2012
We report that regulatory dendritic cells can induce splenic B cells to differentiate into a distinct subtype of IL-10-producing regulatory B cells with unique phenotype CD19(hi)FcgammaIIb(hi).
CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis.
Thomas-Tikhonenko et al., Philadelphia, United States. In J Clin Invest, 2012
CD19 is a major BCR-independent regulator of MYC-driven neoplastic growth in B cell neoplasms.
More papers using CD19 antibodies
FoxM1 is required for execution of the mitotic programme and chromosome stability.
Mosley R., In PLoS ONE, 2004
... anti-CD3 (OKT3), anti-CD8 (OKT8), anti-CD45RO (UCHL-1), and anti-HLA-DR (L243; American Type Culture Collection, Manassas, VA); anti-CD19 (Dako Cytomation, Glostrup, Denmark); FITC-conjugated ...
Prostaglandin E2 drives cyclooxygenase-2 expression via cyclic AMP response element activation in human pancreatic cancer cells.
Matloubian Mehrdad, In PLoS ONE, 2004
... or PBMC were washed in 5% human serum, followed by staining of surface marker with anti-CD19-PerCP mouse monoclonal antibody (Becton Dickinson, San Jose, CA) ...
An anti-CD45RO/RB monoclonal antibody modulates T cell responses via induction of apoptosis and generation of regulatory T cells.
Rénia Laurent, In PLoS ONE, 2004
... Leukocytes were labelled with a combination of antimurine CD4-allophycocyanin (rat IgG2a, clone RM4-5, BD Biosciences), CD19-PE-Cyanin7 (rat IgG2a, clone 1D3, BD Biosciences), and CD8-APC-Cyanin7 (rat IgG2a, ...
MAPK signalling pathways as molecular targets for anti-inflammatory therapy–from molecular mechanisms to therapeutic benefits.
Gay Nick, In PLoS ONE, 2004
... Brefeldin A, and antibodies to human CD14, CD16b, CD3, CD19 and TNFα were purchased from eBioscience, San Diego, CA ...
IFN-g production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
Zheng Song Guo, In PLoS ONE, 2004
... (UCHT1, BD Biosciences), anti-CD4 (RPAT-4, BD Pharmingen), anti-CD11c (B-ly6; BD Biosciences), anti-CD14 (M5E2, BD Biosciences), anti-CD19 (HIB19, BD Biosciences), anti-CD40 (5C3, BD Biosciences), ...
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.
Alberola-Ila Jose, In PLoS ONE, 2003
BioLegend), CD19 (6D5, BioLegend), CD45R (RA3-6B2, eBioscience), CD127 ...
Guideline to reference gene selection for quantitative real-time PCR.
Joly Etienne, In PLoS ONE, 2003
... B cells were isolated with anti-CD19 PE antibodies (BD Biosciences PharMingen) and anti-PE microbeads ...
Aberrant T-cell receptor signaling of interferon-gamma- and tumor necrosis factor-alfa-producing cytotoxic CD8+ Vdelta1/Vbeta16 T cells in a patient with chronic neutropenia
Maryniak Renata et al., In Arthritis Research & Therapy, 2002
... Lymphocytes were treated with monoclonal antibodies against CD45 and HLA-DR; pan-B antigen: CD19 (BD); pan-T antigens: CD3 (DAKO), CD2, CD4, CD5, CD7, ...
Surrogate Light Chain Expressing Human Peripheral B Cells Produce Self-reactive Antibodies
Nussenzweig Michel C. et al., In The Journal of Experimental Medicine, 2001
... Schiff, Centre d'Immunologie de Marseille-Luminy, Marseille, France), and APC anti-CD19 (BD Biosciences).
T Cell–specific Ablation of Fas Leads to Fas Ligand–mediated Lymphocyte Depletion and Inflammatory Pulmonary Fibrosis
Rajewsky Klaus et al., In The Journal of Experimental Medicine, 2000
... CD19-cre transgenic mice ( ...
High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma.
Ballestar Esteban, In PLoS ONE, 2000
... cells were enriched by Magnetic Cell Sorting using CD3 or CD19 human microbeads, respectively (Miltenyi Biotec, Cologne, Germany) and the ...
Sequential use of paraformaldehyde and methanol as optimal conditions for the direct quantification of ZEBRA and rta antigens by flow cytometry
Speck Samuel H., In PLoS Pathogens, 1999
... Cells were stained with anti-human CD19 (coupled to eFluor 450; eBioscience), anti-human CD38 (clone HIT2, ...
BDCA-2, a Novel Plasmacytoid Dendritic Cell–specific Type II C-type Lectin, Mediates Antigen Capture and Is a Potent Inhibitor of Interferon α/β Induction
Schmitz Jürgen et al., In The Journal of Experimental Medicine, 1999
... cell sorting with a FACSVantage™ (Becton Dickinson) using mAb against CD3 (mAb SK9, IgG2b; Becton Dickinson), CD19 (mAb 4G7, IgG1; Becton Dickinson), CD56 (mAb MY31, IgG1; ...
Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK
Andrew David P. et al., In The Journal of Experimental Medicine, 1998
... CD4, CD8, CD14, CD56, and CD19 populations were purified from mononuclear cells with the relevant microbeads (Miltenyi Biotec) using 20 μl of ...
Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis.
Lipsky Peter E et al., In Arthritis Research, 1996
generous gift of Dr G Trinchieri, The Wistar Institute, Philadelphia, PA, USA), anti-CD19 (Dako, Glostrup, Denmark), anti-CD45RO (UCHL1; ...
Silencing of B Cell Receptor Signals in Human Naive B Cells
Müschen Markus et al., In The Journal of Experimental Medicine, 1996
... Thereafter, pre-B cells were enriched using anti-CD19 immunomagnetic multisort-beads (Miltenyi Biotec).
Phenotypic and functional characterization of mice that lack the type I receptor for IL-1
Galy Anne et al., In Molecular Therapy, 1996
... To prepare T cells for adoptive transfer, the residual unselected cells leftover from the CD19 positive selection experiments were labeled with the pan-T cell negative isolation kit (Miltenyi Biotec) and sorted with the ...
H2AX regulates meiotic telomere clustering
Nussenzweig André et al., In The Journal of Cell Biology, 1996
... B lymphocytes were isolated using CD19 microbeads (Miltenyi Biotec), and were stimulated with ...
Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2
Winyard Paul G. et al., In The International Journal of Biochemistry & Cell Biology, 1996
... Phycoerythrin (PE)-conjugated anti-human CD3 and PE-conjugated anti-human CD19 antibodies were from Biolegend (San Diego, USA) ...
Costimulation of CD28- T lymphocytes by 4-1BB ligand
Steinberger Peter et al., In Immunology Letters, 1996
... The mAb to CD14 (MEM-18) was purchased from An der Grub (Kaumberg, Austria), CD19 mAb (BU12) from Ancell (Bayport, MN), 4-1BBL from ...
Contact-dependent Stimulation and Inhibition of Dendritic Cells by Natural Killer Cells
Valiante Nicholas M. et al., In The Journal of Experimental Medicine, 1995
... ) and subset purifications were: anti-CD3, anti-CD14, and anti-CD19 (Becton Dickinson).
High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice.
Rameshwar Pranela, In PLoS ONE, 1994
... CD34, phycoerythrin (PE)-conjugated CD73, PE-conjugated CD14, PE-conjugated CD166, phycoerythrin-cyanine 5 (PC5)-conjugated Anti-HLA-DR, PC5-conjugated CD45, and PC5-conjugated CD19 (all from Becton Dickinson Biosciences, San Jose, CA, ...
Hořejší Václav et al., In The Journal of Experimental Medicine, 1993
... by flow sorting using anti–CD4-FITC (MEM-241), anti–CD8-PE (BD Biosciences), anti–CD2-PE (Immunotech), anti–CD4-biotin (Serotec), anti–CD8-biotin (Serotec), anti–CD19-biotin (Serotec), and Streptavidin-FITC (BD Biosciences) mAbs ...
CD44 is necessary for optimal contact allergic responses but is not required for normal leukocyte extravasation
Jalkanen Sirpa et al., In The Journal of Experimental Medicine, 1992
... FITC-conjugated mAbs against CD4, CD8, and CD14 and PE-conjugated mAbs against CD16 and CD19 were purchased from Becton Dickinson ...
Gene Expression Profiling of B Cell Chronic Lymphocytic Leukemia Reveals a Homogeneous Phenotype Related to Memory B Cells〉
Dalla-Favera Riccardo et al., In The Journal of Experimental Medicine, 1992
... After Ficoll-Isopaque™ density centrifugation, PBMCs were incubated with CD19-microbeads (MB) (Miltenyi Biotec).
Precise gene fusion by PCR.
Kanellopoulos Jean, In PLoS ONE, 1988
... Chantal Rabourdin-Combe, France), anti-CD19 (AbD Serotec, 10 µg/ml), or irrelevant ...
A new generation of Ca2+indicators with greatly improved fluorescence properties
Cambier John C. et al., In The Journal of Experimental Medicine, 1984
... purchased from UBI (Lake Placid, NY), anti-phosphotyrosine (AB-2) from Oncogene Science (Uniondale, NY), monoclonal anti-human CD19 from DAKO (Carpinteria, CA), and rabbit ...
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