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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Colony stimulating factor 2 receptor, beta, low-affinity

CD131, CSF2RB, IL5RB, Cytokine receptor common beta subunit, Colony stimulating factor 2 receptor, beta
The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: erythropoietin, erythropoietin receptor, V1a, CsF, GMR
Papers on CD131
Auger electron-emitting (111)In-DTPA-NLS-CSL360 radioimmunoconjugates are cytotoxic to human acute myeloid leukemia (AML) cells displaying the CD123(+)/CD131(-) phenotype of leukemia stem cells.
New
Reilly et al., Toronto, Canada. In Appl Radiat Isot, Jan 2016
UNASSIGNED: Chimeric IgG1 monoclonal antibody CSL360 recognizes the CD123(+)/CD131(-) phenotype expressed by leukemic stem cells (LSC).
CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common beta chain of the IL-3, GM-CSF and IL-5 receptors.
New
Owczarek et al., Australia. In Mabs, Jan 2016
UNASSIGNED: The beta common-signaling cytokines interleukin (IL)-3, granulocyte-macrophage colony stimulating factor (GM-CSF) and IL-5 stimulate pro-inflammatory activities of hematopoietic cells via a receptor complex incorporating cytokine-specific alpha and shared beta common (βc, CD131) receptor.
Transcriptome profiling of human FoxP3(+) regulatory T cells.
New
Shevach et al., Bethesda, United States. In Hum Immunol, Jan 2016
Notably, a number of yet uncharacterized genes (RTKN2, LAYN, UTS2, CSF2RB, TRIB1, F5, CECAM4, CD70, ENC1 and NKG7) were identified and validated as being differentially expressed in human Tregs.
[Expression of CD131 Gene in Acute Myeloid Leukemic Cells].
New
Chen et al., Fuzhou, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, Dec 2015
OBJECTIVE: To detect the expression level and the mutantion of CD131 in acute myeloid leukemic (AML) cells, and to analyze the relationship of CD131 expression level with clinical features.
Targeted imputation of sequence variants and gene expression profiling identifies twelve candidate genes associated with lactation volume, composition and calving interval in dairy cattle.
New
Hayes et al., Australia. In Mamm Genome, Dec 2015
There was statistical support for imputed sequence variants in or close to BTRC, MGST1, SLC37A1, STAT5A, STAT5B, PAEP, VDR, CSF2RB, MUC1, NCF4, and GHDC associated with milk production, and EPGN for calving interval.
Carbamylated erythropoietin mediates retinal neuroprotection in streptozotocin-induced early-stage diabetic rats.
New
Xu et al., Shanghai, China. In Graefes Arch Clin Exp Ophthalmol, Aug 2015
Gene and protein levels of colony-stimulating factor 2 receptor beta, low-affinity (CD131), EPO receptor (EPOR), THY1, glial fibrillary acidic protein (GFAP), and vascular endothelial growth factor (VEGF-A) in retinal tissues were determined by real-time PCR and western blotting, respectively.
Discovery and Characterization of Nonpeptidyl Agonists of the Tissue-Protective Erythropoietin Receptor.
New
Punnonen et al., Menlo Park, United States. In Mol Pharmacol, Aug 2015
Here, we describe the discovery and characterization of the nonpeptidyl compound STS-E412 (2-[2-(4-chlorophenoxy)ethoxy]-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine), which selectively activates the tissue-protective EPO receptor, comprising an EPO receptor subunit (EPOR) and the common β-chain (CD131).
Engineering superactive granulocyte macrophage colony-stimulating factor transferrin fusion proteins as orally-delivered candidate agents for treating neurodegenerative disease.
New
Priebe et al., Norman, United States. In Biotechnol Prog, May 2015
Flow cytometric screening of 37 yeast-displayed GM-CSF saturation mutant libraries revealed residues P12, H15, R23, R24, and K72 as key determinants of GM-CSF's CD116 and CD131 GM-CSF receptor (GM-CSFR) subunit binding affinity.
The lack of CD131 and the inhibition of Neuro-2a growth by carbamylated erythropoietin.
New
Xiao et al., Shanghai, China. In Cell Biol Toxicol, Feb 2015
As compared to primary neurons, the expression of CD131, as a receptor complex binding to CEPO, is almost lacking in Neuro-2a cells.
Agonists of the tissue-protective erythropoietin receptor in the treatment of Parkinson's disease.
Review
Spencer et al., Menlo Park, United States. In Curr Top Med Chem, 2014
The tissue-protective erythropoietin (EPO) receptor, EPOR/CD131, has emerged as one promising target for disease-modifying therapies.
Pulmonary macrophage transplantation therapy.
Impact
Trapnell et al., Cincinnati, United States. In Nature, 2014
Here, using granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor-β-deficient (Csf2rb(-/-)) mice that develop a myeloid cell disorder identical to hereditary pulmonary alveolar proteinosis (hPAP) in children with CSF2RA or CSF2RB mutations, we show that pulmonary macrophage transplantation (PMT) of either wild-type or Csf2rb-gene-corrected macrophages without myeloablation was safe and well-tolerated and that one administration corrected the lung disease, secondary systemic manifestations and normalized disease-related biomarkers, and prevented disease-specific mortality.
Erythropoietin: multiple targets, actions, and modifying influences for biological and clinical consideration.
Review
Broxmeyer, Indianapolis, United States. In J Exp Med, 2013
EPO signals via two receptors, one comprising EPO receptor (EPOR) homodimers and the other a heterodimer of EPOR and CD131-the common β chain component of the GM-CSF, interleukin (IL)-3, and IL-5 receptors.
The receptor that tames the innate immune response.
Review
Cerami et al., Ossining, United States. In Mol Med, 2011
On the basis of current evidence, the TPR is composed of the β common receptor subunit (CD131) in combination with the same EPO receptor subunit that is involved in erythropoiesis.
Three lysine residues in the common β chain of the interleukin-5 receptor are required for Janus kinase (JAK)-dependent receptor ubiquitination, endocytosis, and signaling.
GeneRIF
Martinez-Moczygemba et al., Houston, United States. In J Biol Chem, 2011
JAK kinase binding to betac requires the presence of three critical betac lysine residues, and this binding event is essential for receptor ubiquitination, endocytosis, and signaling.
Common SNPs in CSF2RB are associated with major depression and schizophrenia in the Chinese Han population.
GeneRIF
Shi et al., Shanghai, China. In World J Biol Psychiatry, 2011
The results of the study support CSF2RB as a risk factor common to both schizophrenia and major depression in the Chinese Han population.
Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations.
GeneRIF
Trapnell et al., In Eur Respir J, 2011
Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations [case report]
Down-regulating the expression of IL-3Rβ interfered with the proliferation, not differentiation in NB4 cells.
GeneRIF
Chen et al., Fuzhou, China. In Int J Hematol, 2011
the up-regulation of IL-3Rbeta expression may contribute to the maintenance of proliferation rather than cell differentiation.
[Expression change of IL-3 receptor system in all-trans retinoic acid induced differentiation of NB4 cells].
GeneRIF
Chen et al., Fuzhou, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2010
Over expression of IL-3Ralpha and truncated mutation of hbetac may be involved in proliferation and differentiation block in NB4 cells.
Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii.
Review
Carter, Hastings, United Kingdom. In Schizophr Bull, 2009
Genes encoding for proteins related to the innate immune response, including cytokine related (CCR5, CSF2RA, CSF2RB, IL1B, IL1RN, IL2, IL3, IL3RA, IL4, IL10, IL10RA, IL18RAP, lymphotoxin-alpha, tumor necrosis factor alpha [TNF]), human leukocyte antigen (HLA) antigens (HLA-A10, HLA-B, HLA-DRB1), and genes involved in antigen processing (angiotensin-converting enzyme and tripeptidyl peptidase 2) are all concerned with defense against invading pathogens.
Discovering erythropoietin's extra-hematopoietic functions: biology and clinical promise.
Review
Cerami et al., Ossining, United States. In Kidney Int, 2006
Experimental observations also suggest the existence of EPO receptor (EPOR) isoforms mediating EPO's diverse biological activities and have identified a tissue-protective receptor complex consisting of the EPOR and the beta common receptor (CD131) subunit that is also employed by granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5.
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