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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

CD151 molecule

CD151, MER2, PETA-3
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Tetraspanin, CD63, CAN, CD81, HAD
Papers on CD151
Glycosylation of the laminin receptor (α3β1) regulates its association with tetraspanin CD151: Impact on cell spreading, motility, degradation and invasion of basement membrane by tumor cells.
New
Kalraiya et al., Mumbai, India. In Exp Cell Res, May 2014
Here we show that glycosylation on α3β1 impedes its association with CD151 and modulates spreading and motility of cells apparently to reach an optimum required for invasion of BM.
MiR-22 suppresses the proliferation and invasion of gastric cancer cells by inhibiting CD151.
New
Hu et al., Wuhan, China. In Biochem Biophys Res Commun, Mar 2014
CD151 was found to be a target of miR-22.
The tetraspanin CD151 in papillomavirus infection.
New
Florin et al., Mainz, Germany. In Viruses, Feb 2014
Over the last two decades, many host-cell proteins such as heparan sulfate proteoglycans, integrins, growth factor receptors, actin and the tetraspanin CD151 have been described to be involved in the process of infectious entry of HPV16.
Targets in small cell lung cancer.
Review
New
Teicher, Bethesda, United States. In Biochem Pharmacol, Feb 2014
The glucose transporter GLUT1, the tetraspanin family member PETA/CD151 and the immunoglobulin superfamily member ALCAM/CD166 are also overexpressed by SCLC.
[Long term in-vitro expansion reduces immune modulation function of placental chorionic villi mesenchymal stem cells].
New
Han et al., Tianjin, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, Dec 2013
The results showed that after long term culture, the CV-MSC kept the MSC morphology and most of the phenotypes including CD31, CD34, CD44, CD45, CD62L, CD73, CD90, CD105, CD117, CD151, CD235a, CD271 and HLA-DR, while the CD49d was significantly up-regulated.
N-glycoproteome analysis of the secretome of human metastatic hepatocellular carcinoma cell lines combining hydrazide chemistry, HILIC enrichment and mass spectrometry.
Qian et al., Beijing, China. In Plos One, 2012
Coupling label-free quantification with a hierarchical clustering strategy, we determined the differential regulation of several N-glycoproteins that are related to metastasis, among which AFP, DKK1, FN1, CD151 and TGFβ2 were up-regulated in HCCLM3 cells.
Proteomic analysis of microvesicles released by the human prostate cancer cell line PC-3.
GeneRIF
Llorente et al., Oslo, Norway. In Mol Cell Proteomics, 2012
Secreted CD151 can be a useful genetic marker for the diagnosis of metastatic prostate cancer.
Morphology and migration of podocytes are affected by CD151 levels.
GeneRIF
Endlich et al., Greifswald, Germany. In Am J Physiol Renal Physiol, 2012
CD151 importantly modulates podocyte function.
β-Thalassemia trait association with autoimmune diseases: β-globin locus proximity to the immunity genes or role of hemorphins?
Review
Deniz et al., İstanbul, Turkey. In Immunopharmacol Immunotoxicol, 2012
These associations make sense when considering that the hemoglobin β-chain locus at 11p15.5 resides in close proximity to eight genes with profound roles in immune regulation: STIM1, CD151, TC21/RRAS2, SIGIRR/TOLL/IL1R8, pp52/LSP1 (lymphocyte specific protein), TRIM21, toll interacting protein (TOLLIP) and SLEN3.
Clinical significance of CD151 overexpression in subtypes of invasive breast cancer.
GeneRIF
Choi et al., Suwŏn, South Korea. In Br J Cancer, 2012
CD151 overexpression in breast cancer was found to be significantly associated with larger tumour size, higher nodal stage, advanced stage, absence of oestrogen receptor and progesterone receptor and human epidermal growth factor receptor 2 overexpression
Blood pressure influences end-stage renal disease of Cd151 knockout mice.
GeneRIF
Sonnenberg et al., Amsterdam, Netherlands. In J Clin Invest, 2012
establish CD151 as a crucial modifier of integrin-mediated adhesion of podocytes to the GBM and show that blood pressure is an important factor in the initiation and progression of Cd151 knockout-induced nephropathy
The emerging role of tetraspanin microdomains on endothelial cells.
Review
Tomlinson et al., Birmingham, United Kingdom. In Biochem Soc Trans, 2011
Tetraspanin CD151 is essential for pathological angiogenesis, which may in part be due to regulation of its main partner proteins, the laminin-binding integrins α3β1, α6β1 and α6β4.
Tetraspanin CD151 as a target for antibody-based cancer immunotherapy.
Review
GeneRIF
Corvaia et al., Saint-Pierre-des-Corps, France. In Biochem Soc Trans, 2011
mAbs targeting CD151 may be of significant interest for cancer biotherapy.
Tetraspanin protein contributions to cancer.
Review
Hemler et al., Boston, United States. In Biochem Soc Trans, 2011
Among the 33 human tetraspanin proteins, CD151, CD9 and Tspan12 play particularly important roles in cancer.
Profiling of the tetraspanin CD151 web and conspiracy of CD151/integrin β1 complex in the progression of hepatocellular carcinoma.
GeneRIF
Zhou et al., Shanghai, China. In Plos One, 2010
Data show that CD151 acts as an important player in the progression of HCC in an integrin beta1-dependent manner.
The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151.
Impact
GeneRIF
Quigley et al., Los Angeles, United States. In Cancer Cell, 2008
Demonstrate that promoting immobility through a CD151-specific metastasis blocking mAb prevents tumor cell dissemination by inhibiting intravasation without affecting primary tumor growth, tumor cell arrest, extravasation, or growth at the secondary site.
CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system.
Review
Impact
Maecker et al., Stanford, United States. In Annu Rev Immunol, 1997
The tetraspanin superfamily (or TM4SF) includes CD81, CD9, CD37, CD53, CD63, CD82, CD151, and an increasing number of additional proteins.
Mutations in U1 snRNA bypass the requirement for a cell type-specific RNA splicing factor.
Impact
Roeder et al., New Haven, United States. In Cell, 1993
Previous studies have demonstrated that efficient splicing of the primary transcript of the yeast MER2 gene requires the MER1 protein, which is produced only in meiotic cells.
Meiosis-specific RNA splicing in yeast.
Impact
Roeder et al., New Haven, United States. In Cell, 1991
The MER2 gene is transcribed in mitosis as well as meiosis; however, the transcript is spliced efficiently to generate a functional gene product only in meiosis.
Meiotic gene conversion and crossing over: their relationship to each other and to chromosome synapsis and segregation.
Impact
Roeder et al., New Haven, United States. In Cell, 1990
A gene called MER2 partially suppresses the mer1 phenotype when present in high copy number.
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