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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


CD13, aminopeptidase N, APN, p150, aminopeptidase M
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: aminopeptidase, CAN, HAD, adiponectin, CD34
Papers using CD13 antibodies
Microtubules containing detyrosinated tubulin are less dynamic
Greber Urs F. et al., In Viruses, 1986
... The construct mEGFP-CC1 was cloned by inserting the chicken CC1 domain of p150/Glued [57] into the pEGFP-C1 vector (Clontech) employing the restriction sites ...
Papers on CD13
Systemic and tumor-targeted delivery of siRNA by cyclic NGR and isoDGR motif-containing peptides.
Liang et al., Beijing, China. In Biomater Sci, Feb 2016
The cyclic NGR motif and its isomerization product isoDGR recruit CD13 and integrin as their specific receptors, both of which are overexpressed by tumor and neovascular cells.
Evaluation of (188)Re-labeled NGR-VEGI protein for radioimaging and radiotherapy in mice bearing human fibrosarcoma HT-1080 xenografts.
Wang et al., Xi'an, China. In Tumour Biol, Feb 2016
The NGR (asparagine-glycine-arginine)-containing peptides can specifically bind to CD13 (Aminopeptidase N) receptor which is overexpressed in angiogenic blood vessels and tumor cells.
Aminopeptidase N (APN/CD13) as a target molecule for scirrhous gastric cancer.
Kajiyama et al., Tokyo, Japan. In Clin Res Hepatol Gastroenterol, Feb 2016
In contrast, CD13(-high) subpopulation of HSC-58 was more sensitive to an aminopeptidase N inhibitor bestatin.
CD13 and ROR2 Permit Isolation of Highly Enriched Cardiac Mesoderm from Differentiating Human Embryonic Stem Cells.
Ardehali et al., Los Angeles, United States. In Stem Cell Reports, Feb 2016
Here, we identify CD13 and ROR2 as cell-surface markers capable of selecting early cardiac mesoderm emerging during hESC differentiation.
Immunophenotypic markers in adult acute lymphoblastic leukemia: the prognostic significance of CD20 and TdT expression.
Park et al., Seoul, South Korea. In Blood Res, Dec 2015
Expression of CD20, CD13, CD34, and TdT was associated with HRFS rate, and expression of CD20 and CD13 was associated with OS rate, as was the performance of allo-HCT.
Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development.
Stetson et al., Seattle, United States. In Immunity, Dec 2015
We showed that the p150 isoform of ADAR1 uniquely regulated the MDA5 pathway, whereas both the p150 and p110 isoforms contributed to development.
Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.
Williams et al., Brussels, Belgium. In Science, Nov 2015
We present the 4.4 angstrom crystal structure of the 385-kilodalton endosomal complex II (PIK3C3-CII), consisting of Vps34, Vps15 (p150), Vps30/Atg6 (Beclin 1), and Vps38 (UVRAG).
The role of the chromatin assembly complex (CAF-1) and its p60 subunit (CHAF1b) in homeostasis and disease.
Crispino et al., Chicago, United States. In Biochim Biophys Acta, Aug 2015
Whereas the diverse functions of the large (CAF-1-p150, CHAF1a) and small (RbAp48, p48) subunits of the CAF-1 complex have been well-characterized in many tissues and extend beyond histone chaperone activity, the contributions of the medium subunit (CAF-1-p60, CHAF1b) are much less well understood.
Grabbing the genome by the NADs.
Kaufman et al., Worcester, United States. In Chromosoma, Aug 2015
Recently published studies from several multicellular eukaryotes have begun to reveal the trans-acting factors involved in NAD localization, including the insulator protein CCCTC-binding factor (CTCF), chromatin assembly factor (CAF)-1 subunit p150, several nucleolar proteins, and two long non-coding RNAs (lncRNAs).
Autoregulatory mechanism for dynactin control of processive and diffusive dynein transport.
Gross et al., Irvine, United States. In Nat Cell Biol, 2014
The latter function was thought to involve the N-terminal microtubule-binding region of the major dynactin polypeptide p150(Glued), although recent results disputed this.
The diverse roles of adiponectin in non-small-cell lung cancer: current data and future perspectives.
Syrigos et al., Athens, Greece. In Future Oncol, 2014
Adiponectin (APN) is the most abundant circulating adipokine, and a key mediator of several cancer-related processes, such as cell proliferation, apoptosis, regulation of tumor cell invasion and angiogenesis.
Successful long-term control of recurrent primary central nervous system anaplastic large cell lymphoma after autologous hematopoietic stem cell transplantation with concurrent whole brain and spinal cord radiotherapy.
Kobayashi et al., Nagano, Japan. In Rinsho Ketsueki, 2014
Cerebrospinal fluid (CSF) cytology showed large atypical cells expressing CD2, cytoplasmic CD3, CD7, CD13 and CD30.
Hepatocellular Carcinoma: Basic and Transitional Research.
Xie et al., Shanghai, China. In Gastrointest Tumors, 2014
CSC-based therapies are still in the earlier stages of development and include a neutralizing anti-CD44 antibody, small interfering RNA to suppress epithelial cell adhesion molecular levels, a neutralizing anti-CD13 antibody and a CD13 inhibitor.
Acute myeloid leukemia in first remission: to choose transplantation or not?
Stone, Boston, United States. In J Clin Oncol, 2013
Bone marrow examination revealed 90% infiltration with myeloid-appearing blasts, and flow cytometry analysis confirmed the diagnosis of acute myeloid leukemia (AML) with expression of CD33, CD13, and CD117.
PtdIns(4)P regulates retromer-motor interaction to facilitate dynein-cargo dissociation at the trans-Golgi network.
Liu et al., Beijing, China. In Nat Cell Biol, 2013
We report that phosphotidylinositol-4-phosphate (PtdIns(4)P), a Golgi-enriched phosphoinositide, negatively regulates the protein-protein interaction between the p150(Glued) subunit of dynein-dynactin and the retromer component SNX6.
Intestinal peptidases form functional complexes with the neutral amino acid transporter B(0)AT1.
Bröer et al., Canberra, Australia. In Biochem J, 2012
the presence of digestive protein complexes in the intestinal brush-border containing the peptidases APN and ACE2 and the neutral amino acid transporter B0AT1
CD13 regulates dendritic cell cross-presentation and T cell responses by inhibiting receptor-mediated antigen uptake.
Shapiro et al., Farmington, United States. In J Immunol, 2012
Myeloid cell surface peptidase CD13 is highly and specifically expressed on a subset of dendritic cells (DCs) responsible for cross-presentation: transgenic CD8+ murine splenic DCs.
Promoter methylation of aminopeptidase N/CD13 in malignant melanoma.
Seliger et al., Halle, Germany. In Carcinogenesis, 2012
Staining of tissue microarrays generated from a large series of melanoma samples and control tissues demonstrated a higher APN expression in primary melanoma lesions when compared with nevi and metastases
Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment.
Pasqualini et al., Houston, United States. In Proc Natl Acad Sci U S A, 2012
cooperation in APN expression by both cancer cells and nonmalignant stromal cells within the tumor microenvironment promotes angiogenesis, tumor growth, and metastasis
Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia.
Striggow et al., Magdeburg, Germany. In J Neuroinflammation, 2011
This study demonistrated that aminopeptidase N were up-regulated ipsilaterally from 6 h to 7 days post ischemia
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