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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 04 Aug 2015.

CD151 molecule

CD151, MER2, PETA-3
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Tetraspanin, CD63, CAN, CD81, HAD
Papers on CD151
CD97 promotion of gastric carcinoma lymphatic metastasis is exosome dependent.
New
Chen et al., Hangzhou, China. In Gastric Cancer, 02 Sep 2015
Intrafootpad injections of SGC-L, but not SGC-L/CD97-kd exosomes or conditioned medium, strongly promoted SGC-L and SGC-L/CD97-kd cell accumulation in the draining lymph nodes (p < 0.01) and increased CD55, CD44v6, α5β1, CD31, epithelial cell adhesion molecule, and CD151 expression.
Tetraspanin CD151 Is a Negative Regulator of FcεRI-Mediated Mast Cell Activation.
New
Berdnikovs et al., Chicago, United States. In J Immunol, 01 Aug 2015
The tetraspanin CD151 is a poorly understood member of this family and is specifically induced on mouse and human mast cells upon FcεRI aggregation but its functional effects are unknown.
PRRS virus receptors and their role for pathogenesis.
Review
New
Yoo et al., Urbana, United States. In Vet Microbiol, 12 Jul 2015
At least six cellular molecules have been described so far as putative receptors for PRRSV, and they include heparan sulfate, vimentin, CD151, sialoadhesin (CD169; siglec-1), dendritic cell-specific intercellular adhesion melecule-3-grabbing non-integrin (DC-SIGN; CD209), and CD163 (SRCR, cysteine-rich scavenger receptor).
Molecular architecture and function of the hemidesmosome.
New
Wiche et al., London, United Kingdom. In Cell Tissue Res, Jun 2015
Other important components are BPAG1e, the epithelial isoform of bullous pemphigoid antigen 1, BPAG2, a collagen-type transmembrane protein and CD151.
Targeting CD151 by lentivirus-mediated RNA interference inhibits luminal and basal-like breast cancer cell growth and invasion.
New
Li et al., Changchun, China. In Mol Cell Biochem, Jun 2015
UNASSIGNED: CD151 is a member of the tetraspanin family, which is involved in diverse cellular processes, including proliferation, motility, and invasion.
Versatile hemidesmosomal linker proteins: structure and function.
Review
New
Vaidya et al., Mumbai, India. In Histol Histopathol, Apr 2015
In complex epithelia like skin, hemidesmosomes are composed of transmembrane proteins like α6β4 integrin, BP180, CD151 and cytoplasmic proteins like BPAG1e and plectin.
Genome-wide analysis of positively selected genes in seasonal and non-seasonal breeding species.
New
Wang et al., Guangzhou, China. In Plos One, Dec 2014
Validated, positively-selected genes, including CGA, DNAH1, INVS, and CD151, were related to reproductive behaviors such as spermatogenesis and cell proliferation in non-seasonal breeding species.
CD151-A Striking Marker for Cancer Therapy.
Review
New
Malla et al., Vishākhapatnam, India. In Biomark Cancer, Dec 2014
Cluster of differentiation 151 (CD151) is a member of the mammalian tetraspanin family, which is involved in diverse functions such as maintaining normal cellular integrity, cell-to-cell communication, wound healing, platelet aggregation, trafficking, cell motility and angiogenesis.
TM4SF5-mediated protein-protein networks and tumorigenic roles.
Review
New
Lee, Seoul, South Korea. In Bmb Rep, Sep 2014
TM4SF5 is shown to interact with integrins α2, α5, and β1, EGFR, IL6R, CD151, focal adhesion kinase (FAK), and c-Src.
Raph blood group system.
Review
Hayes, Johnstown, United States. In Immunohematology, 2013
This review describes the current state of knowledge of the Raph blood group system, which consists of a single antigen, MER2.
Proteomic analysis of microvesicles released by the human prostate cancer cell line PC-3.
GeneRIF
Llorente et al., Oslo, Norway. In Mol Cell Proteomics, 2012
Secreted CD151 can be a useful genetic marker for the diagnosis of metastatic prostate cancer.
Morphology and migration of podocytes are affected by CD151 levels.
GeneRIF
Endlich et al., Greifswald, Germany. In Am J Physiol Renal Physiol, 2012
CD151 importantly modulates podocyte function.
Clinical significance of CD151 overexpression in subtypes of invasive breast cancer.
GeneRIF
Choi et al., Suwŏn, South Korea. In Br J Cancer, 2012
CD151 overexpression in breast cancer was found to be significantly associated with larger tumour size, higher nodal stage, advanced stage, absence of oestrogen receptor and progesterone receptor and human epidermal growth factor receptor 2 overexpression
Blood pressure influences end-stage renal disease of Cd151 knockout mice.
GeneRIF
Sonnenberg et al., Amsterdam, Netherlands. In J Clin Invest, 2012
establish CD151 as a crucial modifier of integrin-mediated adhesion of podocytes to the GBM and show that blood pressure is an important factor in the initiation and progression of Cd151 knockout-induced nephropathy
Profiling of the tetraspanin CD151 web and conspiracy of CD151/integrin β1 complex in the progression of hepatocellular carcinoma.
GeneRIF
Zhou et al., Shanghai, China. In Plos One, 2010
Data show that CD151 acts as an important player in the progression of HCC in an integrin beta1-dependent manner.
The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151.
Impact
GeneRIF
Quigley et al., Los Angeles, United States. In Cancer Cell, 2008
Demonstrate that promoting immobility through a CD151-specific metastasis blocking mAb prevents tumor cell dissemination by inhibiting intravasation without affecting primary tumor growth, tumor cell arrest, extravasation, or growth at the secondary site.
CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system.
Review
Impact
Maecker et al., Stanford, United States. In Annu Rev Immunol, 1997
The tetraspanin superfamily (or TM4SF) includes CD81, CD9, CD37, CD53, CD63, CD82, CD151, and an increasing number of additional proteins.
Mutations in U1 snRNA bypass the requirement for a cell type-specific RNA splicing factor.
Impact
Roeder et al., New Haven, United States. In Cell, 1993
Previous studies have demonstrated that efficient splicing of the primary transcript of the yeast MER2 gene requires the MER1 protein, which is produced only in meiotic cells.
Meiosis-specific RNA splicing in yeast.
Impact
Roeder et al., New Haven, United States. In Cell, 1991
The MER2 gene is transcribed in mitosis as well as meiosis; however, the transcript is spliced efficiently to generate a functional gene product only in meiosis.
Meiotic gene conversion and crossing over: their relationship to each other and to chromosome synapsis and segregation.
Impact
Roeder et al., New Haven, United States. In Cell, 1990
A gene called MER2 partially suppresses the mer1 phenotype when present in high copy number.
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