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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 04 Mar 2015.

CD151 molecule

CD151, MER2, PETA-3
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Tetraspanin, CD63, CAN, CD81, HAD
Papers on CD151
Integrin α6β1 Expressed in ESCs Instructs the Differentiation to Endothelial Cells.
New
Malik et al., Chicago, United States. In Stem Cells, 19 Mar 2015
We observed that α6β1 binding to LN1 was required for differentiation to ECs. α6β1 functioned by recruiting the adaptor tetraspanin protein CD151, which activated FAK and Akt signaling and mediated the EC lineage-specifying transcription factor Er71.
PRRSV receptors and their roles in virus infection.
New
Zhang et al., Lanzhou, China. In Arch Microbiol, 11 Mar 2015
Up to now, heparin sulfate, sialoadhesin, CD163, CD151 and vimentin have been identified as the important PRRSV receptors via their involvement in virus attachment, internalization or uncoating.
The tetraspanins CD151 and Tspan8 are essential exosome components for the crosstalk between cancer initiating cells and their surrounding.
New
Zöller et al., Heidelberg, Germany. In Oncotarget, 10 Mar 2015
Tspan8 and CD151 are metastasis-promoting tetraspanins and a knockdown (kd) of Tspan8 or CD151 and most pronounced of both tetraspanins affects the metastatic potential of the rat pancreatic adenocarcinoma line ASML.
Involvement of activation of C-met signaling pathway in CD151-induced HUVECs angiogenesis.
New
Liu et al., Wuhan, China. In J Huazhong Univ Sci Technolog Med Sci, 28 Feb 2015
CD151 is a member of the tetraspanin family that is implicated as a promoter of pathological or physiological angiogenesis.
Molecular architecture and function of the hemidesmosome.
New
Wiche et al., London, United Kingdom. In Cell Tissue Res, Jan 2015
Other important components are BPAG1e, the epithelial isoform of bullous pemphigoid antigen 1, BPAG2, a collagen-type transmembrane protein and CD151.
Versatile hemidesmosomal linker proteins: Structure and function.
Review
New
Vaidya et al., Mumbai, India. In Histol Histopathol, Dec 2014
In complex epithelia like skin, hemidesmosomes are composed of transmembrane proteins like α6β4 integrin, BP180, CD151 and cytoplasmic proteins like BPAG1e and plectin.
The tetraspanin CD151 in papillomavirus infection.
Review
New
Florin et al., Mainz, Germany. In Viruses, Feb 2014
Over the last two decades, many host-cell proteins such as heparan sulfate proteoglycans, integrins, growth factor receptors, actin and the tetraspanin CD151 have been described to be involved in the process of infectious entry of HPV16.
Targets in small cell lung cancer.
Review
New
Teicher, Bethesda, United States. In Biochem Pharmacol, Feb 2014
The glucose transporter GLUT1, the tetraspanin family member PETA/CD151 and the immunoglobulin superfamily member ALCAM/CD166 are also overexpressed by SCLC.
CD151 in cancer progression and metastasis: a complex scenario.
Review
Romanska et al., Gdańsk, Poland. In Lab Invest, 2014
Originally identified as a molecular organizer of interacting proteins into tetraspanin-enriched microdomains, the tetraspanin CD151 has now been shown to be involved in tumour progression.
Raph blood group system.
Review
Hayes, Johnstown, United States. In Immunohematology, 2013
This review describes the current state of knowledge of the Raph blood group system, which consists of a single antigen, MER2.
Proteomic analysis of microvesicles released by the human prostate cancer cell line PC-3.
GeneRIF
Llorente et al., Oslo, Norway. In Mol Cell Proteomics, 2012
Secreted CD151 can be a useful genetic marker for the diagnosis of metastatic prostate cancer.
Morphology and migration of podocytes are affected by CD151 levels.
GeneRIF
Endlich et al., Greifswald, Germany. In Am J Physiol Renal Physiol, 2012
CD151 importantly modulates podocyte function.
Clinical significance of CD151 overexpression in subtypes of invasive breast cancer.
GeneRIF
Choi et al., Suwŏn, South Korea. In Br J Cancer, 2012
CD151 overexpression in breast cancer was found to be significantly associated with larger tumour size, higher nodal stage, advanced stage, absence of oestrogen receptor and progesterone receptor and human epidermal growth factor receptor 2 overexpression
Blood pressure influences end-stage renal disease of Cd151 knockout mice.
GeneRIF
Sonnenberg et al., Amsterdam, Netherlands. In J Clin Invest, 2012
establish CD151 as a crucial modifier of integrin-mediated adhesion of podocytes to the GBM and show that blood pressure is an important factor in the initiation and progression of Cd151 knockout-induced nephropathy
Profiling of the tetraspanin CD151 web and conspiracy of CD151/integrin β1 complex in the progression of hepatocellular carcinoma.
GeneRIF
Zhou et al., Shanghai, China. In Plos One, 2010
Data show that CD151 acts as an important player in the progression of HCC in an integrin beta1-dependent manner.
The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151.
Impact
GeneRIF
Quigley et al., Los Angeles, United States. In Cancer Cell, 2008
Demonstrate that promoting immobility through a CD151-specific metastasis blocking mAb prevents tumor cell dissemination by inhibiting intravasation without affecting primary tumor growth, tumor cell arrest, extravasation, or growth at the secondary site.
CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system.
Review
Impact
Maecker et al., Stanford, United States. In Annu Rev Immunol, 1997
The tetraspanin superfamily (or TM4SF) includes CD81, CD9, CD37, CD53, CD63, CD82, CD151, and an increasing number of additional proteins.
Mutations in U1 snRNA bypass the requirement for a cell type-specific RNA splicing factor.
Impact
Roeder et al., New Haven, United States. In Cell, 1993
Previous studies have demonstrated that efficient splicing of the primary transcript of the yeast MER2 gene requires the MER1 protein, which is produced only in meiotic cells.
Meiosis-specific RNA splicing in yeast.
Impact
Roeder et al., New Haven, United States. In Cell, 1991
The MER2 gene is transcribed in mitosis as well as meiosis; however, the transcript is spliced efficiently to generate a functional gene product only in meiosis.
Meiotic gene conversion and crossing over: their relationship to each other and to chromosome synapsis and segregation.
Impact
Roeder et al., New Haven, United States. In Cell, 1990
A gene called MER2 partially suppresses the mer1 phenotype when present in high copy number.
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