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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Integrin, alpha E

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, CD8, CD11b, CD25, CAN
Papers on CD103
Reduced numbers of mucosal DR(int) macrophages and increased numbers of CD103(+) dendritic cells during anti-TNF-α treatment in patients with Crohn's disease.
Agnholt et al., Århus, Denmark. In Scand J Gastroenterol, Feb 2016
The numbers of lamina propria CD14 (+) DR(int) and CD14 (+) DR(hi) MQs, CD141(+), CD141(-) and CD103(+ )DCs subsets, and circulating monocytes and DCs were analyzed using flow cytometry.
Imaging of the cross-presenting dendritic cell subsets in the skin-draining lymph node.
Okada et al., Yokohama, Japan. In Proc Natl Acad Sci U S A, Feb 2016
Xcr1-expressing DCs in the SDLNs are composed of two different populations: migratory (CD103(hi)) DCs, which immigrate from the skin, and resident (CD8α(hi)) DCs, which develop in the nodes.
IRF4 and IRF8 Act in CD11c+ Cells To Regulate Terminal Differentiation of Lung Tissue Dendritic Cells.
Kovats et al., Oklahoma City, United States. In J Immunol, Feb 2016
CD11c-cre-Irf8(-/-) mice lacked lung-resident CD103(+) DCs and splenic CD8α(+) DCs, yet harbored increased IRF4-dependent DCs.
Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses.
McKenzie et al., Columbia, United States. In Nat Immunol, Jan 2016
ILC2-derived interleukin 13 (IL-13) is critical for eliciting production of the TH2 cell-attracting chemokine CCL17 by IRF4(+)CD11b(+)CD103(-) dendritic cells (DCs).
T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate.
Carbone et al., Melbourne, Australia. In Immunity, Jan 2016
Here we showed that CD8(+)CD103(+) Trm cells, independent of circulating memory T cells, were sufficient for protection against infection and described molecular elements that were crucial for their development in skin and lung.
Bone marrow and splenic histology in hairy cell leukaemia.
Sena Teixeira Mendes et al., London, United Kingdom. In Best Pract Res Clin Haematol, Dec 2015
The cells stain for B-cell related antigens as well as with antibodies against tartrate-resistant acid phosphatase, DBA44 (CD72), CD11c, CD25, CD103, CD123, cyclin D1 and annexin A1.
Hairy cell leukaemia-variant: Disease features and treatment.
Campo et al., Barcelona, Spain. In Best Pract Res Clin Haematol, Dec 2015
The immunophenotype is that of a clonal B-cell CD11c and CD103 positive but, unlike classical HCL, CD25, CD123 and CD200 negative.
Oral Probiotic VSL#3 Prevents Autoimmune Diabetes by Modulating Microbiota and Promoting Indoleamine 2,3-Dioxygenase-Enriched Tolerogenic Intestinal Environment.
Falcone et al., Milano, Italy. In J Diabetes Res, Dec 2015
Those modifications of the intestinal microenvironment in VSL#3-treated NOD mice modulate gut immunity by promoting differentiation of tolerogenic CD103(+) DCs and reducing differentiation/expansion of Th1 and Th17 cells in the intestinal mucosa and at the sites of autoimmunity, that is, within the pancreatic lymph nodes (PLN) of VSL#3-treated NOD mice.
3,3'-Diindolylmethane Inhibits Flt3L/GM-CSF-induced-bone Marrow-derived CD103(+) Dendritic Cell Differentiation Regulating Phosphorylation of STAT3 and STAT5.
Jeong et al., Ch'angwŏn, South Korea. In Immune Netw, Dec 2015
One mechanism of oral tolerance is mediated by regulatory T cell (Treg)s, of which differentiation is regulated by a subset of dendritic cell (DC)s, primarily CD103(+) DCs.
PI3-Kinase-γ Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development.
Kopf et al., Zürich, Switzerland. In Immunity, Nov 2015
Here we show that the Ras-PI3Kγ-Akt-mTOR signaling axis acted downstream of FLT3L signaling and was required for development of lung CD103(+) DCs and, to a smaller extent, for lung CD11b(+) DCs, but not related DC populations in other non-lymphoid organs.
Distinct Murine Mucosal Langerhans Cell Subsets Develop from Pre-dendritic Cells and Monocytes.
Hovav et al., Jerusalem, Israel. In Immunity, Sep 2015
Mucosal LCs can be segregated into CD103(+)CD11b(lo) (CD103(+)) and CD11b(+)CD103(-) (CD11b(+)) subsets.
Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria.
Spits et al., Amsterdam, Netherlands. In Immunity, Aug 2015
Human group 1 ILCs consist of at least three phenotypically distinct subsets, including NK cells, CD127(+) ILC1, and intraepithelial CD103(+) ILC1.
Essential role for CD103+ cells in the pathogenesis of spondyloarthritides.
Josien et al., Nantes, France. In Joint Bone Spine, 2015
This membrane integrin conjugates the beta7 subunit and the alphaE subunit, also known as CD103.
Dendritic cell and epithelial cell interactions at the origin of murine asthma.
Hammad et al., Gent, Belgium. In Ann Am Thorac Soc, 2014
Migratory conventional DCs (cDCs) expressing CD11b mediate Th2 priming to respiratory allergens, whereas cDCs expressing CD103 mediate tolerance to them.
Profile of CD103 expression in T-cell neoplasms: immunoreactivity is not restricted to enteropathy-associated T-cell lymphoma.
Pinkus et al., Los Angeles, United States. In Am J Surg Pathol, 2014
Intestinal intraepithelial T lymphocytes express the α E subunit of integrin αEβ7, which is detected by antibodies to CD103.
Flt3 ligand expands CD103⁺ dendritic cells and FoxP3⁺ T regulatory cells, and attenuates Crohn's-like murine ileitis.
Rivera-Nieves et al., Aurora, United States. In Gut, 2012
Flt3-ligand administration resulted in a preferential expansion of CD103(+) DC that attenuated the severity of ileitis in 20-week-old TNFDeltaARE mice, mediated by increased CD4(+)/CD25(+)/FoxP3(+) regulatory T cells.
The indispensable role of CCR5 for in vivo suppressor function of tumor-derived CD103+ effector/memory regulatory T cells.
Lin et al., Taiwan. In J Immunol, 2012
Unexpectedly, both CD103-positive and CD103-negative regulatory T cells (Tregs) have similar suppression capacity in vitro.
Mouse CD11bhigh lung dendritic cells have more potent capability to induce IgA than CD103+ lung dendritic cells in vitro.
Chida et al., Hamamatsu, Japan. In Am J Respir Cell Mol Biol, 2012
findings suggest that, of the two major LDCs, CD11b(high) LDCs more efficiently induce IgA than do CD103(+) LDCs, possibly through their potent capacity to produce IgA-inducing cytokines
Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine.
Miller et al., Saint Louis, United States. In Nature, 2012
small intestine goblet cells function as passages delivering low molecular weight soluble antigens from the intestinal lumen to underlying CD103(+) lamina propria-dendritic cells
Pulmonary CD103(+) dendritic cells prime Th2 responses to inhaled allergens.
Cook et al., United States. In Mucosal Immunol, 2012
knock-out mice display diminished Th2 priming to various inhaled allergens
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