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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Basigin

CD147, EMMPRIN, M-6, BSG
The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, MMP-9, MMP-2, CD45, V1a
Papers using CD147 antibodies
Getting in Touch with the Clathrin Terminal Domain
Supplier
Rappoport Joshua Z., In PLoS ONE, 2011
... directed towards MHCI (clone w6/32), CD59 (clone p282/H19), CD44 (clone BJ18), CD98 (clone MEM-108) and CD147 (clone HIM6) were from Biolegend.
Macrophages and atherosclerotic plaque stability
Supplier
Lee Won-Ha et al., In Mediators of Inflammation, 1995
... mAb for CD147 (clone MEM-M6/1) was from Abcam (MA, USA) anti-IFITM1 mAb ...
Papers on CD147
Vaginal Inflammation: Association between Leukocyte Concentration and Levels of Immune Mediators.
New
Gonçalves et al., Campinas, Brazil. In Am J Reprod Immunol, Feb 2016
We correlated extracellular matrix metalloproteinase inducer (EMMPRIN), matrix metalloproteinase-8 (MMP-8), hyaluronan (HA), hyaluronidase-1 (Hyal-1), human β-defensin-2 (hBD2), and neutrophil gelatinase-associated lipocalin (NGAL) concentrations with the extent of leukocyte infiltration into the vagina and suggest their participation in vaginal inflammation.
NS‑398 promotes pancreatic cancer cell invasion by CD147 and MMP‑2 via the activation of P38.
New
Gao et al., Shanghai, China. In Mol Med Report, Feb 2016
The results showed that NS‑398‑induced the expression of CD147 and MMP‑2 via the activation of P38, which was involved in antiproliferative activity and induced pancreatic cancer cell invasiveness.
TRAF6 regulates melanoma invasion and metastasis through ubiquitination of Basigin.
New
Chen et al., Changsha, China. In Oncotarget, Feb 2016
Notably, we demonstrated that Basigin (BSG)/CD147, a critical molecule for cancer cell invasion and metastasis, is a novel interacting partner of TRAF6.
Association of CD147 and Calcium Exporter PMCA4 Uncouples IL-2 Expression from Early TCR Signaling.
New
Stockinger et al., Vienna, Austria. In J Immunol, Feb 2016
UNASSIGNED: The Ig superfamily member CD147 is upregulated following T cell activation and was shown to serve as a negative regulator of T cell proliferation.
Effects of process parameters on the properties of barley containing snacks enriched with brewer's spent grain.
New
Jouppila et al., Helsinki, Finland. In J Food Sci Technol, Jan 2016
Brewer's spent grain (BSG), a by-product of malting of barley in the production of malt extract, was used as an ingredient in extruded barley-based snacks in order to improve the nutritional value of the snacks and widen the applications of this by-product in food sector.
Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners.
Review
New
Muramatsu, Nagoya, Japan. In J Biochem, Jan 2016
UNASSIGNED: Basigin, also called CD147 or EMMPRIN, is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily.
The roles of CD147 in the progression of gliomas.
Review
New
Chen et al., Xi'an, China. In Expert Rev Anticancer Ther, Nov 2015
CD147, a highly glycosylated transmembrane glycoprotein with two Ig-like extracellular domains that belongs to the immunoglobulin superfamily, plays an important role in the regulation of tumor invasiveness, angiogenesis and glycolysis by inducing the secretion of matrix metalloproteinases and vascular endothelial growth factor and by interacting with monocarboxylate transporters.
The role of EMMPRIN in T cell biology and immunological diseases.
Review
New
Yong et al., Calgary, Canada. In J Leukoc Biol, Jul 2015
EMMPRIN (CD147), originally described as an inducer of the expression of MMPs, has gained attention in its involvement in various immunologic diseases, such that anti-EMMPRIN antibodies are considered as potential therapeutic medications.
The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells.
New
Impact
Carrasco et al., Boston, United States. In Nat Med, Jun 2015
We found that extracellular CyPA (eCyPA), secreted by bone marrow endothelial cells (BMECs), promoted the colonization and proliferation of MM cells in an in vivo scaffold system via binding to its receptor, CD147, on MM cells.
How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity.
Review
Toole et al., Charleston, United States. In Biosci Rep, 2014
Subsequent studies demonstrated that EMMPRIN was identical with several other protein factors, including basigin (Bsg), all of which are now commonly termed CD147.
Prognostic Indications of Elevated MCT4 and CD147 across Cancer Types: A Meta-Analysis.
Review
Curry et al., Philadelphia, United States. In Biomed Res Int, 2014
The transporters MCT1 and MCT4 are regulated via expression of their chaperone, CD147.
Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies.
Impact
Higgins et al., Hørsholm, Denmark. In Nature, 2014
RH5 from Plasmodium falciparum (PfRH5) is the only member of either family demonstrated to be necessary for erythrocyte invasion in all tested strains, through its interaction with the erythrocyte surface protein basigin (also known as CD147 and EMMPRIN).
Antigen-specific immune responses and clinical outcome after vaccination with glioma-associated antigen peptides and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in children with newly diagnosed malignant brainstem and nonbrainstem gliomas.
Impact
Okada et al., Pittsburgh, United States. In J Clin Oncol, 2014
Having identified a series of glioma-associated antigens (GAAs) commonly overexpressed in pediatric gliomas, we initiated a pilot study of subcutaneous vaccinations with GAA epitope peptides in HLA-A2-positive children with newly diagnosed BSG and HGG.
Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.
Impact
Yan et al., Beijing, China. In Nat Genet, 2014
PPM1D mutations were mutually exclusive with TP53 mutations in BSG and attenuated p53 activation in vitro.
Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization.
Impact
Bourdoulous et al., Paris, France. In Nat Med, 2014
Here, we report that the immunoglobulin superfamily member CD147 (also called extracellular matrix metalloproteinase inducer (EMMPRIN) or Basigin) is a critical host receptor for the meningococcal pilus components PilE and PilV.
CD147 and AGR2 expression promote cellular proliferation and metastasis of head and neck squamous cell carcinoma.
GeneRIF
Rosenthal et al., Birmingham, United States. In Exp Cell Res, 2012
In vitro, knockdown of CD147 or AGR2 decreased cellular proliferation, migration and invasion. In vivo, knockdown of CD147 or AGR2 expression decreased primary tumor growth as well as regional and distant metastasis.
Release of overexpressed CypB activates ERK signaling through CD147 binding for hepatoma cell resistance to oxidative stress.
GeneRIF
Choe et al., Seoul, South Korea. In Apoptosis, 2012
CypB has an essential function in protecting hepatoma cells against oxidative stress through binding to CD147 and regulating the ERK pathway
Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors.
GeneRIF
Xing et al., Shanghai, China. In Carcinogenesis, 2012
observed that CD147 promoted tumor growth, inhibited tumor cell apoptosis and enhanced their invasion ability under hypoxia
CD147 expression in advanced cutaneous squamous cell carcinoma.
GeneRIF
Rosenthal et al., Birmingham, United States. In J Cutan Pathol, 2012
CD147 may represent a biomarker or potential therapeutic target in advanced cutaneous SCC.
Comparison of p38MAPK (mitogene activated protein kinase), p65 NFkappaB (nuclear factor kappa b) and EMMPRIN (extracellular matrix metalloproteinase inducer) expressions with tumor grade and stage of superficial and invasive bladder tumors.
GeneRIF
Somay et al., İstanbul, Turkey. In Arch Ital Urol Androl, 2011
In both TUR and radical cystectomy specimens of bladder tumors, EMMPRIN, expression was higher than in normal tissue samples. EMMPRIN expression was also increased according to tumor grade.
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