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Fc fragment of IgG, low affinity IIIa, receptor

CD16, FcgammaRIII
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD14, CD56, CAN, CD4, HAD
Papers using CD16 antibodies
Nomenclature of monocytes and dendritic cells in blood.
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Boasso Adriano, In PLoS ONE, 2009
... monocyte subsets were isolated using the CD16 monocyte isolation kit (Miltenyi Biotec, Singapore) according to the ...
Heterogeneity and plasticity of T helper cells
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Paulie S et al., In Scandinavian Journal of Immunology, 2009
... Phycoerythrin (PE)-conjugated anti-CD3 (clone HIT3a), anti-CD19 (clone HIB19), anti-CD56 (clone MEM-188) and Alexa Fluor 488-conjugated anti-CD16 (clone 3G8) mAb (including recommended isotype controls) were purchased from BioLegend.
Hybridization of pulsed-Q dissociation and collision-activated dissociation in linear ion trap mass spectrometer for iTRAQ quantitation
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Wong S-C et al., In Cell Death & Disease, 2007
... The Abs for flow cytometry are CD16 (3G8) (Biolegend, San Diego, CA, USA), ...
Mechanisms of deoxynivalenol-induced gene expression and apoptosis
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Guzylack-Piriou Laurence et al., In Veterinary Research, 2007
... Anti-SWC3 antibodies (clones 74-22-15A and 74-22-15), CD14 (CAM36A), CD16 (G7) and MHCII (MSA3) were commercialised by VMRD (Pullman, USA) ...
Basophils are essential initiators of a novel type of chronic allergic inflammation.
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Unutmaz Derya, In PLoS ONE, 2006
... Anti-CD16/32 (2.4G2), anti-CD117 (c-kit), anti-FcεRI (MAR-1) were obtained from BD Biosciences.
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Papers on CD16
Monocyte Recruitment following High-Intensity and High-Volume Resistance Exercise.
New
Stout et al., Kennesaw, United States. In Med Sci Sports Exerc, Feb 2016
CD11b expression on CD14 CD16 was significantly greater at IP (p<0.014), and 1H (p=0.009).
Natural killer (NK) cells and anti-tumor therapeutic mAb: unexplored interactions.
Review
New
Palmieri et al., Roma, Italy. In J Leukoc Biol, Jan 2016
As the CD16 (low-affinity FcγRIIIA)-activating receptor is expressed on the majority of NK cells, its effector functions can be ideally recruited against therapeutic mAb-opsonized tumor cells.
TG4010 immunotherapy and first-line chemotherapy for advanced non-small-cell lung cancer (TIME): results from the phase 2b part of a randomised, double-blind, placebo-controlled, phase 2b/3 trial.
New
Impact
Limacher et al., Strasbourg, France. In Lancet Oncol, Jan 2016
TG4010 is a modified vaccinia Ankara expressing MUC1 and interleukin 2. In a previous study, TG4010 combined with chemotherapy showed activity in non-small-cell lung cancer and the baseline value of CD16, CD56, CD69 triple-positive activated lymphocytes (TrPAL) was shown to be potentially predictive of TG4010 efficacy.
Overexpression of TLR2 and TLR9 on monocyte subsets of active rheumatoid arthritis patients contributes to enhance responsiveness to TLR agonists.
New
Gosselin et al., Québec, Canada. In Arthritis Res Ther, Dec 2015
METHODS: Prevalence of monocyte subsets CD14(++) CD16(-), CD14(+) CD16(+) and CD14(low) CD16(++) was evaluated in blood and synovial fluids of active RA patients and levels of TLR2 and TLR9 in monocyte subsets were measured by flow cytometry.
Extranodal NK/T cell lymphoma and aggressive NK cell leukaemia: evidence for their origin on CD56+bright CD16-/+dim NK cells.
Review
New
Lima, Porto, Portugal. In Pathology, Oct 2015
The tumour NK cells usually express brightly the CD56 adhesion molecule and CD94 lectin type killer receptor, and have an activation-related (cytoplasmic CD3ε, CD7, CD45RO, HLA-DR) phenotype; in contrast, CD16 and killer immunoglobulin-like receptors are frequently negative, and CD57 expression is almost never observed.
The Role of Different Monocyte Subsets in the Pathogenesis of Atherosclerosis and Acute Coronary Syndromes.
Review
New
Moniuszko et al., Białystok, Poland. In Scand J Immunol, Sep 2015
Monocytes are currently being divided into three functionally distinct subsets with different levels of CD14 (cluster of differentiation 14) and CD16 expression.
Nonclassical patrolling monocyte function in the vasculature.
Review
New
Hanna et al., Los Angeles, United States. In Arterioscler Thromb Vasc Biol, Jun 2015
Patrolling monocyte subsets (CX3CR1(high)Ly6C(-) in mouse and CX3CR1(high)CD14(dim)CD16(+) in humans) are distinct from the classical monocyte subsets (CCR2(high)Ly6C(+) in mouse and CCR2(high)CD14(+)CD16(-) in humans) and exhibit unique functions in the vasculature and inflammatory disease.
Natural killer cell maturation markers in the human liver and expansion of an NKG2C+KIR+ population.
New
Impact
Khakoo et al., Southampton, United Kingdom. In Lancet, Mar 2015
Mononuclear cells were isolated by ficoll separation and cell surface staining performed for CD3, CD56, CD16, CD57, CD117, CD161, CD158a, CD158b, CD49a, CD49b, CXCR6, NKG2C, and NKp46.
Direct and Indirect Effects of Cytomegalovirus-Induced γδ T Cells after Kidney Transplantation.
Review
Déchanet-Merville et al., Bordeaux, France. In Front Immunol, 2014
A singularity of CMV-induced Vδ2(neg) γδ T cells is to acquire CD16 expression and to exert an antibody-dependent cell-mediated inhibition on CMV replication, which is controlled by a specific cytokine microenvironment.
Flow Cytometric Analysis of T, B, and NK Cells Antigens in Patients with Mycosis Fungoides.
Tunali et al., Bursa, Turkey. In J Immunol Res, 2014
Fluorescent labeled monoclonal antibodies were used to detect cell surface antigens: T cells (CD3(+), CD4(+), CD8(+), TCRαβ (+), TCRγδ (+), CD7(+), CD4(+)CD7(+), CD4(+)CD7(-), and CD71(+)), B cells (HLA-DR(+), CD19(+), and HLA-DR(+)CD19(+)), NKT cells (CD3(+)CD16(+)CD56(+)), and NK cells (CD3(-)CD16(+)CD56(+)).
Increased CD56(+) NK cells and enhanced Th1 responses in human unexplained recurrent spontaneous abortion.
Wang et al., Guiyang, China. In Genet Mol Res, 2014
We found that there are a higher proportion of CD4(+) T cells and CD16(+)CD56(+) NK cells and a lower number of CD8(+) T cells in the decidual tissue of URSA patients compared to normal controls.
Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells.
Impact
Dunbar et al., Bethesda, United States. In Cell Stem Cell, 2014
Surprisingly, reconstitution of the natural killer (NK) cell lineage, and particularly the major CD16(+)/CD56(-) peripheral blood NK compartment, showed limited clonal overlap with T, B, or myeloid lineages, and therefore appears to be ontologically distinct.
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues.
Impact
Spits et al., Amsterdam, Netherlands. In Nat Immunol, 2013
ILC1 cells were distinct from natural killer (NK) cells as they lacked perforin, granzyme B and the NK cell markers CD56, CD16 and CD94, and could develop from RORγt(+) ILC3 under the influence of IL-12.
Mechanisms involved in curcumin-induced human neutrophil apoptosis: Evidence that curcumin activates the endoplasmic reticulum stress-induced cell apoptosis pathway.
Girard et al., Québec, Canada. In Sage Open Med, 2012
Herein, we confirmed that curcumin induces human neutrophil apoptosis as assessed by cytology and by increase in the cell surface expression of annexin-V and CD16 shedding.
Correlation between CD16a binding and immuno effector functionality of an antigen specific immunoglobulin Fc fragment (Fcab).
GeneRIF
Woisetschläger et al., Vienna, Austria. In Arch Biochem Biophys, 2012
CD16a binding and antibody dependent cellular cytotoxicity functionality of a Her-2 binding binding Fc fragment are shown to correlate.
Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma.
Impact
Seeger et al., Los Angeles, United States. In J Clin Oncol, 2012
Expression of genes representing TAMs (CD33/CD16/IL6R/IL10/FCGR3) contributed to 25% of the accuracy of a novel 14-gene tumor classification score.
The significant increase of FcγRIIIA (CD16), a sensitive marker, in patients with coronary heart disease.
GeneRIF
Chen et al., Beijing, China. In Gene, 2012
data demonstrated that FcgammaRIIIA (CD16) is involved in the pathogenesis of CHD by activating monocytes and stimulating inflammation
Role of activating FcγR gene polymorphisms in Kawasaki disease susceptibility and intravenous immunoglobulin response.
GeneRIF
Portman et al., Birmingham, United States. In Circ Cardiovasc Genet, 2012
The FcgammaRIIIB-NA1 variant, which confers higher affinity for IgG than the NA2 variant, is a determining factor for treatment response.
Role of ADAM10 and ADAM17 in CD16b shedding mediated by different stimulators.
GeneRIF
Zhang et al., Beijing, China. In Chin Med Sci J, 2012
Both ADAM10 and ADAM17 could shed CD16b, but they possess differed preferences. ADAM10 is the main sheddase under stimulation of ionomycin, while ADAM17 is the main sheddase under stimulation of PMA.
ABCB1, FCGR2A, and FCGR3A polymorphisms in patients with HER2-positive metastatic breast cancer who were treated with first-line taxane plus trastuzumab chemotherapy.
GeneRIF
Bang et al., Seoul, South Korea. In Oncology, 2011
FCGR3A polymorphisms are not associated with response to therapy in HER2-positive metastatic breast cancer.
More papers using CD16 antibodies
Guideline on validation of the Limulus amebocyte test as an end-product endotoxin test for human and animal parenteral drugs, biological products, and medical devices
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Narasimhan Balaji et al., In Scientific Reports, 2005
... Materials used in flow cytometry included fixative buffer (BD Bioscience); mouse serum; anti-mouse CD16/32 FcγR purchased from eBioscience (San Diego, CA); β-mercaptoethanol ...
Methods for quantifying follicular numbers within the mouse ovary.
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Escriva Hector, In PLoS ONE, 2003
... antibodies were BMA12, Abm30 clones and CD16/32 (clone2.4G2)
New therapeutic key for cystic fibrosis: a role for lipoxins
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Quattrucci Serena et al., In Lipids in Health and Disease, 2003
... The purity of CD16+ neutrophils (phycoerythrin conjugated CD16 and isotype-matched Ig from Becton Dickinson, Milan, Italy) was greater ...
Aberrant T-cell receptor signaling of interferon-gamma- and tumor necrosis factor-alfa-producing cytotoxic CD8+ Vdelta1/Vbeta16 T cells in a patient with chronic neutropenia
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Maryniak Renata et al., In Arthritis Research & Therapy, 2002
... CD3 (DAKO), CD2, CD4, CD5, CD7, CD8, CD43, TCRαβ, and TCRγδ (BD); and NK-specific markers: CD16 (DAKO), CD56 (BD), CD57 (Sigma-Aldrich, ...
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR-1 and TLR-2 deficient mice
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Gupta Sudhir et al., In Journal of Clinical Immunology, 2001
... on monocyte subsets was determined by flow cytometry using FITC- conjugated anti-CD14, Alexa Fluor 647-labeled anti-CD16 antibodies (BD Biosciences, San Diego, CA, USA) ...
Microarray analysis of eosinophils reveals a number of candidate survival and apoptosis genes
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Kankaanranta Hannu et al., In Journal of Inflammation (London, England), 2000
... were obtained as follows: antibiotics, fetal calf serum, RPMI 1640 (Gibco BRL, Paisley, Scotland, UK), anti-CD16 microbeads and magnetic cell separation system (Miltenyi Biotec Ltd., Surrey, UK), human ...
Tumor necrosis factor a stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction
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Miyasaka Nobuyuki et al., In Arthritis Research & Therapy, 1999
... monocytes, using CD16 MicroBeads (Miltenyi Biotec).
Interaction of SLP adaptors with the SH2 domain of Tec family kinases
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Kurosaki Tomohiro et al., In The Journal of Experimental Medicine, 1998
... Cell surface expression of BCR or CD16 was analyzed by FACScan™ (Becton Dickinson) using FITC-conjugated anti–chicken IgM ...
Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b
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Simon Hans-Uwe et al., In The Journal of Experimental Medicine, 1996
... Anti-CD16 mAb microbeads were from Miltenyi Biotec (Bergisch-Gladbach, Germany) ...
1α,25-dihydroxyvitamin D3 and a variety of its natural metabolites transcriptionally repress nuclear-factor-κB-mediated interleukin-8 gene expression
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Lefebvre P. P. et al., In Mediators of Inflammation, 1996
... further purified by negative selection immunomagnetic cell separation (MACS; Miltenyi Biotec, Bergisch Gladbach, Germany), using anti-CD16 magnetic beads for eosinophils purification, and a cocktail of biotin-conjugated antibodies against lineage-specific antigens and a cocktail of microbeads (NK Cell Isolation Kit-human, Miltenyi Biotec, Bergisch Gladbach, Germany) for ...
Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor–associated factors
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Liu Yong-Jun et al., In The Journal of Experimental Medicine, 1995
... , Mountain View, CA), anti–CD3-FITC and CD34-FITC (Immunotech), anti–CD20-FITC and anti–CD16-FITC (Becton Dickinson ...
Eosinophil adhesion under flow conditions activates mechanosensitive signaling pathways in human endothelial cells
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Patel Kamala D. et al., In The Journal of Experimental Medicine, 1984
... Anti-CD16 and anti-CD3 paramagnetic beads were obtained from StemCell Technologies Inc ...
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