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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Fucosyltransferase 4

CD15, Lewis X, Lex, SSEA-1
The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, CD45, CD30, CD20
Papers using CD15 antibodies
Good manufacturing practice and clinical-grade human embryonic stem cell lines
Supplier
Hovatta Outi et al., In In Vitro Cellular & Developmental Biology. Animal, 2007
... hESC lines was carried out using primary antibodies specific for Oct-4 (Chemicon), Nanog, TRA-1–60, TRA-1–81, SSEA-1, and SSEA-4 (all from Santa Cruz Biotechnology Inc., Santa Cruz, CA), ...
Bioconductor: open software development for computational biology and bioinformatics
Supplier
Cheriyath Venugopalan, In PLoS ONE, 2003
... by labelling bone marrow cells with an anti-CD34 mAb, anti-CD3 mAb, anti-CD14 mAb, or an anti-CD15 mAbs (all from BD Biosciences) and CD34+, CD3+, CD14+, ...
ArrayExpress
Supplier
Ashcroft Gillian S et al., In Genome Biology, 2002
... (5 μm) were stained with hematoxylin and eosin, or subjected to immunohistochemistry with mouse monoclonal anti-CD15 (BD Biosciences, Pharmingen, Oxford, UK), mouse ...
De novo CD5+ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients
Supplier
Stein Harald et al., In Virchows Archiv, 2001
... CD15C3D1Citrate1:20Dako ...
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis.
Supplier
Callaerts Patrick, In PLoS ONE, 1994
... (Molecular Probes), mouse monoclonal anti-β-III tubulin (Promega, Madison, WI); mouse monoclonal anti-MAP-2 (Sigma); monoclonal anti-LeX (CD15 FITC) (Becton Dickinson); mouse monoclonal anti-PCNA (Chemicon) ...
Papers on CD15
Targeting of Neutrophil Lewis X Blocks Transepithelial Migration and Increases Phagocytosis and Degranulation.
New
Parkos et al., Atlanta, United States. In Am J Pathol, Feb 2016
Herein, we show that antibody blockade of Lewis X (Le(x)) displayed as terminal glycan residues on the PMN surface blocks chemotaxis and TEM while enhancing PMN-adhesive interactions with intestinal epithelia.
Residual disease detected by multidimensional flow cytometry shows prognostic significance in childhood acute myeloid leukemia with intermediate cytogenetics and negative FLT3-ITD: a report from the Tokyo Children's Cancer Study Group.
New
Ohara et al., Kawasaki, Japan. In Int J Hematol, Feb 2016
RD was evaluated by detecting the immature cells showing abnormal antigen expression pattern; CD34(+), CD15(+), CD7(+).
Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancer.
New
Reis et al., Porto, Portugal. In Biochim Biophys Acta, Jan 2016
BACKGROUND: Terminal α2-3 and α2-6 sialylation of glycans precludes further chain elongation, leading to the biosynthesis of cancer relevant epitopes such as sialyl-Lewis X (SLe(X)).
Hodgkin Lymphoma of the Nasopharynx: Case Report with Review of the Literature.
Review
New
McBee et al., Pittsburgh, United States. In Head Neck Pathol, Sep 2015
Immunohistochemical analysis revealed CD15, CD30, OCT-2, BOB.1, and MUM-1 expression by the neoplastic cells and a lack of expression of CD45, CD20, CD3, EMA, and EBER.
[Clinicopathologic analysis of angioimmunoblastic T-cell lymphoma with Hodgkin/Reed-Sternberg-like cells].
New
Zhou et al., Beijing, China. In Zhonghua Bing Li Xue Za Zhi, Aug 2015
The HRS-like cells were positive for MUM-1 and Ki-67, variable intensity positive for CD30, CD20, and PAX-5, but negative for CD15.
Skin wounds vitality markers in forensic pathology: An updated review.
Review
New
Gauchotte et al., Nancy, France. In Med Sci Law, Jul 2015
Some markers are promising, such as CD15, TNFα, IL-6, IL-1β, TGFα or TGFβ1.
Colon Targeted Liposomal Systems (CTLS): Theranostic Potential.
Review
Jain et al., Sāgar, India. In Curr Mol Med, 2014
RGD, NGR, fibronectin mimetic peptide, and transferrin), Sialyl Lewis X (SLX), low molecular weight ligand like folate, monoclonal antibodies, endostatin gene and sulfatide etc.
Discordant lymphoma consisting of mediastinal large B-cell lymphoma and nodular sclerosis Hodgkin lymphoma in the right supraclavicular lymph nodes: a case report.
Liu et al., Chongqing, China. In Diagn Pathol, 2014
These tissues stained strongly positive for PAX5 and CD30, weakly positive for CD15, and negative for Epstein-Barr viral RNA.
Medullary thymic epithelial stem cells maintain a functional thymus to ensure lifelong central T cell tolerance.
Impact
Minato et al., Kyoto, Japan. In Immunity, 2014
A minor SSEA-1(+) fraction within the embryonic Cld3,4(hi) TECs contained self-renewable clonogenic TECs, capable of preferentially generating mature mTECs in vivo.
The molecular nature of very small embryonic-like stem cells in adult tissues.
Review
Shin et al., Seoul, South Korea. In Int J Stem Cells, 2014
We also recently demonstrated that a population of pluripotent Oct4(+) SSEA-1(+)Sca-1(+)Lin(-)CD45(-) very small embryonic-like stem cells (VSELs) resides in the adult murine bone marrow (BM) and in other murine tissue.
Myeloid-derived suppressor cells in multiple myeloma: pre-clinical research and translational opportunities.
Review
Tassone et al., Catanzaro, Italy. In Front Oncol, 2013
While murine MDSCs are usually identified by the expression of CD11b and Gr1, human MDSCs represent a more heterogeneous population characterized by the expression of CD33 and CD11b, low or no HLA-DR, and variable CD14 and CD15.
TNF regulates sialyl-Lewisx and 6-sulfo-sialyl-Lewisx expression in human lung through up-regulation of ST3GAL4 transcript isoform BX.
GeneRIF
Groux-Degroote et al., Villeneuve-d'Ascq, France. In Biochimie, 2012
TNF increases the expression of alpha2,3-sialyltransferase gene ST3GAL4
Lewis X-carrying N-glycans regulate the proliferation of mouse embryonic neural stem cells via the Notch signaling pathway.
GeneRIF
Kato et al., Nagoya, Japan. In J Biol Chem, 2012
Findings suggest that Lewis X carbohydrates, which have so far been characterized as undifferentiation markers, actually operate as activators of the Notch signaling pathway for the maintenance of NSC stemness during brain development.
Differential fucosyltransferase IV expression in squamous carcinoma cells is regulated by promoter methylation.
GeneRIF
Wang et al., Dalian, China. In Cell Mol Biol Lett, 2012
FUT4 expression is negatively correlated with the methylation degree of a CpG island in the FUT4 promoter.
Differential expression of LeY and fucosyltransferase IV correlates with the receptivity of RL95-2 and HEC-1A human uterine epithelial cells.
GeneRIF
Yan et al., Dalian, China. In Cell Biol Int, 2012
the expression of Lewis Y and FUT4 correlates with endometrial receptivity
The micro-RNA 199b-5p regulatory circuit involves Hes1, CD15, and epigenetic modifications in medulloblastoma.
GeneRIF
Zollo et al., Napoli, Italy. In Neuro Oncol, 2012
High CD15 expression is associated with medulloblastoma.
In vitro generation of human cells with cancer stem cell properties.
Impact
GeneRIF
Misteli et al., Bethesda, United States. In Nat Cell Biol, 2011
Data show that tumours induced by transformed fibroblasts are hierarchically organized, and the cells that act as CSCs to initiate and maintain tumour growth are marked by the stage-specific embryonic antigen SSEA-1.
SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma.
Impact
Fine et al., Bethesda, United States. In Cell Stem Cell, 2009
Here we demonstrate that stage-specific embryonic antigen 1(SSEA-1/LeX)+ GBM cells fulfill the functional criteria for TSC/TIC, since (1) SSEA-1+ cells are highly tumorigenic in vivo, unlike SSEA-1- cells; (2) SSEA-1+ cells can give rise to both SSEA-1+ and SSEA-1- cells, thereby establishing a cellular hierarchy; and (3) SSEA-1+ cells have self-renewal and multilineage differentiation potentials.
Identifying the perpetrator in medulloblastoma: Dorian Gray versus Benjamin Button.
Impact
Temple et al., New York City, United States. In Cancer Cell, 2009
In this issue, Read, Wechsler-Reya, and colleagues show that in an animal model of medulloblastoma, TPCs express the surface marker CD15 and have properties distinct from neural stem cells.
Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma.
Impact
GeneRIF
Wechsler-Reya et al., Durham, United States. In Cancer Cell, 2009
Data show that tumors from a model of medulloblastoma, the Patched mutant mouse, are propagated not by CD133(+) cells but by cells expressing the progenitor markers Math1 and CD15/SSEA-1.
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