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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 13 Nov 2015.

CD151 molecule

CD151, MER2, PETA-3
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Tetraspanin, CAN, CD63, CD81, HAD
Papers on CD151
Homozygous Loss of Mouse Tetraspanin CD82 Enhances Integrin αIIbβ3 Expression and Clot Retraction in Platelets.
Miranti et al., Grand Rapids, United States. In Exp Cell Res, 09 Dec 2015
Tetraspanins are well-established regulators of integrins and genetic loss of tetraspanin CD151 or TSSC6 in mice leads to increased bleeding due to inadequate integrin αIIbβ3 outside-in signaling.
CD151 Regulates T-Cell Migration in Health and Inflammatory Bowel Disease.
Shachar et al., Israel. In Inflamm Bowel Dis, 02 Dec 2015
Here, we characterized the tetraspanin molecule, CD151, as a regulator of T cell motility in health and in models of inflammatory bowel disease.
CD151 Promotes α3β1 Integrin-Dependent Organization of Carcinoma Cell Junctions and Restrains Collective Cell Invasion.
Stipp et al., Iowa City, United States. In Cancer Biol Ther, 29 Oct 2015
For example, tetraspanin CD151 directly associates with α3β1 integrin in carcinoma cells and promotes rapid α3β1-dependent single cell motility, but CD151 also promotes organized adherens junctions and restrains collective carcinoma cell migration on 2D substrates.
PRRS virus receptors and their role for pathogenesis.
Yoo et al., Urbana, United States. In Vet Microbiol, Jul 2015
At least six cellular molecules have been described so far as putative receptors for PRRSV, and they include heparan sulfate, vimentin, CD151, sialoadhesin (CD169; siglec-1), dendritic cell-specific intercellular adhesion melecule-3-grabbing non-integrin (DC-SIGN; CD209), and CD163 (SRCR, cysteine-rich scavenger receptor).
PRRSV receptors and their roles in virus infection.
Zhang et al., Lanzhou, China. In Arch Microbiol, May 2015
Up to now, heparin sulfate, sialoadhesin, CD163, CD151 and vimentin have been identified as the important PRRSV receptors via their involvement in virus attachment, internalization or uncoating.
Versatile hemidesmosomal linker proteins: structure and function.
Vaidya et al., Mumbai, India. In Histol Histopathol, Apr 2015
In complex epithelia like skin, hemidesmosomes are composed of transmembrane proteins like α6β4 integrin, BP180, CD151 and cytoplasmic proteins like BPAG1e and plectin.
Wu et al., In Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, Jan 2015
The differentiation rate was calculated as the product of CD151/CD44+ cells and cells with Col I high expression.
CD151-A Striking Marker for Cancer Therapy.
Malla et al., Vishākhapatnam, India. In Biomark Cancer, Dec 2014
Cluster of differentiation 151 (CD151) is a member of the mammalian tetraspanin family, which is involved in diverse functions such as maintaining normal cellular integrity, cell-to-cell communication, wound healing, platelet aggregation, trafficking, cell motility and angiogenesis.
Expression of CD151/Tspan24 and integrin alpha 3 complex in aid of prognostication of HER2-negative high-grade ductal carcinoma in situ.
Kordek et al., Poland. In Int J Clin Exp Pathol, Dec 2014
The pro-tumorigenic and pro-metastatic functions of the tetraspanin protein CD151 (Tspan24) are thought to be dependent on its ability to form complexes with laminin-binding integrin receptors (i.e.
Raph blood group system.
Hayes, Johnstown, United States. In Immunohematology, 2013
This review describes the current state of knowledge of the Raph blood group system, which consists of a single antigen, MER2.
Proteomic analysis of microvesicles released by the human prostate cancer cell line PC-3.
Llorente et al., Oslo, Norway. In Mol Cell Proteomics, 2012
Secreted CD151 can be a useful genetic marker for the diagnosis of metastatic prostate cancer.
Morphology and migration of podocytes are affected by CD151 levels.
Endlich et al., Greifswald, Germany. In Am J Physiol Renal Physiol, 2012
CD151 importantly modulates podocyte function.
Clinical significance of CD151 overexpression in subtypes of invasive breast cancer.
Choi et al., Suwŏn, South Korea. In Br J Cancer, 2012
CD151 overexpression in breast cancer was found to be significantly associated with larger tumour size, higher nodal stage, advanced stage, absence of oestrogen receptor and progesterone receptor and human epidermal growth factor receptor 2 overexpression
Blood pressure influences end-stage renal disease of Cd151 knockout mice.
Sonnenberg et al., Amsterdam, Netherlands. In J Clin Invest, 2012
establish CD151 as a crucial modifier of integrin-mediated adhesion of podocytes to the GBM and show that blood pressure is an important factor in the initiation and progression of Cd151 knockout-induced nephropathy
Profiling of the tetraspanin CD151 web and conspiracy of CD151/integrin β1 complex in the progression of hepatocellular carcinoma.
Zhou et al., Shanghai, China. In Plos One, 2010
Data show that CD151 acts as an important player in the progression of HCC in an integrin beta1-dependent manner.
The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151.
Quigley et al., Los Angeles, United States. In Cancer Cell, 2008
Demonstrate that promoting immobility through a CD151-specific metastasis blocking mAb prevents tumor cell dissemination by inhibiting intravasation without affecting primary tumor growth, tumor cell arrest, extravasation, or growth at the secondary site.
CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system.
Maecker et al., Stanford, United States. In Annu Rev Immunol, 1997
The tetraspanin superfamily (or TM4SF) includes CD81, CD9, CD37, CD53, CD63, CD82, CD151, and an increasing number of additional proteins.
Mutations in U1 snRNA bypass the requirement for a cell type-specific RNA splicing factor.
Roeder et al., New Haven, United States. In Cell, 1993
Previous studies have demonstrated that efficient splicing of the primary transcript of the yeast MER2 gene requires the MER1 protein, which is produced only in meiotic cells.
Meiosis-specific RNA splicing in yeast.
Roeder et al., New Haven, United States. In Cell, 1991
The MER2 gene is transcribed in mitosis as well as meiosis; however, the transcript is spliced efficiently to generate a functional gene product only in meiosis.
Meiotic gene conversion and crossing over: their relationship to each other and to chromosome synapsis and segregation.
Roeder et al., New Haven, United States. In Cell, 1990
A gene called MER2 partially suppresses the mer1 phenotype when present in high copy number.
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