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Integrin, alpha D

CD11d, ITGAD
human homolog is the alpha X chain of integrin; interacts with beta 2 chain (ITGB2) to form a leukocyte-specific integrin [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CD11b, CD11c, HAD, beta2, CD45
Papers on CD11d
Cutaneous histiocytic sarcoma with E-cadherin expression in a Pembroke Welsh Corgi dog.
New
Moore et al., Gifu, Japan. In J Vet Diagn Invest, Sep 2015
Neoplastic cells were positive for vimentin, HLA-DR antigen, Iba1, CD18, and E-cadherin, but cells did not express cytokeratin, S100, CD20, CD79α, CD3, MUM-1, lambda light chain, kappa light chain, lysozyme, CD204, or CD11d by immunohistochemistry. Electron microscopic analysis revealed dendrites on these cells.
CD11d integrin blockade reduces the systemic inflammatory response syndrome after traumatic brain injury in rats.
New
Brown et al., London, Canada. In Exp Neurol, Sep 2015
We have shown that the SIRS caused by spinal cord injury is greatly reduced by acute intravenous treatment with an antibody against the CD11d subunit of the CD11d/CD18 integrin expressed by neutrophils and monocyte/macrophages, a treatment that reduces their efflux from the circulation.
Whole genome and transcriptome sequencing of matched primary and peritoneal metastatic gastric carcinoma.
Yu et al., Shanghai, China. In Sci Rep, 2014
We identified 27 mutated genes, of which 19 genes are reported in COSMIC database (ZNF208, CRNN, ATXN3, DCTN1, RP1L1, PRB4, PRB1, MUC4, HS6ST3, MUC17, JAM2, ITGAD, IREB2, IQUB, CORO1B, CCDC121, AKAP2, ACAN and ACADL), and eight genes have not previously been described in gastric cancer (CCDC178, ARMC4, TUBB6, PLIN4, PKLR, PDZD2, DMBT1and DAB1).Additionally,GPX4 and MPND in 19q13.3-13.4
Resistant starch improves insulin resistance and reduces adipose tissue weight and CD11c expression in rat OLETF adipose tissue.
Goda et al., Shizuoka, Japan. In Nutrition, 2014
CD68 expression, a macrophage infiltration marker, was not changed by the RS diet, whereas the gene expression levels of integrins such as CD11c, CD11d, and CD18, but not CD11a, and CD11b, were significantly reduced.
Immunohistochemical evaluation of the effects of paraffin section storage on biomarker stability.
Miller et al., West Lafayette, United States. In Vet Pathol, 2014
Markers with complete loss after light exposure also had reduced immunoreactivity when stored in the dark, as early as day 3. Eight markers (Bartonella spp, CD11d, high molecular weight cytokeratins, feline coronavirus, GATA-4, insulin, p63, progesterone receptor) had minimal decrease in immunoreactivity, regardless of treatment.
A review of histiocytic diseases of dogs and cats.
Review
Moore, Davis, United States. In Vet Pathol, 2014
In dogs, histiocytes in hemophagocytic HS express CD11d/CD18, which is a leuko-integrin highly expressed by macrophages in splenic red pulp and bone marrow.
Differential expression of leukocyte β2 integrin signal transduction‑associated genes in patients with symptomatic pulmonary embolism.
Song et al., Shanghai, China. In Mol Med Report, 2014
In five subunit‑associated mRNAs, the mRNA expression of ITGAL, ITGAM, ITGAX and ITGB2, which encode for the subunits of αL, αM, αX and β2, were upregulated in the PE group and the differences, with the exception of ITGB2, were statistically significant (P<0.05).
Integrin αDβ2 (CD11d/CD18) is expressed by human circulating and tissue myeloid leukocytes and mediates inflammatory signaling.
Zimmerman et al., Tokyo, Japan. In Plos One, 2013
Integrin α(D)β(2) is the most recently identified member of the leukocyte, or β(2), subfamily of integrin heterodimers.
Ex vivo expansion of canine cytotoxic large granular lymphocytes exhibiting characteristics of natural killer cells.
Kim et al., Yesan, South Korea. In Vet Immunol Immunopathol, 2013
The phenotype of the majority of the CLGLs was CD5(dim)CD3(+)CD8(+) TCRαβ(-)TCRγδ(-)CD4(-)CD21(-)CD11c(+/-)CD11d(+/-)CD44(+).
Gene expression profiling of histiocytic sarcomas in a canine model: the predisposed flatcoated retriever dog.
Rutteman et al., Utrecht, Netherlands. In Plos One, 2012
RESULTS: QPCR analyses identified the significantly altered expression of nine genes; PPBP, SpiC, VCAM1, ENPEP, ITGAD (down-regulated), and GTSF1, Col3a1, CD90 and LUM (up-regulated) in the comparison of both the soft tissue and the visceral form with healthy spleen.
PP065. dNK and dNK-CM mediated alterations of DNA methylation in extravillous cytotrophoblasts (EVTS).
Robinson et al., Vancouver, Canada. In Pregnancy Hypertens, 2012
dNK-CM but not dNK reduced methylation of ITGAD and PCDH8 (protocadherin 8) and increased methylation of CDH4 and CDH6.
Anti-CD11d monoclonal antibody treatment for rat spinal cord compression injury.
GeneRIF
Dietrich et al., Miami, United States. In Exp Neurol, 2012
An anti-CD11d monoclonal antibody improves motor performance, reduces pain and histopathological damage in animals following clip-compression injury.
On the potential involvement of CD11d in co-stimulating the production of interferon-γ by natural killer cells upon interaction with neutrophils via intercellular adhesion molecule-3.
GeneRIF
Cassatella et al., Verona, Italy. In Haematologica, 2011
the cross-talk between neutrophils and NK cells is mediated by ICAM-3 and CD11d/CD18, respectively.
A systematic review of non-invasive pharmacologic neuroprotective treatments for acute spinal cord injury.
Review
Tetzlaff et al., Vancouver, Canada. In J Neurotrauma, 2011
These include: erythropoietin, NSAIDs, anti-CD11d antibodies, minocycline, progesterone, estrogen, magnesium, riluzole, polyethylene glycol, atorvastatin, inosine, and pioglitazone.
A systematic review of directly applied biologic therapies for acute spinal cord injury.
Review
Tetzlaff et al., Vancouver, Canada. In J Neurotrauma, 2011
These included: erythropoietin, NSAIDs, anti-CD11d antibodies, minocycline, progesterone, estrogen, magnesium, riluzole, polyethylene glycol, atorvastatin, inosine, and pioglitazone.
Inflammatory phenotyping identifies CD11d as a gene markedly induced in white adipose tissue in obese rodents and women.
GeneRIF
Adams et al., Davis, United States. In J Nutr, 2011
Relative white adipose tissue (WAT) expression of CD11d was massively induced by obesity to an extent greater than any other inflammatory marker (to >300-fold of controls in the 45 and 60% fat groups) and this induction was WAT specific.
Natural recovery from antiglomerular basement membrane glomerulonephritis is associated with glomeruli-infiltrating CD8α+CD11c+MHC class II+ cells.
GeneRIF
Lou et al., Houston, United States. In Am J Nephrol, 2010
Recovery from Antiglomerular Basement Membrane Glomerulonephritis Is Associated with Glomeruli-Infiltrating CD8alpha+CD11c+MHC Class II+ Cells
beta2-integrins in demyelinating disease: not adhering to the paradigm.
Review
Barnum et al., Birmingham, United States. In J Leukoc Biol, 2010
Studies in EAE, the animal model for multiple sclerosis, show differential requirements for beta(2)-integrins in this disease model, ranging from critical in the case of LFA-1 (CD11a/CD18) to unimportant in the case of CD11d/CD18.
The extracellular domain of CD11d regulates its cell surface expression.
GeneRIF
Dekaban et al., London, Canada. In J Leukoc Biol, 2009
multiple CD11d domains play a role in controlling intracellular location and association with CD18.
Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma.
Review
Mosher et al., Madison, United States. In J Leukoc Biol, 2008
Eosinophils express seven integrin heterodimeric adhesion molecules: alpha 4 beta 1 (CD49d/29), alpha 6 beta 1 (CD49f/29), alpha M beta 2 (CD11b/18), alpha L beta 2 (CD11a/18), alpha X beta 2 (CD11c/18), alpha D beta2 (CD11d/18), and alpha 4 beta 7 (CD49d/beta 7).
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