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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interleukin 3 receptor, alpha

CD123, IL-3R, interleukin-3 receptor, IL-3Ralpha
The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Interleukin-3, CD11c, CAN, CD4, CD34
Papers using CD123 antibodies
IFN-g production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
Zheng Song Guo, In PLoS ONE, 2004
... Biosciences), anti-CD45RO (UCHL1, BD Biosciences), anti-CD58 (AICD85, Immunotech), anti-CD80 (MAB104, Beckman Coulter), anti-CD86 (BU63, Serotec), anti-CD123 (9F5, BD Biosciences), anti-CD127 (HIL-7R-M21, BD Pharmingen), ...
Toxoplasma gondii: localization of purine nucleoside phosphorylase activity in vitro and in vivo by electron microscopy.
Metzger Dennis W., In PLoS ONE, 2004
... Purity of sorted pDCs (85 to 95%) was analysed by staining with anti-BDCA-2 and anti-CD123 monoclonal antibodies (Miltenyi Biotec) by flow cytometry (FACSCAN) ...
Plasmacytoid predendritic cells initiate psoriasis through interferon-α production
Gilliet Michel et al., In The Journal of Experimental Medicine, 2003
... cryopreserved specimens were stained with unlabeled anti–BDCA-2 mAb followed by FITC-labeled anti–mouse IgG mAb (DakoCytomation), anti-CD123 PE (BD Biosciences), and anti-CD3 APCs (BD ...
SOCS proteins: negative regulators of cytokine signaling.
Hartl Dominik, In PLoS ONE, 2000
... 303522, 3 µl per sample), CD123-PE (BioLegend, Cat ...
Papers on CD123
Soluble Expression and Characterization of a New scFv Directed to Human CD123.
Shokrgozar et al., Tehrān, Iran. In Appl Biochem Biotechnol, Feb 2016
UNASSIGNED: Leukemic cancer stem cells (LSCs), as a unique cell population in acute myeloid leukemia (AML) marked by CD123 overexpression, are thought to play a key role in relapsed AML after chemotherapy.
Human kidney damage in fatal dengue hemorrhagic fever results of glomeruli injury mainly induced by IL17.
Duarte et al., São Paulo, Brazil. In J Clin Virol, Jan 2016
S100, Foxp3 and CD123 cells were not identified.
CD123 redirected multiple virus-specific T cells for acute myeloid leukemia.
Song et al., Jinan, China. In Leuk Res, Jan 2016
In this article, we now describe the generation of VST cells that are engineered to express CAR for a specific AML cell-surface antigen CD123 (CD123-CAR-VST).
Auger electron-emitting (111)In-DTPA-NLS-CSL360 radioimmunoconjugates are cytotoxic to human acute myeloid leukemia (AML) cells displaying the CD123(+)/CD131(-) phenotype of leukemia stem cells.
Reilly et al., Toronto, Canada. In Appl Radiat Isot, Jan 2016
UNASSIGNED: Chimeric IgG1 monoclonal antibody CSL360 recognizes the CD123(+)/CD131(-) phenotype expressed by leukemic stem cells (LSC).
Bone marrow and splenic histology in hairy cell leukaemia.
Sena Teixeira Mendes et al., London, United Kingdom. In Best Pract Res Clin Haematol, Dec 2015
The cells stain for B-cell related antigens as well as with antibodies against tartrate-resistant acid phosphatase, DBA44 (CD72), CD11c, CD25, CD103, CD123, cyclin D1 and annexin A1.
Targeting LSCs through membrane antigens selectively or preferentially expressed on these cells.
Testa et al., Roma, Italy. In Blood Cells Mol Dis, Dec 2015
Concerning this last point, the most promising therapeutic targets are CD33 and CD123.
Hairy cell leukaemia-variant: Disease features and treatment.
Campo et al., Barcelona, Spain. In Best Pract Res Clin Haematol, Dec 2015
The immunophenotype is that of a clonal B-cell CD11c and CD103 positive but, unlike classical HCL, CD25, CD123 and CD200 negative.
T cells expressing CD123 chimeric antigen receptors for treatment of acute myeloid leukemia.
Budde et al., Duarte, United States. In Curr Opin Hematol, Nov 2015
PURPOSE OF REVIEW: The purpose of this article is to discuss the rationale of targeting CD123 using chimeric antigen receptor (CAR) T cells for the treatment of leukemia.
Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues.
Sitnicka et al., Lund, Sweden. In Immunity, Sep 2015
Here we demonstrate that a Lin(-)CD34(+)CD38(+)CD123(-)CD45RA(+)CD7(+)CD10(+)CD127(-) population represents a NK lineage-restricted progenitor (NKP) in fetal development, umbilical cord blood, and adult tissues.
Perspectives for therapeutic targeting of gene mutations in acute myeloid leukaemia with normal cytogenetics.
Martelli et al., Perugia, Italy. In Br J Haematol, Aug 2015
Potential approaches for therapeutic targeting of NPM1-mutated AML include: (i) reverting the aberrant nuclear export of NPM1 mutant using exportin-1 inhibitors; (ii) disruption of the nucleolus with drugs blocking the oligomerization of wild-type nucleophosmin or inducing nucleolar stress; and (iii) immunotherapeutic targeting of highly expressed CD33 and IL3RA (CD123) antigens.
Plasmacytoid Dendritic Cells Producing Interferon-α (IFN-α) and Inducing Mx1 Play an Important Role for CD4(+) Cells and CD8(+) Cells in Necrotizing Lymphadenitis.
Wakasa et al., Oral, Kazakhstan. In J Clin Exp Hematop, 2014
Histopathology of NEL was characterized by the presence of CD8(+) immunoblasts, CD123(+) cells (plasmacytoid dendritic cells; PDCs), histiocytes and macrophages phagocytizing CD4(+) apoptotic lymphocytes, but no granulocytes or bacteria.
High levels of CD34+CD38low/-CD123+ blasts are predictive of an adverse outcome in acute myeloid leukemia: a Groupe Ouest-Est des Leucemies Aigues et Maladies du Sang (GOELAMS) study.
Bardet et al., Paris, France. In Haematologica, 2011
High levels of CD34+CD38low/-CD123+ blasts are predictive of an adverse outcome in acute myeloid leukemia
Opposing regulation of PROX1 by interleukin-3 receptor and NOTCH directs differential host cell fate reprogramming by Kaposi sarcoma herpes virus.
Hong et al., Los Angeles, United States. In Plos Pathog, 2011
we report that IL3 receptor alpha (IL3Ralpha) and NOTCH play integral roles in the host cell type-specific regulation of PROX1 by Kaposi sarcoma herpes virus
Hypertrophic lupus erythematosus: the diagnostic utility of CD123 staining.
McNiff et al., New Haven, United States. In J Cutan Pathol, 2011
The pattern of CD123 staining can be a useful feature to distinguish hypertrophic lupus erythematosus, squamous cell carcinoma and hypertrophic actinic keratosis.
Characteristic CD103 and CD123 expression pattern defines hairy cell leukemia: usefulness of CD123 and CD103 in the diagnosis of mature B-cell lymphoproliferative disorders.
Stetler-Stevenson et al., Bethesda, United States. In Am J Clin Pathol, 2011
These findings support the usefulness of CD123 and CD103 to aid in the differential diagnosis of B-cell lymphoproliferative disorders
TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation.
Artis et al., Philadelphia, United States. In Nature, 2011
Critically, TSLP could elicit basophil responses in both IL-3-IL-3R-sufficient and -deficient environments, and genome-wide transcriptional profiling and functional analyses identified heterogeneity between TSLP-elicited versus IL-3-elicited basophils.
Overexpression of IL-3Rα on CD34+CD38- stem cells defines leukemia-initiating cells in Fanconi anemia AML.
Pang et al., Cincinnati, United States. In Blood, 2011
Interleukin 3 receptor alpha is a cell-surface marker present on leukemia-initiating cells of patients with Fanconi anemia-acute myeloid leukemia, and may be a promising therapeutic target for these patients.
Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition.
Corey et al., Seattle, United States. In Nat Med, 2009
The CD4(+) T cells that persisted reacted to HSV-2 antigen, were enriched for expression of the chemokine receptor CCR5, and were contiguous to DCs expressing the interleukin-3 receptor CD123 or DC-SIGN.
Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells.
Lock et al., Toronto, Canada. In Cell Stem Cell, 2009
We report that an anti-interleukin-3 (IL-3) receptor alpha chain (CD123)-neutralizing antibody (7G3) targeted AML-LSCs, impairing homing to bone marrow (BM) and activating innate immunity of nonobese diabetic/severe-combined immunodeficient (NOD/SCID) mice.
Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase.
Mellor et al., Augusta, United States. In Science, 2002
IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6.
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