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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CD163 molecule

CD163, soluble CD163, sCD163, M130
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: CD68, Hoxa5, HAD, CAN, IL-10
Papers using CD163 antibodies
Comparative assessment of the recognition of domain-specific CD163 monoclonal antibodies in human monocytes explains wide discrepancy in reported levels of cellular surface CD163 expression
Moestrup Søren K et al., In Molecular Therapy, 2010
... solution in DMSO were added slowly to 1 ml of a 1 mg/ml solution of the rat CD163 antibody Ed-2 (AbD Serotec, Düsseldorf, Germany) (anti-CD163) or ...
Lack of association of tumor associated macrophages with clinical outcome in patients with classical Hogkin's lymphoma
Ibrahim Sherif et al., In Diagnostic Pathology, 2010
... We performed immunohistochemical stains using CD68, Clone KP-1, and CD163, Clone MRQ-26, (Ventana Medical Systems, Tucson AZ) on representative ...
The human CD6 gene is transcriptionally regulated by RUNX and Ets transcription factors in T cells.
Langmann Thomas, In PLoS ONE, 2008
... Phenotypic analysis was carried out by direct immunofluorescence using FITC-labeled anti-ICAM-3 (BD Biosciences) and FITC-labeled anti-CD163 monoclonal antibodies (MBL International Corp, MA) ...
Mechanisms of deoxynivalenol-induced gene expression and apoptosis
Guzylack-Piriou Laurence et al., In Veterinary Research, 2007
... CD163 antibody (clone EDHu-1) was purchased from AbD Serotec (Oxford, UK) ...
Papers on CD163
Blood Myeloid Dendritic Cells and slanDC in Antiretroviral Therapy-Suppressed HIV-Infected Patients.
Vullo et al., Roma, Italy. In Curr Hiv Res, Feb 2016
We evaluated the numbers of mDCs and slanDC in the context of different degree of CD4+ T cell recovery, persistent T cell activation (as CD38+HLADR+ expression) and monocyte-macrophage activation assessed in terms of circulating levels of both sCD14 and sCD163.
Software-assisted morphometric and phenotype analyses of human peripheral blood monocyte-derived macrophages induced by a microenvironment model of human esophageal squamous cell carcinoma.
Yokozaki et al., Kōbe, Japan. In Pathol Int, Feb 2016
Morphological changes of the cells and the induction of CD163/CD204 proteins were detected in the TECM-exposed model TAMs by immunofluorescence.
Hemoglobin-Induced Neuronal Degeneration in the Neonatal Hippocampus after Intraventricular Hemorrhage.
Strahle et al., Ann Arbor, United States. In Brain Res, Feb 2016
Hb upregulated p-JNK (1.8 fold increase; p<0.05) and increased expression of the Hb/haptoglobin endocytotic receptor CD163 in neurons in vivo and in vitro (cultured cortical neurons).
Hyperactivated mTOR and JAK2/STAT3 Pathways: Molecular Drivers and Potential Therapeutic Targets of Inflammatory and Invasive Ductal Breast Cancers After Neoadjuvant Chemotherapy.
Schneider et al., New Haven, United States. In Clin Breast Cancer, Jan 2016
PATIENTS AND METHODS: Archival tumor tissue from 3 disease types (IBC treated with neoadjuvant chemotherapy [NAC], n = 45; invasive ductal carcinoma [IDC] treated with NAC [n = 24; 'treated IDC'; and untreated IDC [n = 27; 'untreated IDC']) was analyzed for the expression of biomarkers phospho-S6 (pS6) (mTOR), phospho-JAK2 (pJAK2), pSTAT3, interleukin (IL)-6, CD68 (monocytes, macrophages), and CD163 (TAMs).
Anti-inflammatory liposomes have no impact on liver regeneration in rats.
Mortensen et al., Århus, Denmark. In Ann Med Surg (lond), Dec 2015
Paired groups from each set received treatment with placebo, low dose dexamethasone, high dose dexamethasone or low dose anti-CD163 dexamethasone.
Phase II Investigator-Initiated Study of Brentuximab Vedotin in Mycosis Fungoides and Sézary Syndrome With Variable CD30 Expression Level: A Multi-Institution Collaborative Project.
Horwitz et al., Stanford, United States. In J Clin Oncol, Dec 2015
CD163 positive tumor-associated macrophages, many of which coexpress CD30, were abundant in tissue.
Biomarkers in multiple sclerosis.
Hafler et al., New Haven, United States. In Clin Immunol, Nov 2015
We go on to discuss other potential biomarkers from MS serum and cerebrospinal fluid including Markers of neurodegeneration including neurofilament and GFAP, the monocyte macrophage marker CD163, the glial activation marker YKL-40, the B cell chemoattractant CXCL13, miRNA and mRNA, myelin reactive t cells, Kir4.1 antibodies, osteopontin, and microbiome associated lipopeptides.
Bovine gamma delta T cells and the function of gamma delta T cell specific WC1 co-receptors.
Baldwin et al., Amherst Center, United States. In Cell Immunol, Jul 2015
We review the utilization of the γδ T cell specific scavenger receptor cysteine-rich (SRCR) glycoproteins known as WC1, and that are part of the CD163 family, which function as both γδ T cell activating co-receptors and pattern recognition receptors (PRR) for bovine γδ T cells and highlight the presence and evolution of this multigenic array, with potential for the same function, in birds, reptiles, jawless and bony fishes, and prototherian and eutherian mammals.
Changes in transcriptome of macrophages in atherosclerosis.
Orekhov et al., Moscow, Russia. In J Cell Mol Med, Jun 2015
Compared to M0 macrophages, M4 cells have a unique transcriptome, with expression of surface markers such as S100A8, mannose receptor CD206 and matrix metalloproteinase 7. M4 macrophages did not express CD163, a scavenger receptor for haemoglobin/haptoglobin complex.
Can macrophages within the microenvironment of locally invasive rectal cancers predict response to radiotherapy?
Jayne et al., Leeds, United Kingdom. In Lancet, Mar 2015
Dual-staining immunohistochemistry was performed with CD68 as macrophage marker, HLA-DR as M1 marker, and CD163 as M2 marker.
Drug Trafficking into Macrophages via the Endocytotic Receptor CD163.
Moestrup et al., Odense, Denmark. In Membranes (basel), 2014
CD163 is a highly expressed macrophage-specific endocytic receptor that has been studied for intracellular delivery of small molecule drugs to macrophages using targeted liposomes or antibody drug conjugates.
Histiocytic Sarcoma Originating in the Lung in a 16-Year-Old Male.
Nakamura et al., Funaishikawa, Japan. In J Clin Exp Hematop, 2014
The tumor cells were immunohistochemically positive for CD68 and CD163, indicating histiocytic lineage and the MIB-1-positive rate was low.
Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy.
Rüttinger et al., Penzberg, Germany. In Cancer Cell, 2014
Administration of RG7155 to patients led to striking reductions of CSF-1R(+)CD163(+) macrophages in tumor tissues, which translated into clinical objective responses in diffuse-type giant cell tumor (Dt-GCT) patients.
Structure of the haptoglobin-haemoglobin complex.
Moestrup et al., Århus, Denmark. In Nature, 2012
The haptoglobin loop previously shown to be essential for binding of haptoglobin-haemoglobin to the macrophage scavenger receptor CD163 (ref.
α(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.
Maruyama et al., Kumamoto, Japan. In J Biol Chem, 2012
alpha(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.
Arterial inflammation in patients with HIV.
Grinspoon et al., Boston, United States. In Jama, 2012
OBJECTIVE: To assess arterial wall inflammation in HIV, using 18fluorine-2-deoxy-D-glucose positron emission tomography (18F-FDG-PET), in relationship to traditional and nontraditional risk markers, including soluble CD163 (sCD163), a marker of monocyte and macrophage activation.
Impact of methylprednisolone in priming solution of cardiopulmonary bypass on anti-inflammatory CD163 receptor during cardiac surgery.
Andrys et al., Hradec Králové, Czech Republic. In Perfusion, 2012
the expression of hemoglobin scavenger receptor CD163 on monocytes of cardiac surgical patients is induced by methylprednisolone present in cardiopulmonary bypass fluid
Soluble CD163 promotes recognition, phagocytosis and killing of Staphylococcus aureus via binding of specific fibronectin peptides.
Barczyk et al., Münster, Germany. In Cell Microbiol, 2012
invading bacterial fibronectins are a novel ligand for the soluble form of scavenger receptor CD163 in the innate immune response
Soluble CD163: a biomarker linking macrophages and insulin resistance.
Møller et al., Århus, Denmark. In Diabetologia, 2012
Macrophage-specific sCD163 was strongly associated with insulin resistance independently of TNF-alpha and other predictors.
Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria.
Barral-Netto et al., Salvador, Brazil. In Infect Immun, 2012
increased plasma concentrations of heme, haptoglobin , heme oxygenase-1, and sCD163 were associated with susceptibility to malaria.
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