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Integrin, alpha X

CD11c
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD11b, CAN, CD4, HAD, CD8
Papers using CD11c antibodies
Macrophage expression of interleukin-10 is a prognostic factor in nonsmall cell lung cancer
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Berwin Brent et al., In Frontiers in Immunology, 2006
... (M5/114.15.2), and CD45.1 (A20) antibodies from eBioscience (San Diego, CA, USA); and anti-mouse Thy1.1 (OX-7), CD11c (N418), and IFN-γ (XMG1.2) antibodies from Biolegend (San Diego, CA, USA) ...
Monocytes give rise to mucosal, but not splenic, conventional dendritic cells.
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Mosley R. Lee, In PLoS ONE, 2006
... CD11c-DTR transgenic mice (B6.FVB-Tg Itgax-DTR/GFP 57Lan/J), ...
Plasmacytoid dendritic cells inhibit pulmonary immunopathology and promote clearance of respiratory syncytial virus.
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Sandberg Johan K., In PLoS ONE, 2005
... month aged and young (6–8 wks) C57BL/6 mice were purchased from Charles River (Germantown, MD), CD11c DTR/EGFP mice, OTI TCR transgenic and CD45.1 congenic C57BL/6 ...
Traumatic injury and the presence of antigen differentially contribute to T-cell recruitment in the CNS.
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Goletti Delia, In PLoS ONE, 2005
... CD11c-EYFP transgenic mice on the C57BL/6 ...
IFN-g production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
Supplier
Zheng Song Guo, In PLoS ONE, 2004
Serotec), anti-GARP (G14D9, eBioscience), mouse IgG: anti-CD3 (UCHT1, BD Biosciences), anti-CD4 (RPAT-4, BD Pharmingen), anti-CD11c (B-ly6; BD Biosciences), anti-CD14 (M5E2, BD Biosciences), ...
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Papers on CD11c
A Matter of Perspective: Moving from a Pre-omic to a Systems-Biology Vantage of Monocyte-Derived Cell Function and Nomenclature.
New
Impact
Malissen et al., Gent, Belgium. In Immunity, Feb 2016
emphasized that even by focusing on CD11c(+)MHC II(+) cells, this model yields a mixed bag of myeloid cells that derive from both common dendritic cell (DC) precursors and common monocyte precursors and showed gene-expression profiles distantly mimicking those expressed by their in vivo counterparts.
PAFR in adipose tissue macrophages is associated with anti-inflammatory phenotype and metabolic homeostasis.
New
Rios et al., São Paulo, Brazil. In Clin Sci (lond), Feb 2016
Moreover, the adipose tissue of PAFRKO presented higher pro-inflammatory macrophages, characterized by an increased frequency of F4/80(+)CD11c(+) cells.
IL-6 down-regulates HLA class II expression and IL-12 production of human dendritic cells to impair activation of antigen-specific CD4(+) T cells.
New
Taketomi et al., Sapporo, Japan. In Cancer Immunol Immunother, Feb 2016
Human leukocyte antigen (HLA)-DR and CD86 expression was significantly reduced in CD11b(+)CD11c(+) cells obtained from peripheral blood mononuclear cells (PBMCs) of healthy donors by IL-6 treatment and was STAT3 dependent.
Analysis of dendritic cell subpopulations in follicular lymphoma with respect to the tumor immune microenvironment.
New
Veelken et al., Freiburg, Germany. In Leuk Lymphoma, Feb 2016
Treg numbers particularly correlated with the subset of conventional CD11c(+ )DCs.
Early Tumor-Infiltrating Dendritic Cells Change their Characteristics Drastically in Association with Murine Melanoma Progression.
New
Furue et al., Fukuoka, Japan. In J Invest Dermatol, Jan 2016
Flow cytometric analysis revealed that the tumors were infiltrated by a significant population of CD11c(+) major histocompatibility complex II(+) DCs, especially at an early stage of tumor growth.
Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection.
New
Impact
Sigal et al., Philadelphia, United States. In Immunity, Jan 2016
Here, we showed that after infection with ECTV, the TLR9-MyD88-IRF7 pathway was necessary in CD11c(+) cells for the expression of proinflammatory cytokines and the recruitment of inflammatory monocytes (iMos) to the draining lymph node (dLN).
Bone marrow and splenic histology in hairy cell leukaemia.
Review
New
Sena Teixeira Mendes et al., London, United Kingdom. In Best Pract Res Clin Haematol, Dec 2015
The cells stain for B-cell related antigens as well as with antibodies against tartrate-resistant acid phosphatase, DBA44 (CD72), CD11c, CD25, CD103, CD123, cyclin D1 and annexin A1.
Hairy cell leukaemia-variant: Disease features and treatment.
Review
New
Campo et al., Barcelona, Spain. In Best Pract Res Clin Haematol, Dec 2015
The immunophenotype is that of a clonal B-cell CD11c and CD103 positive but, unlike classical HCL, CD25, CD123 and CD200 negative.
Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease.
New
Impact
Godson et al., San Diego, United States. In Cell Metab, Aug 2015
LXA4 decreased obesity-induced adipose inflammation, attenuating TNF-α and CD11c(+) M1-macrophages (MΦs), while restoring CD206(+) M2-MΦs and increasing Annexin-A1.
GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c(+)MHCII(+) Macrophages and Dendritic Cells.
New
Impact
Reis e Sousa et al., London, United Kingdom. In Immunity, Jul 2015
BMDCs express CD11c and MHC class II (MHCII) molecules and share with DCs isolated from tissues the ability to present exogenous antigens to T cells and to respond to microbial stimuli by undergoing maturation.
Understanding high endothelial venules: Lessons for cancer immunology.
Review
New
May et al., Philadelphia, United States. In Oncoimmunology, Jun 2015
Recent elegant studies using gene-targeted mice have demonstrated clearly that triggering the lymphotoxin-β receptor in endothelial cells (EC) induces the differentiation of HEV and that CD11c(+) dendritic cells play a crucial role in this process.
Epidermal Fatty Acid binding protein promotes skin inflammation induced by high-fat diet.
New
Impact
Li et al., Austin, United States. In Immunity, Jun 2015
We demonstrated that HFD induced the accumulation of a specific type of CD11c(+) macrophages in skin preceding detectable lesions.
Fate mapping of dendritic cells.
Review
Schraml et al., München, Germany. In Front Immunol, 2014
They are classified predominantly based on phenotypic and functional properties, namely their stellate morphology, expression of the integrin CD11c, and major histocompatibility class II molecules, as well as their superior capacity to migrate to secondary lymphoid organs and stimulate naïve T cells.
DC targeting DNA vaccines induce protective and therapeutic antitumor immunity in mice.
Zhao et al., Shanghai, China. In Int J Clin Exp Med, 2014
To exploit these properties for immunization purposes, we obtained DC-targeting DNA vaccines by fusing tumor-associated antigen HER2/neu ectodomain to single chain antibody fragment (scFv) from N418 (scFv(N418)), a monoclonal antibody binding the mouse DC-restricted surface molecule CD11c, and explored its antitumoral efficacy and underlying mechanisms in mouse breast cancer models.
Induction of osteoclast progenitors in inflammatory conditions: key to bone destruction in arthritis.
Review
Grčević et al., Zagreb, Croatia. In Int Orthop, 2014
Collectively, current studies suggest that the most potent murine bone marrow OCP population can be identified among lymphoid negative population within the immature myeloid lineage cells, as B220(-)CD3(-)CD11b(-/lo)CD115(+)CD117(+)CX3CR1(+) and possibly also Ter119(-)CD11c(-)CD135(lo)Ly6C(+)RANK(-).
Integrin αXβ₂ is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.
GeneRIF
Soloviev et al., Cleveland, United States. In J Immunol, 2012
Residential macrophages require integrin alphaXbeta2 to control Candida albicans invasion of the brain in vivo.
Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell differentiation and induces autoimmunity.
GeneRIF
Matozaki et al., Maebashi, Japan. In J Immunol, 2012
Mice lacking protein tyrosine phosphatase Shp1 specifically in dendritic cells (DCs) develop splenomegaly associated with more CD11c+ DCs.
Molecular basis for complement recognition by integrin αXβ2.
GeneRIF
Springer et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
analysis of complement recognition by integrin alphaXbeta2
CD11c+HLADR+ dendritic cells are present in human ovarian follicular fluid, and their maturity correlates with serum estradiol levels in response to gonadotropins.
GeneRIF
Ellenbogen et al., H̱adera, Israel. In Fertil Steril, 2012
CD11c+HLADR+ dendritic cells are present in human ovarian follicular fluid, and their maturity correlates with serum estradiol levels in response to gonadotropins.
[Participation of beta2-integrins CD11b/CD18 and CD11c/CD18 in adhesion and migration of cells on fibrinogen].
GeneRIF
Aref'eva et al., In Ross Fiziol Zh Im I M Sechenova, 2011
The data obtained suggest that spontaneous cell adhesion to fibrinogen is mediated to a greater extent by CD11b/CD18 integrins, while chemokine-stimulated adhesion and migration is mostly dependent on CD11c/CD18 molecules.
More papers using CD11c antibodies
Natural killer cell activation primes macrophages to clear bacterial infection.
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Coers Jörn, In PLoS ONE, 2002
... This study involved also the use of the C57BL/6 mouse strain CD11c:Diphtheria toxin (DTx) receptor (DTR) transgenic mice (B6.FVB-Tg (Itgax-DTR/GFP)57Lan/J; The ...
Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation
Supplier
Grinstein Sergio et al., In The Journal of Cell Biology, 2000
... The hamster anti–mouse Cd11c antibody (clone N418) was from eBioscience.
The first step of adenovirus type 2 disassembly occurs at the cell surface, independently of endocytosis and escape to the cytosol.
Supplier
Früh Klaus, In PLoS Pathogens, 1999
... deficient mice and CD11c-diphtheria toxin receptor (DTR)/GFP transgenic mice ...
Real-time PCR quantification of full-length and exon 11 spliced BRCA1 transcripts in human breast cancer cell lines.
Supplier
Koch Alisa E et al., In Arthritis Research, 1999
... Macrophage identity was confirmed by reactivity of cells with the mouse antihuman mAb, CD11c (Becton Dickinson, Mountain View, CA, USA) ...
Interleukin-17 is a negative regulator of established allergic asthma
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Schnyder Bruno et al., In The Journal of Experimental Medicine, 1998
... The antibodies used for FACS analysis, PE–anti-CD3 (clone 145-2C11), APC–anti-CD11b (clone M1/70), FITC–anti-CD11c (HL3), isotype-matched control antibodies for FACS analysis, and isotype-matched control antibody IgG1a for in vivo application were purchased from BD Biosciences.
Differential Regulation of Cathepsin S and Cathepsin L in Interferon γ–treated Macrophages
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Rudensky Alexander et al., In The Journal of Experimental Medicine, 1997
... To generate CD11c-catL transgenic (tg) mice, purified DNA ...
Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor–associated factors
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Liu Yong-Jun et al., In The Journal of Experimental Medicine, 1995
... The remaining cells were stained with mouse anti– CD4-PE-Cy5 (Immunotech), anti–CD11c-PE (Becton Dickinson ...
Collagen-induced arthritis in mice: synergistic effect of E. coli lipopolysaccharide bypasses epitope specificity in the induction of arthritis with monoclonal antibodies to type II collagen
Supplier
Koteliansky Victor et al., In Molecular therapy. Nucleic acids, 1994
... specific for mouse CD45, CD19, CD11b, CD86, B220, MHCII, TCRb (eBioscience, San Diego, CA), or CD11c (BD Biosciences – Pharmingen) were used ...
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