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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

CD151 molecule

CD151, MER2, PETA-3
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Tetraspanin, CAN, CD63, CD81, V1a
Papers on CD151
Tetraspanin CD151 and integrin α6β1 mediate platelet-enhanced endothelial colony forming cell angiogenesis.
New
Li et al., Stockholm, Sweden. In J Thromb Haemost, 08 Feb 2016
Furthermore, platelet-expressed, but not ECFC-expressed, CD151 was important for the enhancement, as pre-treatment of platelets, but not ECFCs, with a CD151-blocking antibody attenuated the effect.
Generation and characterization of a tetraspanin CD151/integrin α6β1-binding domain competitively binding monoclonal antibody for inhibition of tumor progression in HCC.
New
Shi et al., Shanghai, China. In Oncotarget, 07 Feb 2016
We successfully produced a CD151 mAb 9B targeting the CD151/integrin α6β1-binding domain, which not only can displayed good reactivity to the CD151 antigen but also prevented tumor progression in HCC.
Hemidesmosomes: how much plakins do they need?
New
Has, Freiburg, Germany. In Exp Dermatol, 06 Feb 2016
In stratified and pseudostratified epithelia, the structural components of hemidesmosomes belong to four protein families - plakins (the bullous pemphigoid antigen 1 (BPAG1) and plectin), integrins (α6β4), collagens (collagen XVII) and tetraspanins (CD151) (2).
CD151 knockdown inhibits osteosarcoma metastasis through the GSK-3β/β-catenin/MMP9 pathway.
New
Sun et al., Shenyang, China. In Oncol Rep, 24 Jan 2016
Tetraspanin CD151 is involved in facilitating tumor metastasis.
Homozygous loss of mouse tetraspanin CD82 enhances integrin αIIbβ3 expression and clot retraction in platelets.
New
Miranti et al., Grand Rapids, United States. In Exp Cell Res, 10 Jan 2016
Tetraspanins are well-established regulators of integrins and genetic loss of tetraspanin CD151 or TSSC6 in mice leads to increased bleeding due to inadequate integrin αIIbβ3 outside-in signaling.
Lack of CD151/integrin α3β1 complex is predictive of poor outcome in node-negative lobular breast carcinoma: opposing roles of CD151 in invasive lobular and ductal breast cancers.
New
Berditchevski et al., Łódź, Poland. In Br J Cancer, 03 Dec 2015
BACKGROUND: The proposed involvement of CD151 in breast cancer (BCa) progression is based on findings from studies in invasive ductal carcinoma (IDC).
CD151 Regulates T-Cell Migration in Health and Inflammatory Bowel Disease.
New
Shachar et al., Israel. In Inflamm Bowel Dis, 02 Dec 2015
Here, we characterized the tetraspanin molecule, CD151, as a regulator of T cell motility in health and in models of inflammatory bowel disease.
CD151 promotes α3β1 integrin-dependent organization of carcinoma cell junctions and restrains collective cell invasion.
New
Stipp et al., Iowa City, United States. In Cancer Biol Ther, Nov 2015
For example, tetraspanin CD151 directly associates with α3β1 integrin in carcinoma cells and promotes rapid α3β1-dependent single cell motility, but CD151 also promotes organized adherens junctions and restrains collective carcinoma cell migration on 2D substrates.
[CONDITIONS OF SYNOVIAL MESENCHYMAL STEM CELLS DIFFERENTIATING INTO FIBROCARTILAGE CELLS].
Wu et al., In Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2015
The differentiation rate was calculated as the product of CD151/CD44+ cells and cells with Col I high expression.
Expression of CD151/Tspan24 and integrin alpha 3 complex in aid of prognostication of HER2-negative high-grade ductal carcinoma in situ.
Kordek et al., Poland. In Int J Clin Exp Pathol, 2014
The pro-tumorigenic and pro-metastatic functions of the tetraspanin protein CD151 (Tspan24) are thought to be dependent on its ability to form complexes with laminin-binding integrin receptors (i.e.
Proteomic analysis of microvesicles released by the human prostate cancer cell line PC-3.
GeneRIF
Llorente et al., Oslo, Norway. In Mol Cell Proteomics, 2012
Secreted CD151 can be a useful genetic marker for the diagnosis of metastatic prostate cancer.
Morphology and migration of podocytes are affected by CD151 levels.
GeneRIF
Endlich et al., Greifswald, Germany. In Am J Physiol Renal Physiol, 2012
CD151 importantly modulates podocyte function.
Clinical significance of CD151 overexpression in subtypes of invasive breast cancer.
GeneRIF
Choi et al., Suwŏn, South Korea. In Br J Cancer, 2012
CD151 overexpression in breast cancer was found to be significantly associated with larger tumour size, higher nodal stage, advanced stage, absence of oestrogen receptor and progesterone receptor and human epidermal growth factor receptor 2 overexpression
Blood pressure influences end-stage renal disease of Cd151 knockout mice.
GeneRIF
Sonnenberg et al., Amsterdam, Netherlands. In J Clin Invest, 2012
establish CD151 as a crucial modifier of integrin-mediated adhesion of podocytes to the GBM and show that blood pressure is an important factor in the initiation and progression of Cd151 knockout-induced nephropathy
Profiling of the tetraspanin CD151 web and conspiracy of CD151/integrin β1 complex in the progression of hepatocellular carcinoma.
GeneRIF
Zhou et al., Shanghai, China. In Plos One, 2010
Data show that CD151 acts as an important player in the progression of HCC in an integrin beta1-dependent manner.
The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151.
Impact
GeneRIF
Quigley et al., Los Angeles, United States. In Cancer Cell, 2008
Demonstrate that promoting immobility through a CD151-specific metastasis blocking mAb prevents tumor cell dissemination by inhibiting intravasation without affecting primary tumor growth, tumor cell arrest, extravasation, or growth at the secondary site.
CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system.
Impact
Maecker et al., Stanford, United States. In Annu Rev Immunol, 1997
The tetraspanin superfamily (or TM4SF) includes CD81, CD9, CD37, CD53, CD63, CD82, CD151, and an increasing number of additional proteins.
Mutations in U1 snRNA bypass the requirement for a cell type-specific RNA splicing factor.
Impact
Roeder et al., New Haven, United States. In Cell, 1993
Previous studies have demonstrated that efficient splicing of the primary transcript of the yeast MER2 gene requires the MER1 protein, which is produced only in meiotic cells.
Meiosis-specific RNA splicing in yeast.
Impact
Roeder et al., New Haven, United States. In Cell, 1991
The MER2 gene is transcribed in mitosis as well as meiosis; however, the transcript is spliced efficiently to generate a functional gene product only in meiosis.
Meiotic gene conversion and crossing over: their relationship to each other and to chromosome synapsis and segregation.
Impact
Roeder et al., New Haven, United States. In Cell, 1990
A gene called MER2 partially suppresses the mer1 phenotype when present in high copy number.
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