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Mannose-6-phosphate receptor

CD-MPR, M6PR, MPR 46, 46-kDa mannose 6-phosphate receptor
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: MPR, ACID, Igf2r, CAN, Insulin
Papers using CD-MPR antibodies
Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1
Irvine Robin F. et al., In Biochemical Journal, 2007
... Polyclonal rabbit anti-giantin antibody and anti-M6PR (mannose-6-phosphate receptor) antibody (both from Abcam) were used at a 1:500 ...
Papers on CD-MPR
Single-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide-specific binding pocket that distinguishes N-glycan phosphorylation in a branch-specific manner†.
Müller-Loennies et al., Atlanta, United States. In Glycobiology, Feb 2016
The acquisition of mannose 6-phosphate (Man6P) on N-linked glycans of lysosomal enzymes is a structural requirement for their transport from the Golgi apparatus to lysosomes mediated by the mannose 6-phosphate receptors, 300 kDa cation-independent mannose 6-phosphate receptor (MPR300) and 46 kDa cation-dependent mannose 6-phosphate receptor (MPR46).
Vps26B-retromer negatively regulates plasma membrane resensitization of PAR-2.
Teasdale et al., Brisbane, Australia. In Cell Biol Int, Nov 2015
Although endosomally associated, Vps26B-retromer does not bind the established retromer transmembrane cargo protein, cation-independent mannose 6-phosphate receptor (CI-M6PR), indicating it has a distinct role to retromer containing the Vps26A paralog.
Functional Networks of Highest-Connected Splice Isoforms: From The Chromosome 17 Human Proteome Project.
Guan et al., Ann Arbor, United States. In J Proteome Res, Oct 2015
Using proteomic data from normal human retina and placenta, we showed that HCIs are a promising indicator of expressed protein isoforms exemplified by NUDFB6 and M6PR.
Differential expression of mannose-6-phosphate receptor regulates T cell contraction.
Xiang et al., Saskatoon, Canada. In J Leukoc Biol, Sep 2015
This study tested the hypothesis that differential cell-surface expression of M6PR, a multifunctional receptor that regulates lysozyme biogenesis, but also uptakes apoptosis-inducing serine-protease Gzm-B, critically determines life vs.
Mannose receptor-mediated delivery of moss-made α-galactosidase A efficiently corrects enzyme deficiency in Fabry mice.
Schaaf et al., Dallas, United States. In J Inherit Metab Dis, Sep 2015
Intravenously infused enzymes are taken up by tissues through either the mannose 6-phosphate receptor (M6PR) or the mannose receptor (MR).
Monitoring receptor trafficking following retromer and WASH deregulation.
Billadeau et al., Rochester, United States. In Methods Cell Biol, 2014
In this chapter, we describe fluorescent- and flow cytometry-based methods for analyzing the recycling and retrograde trafficking of two receptors, α5β1 and CI-M6PR, whose intracellular fates are regulated by WASH and retromer activity.
Direct identification of ligand-receptor interactions on living cells and tissues.
Wollscheid et al., Zürich, Switzerland. In Nat Biotechnol, 2012
Using TRICEPS to label intact mature vaccinia viruses, we identified the cell surface proteins AXL, M6PR, DAG1, CSPG4 and CDH13 as binding factors on human cells.
Rab GTPases regulating receptor trafficking at the late endosome-lysosome membranes.
Tang et al., Singapore, Singapore. In Cell Biochem Funct, 2012
We discuss what is known about the roles of these Rab proteins and their interacting partners on the regulation of traffic of important receptor proteins such as the epidermal growth factor receptor (EGFR) and the mannose 6-phosphate receptor (M6PR), in association with the late endosome-lysosome system.
In vitro human immunodeficiency virus and sperm cell interaction mediated by the mannose receptor.
Rugeles et al., Medellín, Colombia. In J Reprod Immunol, 2011
mediates in vitro human immunodeficiency virus and sperm cell interaction
Enzyme replacement therapy for lysosomal storage diseases.
Lachmann, London, United Kingdom. In Curr Opin Pediatr, 2011
Uptake of recombinant enzyme is via the mannose-6-phosphate receptor (M6PR).
The distribution of mannose-6-phosphate receptors changes from newborns to adults in rat liver.
Sosa et al., Mendoza, Argentina. In Biochem Biophys Res Commun, 2011
This evidence may also suggest that CD-MPR and CI-MPR have different functions, mainly at early stages in the development of organs.
Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody.
Scholler et al., Philadelphia, United States. In Plos One, 2010
Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody
Castration induces changes in the cation-dependent mannose-6-phosphate receptor in rat epididymis: possible implications in secretion of lysosomal enzymes.
Sosa et al., Mendoza, Argentina. In J Cell Biochem, 2010
Data show that the CD-MPR might be regulated by hormones and that this receptor might be involved in the secretion of specific enzymes into the rat epididymis.
Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice.
Salama et al., London, United Kingdom. In J Clin Invest, 2010
Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice
Evolution of mannose 6-phosphate receptors (MPR300 and 46): lysosomal enzyme sorting proteins.
Amancha et al., Hyderābād, India. In Curr Protein Pept Sci, 2010
Lysosomal enzymes undergo phosphorylation on their mannose residues in the Golgi apparatus and are recognized by two distinct type I transmembrane glycoproteins designated as the mannose 6-phosphate receptors; MPR300, (Mr 300 kDa) and MPR46, (Mr 46 kDa) that internally transport them to the lysosomes.
Carbohydrate recognition by the mannose-6-phosphate receptors.
Dahms et al., Milwaukee, United States. In Curr Opin Struct Biol, 2009
The two P-type lectins, the 46kDa cation-dependent mannose-6-phosphate (Man-6-P) receptor (CD-MPR), and the 300kDa cation-independent Man-6-P receptor (CI-MPR), are the founding members of the growing family of mannose-6-phosphate receptor homology (MRH) proteins.
Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.
Kim et al., Milwaukee, United States. In Glycobiology, 2008
The two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues.
A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex.
Hirokawa et al., Tokyo, Japan. In Cell, 2000
The cargo vesicles of KIF13A contained AP-1 and mannnose-6-phosphate receptor (M6PR).
Molecular basis of lysosomal enzyme recognition: three-dimensional structure of the cation-dependent mannose 6-phosphate receptor.
Kim et al., Milwaukee, United States. In Cell, 1998
Targeting of newly synthesized lysosomal hydrolases to the lysosome is mediated by the cation-dependent mannose 6-phosphate receptor (CD-MPR) and the insulin-like growth factor II/cation-independent mannose 6-phosphate receptor (IGF-II/CI-MPR).
Brefeldin A causes a microtubule-mediated fusion of the trans-Golgi network and early endosomes.
Brown et al., Ithaca, United States. In Cell, 1991
In the presence of BFA, a mannose-6-phosphate receptor (M6PR)-enriched tubular network rapidly forms from the TGN, not from the prelysosomal compartment, and can be labeled with endocytic tracers after only 5 min of uptake at either 20 degrees C or 37 degrees C, indicating that it is also functionally an early endosome.
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