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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.


CD13, aminopeptidase N, APN, p150, aminopeptidase M
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using CD13 antibodies
Microtubules containing detyrosinated tubulin are less dynamic
Greber Urs F. et al., In Viruses, 1986
... The construct mEGFP-CC1 was cloned by inserting the chicken CC1 domain of p150/Glued [57] into the pEGFP-C1 vector (Clontech) employing the restriction sites ...
Papers on CD13
Intestinal peptidases form functional complexes with the neutral amino acid transporter B(0)AT1.
Bröer et al., Canberra, Australia. In Biochem J, 2012
the presence of digestive protein complexes in the intestinal brush-border containing the peptidases APN and ACE2 and the neutral amino acid transporter B0AT1
CD13 regulates dendritic cell cross-presentation and T cell responses by inhibiting receptor-mediated antigen uptake.
Shapiro et al., Farmington, United States. In J Immunol, 2012
Myeloid cell surface peptidase CD13 is highly and specifically expressed on a subset of dendritic cells (DCs) responsible for cross-presentation: transgenic CD8+ murine splenic DCs.
Promoter methylation of aminopeptidase N/CD13 in malignant melanoma.
Seliger et al., Halle, Germany. In Carcinogenesis, 2012
Staining of tissue microarrays generated from a large series of melanoma samples and control tissues demonstrated a higher APN expression in primary melanoma lesions when compared with nevi and metastases
Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment.
Pasqualini et al., Houston, United States. In Proc Natl Acad Sci U S A, 2012
cooperation in APN expression by both cancer cells and nonmalignant stromal cells within the tumor microenvironment promotes angiogenesis, tumor growth, and metastasis
Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia.
Striggow et al., Magdeburg, Germany. In J Neuroinflammation, 2011
This study demonistrated that aminopeptidase N were up-regulated ipsilaterally from 6 h to 7 days post ischemia
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